The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures (467 views)
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Mar; 61 (3 ): 209-220.
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Paper type: Comparative Study , Journal Article,
Impact factor: 2.275, 5-year impact factor: 2.215
Url: Not available.
Keywords: Adult , Aging Genetics Metabolism , Bone Morphogenetic Proteins Genetics Metabolism , Cells, Cultured , Collagen Type I Metabolism , Collagen Type Iii Metabolism , Fibroblasts Cytology Drug Effects Metabolism , Gene Expression Regulation Drug Effects , Growth Differentiation Factors Genetics Metabolism , Humans , Infant, Newborn , Lotus Chemistry , Peptides Pharmacology , Plant Extracts Pharmacology , Signal Transduction Drug Effects , Skin Cytology Drug Effects Metabolism , Smad Proteins Metabolism , Sugars Pharmacology , Collagen Induction , Growth Differentiation Factor 11 , Neonatal And Adult Fibroblasts , Peptide Sugar Extract , Skin Ageing,
Affiliations:
*** IBB - CNR ***
Arterra Bioscience srl, via B. Brin 69, 80142, Napoli, Italy.
Vitalab srl, via B. Brin 69, 80142, Napoli, Italy.
Istituto di Biostrutture e Bioimmagini and CIRPeB, via Mezzocannone 16, 80134, Napoli, Italy.
DISTABIF, Universita della Campania L. Vanvitelli, via Vivaldi 43, 81100, Caserta, Italy.
References:
Not available.
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Mar; 61 (3 ): 209-220.
Export to BibTeX Export to EndNote
Paper type: Comparative Study , Journal Article,
Impact factor: 2.275, 5-year impact factor: 2.215
Url: Not available.
Keywords: Adult , Aging Genetics Metabolism , Bone Morphogenetic Proteins Genetics Metabolism , Cells, Cultured , Collagen Type I Metabolism , Collagen Type Iii Metabolism , Fibroblasts Cytology Drug Effects Metabolism , Gene Expression Regulation Drug Effects , Growth Differentiation Factors Genetics Metabolism , Humans , Infant, Newborn , Lotus Chemistry , Peptides Pharmacology , Plant Extracts Pharmacology , Signal Transduction Drug Effects , Skin Cytology Drug Effects Metabolism , Smad Proteins Metabolism , Sugars Pharmacology , Collagen Induction , Growth Differentiation Factor 11 , Neonatal And Adult Fibroblasts , Peptide Sugar Extract , Skin Ageing,
Affiliations:
*** IBB - CNR ***
Arterra Bioscience srl, via B. Brin 69, 80142, Napoli, Italy.
Vitalab srl, via B. Brin 69, 80142, Napoli, Italy.
Istituto di Biostrutture e Bioimmagini and CIRPeB, via Mezzocannone 16, 80134, Napoli, Italy.
DISTABIF, Universita della Campania L. Vanvitelli, via Vivaldi 43, 81100, Caserta, Italy.
References:
Not available.
The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures
Ageing is a complex and progressive phenomenon, during which the accumulation of morphological and chemical changes seriously compromises the capacity of the cells to proliferate and fulfil their biological tasks. The increase in the average age of the world population, associated with a higher occurrence of age-related diseases, is prompting scientific research to look for new strategies and molecular targets that may help in alleviating age-related phenotypes. Growth factors, responsible for modulating several aging markers in many tissues and organs, represent valuable targets to fight age-associated dysfunctions. The growth differentiation factor GDF11, a TGF-beta family member, has been associated with the maintenance of youth phenotypes in different human tissues and organs, and in the skin has been related to an inhibition of the inflammatory response. We investigated the role of GDF11 in skin dermal fibroblasts, and we observed that its expression and activity were reduced in fibroblasts deriving from adult donors compared to neonatal ones. The main effect of GDF11 was the induction of collagen I and III, in both neonatal and adult fibroblasts, by triggering Smad signalling in a TGF-beta-like fashion. Moreover, by analysing a number of plant extracts having GDF11 inducing activity, we found that a peptide/sugar preparation, obtained from Lotus japonicus somatic embryo cultures, was capable of restoring GDF11 expression in older fibroblasts and to activate the synthesis of collagen I, collagen III and periostin, an important protein involved in collagen assembly.
Ageing is a complex and progressive phenomenon, during which the accumulation of morphological and chemical changes seriously compromises the capacity of the cells to proliferate and fulfil their biological tasks. The increase in the average age of the world population, associated with a higher occurrence of age-related diseases, is prompting scientific research to look for new strategies and molecular targets that may help in alleviating age-related phenotypes. Growth factors, responsible for modulating several aging markers in many tissues and organs, represent valuable targets to fight age-associated dysfunctions. The growth differentiation factor GDF11, a TGF-beta family member, has been associated with the maintenance of youth phenotypes in different human tissues and organs, and in the skin has been related to an inhibition of the inflammatory response. We investigated the role of GDF11 in skin dermal fibroblasts, and we observed that its expression and activity were reduced in fibroblasts deriving from adult donors compared to neonatal ones. The main effect of GDF11 was the induction of collagen I and III, in both neonatal and adult fibroblasts, by triggering Smad signalling in a TGF-beta-like fashion. Moreover, by analysing a number of plant extracts having GDF11 inducing activity, we found that a peptide/sugar preparation, obtained from Lotus japonicus somatic embryo cultures, was capable of restoring GDF11 expression in older fibroblasts and to activate the synthesis of collagen I, collagen III and periostin, an important protein involved in collagen assembly.
The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures
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The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures
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Santagata S, Portella L, Napolitano M, Greco A, D'Alterio C, Barone MV, Luciano A, Gramanzini M, Auletta L, Arra C, Zannetti A, Scala S
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* A novel CXCR4-targeted near-infrared (NIR) fluorescent probe (Peptide R-NIR750) specifically detects CXCR4 expressing tumors (539 views) (PDF 238 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 May 31; 7(1): 2554-2554.
Impact Factor: 4.122
View Export to BibTeX Export to EndNote
1 Records (1 excluding Abstracts).
Total impact factor: 4.122 (4.122 excluding Abstracts).
Total 5 year impact factor: 4.609 (4.609 excluding Abstracts).
Total impact factor: 4.122 (4.122 excluding Abstracts).
Total 5 year impact factor: 4.609 (4.609 excluding Abstracts).
467 views. Last view on Wednesday 15 January 2025, 1:59:32
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