Preclinical Imaging in Targeted Cancer Therapies (522 views)
Semin Nucl Med (ISSN: 0001-2998linking), 2019 Sep; 49(5): 369-381.
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Paper type: Journal Article, Review,
Impact factor: 3.798, 5-year impact factor: 0
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Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy., Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy., Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy. Electronic address: delvecc@unina.it.,
References:
Not available.
Semin Nucl Med (ISSN: 0001-2998linking), 2019 Sep; 49(5): 369-381.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Review,
Impact factor: 3.798, 5-year impact factor: 0
Url: Not available.
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy., Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy., Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy. Electronic address: delvecc@unina.it.,
References:
Not available.
Preclinical Imaging in Targeted Cancer Therapies
Preclinical imaging with radiolabeled probes can provide noninvasive tools to test the efficacy of targeted agents in tumors harboring specific genetic alterations and to identify imaging parameters that can be used as pharmacodynamics markers in cancer patients. The present review will primarily focus on preclinical imaging studies that can accelerate the clinical approval of targeted agents and promote the development of imaging biomarkers for clinical applications. Since only subgroups of patients may benefit from treatment with targeted anticancer agents, the identification of a patient population expressing the target is of primary importance for the success of clinical trials. Preclinical imaging studies tested the ability of new radiolabeled compounds to recognize mutant, amplified, or overexpressed targets and some of these tracers were transferred to the clinical setting. More common tracers such as (18)F-Fluorothymidine and (18)F-Fluorodeoxyglucose were employed in animal models to test the inhibition of the target and downstream pathways through the evaluation of early changes of proliferation and glucose metabolism allowing the identification of sensitive and resistant tumors. Furthermore, since the majority of patients treated with targeted anticancer agents will invariably develop resistance, preclinical imaging studies were performed to test the efficacy of reversal agents to overcome resistance. These studies provided consistent evidence that imaging with radiolabeled probes can monitor the reversal of drug resistance by newly designed alternative compounds. Finally, despite many difficulties and challenges, preclinical imaging studies targeting the expression of immune checkpoints proved the principle that it is feasible to select patients for immunotherapy based on imaging findings. In conclusion, preclinical imaging can be considered as an integral part of the complex translational process that moves a newly developed targeted agent from laboratory to clinical application intervening in all clinically relevant steps including patient selection, early monitoring of drug effects and reversal of drug resistance.
Preclinical imaging with radiolabeled probes can provide noninvasive tools to test the efficacy of targeted agents in tumors harboring specific genetic alterations and to identify imaging parameters that can be used as pharmacodynamics markers in cancer patients. The present review will primarily focus on preclinical imaging studies that can accelerate the clinical approval of targeted agents and promote the development of imaging biomarkers for clinical applications. Since only subgroups of patients may benefit from treatment with targeted anticancer agents, the identification of a patient population expressing the target is of primary importance for the success of clinical trials. Preclinical imaging studies tested the ability of new radiolabeled compounds to recognize mutant, amplified, or overexpressed targets and some of these tracers were transferred to the clinical setting. More common tracers such as (18)F-Fluorothymidine and (18)F-Fluorodeoxyglucose were employed in animal models to test the inhibition of the target and downstream pathways through the evaluation of early changes of proliferation and glucose metabolism allowing the identification of sensitive and resistant tumors. Furthermore, since the majority of patients treated with targeted anticancer agents will invariably develop resistance, preclinical imaging studies were performed to test the efficacy of reversal agents to overcome resistance. These studies provided consistent evidence that imaging with radiolabeled probes can monitor the reversal of drug resistance by newly designed alternative compounds. Finally, despite many difficulties and challenges, preclinical imaging studies targeting the expression of immune checkpoints proved the principle that it is feasible to select patients for immunotherapy based on imaging findings. In conclusion, preclinical imaging can be considered as an integral part of the complex translational process that moves a newly developed targeted agent from laboratory to clinical application intervening in all clinically relevant steps including patient selection, early monitoring of drug effects and reversal of drug resistance.
