Oil Core-PEG Shell Nanocarriers for In Vivo MRI Imaging
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Oil Core-PEG Shell Nanocarriers for In Vivo MRI Imaging (390 views)

Calcagno V, Vecchione R, Quagliariello V, Marzola P, Busato A, Giustetto P, Profeta M, Gargiulo S, Cicco CD, Yu H, Cassani M, Maurea N, Mancini M, Pellegrino T, Netti PA

Adv Healthc Mater (ISSN: 2192-2640linking), 2019 Feb; 8(3): e1801313-e1801313.

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Paper type: Journal Article,

Impact factor: 5.11, 5-year impact factor: 5.454

Url: Not available.

Keywords: Mri In Vivo Imaging, Pegylation, Core-Shells, In Vitro Photoacoustic Signals, Nanoemulsions,

Affiliations:
*** IBB - CNR ***

Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia, Naples, 80125, Italy., Division of Cardiology, Istituto Nazionale Tumori -IRCCS- Fondazione G.Pascale, Naples, 80131, Italy., Department of Computer Science, Research Area in Experimental and Applied Physics, University of Verona, Verona, 37134, Italy., Fujifilm VisualSonics Consultant, Joop Geesinkweg 140, Amsterdam, 1114 AB, The Netherlands., Institute of Biostructures and Bioimaging, National Council of Research, Naples, 80145, Italy., Istituto Italiano di Tecnologia, Genoa, 16163, Italy.,


References:
Not available.
Oil Core-PEG Shell Nanocarriers for In Vivo MRI Imaging

Oil-in-water emulsions represent a promising carrier for in vivo imaging because of the possibility to convey poorly water-soluble species. To promote accumulation at the tumor site and prolong circulation time, reduction of carrier size and surface PEGylation plays a fundamental role. In this work a novel, simple method to design an oil-core/PEG-shell nanocarrier is reported. A PEG-shell is grown around a monodisperse oil-in-water nanoemulsion with a one-pot method, using the radical polymerization of poly(ethylene glycol)diacrylate. PEG polymerization is triggered by UV, obtaining a PEG-shell with tunable thickness. This core-shell nanosystem combines the eluding feature of the PEG with the ability to confine high payloads of lipophilic species. Indeed, the core is successfully loaded with a lipophilic contrast agent, namely super paramagnetic iron oxide nanocubes. Interestingly, it is demonstrated an in vitro and an in vivo MRI response of the nanocapsules. Additionally, when the nanosystem loaded with nanocubes is mixed with a fluorescent contrast agent, indo-cyanine green, a relevant in vitro photoacoustic effect is observed. Moreover, viability and cellular uptake studies show no significant cell cytotoxicity. These results, together with the choice of low cost materials and the scale up production, make this nanocarrier a potential platform for in vivo imaging.
Oil Core-PEG Shell Nanocarriers for In Vivo MRI Imaging

▼    MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles
Oil Core-PEG Shell Nanocarriers for In Vivo MRI Imaging

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Selis F, Focà G, Sandomenico A, Marra C, Di Mauro C, Jotti GS, Scaramuzza S, Politano A, Sanna R, Ruvo M, Tonon G
* Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen (1015 views) (PDF 293 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2016 Apr 1; 17(4): N/D-N/D.
Impact Factor: 3.226
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1 Records (1 excluding Abstracts).
Total impact factor: 3.226 (3.226 excluding Abstracts).
Total 5 year impact factor: 3.482 (3.482 excluding Abstracts).

Last modified by Sara Gargiulo on Sunday 12 July 2020, 13:14:40
390 views. Last view on Thursday 24 April 2025, 2:03:23