No association between variations in extracranial venous anatomy and clinical outcomes in multiple sclerosis patients over 5 years(313 views) Gandhi S, Marr K, Mancini M, Caprio MG, Jakimovski D, Chandra A, Hagemeier J, Hojnacki D, Kolb C, Weinstock-guttman B, Zivadinov R
Bmc Neurol (ISSN: 1471-2377linking, 1471-2377electronic), 2019 Jun 11; 19(1): 121-121.
Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Institute of Biostructure and Bioimaging, National Research Council of Italy, Rome, Italy.
Jacobs Multiple Sclerosis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA. rzivadinov@bnac.net.
0000 0004 1936 9887grid.273335.3Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY USA
0000 0001 1940 4177grid.5326.2Institute of Biostructure and Bioimaging, National Research Council of Italy, Rome, Italy
References: Not available.
No association between variations in extracranial venous anatomy and clinical outcomes in multiple sclerosis patients over 5 years
BACKGROUND:
No longitudinal, long-term,
follow-up studies have explored the association between presence and
severity of variations in extracranial venous anatomy, and clinical
outcomes in patients with multiple sclerosis (MS).
OBJECTIVE:
This
prospective 5-year follow-up study assessed the relationship of
variations in extracranial venous anatomy, indicative of chronic
cerebrospinal venous insufficiency (CCSVI) on Doppler sonography,
according to the International Society for Neurovascular Disease (ISNVD)
proposed consensus criteria, with clinical outcomes and disease
progression in MS patients.
METHODS:
90 MS patients (52
relapsing-remitting, RRMS and 38 secondary-progressive, SPMS) and 38
age- and sex-matched HIs were prospectively followed for 5.5 years.
Extracranial and transcranial Doppler-based venous hemodynamic
assessment was conducted at baseline and follow-up to determine the
extent of variations in extracranial venous anatomy. Change in Expanded
Disability Status Scale (∆EDSS), development of disability progression
(DP) and annualized relapse rate (ARR) were assessed.
RESULTS:
No
significant differences were observed in MS patients, based on their
presence of variations in extracranial venous anatomy at baseline or at
the follow-up, in ∆EDSS, development of DP or ARR. While more MS
patients had ISNVD CCSVI criteria fulfilled at baseline compared to HIs
(58% vs. 37%, p = 0.03), no differences were found at the 5-year
follow-up (61% vs. 56%, p = 0.486).
DISCUSSION:
This is
the longest follow-up study assessing the longitudinal relationship
between the presence of variations in extracranial venous anatomy and
clinical outcomes in MS patients.
CONCLUSION:
The
presence of variations in extracranial venous anatomy does not influence
clinical outcomes over the 5-year follow-up in MS patients.
No association between variations in extracranial venous anatomy and clinical outcomes in multiple sclerosis patients over 5 years