Management of recurrent nasopharyngeal carcinoma: current perspectives (239 views)
Oncotargets Ther (ISSN: 1178-6930linking), 2019 Feb 26; 12: 1583-1591.
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Paper type: Journal Article , Review,
Impact factor: 2.272, 5-year impact factor: 2.235
Url: Not available.
Keywords: Immunotherapy , Nasopharyngeal Carcinoma , Poly-Chemotherapy , Radioresistant , Re-Irradiation,
Affiliations:
*** IBB - CNR ***
Head and Neck/Sarcoma Medical Oncology Unit, INT IRCCS G Pascale, Naples, Italy, f.perri@istitutotumori.na.it.
Department of Otolaryngology and Head and Neck Surgery, INT IRCCS G Pascale, Naples, Italy.
Department of Radiation Therapy, INT IRCCS G Pascale, Naples, Italy.
Department of Abdominal Surgery, INT IRCCS G Pascale, Naples, Italy.
Italian National Research Council, Institute of Biostructure and Bioimaging, Naples, Italy.
References:
Not available.
Oncotargets Ther (ISSN: 1178-6930linking), 2019 Feb 26; 12: 1583-1591.
Export to BibTeX Export to EndNote
Paper type: Journal Article , Review,
Impact factor: 2.272, 5-year impact factor: 2.235
Url: Not available.
Keywords: Immunotherapy , Nasopharyngeal Carcinoma , Poly-Chemotherapy , Radioresistant , Re-Irradiation,
Affiliations:
*** IBB - CNR ***
Head and Neck/Sarcoma Medical Oncology Unit, INT IRCCS G Pascale, Naples, Italy, f.perri@istitutotumori.na.it.
Department of Otolaryngology and Head and Neck Surgery, INT IRCCS G Pascale, Naples, Italy.
Department of Radiation Therapy, INT IRCCS G Pascale, Naples, Italy.
Department of Abdominal Surgery, INT IRCCS G Pascale, Naples, Italy.
Italian National Research Council, Institute of Biostructure and Bioimaging, Naples, Italy.
References:
Not available.
Management of recurrent nasopharyngeal carcinoma: current perspectives
Nasopharyngeal carcinoma is a rare disease in Western countries. Nevertheless, its incidence in China, Singapore, and other Eastern countries reaches 20 cases per 100,000 people. Being an extremely chemo- and radiosensitive disease, upfront treatment often consists in the association of intensity-modulated radiation therapy and concurrent cisplatin. Unfortunately, about 20% of the patients suffer from a radioresistant disease which recurs after upfront therapy. For these patients, mainly available therapeutic options consist in systemic therapy, in particular poly-chemotherapy. In those showing a single locoregional recurrence, chemotherapy is not considered to be the preferred approach and other different strategies may be employed. Re-irradiation and surgery are strategies that are always used more often, albeit related to high risk of morbidity. Immunotherapy and targeted therapy, such as heavy ions-based re-irradiations, are experimental but very intriguing options.
Nasopharyngeal carcinoma is a rare disease in Western countries. Nevertheless, its incidence in China, Singapore, and other Eastern countries reaches 20 cases per 100,000 people. Being an extremely chemo- and radiosensitive disease, upfront treatment often consists in the association of intensity-modulated radiation therapy and concurrent cisplatin. Unfortunately, about 20% of the patients suffer from a radioresistant disease which recurs after upfront therapy. For these patients, mainly available therapeutic options consist in systemic therapy, in particular poly-chemotherapy. In those showing a single locoregional recurrence, chemotherapy is not considered to be the preferred approach and other different strategies may be employed. Re-irradiation and surgery are strategies that are always used more often, albeit related to high risk of morbidity. Immunotherapy and targeted therapy, such as heavy ions-based re-irradiations, are experimental but very intriguing options.
Management of recurrent nasopharyngeal carcinoma: current perspectives
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Management of recurrent nasopharyngeal carcinoma: current perspectives
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View Export to BibTeX Export to EndNote
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23 Records (21 excluding Abstracts).
Total impact factor: 81.233 (73.21 excluding Abstracts).
Total 5 year impact factor: 72.095 (62.139 excluding Abstracts).
Total impact factor: 81.233 (73.21 excluding Abstracts).
Total 5 year impact factor: 72.095 (62.139 excluding Abstracts).
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