University of Salerno, Baronissi, SA, Italy
Institute of Biostructure and Bioimaging (IBB), Italian National Research Council (CNR), Naples, Italy
Azienda Ospedaliera Universitaria OO.RR. San Giovanni di Dio Ruggi d'Aragona, Salerno, Italy
Columbia University Medical Center, New York, NY, United States
References: Santulli, G., Trimarco, B., Iaccarino, G., G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms (2013) High Blood Press Cardiovasc Prev Off J Italian Soc Hypertens, 20 (1), pp. 5-1
Iaccarino, G., Barbato, E., Cipolletta, E., Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure (2005) Eur Heart J, 26 (17), pp. 1752-1758
Penela, P., Ribas, C., Mayor, F., Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases (2003) Cell Signal, 15 (11), pp. 973-981
Hatton, R., Cvjeticanin, A., Lymperopoulos, A., The adrenergic system of the adrenal glands as a remote control of cardiac function (2015) JCvD, 5 (3), pp. 394-397
Kamal, F.A., Travers, J.G., Blaxall, B.C., G protein-coupled receptor kinases in cardiovascular disease: why "where" matters (2012) Trends Cardiovasc Med, 22 (8), pp. 213-219
Mei, Y., Yin, N., Jin, X., He, J., Yin, Z., The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation (2013) Endocrinology, 154 (12), pp. 4640-4649
Lampri, E., Ioachim, E., (2013) Angiogenesis: something old, something new. Angiogenesis: insight from a systematic overview, pp. 1-30. , Nova Science Publishers, G. Santulli (Ed.)
O'Connell, T.D., Jensen, B.C., Baker, A.J., Simpson, P.C., Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance (2014) Pharmacol Rev, 66 (1), pp. 308-333
Ruuskanen, J.O., Laurila, J., Xhaard, H., Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha 2-adrenoceptors (2005) Br J Pharmacol, 144 (2), pp. 165-177
Vicco, M.H., Pujato, N., Bontempi, I., Rodeles, L., Marcipar, I., Bottasso, O.A., Beta1-Selective adrenoceptor antagonists increase plasma levels of Anti-p2beta antibodies and decrease cardiac involvement in chronic progressive chagas heart disease (2014) Can J Cardiol, 30 (3), pp. 332-337
Santulli, G., Iaccarino, G., Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes (2013) Immun Ageing, 10 (1), p. 10
Belge, C., Hammond, J., Dubois-Deruy, E., Enhanced expression of beta3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase (2014) Circulation, 129 (4), pp. 451-462
Xiao, R.P., Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins (2001) Sci STKE, 2001 (104), p. re15
Santulli, G., Lombardi, A., Sorriento, D., Age-related impairment in insulin release: the essential role of beta(2)-adrenergic receptor (2012) Diabetes, 61 (3), pp. 692-701
Kaya, A.I., Onaran, H.O., Ozcan, G., Cell contact-dependent functional selectivity of beta2-adrenergic receptor ligands in stimulating cAMP accumulation and extracellular signal-regulated kinase phosphorylation (2012) J Biol Chem, 287 (9), pp. 6362-6374
Santulli, G., Marks, A.R., Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging (2015) Curr Mol Pharmacol, 8 (2), pp. 206-222
Yuan, Q., Chen, Z., Santulli, G., Functional role of Calstabin2 in age-related cardiac alterations (2014) Sci Rep, 4, p. 7425
Santulli, G., Wronska, A., Uryu, K., A selective microRNA-based strategy inhibits restenosis while preserving endothelial function (2014) J Clin Invest, 124 (9), pp. 4102-4114
Santulli, G., Basilicata, M.F., De Simone, M., Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (2011) J Transl Med, 9, p. 7
Santulli, G., Ciccarelli, M., Palumbo, G., In vivo properties of the proangiogenic peptide QK (2009) J Transl Med, 7, p. 41
Iaccarino, G., Ciccarelli, M., Sorriento, D., AKT participates in endothelial dysfunction in hypertension (2004) Circulation, 109 (21), pp. 2587-2593
Iaccarino, G., Cipolletta, E., Fiorillo, A., Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension (2002) Circulation, 106 (3), pp. 349-355