Preclinical Imaging in Targeted Cancer Therapies
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Preclinical Imaging in Targeted Cancer Therapies
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Impact Factor: 6.639
View Export to BibTeX Export to EndNote
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Impact Factor: 4.184
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 1.795
View Export to BibTeX Export to EndNote
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Impact Factor: 4.184
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Salvatore B, Caprio MG, Hill BS, Sarnella A, Roviello GN, Zannetti A
* Recent Advances in Nuclear Imaging of Receptor Expression to Guide Targeted Therapies in Breast Cancer (441 views) (PDF 138 views)
Cancers (ISSN: 2072-6694linking), 2019 Oct 22; 11(10): N/D-N/D.
Impact Factor: 6.162
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Gargiulo S, Albanese S, Mancini M
* State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics (385 views)
Contrast Media Mol Imaging (ISSN: 1555-4309linking, 1555-4317electronic), 2019 Apr 30; 2019: 5080267-5080267.
Impact Factor: 1.984
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Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G
* Preclinical toxicology and safety pharmacology of the first-in-class GADD45beta/MKK7 inhibitor and clinical candidate, DTP3 (349 views)
Toxicol Rep (ISSN: 2214-7500linking), 2019 Apr 19; 6: 369-379.
Impact Factor: 1.161
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Korotkyi OH, Vovk AA, Dranitsina AS, Falalyeyeva TM, Dvorshchenko KO, Fagoonee S, Ostapchenko LI
* The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis (529 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2019 Apr 1; 110(5): 419-424.
Impact Factor: 2.863
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Gargiulo S, Albanese S, Mancini M
* State of the art preclinical photoacoustic imaging: recent advances in cancer theranostics (423 views)
Contrast Media & Molecular Imaging, 2019; 2019: Article-Article.
Impact Factor: 2.934
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Pisciotta P, Cammarata FP, Stefano A, Romano F, Marchese V, Torrisi F, Forte GI, Cella L, Cirrone GAP, Petringa G, Gilardi MC, Cuttone G, Russo G
* Monte Carlo GEANT4-based application for in vivo RBE study using small animals at LNS-INFN preclinical hadrontherapy facility (563 views)
Phys Med (ISSN: 1120-1797linking), 2018 Jul 20; 54: 173-178.
Impact Factor: 2.24
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Greco A, Auletta L, Orlandella FM, Iervolino PLC, Klain M, Salvatore G, Mancini M
* Preclinical Imaging for the Study of Mouse Models of Thyroid Cancer (1113 views) (PDF 206 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Dec 16; 18(12): 1-18.
Impact Factor: 3.687
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Torino E, Auletta L, Vecchione D, Orlandella FM, Salvatore G, Iaccino E, Fiorenza D, Grimaldi AM, Sandomenico A, Albanese S, Sarnataro D, Gramanzini M, Palmieri C, Scala G, Quinto I, Netti PA, Salvatore M, Greco A
* Multimodal imaging for a theranostic approach in a murine model of B-cell lymphoma with engineered nanoparticles (819 views) (PDF 213 views)
Nanomedicine (ISSN: 1549-9634, 1549-9642), 2017 Nov 22; 14(2): 483-491.
Impact Factor: 6.5
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Albanese S, Greco A, Auletta L, Mancini M
* Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component (600 views)
Brain Imaging Behav (ISSN: 1931-7557), 2017 Oct 26; N/D: N/D-N/D.
Impact Factor: 3.719
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Graham DY, Fagoonee S, Pellicano R
* Increasing role for modified bismuth-containing quadruple therapies for Helicobacter pylori eradication (620 views)
Minerva Gastroenterol Dietol (ISSN: 1827-1642electronic, 1121-421xlinking), 2017 Jun; 63(2): 77-79.
Impact Factor: 1.29
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Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (514 views) (PDF 261 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
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Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (638 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
Impact Factor: 2.368
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Iommelli F, De Rosa V, Terlizzi C, Del Vecchio S
* Preclinical imaging in oncology: advances and perspectives (677 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2016 Nov 18; 61(1): 33-47.
