Therapeutic Potential of a Novel alphavbeta(3) Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type (422 views) (PDF public 117 views)
Cancers (ISSN: 2072-6694linking), 2019 Jan 24; 11(2): 139-139.
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Paper type: Journal Article,
Impact factor: 6.126, 5-year impact factor: 0
Url: Not available.
Keywords: Cell Migration And Invasion, Epithelial-Mesenchymal Transition, Stemness, Triple-Negative Breast Cancer, Alphavbeta3 Integrin, Psirgdechi,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. billy.hill@ibb.cnr.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. achiara.sarnella@gmail.com., Dipartimento di Farmacia, Universita degli Studi di Napoli "Federico II", 80131 Naples, Italy. domenica.capasso@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. daniela.comegna@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. annarita.delgatto@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. matteo.gramanzini@ibb.cnr.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. sandra.albanese@ibb.cnr.it., Istituto di Cristallografia-CNR, 70126 Bari, Italy. msaviano@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. lzaccaro@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. antonella.zannetti@cnr.it.,
References:
Not available.
Cancers (ISSN: 2072-6694linking), 2019 Jan 24; 11(2): 139-139.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.126, 5-year impact factor: 0
Url: Not available.
Keywords: Cell Migration And Invasion, Epithelial-Mesenchymal Transition, Stemness, Triple-Negative Breast Cancer, Alphavbeta3 Integrin, Psirgdechi,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. billy.hill@ibb.cnr.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. achiara.sarnella@gmail.com., Dipartimento di Farmacia, Universita degli Studi di Napoli "Federico II", 80131 Naples, Italy. domenica.capasso@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. daniela.comegna@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. annarita.delgatto@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. matteo.gramanzini@ibb.cnr.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. sandra.albanese@ibb.cnr.it., Istituto di Cristallografia-CNR, 70126 Bari, Italy. msaviano@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. lzaccaro@unina.it., Istituto di Biostrutture e Bioimmagini-CNR, 80145 Naples, Italy. antonella.zannetti@cnr.it.,
References:
Not available.
Therapeutic Potential of a Novel alphavbeta(3) Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type
The mesenchymal sub-type of triple negative breast cancer (MES-TNBC) has a highly aggressive behavior and worse prognosis, due to its invasive and stem-like features, that correlate with metastatic dissemination and resistance to therapies. Furthermore, MES-TNBC is characterized by the expression of molecular markers related to the epithelial-to-mesenchymal transition (EMT) program and cancer stem cells (CSCs). The altered expression of alphavbeta(3) integrin has been well established as a driver of cancer progression, stemness, and metastasis. Here, we showed that the high levels of alphavbeta(3) are associated with MES-TNBC and therefore exploited the possibility to target this integrin to reduce the aggressiveness of this carcinoma. To this aim, MES-TNBC cells were treated with a novel peptide, named psiRGDechi, that we recently developed and characterized for its ability to selectively bind and inhibit alphavbeta(3) integrin. Notably, psiRGDechi was able to hamper adhesion, migration, and invasion of MES-TNBC cells, as well as the capability of these cells to form vascular-like structures and mammospheres. In addition, this peptide reversed EMT program inhibits mesenchymal markers. These findings show that targeting alphavbeta(3) integrin by psiRGDechi, it is possible to inhibit some of the malignant properties of MES-TNBC phenotype.
The mesenchymal sub-type of triple negative breast cancer (MES-TNBC) has a highly aggressive behavior and worse prognosis, due to its invasive and stem-like features, that correlate with metastatic dissemination and resistance to therapies. Furthermore, MES-TNBC is characterized by the expression of molecular markers related to the epithelial-to-mesenchymal transition (EMT) program and cancer stem cells (CSCs). The altered expression of alphavbeta(3) integrin has been well established as a driver of cancer progression, stemness, and metastasis. Here, we showed that the high levels of alphavbeta(3) are associated with MES-TNBC and therefore exploited the possibility to target this integrin to reduce the aggressiveness of this carcinoma. To this aim, MES-TNBC cells were treated with a novel peptide, named psiRGDechi, that we recently developed and characterized for its ability to selectively bind and inhibit alphavbeta(3) integrin. Notably, psiRGDechi was able to hamper adhesion, migration, and invasion of MES-TNBC cells, as well as the capability of these cells to form vascular-like structures and mammospheres. In addition, this peptide reversed EMT program inhibits mesenchymal markers. These findings show that targeting alphavbeta(3) integrin by psiRGDechi, it is possible to inhibit some of the malignant properties of MES-TNBC phenotype.
Therapeutic Potential of a Novel alphavbeta(3) Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type
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Therapeutic Potential of a Novel alphavbeta(3) Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type
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View Export to BibTeX Export to EndNote
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Impact Factor: 8.537
View Export to BibTeX Export to EndNote
Comegna D, Zannetti A, Del Gatto A, De Paola I, Russo L, Di Gaetano S, Liguoro A, Capasso D, Saviano M, Zaccaro L
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Impact Factor: 6.253
View Export to BibTeX Export to EndNote
Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
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Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
View Export to BibTeX Export to EndNote
Hill BS, Pelagalli A, Passaro N, Zannetti A
* Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype (347 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Sep 22; 8(42): 73296-73311.
Impact Factor: 5.168
View Export to BibTeX Export to EndNote
Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A
* Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (778 views) (PDF 225 views)
Theranostics (ISSN: 1838-7640, 1838-7640electronic), 2017 Aug 22; 7(14): 3595-3607.
Impact Factor: 8.537
View Export to BibTeX Export to EndNote
Camorani S, Crescenzi E, Gramanzini M, Fedele M, Zannetti A, Cerchia L
* Aptamer-mediated impairment of EGFR-integrin alphavbeta3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers (542 views) (PDF 236 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Apr 20; 7: 46659-46659.
Impact Factor: 4.122
View Export to BibTeX Export to EndNote
Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (1067 views) (PDF 304 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
View Export to BibTeX Export to EndNote
Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (528 views) (PDF 257 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Apr 4; 4(6): e578-e578.
Impact Factor: 5.333
View Export to BibTeX Export to EndNote
Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (634 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
View Export to BibTeX Export to EndNote
Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (585 views)
J Transl Med (ISSN: 1479-5876electronic, 1479-5876linking), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
17 Records (16 excluding Abstracts).
Total impact factor: 100.607 (95.274 excluding Abstracts).
Total 5 year impact factor: 79.939 (74.606 excluding Abstracts).
Total impact factor: 100.607 (95.274 excluding Abstracts).
Total 5 year impact factor: 79.939 (74.606 excluding Abstracts).
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