Santulli, G., Angiopoietin-like proteins: a comprehensive look (2014) Front Endocrinol, 5, p. 4
Boer, C., Scheffer, G.J., de Lange, J.J., Westerhof, N., Sipkema, P., Alpha-1-adrenoceptor stimulation induces nitric oxide release in rat pulmonary arteries (1999) J Vasc Res, 36 (1), pp. 79-81
Guimaraes, S., Moura, D., Vascular adrenoceptors: an update (2001) Pharmacol Rev, 53 (2), pp. 319-356
Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E., Chaudhuri, G., Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide (1987) Proc Natl Acad Sci USA, 84 (24), pp. 9265-9269
Palmer, R.M., Ferrige, A.G., Moncada, S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor (1987) Nature, 327 (6122), pp. 524-526
Bockman, C.S., Gonzalez-Cabrera, I., Abel, P.W., Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats (1996) J Pharmacol Exp Ther, 278 (3), pp. 1235-1243
Queen, L.R., Ji, Y., Xu, B., Mechanisms underlying beta2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells (2006) J Physiol, 576 (2 PART), pp. 585-594
Lembo, G., Iaccarino, G., Vecchione, C., Insulin modulation of an endothelial nitric oxide component present in the alpha2- and beta-adrenergic responses in human forearm (1997) J Clin Invest, 100 (8), pp. 2007-2014
Ozaki, M., Kawashima, S., Yamashita, T., Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice (2002) J Clin Invest, 110 (3), pp. 331-340
Endemann, D.H., Schiffrin, E.L., Endothelial dysfunction (2004) J Am Soc Nephrol, 15 (8), pp. 1983-1992
Bouloumie, A., Bauersachs, J., Linz, W., Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production (1997) Hypertension, 30 (4), pp. 934-941
Forstermann, U., Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies (2008) Nat Clin Pract, 5 (6), pp. 338-349
Lambeth, J.D., NOX enzymes and the biology of reactive oxygen (2004) Nat Rev Immunol, 4 (3), pp. 181-189
Theccanat, T., Philip, J.L., Razzaque, A.M., Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2
The role of NADPH oxidase 4 (2016) Cell Signal, 28 (3), pp. 190-203
Droge, W., Free radicals in the physiological control of cell function (2002) Physiol Rev, 82 (1), pp. 47-95
Gutierrez, J., Ballinger, S.W., Darley-Usmar, V.M., Landar, A., Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells (2006) Circul Res, 99 (9), pp. 924-932
Fu, Y.C., Yin, S.C., Chi, C.S., Hwang, B., Hsu, S.L., Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway (2006) Apoptosis, 11 (11), pp. 2053-2063
Lopez Farre, A., Casado, S., Heart failure, redox alterations, and endothelial dysfunction (2001) Hypertension, 38 (6), pp. 1400-1405
Finkel, T., Reactive oxygen species and signal transduction (2001) IUBMB Life, 52 (1-2), pp. 3-6
Gainetdinov, R.R., Bohn, L.M., Sotnikova, T.D., Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice (2003) Neuron, 38 (2), pp. 291-303
Lyubarsky, A.L., Chen, C., Simon, M.I., Pugh, E.N., Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses (2000) J Neurosci, 20 (6), pp. 2209-2217
Walker, J.K., Gainetdinov, R.R., Feldman, D.S., G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation (2004) Am J Physiol Lung Cell Mol Physiol, 286 (2), pp. L312-L319
Kahsai, A.W., Zhu, S., Fenteany, G., G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells (2010) Biochim Biophys Acta, 1803 (2), pp. 300-310
Chen, Y., Sasai, N., Ma, G., Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened (2011) PLoS Biol, 9 (6)
Lodowski, D.T., Pitcher, J.A., Capel, W.D., Lefkowitz, R.J., Tesmer, J.J., Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma (2003) Science, 300 (5623), pp. 1256-1262
Tesmer, V.M., Kawano, T., Shankaranarayanan, A., Kozasa, T., Tesmer, J.J., Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex (2005) Science, 310 (5754), pp. 1686-1690