Impact Factor: 2.481
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Rizzitelli S, Giustetto P, Cutrin JC, Delli Castelli D, Boffa C, Ruzza M, Menchise V, Molinari F, Aime S, Terreno E
* Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound (706 views)
J Control Release (ISSN: 0168-3659), 2015 Jan 24; 202: 21-30.
Impact Factor: 7.441
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Roviello GN, Musumeci D, Roviello V, Pirtskhalava M, Egoyan A, Mirtskhulava M
* Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure (706 views)
Beilstein J Nanotech (ISSN: 2190-4286), 2015; 6(1): 1338-1347.
Impact Factor: 2.778
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Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (650 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
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Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of heart valve dysfunction in Hodgkin lymphoma survivors (673 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Oct 1; 87(2): 304-310.
Impact Factor: 4.176
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (749 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Lanzillo R, Bonavita S, Quarantelli M, Vacca G, Lus G, Amato L, Carotenuto A, Tedeschi G, Orefice G, Brescia Morra V
* Natalizumab is effective in multiple sclerosis patients switching from other disease modifying therapies in clinical practice (598 views)
Neurol Sci (ISSN: 1590-1874, 1590-0187, 1590-3478), 2013 Apr; 34(4): 521-528.
Impact Factor: 0.38
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Doti N, Scognamiglio PL, Madonna S, Scarponi C, Ruvo M, Perretta G, Albanesi C, Marasco D
* New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (1778 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Impact Factor: 4.779
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Gargiulo S, Greco A, Gramanzini M, Esposito S, Affuso A, Brunetti A, Vesce G
* Mice Anesthesia, Analgesia, and Care, Part I: Anesthetic Considerations in Preclinical Research (766 views)
Ilar J (ISSN: 1084-2020, 1930-6180, 1084-2020linking), 2012; 53(1): 55-69.
Impact Factor: 1.582
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Gargiulo S, Greco A, Gramanzini M, Esposito S, Affuso A, Brunetti A, Vesce G
* Mice anesthesia, analgesia, and care, Part II: anesthetic considerations in preclinical imaging studies (694 views)
Ilar J (ISSN: 1930-6180, 1084-2020), 2012; 53(1): 70-81.
Impact Factor: 1.582
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Mancini M, Greco A, Gargiulo S, Gramanzini M, Brunetti A, Salvatore M
* Ultrasound Biomicroscopy In Molecular And Preclinical Imaging (466 views)
J Ultrasound Med, 2012; N/D: 116-116.
Impact Factor: 1.532
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Greco A, Mancini M, Gargiulo S, Gramanzini M, Claudio PP, Brunetti A, Salvatore M
* Ultrasound biomicroscopy in small animal research: Applications in molecular and preclinical imaging (1182 views)
J Biomed Biotechnol (ISSN: 1110-7243, 1110-7251), 2012; 2012: 519238-519238.
Impact Factor: 2.88
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (856 views)
J Transl Med (ISSN: 1479-5876electronic, 1479-5876linking), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (1006 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (1026 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (866 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Storto G, Liuzzi R, Klain M, Albanese C, Salvatore B, Pellegrino T, Cella L, Soricelli A, Pace L, Salvatore M
* Prognostic indicators in patients with differentiated thyroid cancer receiving repeated I-131 therapies (520 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (532 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
Impact Factor: 2.538
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (794 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Benedetti E, Morelli G, Accardo A, Mansi R, Tesauro D, Aloj L
* Criteria for the design and biological characterization of radiolabeled peptide-based pharmaceuticals (880 views)
Biodrugs (ISSN: 1173-8804), 2004; 18(5): 279-295.
Impact Factor: 1.905
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45 Records (41 excluding Abstracts).
Total impact factor: 158.074 (146.087 excluding Abstracts).
Total 5 year impact factor: 130.176 (117.262 excluding Abstracts).
Total impact factor: 158.074 (146.087 excluding Abstracts).
Total 5 year impact factor: 130.176 (117.262 excluding Abstracts).
522 views. Last view on Monday 24 March 2025, 19:44:08
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