Rifabutin-Based Rescue Therapy for Helicobacter pylori Eradication: A Long-Term Prospective Study in a Large Cohort of Difficult-to-Treat Patients (512 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2019 Feb 6; 8(2): N/D-N/D.
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Paper type: Journal Article,
Impact factor: 5.583, 5-year impact factor: 0
Url: Not available.
Keywords: Helicobacter Pylori, Dyspepsia, Gastric Cancer, Gastritis, Peptic Ulcer, Rifabutin,
Affiliations:
*** IBB - CNR ***
Department of Surgical Sciences, University of Turin, 10123 Turin, Italy. davrib_1998@yahoo.com., Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, 10126 Turin, Italy. sharmila.fagoonee@unito.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. marcoastegiano58@gmail.com., Department of Medical Sciences, University of Turin, 10123 Turin, Italy. marilena.durazzo@unito.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. amorgando@cittadellasalute.to.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. sprujevnik@yahoo.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. chiaragiordanino@libero.it., Unit of Gastroenterology, Maria Vittoria Hospital, 10100 Turin, Italy. monica.baronio@aslto2.piemonte.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. eusdeang@hotmail.com., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. giorgiomaria.saracco@unito.it., Department of Medical Sciences, University of Turin, 10123 Turin, Italy. giorgiomaria.saracco@unito.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. rinaldo_pellican@hotmail.com.,
Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, 10126 Turin, Italy. sharmila.fagoonee@unito.it.
Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. marcoastegiano58@gmail.com.
Department of Medical Sciences, University of Turin, 10123 Turin, Italy. marilena.durazzo@unito.it.
References:
Not available.
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2019 Feb 6; 8(2): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.583, 5-year impact factor: 0
Url: Not available.
Keywords: Helicobacter Pylori, Dyspepsia, Gastric Cancer, Gastritis, Peptic Ulcer, Rifabutin,
Affiliations:
*** IBB - CNR ***
Department of Surgical Sciences, University of Turin, 10123 Turin, Italy. davrib_1998@yahoo.com., Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, 10126 Turin, Italy. sharmila.fagoonee@unito.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. marcoastegiano58@gmail.com., Department of Medical Sciences, University of Turin, 10123 Turin, Italy. marilena.durazzo@unito.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. amorgando@cittadellasalute.to.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. sprujevnik@yahoo.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. chiaragiordanino@libero.it., Unit of Gastroenterology, Maria Vittoria Hospital, 10100 Turin, Italy. monica.baronio@aslto2.piemonte.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. eusdeang@hotmail.com., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. giorgiomaria.saracco@unito.it., Department of Medical Sciences, University of Turin, 10123 Turin, Italy. giorgiomaria.saracco@unito.it., Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. rinaldo_pellican@hotmail.com.,
Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, 10126 Turin, Italy. sharmila.fagoonee@unito.it.
Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy. marcoastegiano58@gmail.com.
Department of Medical Sciences, University of Turin, 10123 Turin, Italy. marilena.durazzo@unito.it.
References:
Not available.
Rifabutin-Based Rescue Therapy for Helicobacter pylori Eradication: A Long-Term Prospective Study in a Large Cohort of Difficult-to-Treat Patients
The most commonly used regimens fail to eradicate Helicobacter pylori (H. pylori) infection in 5⁻10% of patients. Those not cured with treatments based on amoxicillin, clarithromycin, nitroimidazoles, fluoroquinolones, bismuth or tetracycline have no other conventional options thereafter. In this prospective long-term monocentric study, patients who failed to eradicate H. pylori following treatment with all conventional antibiotics were included. All subjects were treated with rifabutin 150 mg, amoxicillin 1 g and a standard dose of proton pump inhibitor, twice daily for 14 days. A negative (13)C-urea breath test was used four weeks after treatment completion as an index of H. pylori eradication. Three hundred and two patients were included. Fifty-four percent (164/302) had peptic ulcer disease while 45.7% (138/302) had gastritis or functional dyspepsia. Per-protocol eradication and intention-to-treat eradication were achieved in 72.7% and 71.5%, respectively. A univariate analysis showed that gender, ethnic background, smoking habits and familial history of gastric diseases were not predictive factors of response, while with multiple logistic regression analysis, the ethnic background (Italian) predicted a poor response in the second period of the study (2010⁻2017). In conclusion, this study on a large cohort of very difficult-to-treat patients showed that rifabutin-based rescue therapy is an acceptable and safe strategy after multiple eradication failures with conventional antibiotics.