Fusco, A., Santulli, G., Sorriento, D., Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (2011) Cell Signal, 24 (2), pp. 468-475
Obrenovich, M.E., Morales, L.A., Cobb, C.J., Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation (2009) J Cell Mol Med, 13 (5), pp. 853-865
Vroon, A., Kavelaars, A., Limmroth, V., G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis (2005) J Immunol, 174 (7), pp. 4400-4406
Iacovelli, L., Franchetti, R., Masini, M., De Blasi, A., GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response (1996) Mol Endocrinol, 10 (9), pp. 1138-1146
Ferrer-Alcon, M., La Harpe, R., Garcia-Sevilla, J.A., Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts (2004) Brain Res Mol Brain Res, 121 (1-2), pp. 114-122
Lombardi, M.S., Kavelaars, A., Cobelens, P.M., Schmidt, R.E., Schedlowski, M., Heijnen, C.J., Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system (2001) J Immunol, 166 (3), pp. 1635-1640
King, D.W., Steinmetz, R., Wagoner, H.A., Differential expression of GRK isoforms in nonmalignant and malignant human granulosa cells (2003) Endocrine, 22 (2), pp. 135-142
Mak, J.C., Chuang, T.T., Harris, C.A., Barnes, P.J., Increased expression of G protein-coupled receptor kinases in cystic fibrosis lung (2002) Eur J Pharmacol, 436 (3), pp. 165-172
Liu, S., Premont, R.T., Kontos, C.D., Zhu, S., Rockey, D.C., A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension (2005) Nat Med, 11 (9), pp. 952-958
Eckhart, A.D., Ozaki, T., Tevaearai, H., Rockman, H.A., Koch, W.J., Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure (2002) Mol Pharmacol, 61 (4), pp. 749-758
Santulli, G., MicroRNAs distinctively regulate vascular smooth muscle and endothelial cells: functional implications in angiogenesis, atherosclerosis, and in-stent restenosis (2015) Adv Exp Med Biol, 887, pp. 53-77
Napolitano, R., Campanile, A., Sarno, L., GRK2 levels in umbilical arteries of pregnancies complicated by gestational hypertension and preeclampsia (2012) Am J Hypertens, 25 (3), pp. 366-371
Maynard, S.E., Min, J.Y., Merchan, J., Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia (2003) J Clin Invest, 111 (5), pp. 649-658
Rana, S., Powe, C.E., Salahuddin, S., Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia (2012) Circulation, 125 (7), pp. 911-919
Abd Alla, J., Graemer, M., Fu, X., Quitterer, U., Inhibition of G-protein-coupled receptor kinase 2 prevents the dysfunctional cardiac substrate metabolism in fatty acid synthase-transgenic mice (2015) J Biol Chem, 291 (6), pp. 2583-2600
Izzo, R., Cipolletta, E., Ciccarelli, M., Enhanced GRK2 expression and desensitization of betaAR vasodilatation in hypertensive patients (2008) Clin Transl Sci, 1 (3), pp. 215-220
Borkowski, K.R., Gros, R., Schneider, H., Vascular beta-adrenoceptor-mediated responses in hypertension and ageing in rats (1992) J Auton Pharmacol, 12 (6), pp. 389-401
Gros, R., Benovic, J.L., Tan, C.M., Feldman, R.D., G-protein-coupled receptor kinase activity is increased in hypertension (1997) J Clin Invest, 99 (9), pp. 2087-2093
Gros, R., Chorazyczewski, J., Meek, M.D., Benovic, J.L., Ferguson, S.S., Feldman, R.D., G-Protein-coupled receptor kinase activity in hypertension: increased vascular and lymphocyte G-protein receptor kinase-2 protein expression (2000) Hypertension, 35 (1), pp. 38-42
Santulli, G., Campanile, A., Spinelli, L., G protein-coupled receptor kinase 2 in patients with acute myocardial infarction (2011) Am J Cardiol, 107 (8), pp. 1125-1130
De Boer, M.P., Meijer, R.I., Wijnstok, N.J., Microvascular dysfunction: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension (2012) Microcirculation, 19 (1), pp. 5-18
Santulli, G., The adrenergic system in cardiovascular metabolism and aging. (2015) The cardiovascular adrenergic system, pp. 97-116. , Springer, New York, NY, A. Lymperopoulos (Ed.)
Usui, I., Imamura, T., Babendure, J.L., G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes (2005) Mol Endocrinol, 19 (11), pp. 2760-2768
Ciccarelli, M., Chuprun, J.K., Rengo, G., G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia (2011) Circulation, 123 (18), pp. 1953-1962
Cipolletta, E., Campanile, A., Santulli, G., The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance (2009) Cardiovasc Res, 84 (3), pp. 407-415
Heinonen, I., Wendelin-Saarenhovi, M., Kaskinoro, K., Knuuti, J., Scheinin, M., Kalliokoski, K.K., Inhibition of alpha-adrenergic tone disturbs the distribution of blood flow in the exercising human limb (2013) Am J Physiol Heart Circul Physiol, 305 (2), pp. H163-H172
Wu, L., Liu, L., Systematic review and meta-analysis evaluating the impact of vitamin D on the risk of heart failure: new evidence from population-based studies (2014) J Cardiovasc Dis, 2 (3), pp. 159-173
Al Maluli, H., DeStephan, C., Hemodynamic monitoring in the intensive care unit (2014) J Cardiovas Dis, 2 (2), pp. 101-115
Santulli, G., Adrenal signaling in heart failure: something more than a distant ship's smoke on the horizon (2014) Hypertension, 63 (2), pp. 215-216
Latini, R., Masson, S., Staszewsky, L., Barlera, S., Neurohormonal modulation in heart failure of ischemic etiology: correlates with left ventricular remodeling (2006) Curr Heart Fail Rep, 3 (4), pp. 157-163
Sardu, C., Marfella, R., Santulli, G., Paolisso, G., Functional role of miRNA in cardiac resynchronization therapy (2014) Pharmacogenomics, 15 (8), pp. 1159-1168
Senni, M., Paulus, W.J., Gavazzi, A., New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes (2014) Eur Heart J, 35 (40), pp. 2797-2815
Lymperopoulos, A., Chowdhary, S., Sankar, K., Simon, I., Regulation of catecholamine production from the adrenal medulla (2015) Adrenal glands: from pathophysiology to clinical evidence, , Nova Science Publisher, New York, NY, G. Santulli (Ed.)
Perez-Alvarez, A., Hernandez-Vivanco, A., Albillos, A., Past, present and future of human chromaffin cells: role in physiology and therapeutics (2010) Cell Mol Neurobiol, 30 (8), pp. 1407-1415
Chung, M., Song, J., Imaging of adrenal gland (2015) Adrenal glands: from pathophysiology to clinical evidence, , Nova Science Publisher, New York, NY, G. Santulli (Ed.)
Deo, S.H., Jenkins, N.T., Padilla, J., Parrish, A.R., Fadel, P.J., Norepinephrine increases NADPH oxidase-derived superoxide in human peripheral blood mononuclear cells via alpha-adrenergic receptors (2013) Am J Physiol Regul Integr Comp Physiol, 305 (10), pp. R1124-R1132
Ma, Y., Krueger, J.J., Redmon, S.N., Extracellular norepinephrine clearance by the norepinephrine transporter is required for skeletal homeostasis (2013) J Biol Chem, 288 (42), pp. 30105-30113
Thireau, J., Karam, S., Roberge, S., Beta-adrenergic blockade combined with subcutaneous B-type natriuretic peptide: a promising approach to reduce ventricular arrhythmia in heart failure? (2014) Heart, 100 (11), pp. 833-841
Staroukine, M., Devriendt, J., Decoodt, P., Verniory, A., Relationships between plasma epinephrine, norepinephrine, dopamine and angiotensin II concentrations, renin activity, hemodynamic state and prognosis in acute heart failure (1984) Acta Cardiol, 39 (2), pp. 131-138
Shiny, K.S., Kumar, S.H., Farvin, K.H., Anandan, R., Devadasan, K., Protective effect of taurine on myocardial antioxidant status in isoprenaline-induced myocardial infarction in rats (2005) J Pharm Pharmacol, 57 (10), pp. 1313-1317
Huang, C.J., Webb, H.E., Zourdos, M.C., Acevedo, E.O., Cardiovascular reactivity, stress, and physical activity (2013) Front Physiol, 4, p. 314