The most commonly used regimens fail to eradicate Helicobacter pylori (H. pylori) infection in 5⁻10% of patients. Those not cured with treatments based on amoxicillin, clarithromycin, nitroimidazoles, fluoroquinolones, bismuth or tetracycline have no other conventional options thereafter. In this prospective long-term monocentric study, patients who failed to eradicate H. pylori following treatment with all conventional antibiotics were included. All subjects were treated with rifabutin 150 mg, amoxicillin 1 g and a standard dose of proton pump inhibitor, twice daily for 14 days. A negative (13)C-urea breath test was used four weeks after treatment completion as an index of H. pylori eradication. Three hundred and two patients were included. Fifty-four percent (164/302) had peptic ulcer disease while 45.7% (138/302) had gastritis or functional dyspepsia. Per-protocol eradication and intention-to-treat eradication were achieved in 72.7% and 71.5%, respectively. A univariate analysis showed that gender, ethnic background, smoking habits and familial history of gastric diseases were not predictive factors of response, while with multiple logistic regression analysis, the ethnic background (Italian) predicted a poor response in the second period of the study (2010⁻2017). In conclusion, this study on a large cohort of very difficult-to-treat patients showed that rifabutin-based rescue therapy is an acceptable and safe strategy after multiple eradication failures with conventional antibiotics.
Rifabutin-Based Rescue Therapy for Helicobacter pylori Eradication: A Long-Term Prospective Study in a Large Cohort of Difficult-to-Treat Patients
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Rifabutin-Based Rescue Therapy for Helicobacter pylori Eradication: A Long-Term Prospective Study in a Large Cohort of Difficult-to-Treat Patients
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Impact Factor: 1.29
View Export to BibTeX Export to EndNote
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Minerva Gastroenterol Dietol (ISSN: 1827-1642electronic, 1121-421xlinking), 2018 Sep; 64(3): 235-250.
Impact Factor: 1.29
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.102
View Export to BibTeX Export to EndNote
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Impact Factor: 1.29
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (830 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 13; 8(11): e79455-e79455.
Impact Factor: 3.534
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Camera L, Calabrese M, Romeo V, Scordino F, Mainenti PP, Clemente M, Rapicano G, Salvatore M
* Perforated duodenal ulcer presenting with a subphrenic abscess revealed by plain abdominal X-ray films and confirmed by multi-detector computed tomography: A case report (497 views)
J Med Case Rep (ISSN: 1752-1947, 1752-1947linking), 2013 Nov 11; 7: 257-257.
Impact Factor: 0.895
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Savi L, Ribaldone DG, Fagoonee S, Pellicano R
* Is Helicobacter pylori the infectious trigger for headache?: A review (358 views)
Infect Disord Drug Targets (ISSN: 2212-3989electronic, 1871-5265linking), 2013 Oct; 13(5): 313-317.
Impact Factor: 0
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Avitabile C, Capparelli R, Rigano MM, Fulgione A, Barone A, Pedone C, Romanelli A
* Antimicrobial peptides from plants: Stabilization of the γ core of a tomato defensin by intramolecular disulfide bond (1126 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 240-245.
Impact Factor: 1.862
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Esposito L, Seydel A, Aiello R, Sorrentino G, Cendron L, Zanotti G, Zagari
* The crystal structure of the superoxide dismutase from Helicobacter pylori reveals a structured C-terminal extension (517 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Nov; 1784(11): 1601-1606.
Impact Factor: 2.233
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Loguercio S, Dian C, Flagiello A, Scannella A, Pucci P, Terradot L, Zagari A
* In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure (330 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2008 Oct 15; 582(23-24): 3537-3541.
Impact Factor: 3.264
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Esposito G, Tempesta A, Galati MG, De Bellis M, Rossi GB, Potena MI, Marone P, Daniele B, Del Vecchio S
Mucosal expression of carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with gastritis and gastric cancer (409 views)
Cancer Detect Prev (ISSN: 0361-090x, 0361-090xlinking), 1999; 23(2): 116-122.
Impact Factor: 0.927
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Perrella O, Liguori G, Cattaneo D, Morelli L, Precchia E, Morisco E, Fonti R, Marinelli P
Ig antibody levels to Helicobacter pylori and histology of antral gastritis and duodenal ulcer: What is the correlation? (363 views)
G Mal Infett Parassit (ISSN: 0017-0321), 1992; 44(1): 65-68.
Impact Factor: 0
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Perrella O, Liguori G, Cattaneo D, Morelli L, Precchia E, Morisco E, Fonti R, Marinelli P
Ig antibody levels to Helicobacter pylori and histology of antral gastritis and duodenal ulcer: What is the correlation? [LIVELLI DI IG AD ISOTIPO DIVERSO E QUADRO ISTOLOGICO NELLA PATOLOGIA GASTRICA ASSOCIATA ALL'HELICOBACTER PYLORI: QUALE CORRELAZIONE?] (465 views)
G Mal Infett Parassit (ISSN: 0017-0321), 1992; 44: 65-68.
Impact Factor: 0
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27 Records (25 excluding Abstracts).
Total impact factor: 181.806 (180.911 excluding Abstracts).
Total 5 year impact factor: 142.174 (140.901 excluding Abstracts).
Total impact factor: 181.806 (180.911 excluding Abstracts).
Total 5 year impact factor: 142.174 (140.901 excluding Abstracts).
512 views. Last view on Tuesday 08 October 2024, 19:07:38
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