Weng, T.P., Fu, T.C., Wang, C.H., Hsu, C.C., Wang, J.S., Activation of lymphocyte autophagy/apoptosis reflects haemodynamic inefficiency and functional aerobic impairment in patients with heart failure (2014) Clin Sci, 127 (10), pp. 589-602
Berezin, A., Kremzer, A., Samura, T., Martovitskaya, Y., Apoptotic microparticles to progenitor mononuclear cells ratio in heart failure: relevance of clinical status and outcomes (2014) J Cardiovasc Dis, 2 (2), pp. 50-57
Sorriento, D., Santulli, G., Del Giudice, C., Anastasio, A., Trimarco, B., Iaccarino, G., Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (2012) Hypertension, 60 (1), pp. 129-136
Ciccarelli, M., Santulli, G., Campanile, A., Endothelial alpha1-adrenoceptors regulate neo-angiogenesis (2008) Br J Pharmacol, 153 (5), pp. 936-946
Gao, W., Li, J., Femoral artery occlusion increases muscle pressor reflex and expression of hypoxia-inducible factor-1? in sensory neurons (2014) J Cardiovascu Dis, 1 (2), pp. 34-40
Buroker, N., ADRBK1 (GRK2) rSNPs, transcriptional factor binding sites and cardiovascular disease in the black population (2014) J Cardiovasc Dis, 2 (2), pp. 62-67
Santulli, G., Coronary heart disease risk factors and mortality (2012) JAMA J Am Med Assoc, 307 (11), p. 1137
Szepietowska, B., Zhu, W., Czyzyk, J., Eid, T., Sherwin, R.S., EphA5-EphrinA5 interactions within the ventromedial hypothalamus influence counterregulatory hormone release and local glutamine/glutamate balance during hypoglycemia (2013) Diabetes, 62 (4), pp. 1282-1288
Neglia, D., De Caterina, A., Marraccini, P., Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy (2007) Am J Physiol Heart Circul Physiol, 293 (6), pp. H3270-H3278
Dias, P., Terracciano, C.M., Hyperpolarization-activated cyclic nucleotide-gated channels and ventricular arrhythmias in heart failure: a novel target for therapy? (2013) J Am Heart Assoc, 2 (3)
Li, Y.F., Shi, S.T., Age-dependent differential crosstalk between alpha(1)-adrenergic and angiotensin receptors (2009) Can J Cardiol, 25 (8), pp. 481-485
Chakraborty, M., Phillips, A., Macdonald, J., Windsor, J., Hickey, A., Mitochondrial respiration in mononuclear cells and heart fibers in spontaneously hypertensive rats (2014) J Cardiovascu Dis, 2 (1), pp. 7-14
Leone, T.C., Kelly, D.P., Transcriptional control of cardiac fuel metabolism and mitochondrial function (2011) Cold Spring Harbor Symp Quant Biol, 76, pp. 175-182
Fu, Q., Xu, B., Liu, Y., Insulin inhibits cardiac contractility by inducing a Gi-biased beta2 adrenergic signaling in hearts (2014) Diabetes, 63 (8), pp. 2676-2689
Msolly, A., Miled, A., Kassab, A., Hydrogen peroxide: an oxidant stress indicator in type 2 diabetes mellitus (2014) J Cardiovasc Dis, 1 (2), pp. 48-52
Oriente, F., Iovino, S., Cassese, A., Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression (2009) Diabetologia, 52 (12), pp. 2642-2652
Azevedo, P.S., Minicucci, M.F., Santos, P.P., Paiva, S.A., Zornoff, L.A., Energy metabolism in cardiac remodeling and heart failure (2013) Cardiol Rev, 21 (3), pp. 135-140
Shimizu, I., Minamino, T., Toko, H., Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents (2010) J Clin Invest, 120 (5), pp. 1506-1514
Badimon, L., Hernandez Vera, R., Vilahur, G., Determinants of cardiovascular risk in diabetes beyond hyperglycemia (2014) J Cardiovasc Dis, 1 (2), pp. 53-62
Masuo, K., Rakugi, H., Ogihara, T., Lambert, G.W., Different mechanisms in weight loss-induced blood pressure reduction between a calorie-restricted diet and exercise (2012) Hypertens Res Off J Jpn Soc Hypertens, 35 (1), pp. 41-47
Santulli, G., Effects of low-carbohydrate and low-fat diets (2015) Ann Int Med, 162 (5), p. 392
Quinones, M.J., Nicholas, S.B., Lyon, C.J., Insulin resistance and the endothelium (2005) Curr Diabetes Rep, 5 (4), pp. 246-253
Mongillo, M., John, A.S., Leccisotti, L., Pennell, D.J., Camici, P.G., Myocardial pre-synaptic sympathetic function correlates with glucose uptake in the failing human heart (2007) Eur J Nucl Med Mol Imaging, 34 (8), pp. 1172-1177
Larsen, T.M., Toubro, S., van Baak, M.A., Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men (2002) Am J Clin Nutr, 76 (4), pp. 780-788
Sorriento, D., Ciccarelli, M., Santulli, G., Illario, M., Trimarco, B., Iaccarino, G., Trafficking GRK2: cellular and metabolic consequences of GRK2 subcellular localization (2014) Transl Med UniSa, 10, pp. 3-7
Horinouchi, T., Hoshi, A., Harada, T., Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via G protein-coupled receptor kinase 2 in skeletal muscle cells (2016) Br J Pharmacol, 173 (6), pp. 1018-1032
Lucas, E., Cruces-Sande, M., Briones, A.M., Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2 (2015) Arch Physiol Biochem, 121 (5), pp. 163-177
Mehta, N., Cheng, A.H., Chiang, C.K., GRK2 fine-tunes circadian clock speed and entrainment via transcriptional and post-translational control of PERIOD proteins (2015) Cell Rep, 12 (8), pp. 1272-1288
Chen, M., Sato, P.Y., Chuprun, J.K., Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting (2013) Circul Res, 112 (8), pp. 1121-1134
Taguchi, K., Sakata, K., Ohashi, W., Imaizumi, T., Imura, J., Hattori, Y., Tonic inhibition by G protein-coupled receptor kinase 2 of Akt/endothelial nitric-oxide synthase signaling in human vascular endothelial cells under conditions of hyperglycemia with high insulin levels (2014) J Pharmacol Exp Ther, 349 (2), pp. 199-208
Hata, J.A., Williams, M.L., Koch, W.J., Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization (2004) J Mol Cell Cardiol, 37 (1), pp. 11-21
Santulli, G., Xie, W., Reiken, S.R., Marks, A.R., Mitochondrial calcium overload is a key determinant in heart failure (2015) Proc Natl Acad Sci USA, 112 (36), pp. 11389-11394
Wisneski, J.A., Gertz, E.W., Neese, R.A., Mayr, M., Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans (1987) J Clin Invest, 79 (2), pp. 359-366
Bing, R.J., Siegel, A., Ungar, I., Gilbert, M., Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism (1954) Am J Med, 16 (4), pp. 504-515
Neubauer, S., The failing heart-an engine out of fuel (2007) New Engl J Med, 356 (11), pp. 1140-1151
Kolwicz, S.C., Tian, R., Metabolic therapy at the crossroad: how to optimize myocardial substrate utilization? (2009) Trends Cardiovasc Med, 19 (6), pp. 201-207
Eisenhofer, G., Friberg, P., Rundqvist, B., Cardiac sympathetic nerve function in congestive heart failure (1996) Circulation, 93 (9), pp. 1667-1676
Opie, L.H., Thandroyen, F.T., Muller, C., Bricknell, O.L., Adrenaline-induced "oxygen-wastage" and enzyme release from working rat heart. Effects of calcium antagonism, beta-blockade, nicotinic acid and coronary artery ligation (1979) J Mol Cell Cardiol, 11 (10), pp. 1073-1094
Sasaoka, T., Wada, T., Tsuneki, H., Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity (2006) Pharmacol Ther, 112 (3), pp. 799-809
Banerjee, S., Peterson, L.R., Myocardial metabolism and cardiac performance in obesity and insulin resistance (2007) Curr Cardiol Rep, 9 (2), pp. 143-149
Wagenmakers, A.J., van Riel, N.A., Frenneaux, M.P., Stewart, P.M., Integration of the metabolic and cardiovascular effects of exercise (2006) Essays Biochem, 42, pp. 193-210
Xiao, R.P., Cheng, H., Zhou, Y.Y., Kuschel, M., Lakatta, E.G., Recent advances in cardiac beta(2)-adrenergic signal transduction (1999) Circul Res, 85 (11), pp. 1092-1100
Baruscotti, M., Barbuti, A., Bucchi, A., The cardiac pacemaker current (2010) J Mol Cell Cardiol, 48 (1), pp. 55-64
Santulli, G., Totary-Jain, H., Tailoring mTOR-based therapy: molecular evidence and clinical challenges (2013) Pharmacogenomics, 14 (12), pp. 1517-1526
Perino, A., Ghigo, A., Ferrero, E., Integrating cardiac PIP(3) and cAMP signaling through a PKA anchoring function of p110gamma (2011) Mol Cell, 42 (1), pp. 84-95
Philipson, L.H., Beta-Agonists and metabolism (2002) J Allergy Clin Immunol, 110 (6), pp. S313-S317
Ngala, R.A., O'Dowd, J., Wang, S.J., Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and beta2-adrenoceptor mechanisms (2008) Br J Pharmacol, 155 (3), pp. 395-406
Jo, S.H., Leblais, V., Wang, P.H., Crow, M.T., Xiao, R.P., Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation (2002) Circul Res, 91 (1), pp. 46-53
Zhu, W.Z., Zheng, M., Koch, W.J., Lefkowitz, R.J., Kobilka, B.K., Xiao, R.P., Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes (2001) Proc Natl Acad Sci USA, 98 (4), pp. 1607-1612
Sakamoto, K., Holman, G.D., Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic (2008) Am J Physiol, 295 (1), pp. E29-E37
Maarbjerg, S.J., Sylow, L., Richter, E.A., Current understanding of increased insulin sensitivity after exercise - emerging candidates (2011) Acta Physiol (Oxford, England), 202 (3), pp. 323-335
Perez-Schindler, J., Philp, A., Baar, K., Hernandez-Cascales, J., Regulation of contractility and metabolic signaling by the beta2-adrenergic receptor in rat ventricular muscle (2011) Life Sci, 88 (1-2), pp. 892-897
Hardie, D.G., Ross, F.A., Hawley, S.A., AMPK: a nutrient and energy sensor that maintains energy homeostasis (2012) Nat Rev, 13 (4), pp. 251-262
Nikolaidis, L.A., Poornima, I., Parikh, P., Magovern, M., Shen, Y.T., Shannon, R.P., The effects of combined versus selective adrenergic blockade on left ventricular and systemic hemodynamics, myocardial substrate preference, and regional perfusion in conscious dogs with dilated cardiomyopathy (2006) J Am College Cardiol, 47 (9), pp. 1871-1881
Santulli, G., Cipolletta, E., Sorriento, D., CaMK4 gene deletion induces hypertension (2012) J Am Heart Assoc, 1 (4)
Opie, L.H., Commerford, P.J., Gersh, B.J., Pfeffer, M.A., Controversies in ventricular remodelling (2006) Lancet (London, England), 367 (9507), pp. 356-367
Heusch, G., Libby, P., Gersh, B., Cardiovascular remodelling in coronary artery disease and heart failure (2014) Lancet, 383 (9932), pp. 1933-1943
Ganau, A., Devereux, R.B., Roman, M.J., Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension (1992) J Am College Cardiol, 19 (7), pp. 1550-1558
Gerdes, A.M., Kellerman, S.E., Moore, J.A., Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy (1992) Circulation, 86 (2), pp. 426-430
Pfeffer, M.A., Braunwald, E., Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications (1990) Circulation, 81 (4), pp. 1161-1172
Lorell, B.H., Carabello, B.A., Left ventricular hypertrophy: pathogenesis, detection, and prognosis (2000) Circulation, 102 (4), pp. 470-479
Foppa, M., Duncan, B.B., Rohde, L.E., Echocardiography-based left ventricular mass estimation. How should we define hypertrophy? (2005) Cardiovasc Ultrasound, 3, p. 17
Tarone, G., Balligand, J.L., Bauersachs, J., Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology (2014) Eur J Heart Fail, 16 (5), pp. 494-508
Brodde, O.E., Michel, M.C., Zerkowski, H.R., Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure (1995) Cardiovasc Res, 30 (4), pp. 570-584
Xiao, R.P., Avdonin, P., Zhou, Y.Y., Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes (1999) Circul Res, 84 (1), pp. 43-52
Devic, E., Xiang, Y., Gould, D., Kobilka, B., Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice (2001) Mol Pharmacol, 60 (3), pp. 577-583
Pavoine, C., Behforouz, N., Gauthier, C., Beta2-adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway (2003) Mol Pharmacol, 64 (5), pp. 1117-1125
Moniotte, S., Kobzik, L., Feron, O., Trochu, J.N., Gauthier, C., Balligand, J.L., Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium (2001) Circulation, 103 (12), pp. 1649-1655
Kohout, T.A., Takaoka, H., McDonald, P.H., Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice (2001) Circulation, 104 (20), pp. 2485-2491
Moens, A.L., Leyton-Mange, J.S., Niu, X., Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor (2009) J Mol Cell Cardiol, 47 (5), pp. 576-585
Port, J.D., Bristow, M.R., Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure (2001) J Mol Cell Cardiol, 33 (5), pp. 887-905
Nikolaev, V.O., Moshkov, A., Lyon, A.R., Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation (2010) Science New York, NY, 327 (5973), pp. 1653-1657
Nevzorova, J., Evans, B.A., Bengtsson, T., Summers, R.J., Multiple signalling pathways involved in beta2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells (2006) Br J Pharmacol, 147 (4), pp. 446-454
Koch, W.J., Rockman, H.A., Samama, P., Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor (1995) Science New York, NY, 268 (5215), pp. 1350-1353
Ciccarelli, M., Cipolletta, E., Iaccarino, G., GRK2 at the control shaft of cellular metabolism (2012) Curr Pharm Des, 18 (2), pp. 121-127
Anis, Y., Leshem, O., Reuveni, H., Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes (2004) Diabetologia, 47 (7), pp. 1232-1244
Sorriento, D., Fusco, A., Ciccarelli, M., Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (2013) FEBS Lett, 587 (21), pp. 3487-3494
Obrenovich, M.E., Smith, M.A., Siedlak, S.L., Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions (2006) Neurotox Res, 10 (1), pp. 43-56
Cheng, J.W., A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination (2006) Clin Ther, 28 (5), pp. 666-678
Oparil, S., Davis, B.R., Cushman, W.C., Mortality and morbidity during and after Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: results by sex (2013) Hypertension, 61 (5), pp. 977-986
Gavras, I., Manolis, A.J., Gavras, H., The alpha2 -adrenergic receptors in hypertension and heart failure: experimental and clinical studies (2001) J Hypertens, 19 (12), pp. 2115-2124
Pocock, S., Wilhelmsen, L., Dickstein, K., Francis, G., Wittes, J., The data monitoring experience in the MOXCON trial (2004) Eur Heart J, 25 (22), pp. 1974-1978
Frantz, R.P., Lowes, B.D., Grayburn, P.A., Baseline and serial neurohormones in patients with congestive heart failure treated with and without bucindolol: results of the neurohumoral substudy of the Beta-Blocker Evaluation of Survival Study (BEST) (2007) J Card Fail, 13 (6), pp. 437-444
Deneer, V.H., van Hemel, N.M., Is antiarrhythmic treatment in the elderly different? a review of the specific changes (2011) Drugs Aging, 28 (8), pp. 617-633
Wong, G.W., Laugerotte, A., Wright, J.M., Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension (2015) Cochrane Database Syst Rev, 8
Ellison, K.E., Gandhi, G., Optimising the use of beta-adrenoceptor antagonists in coronary artery disease (2005) Drugs, 65 (6), pp. 787-797
Santulli, G., Beta-Blockers in diabetic patients with heart failure (2015) JAMA Intern Med, 175 (4), p. 657
Lazalde-Ramos, B.P., Martinez-Fierro Mde, L., Galaviz-Hernandez, C., CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico (2014) Pharmacogenomics, 15 (3), pp. 339-348
Rossello, X., Pocock, S.J., Julian, D.G., Long-term use of cardiovascular drugs: challenges for research and for patient care (2015) J Am Coll Cardiol, 66 (11), pp. 1273-1285
Santulli, G., Sympathetic nervous system signaling in heart failure and cardiac aging (2015) Pathophysiology and pharmacotherapy of cardiovascular disease, pp. 83-105. , Springer, G. Jagadeesh (Ed.)
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(349 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote