What Is the Cardiac Impact of Chemotherapy and Subsequent Radiotherapy in Lymphoma Patients?(316 views) Mercurio V, Cuomo A, Della Pepa R, Ciervo D, Cella L, Pirozzi F, Parrella P, Campi G, Franco R, Varricchi G, Abete P, Marone G, Petretta M, Bonaduce D, Pacelli R, Picardi M, Tocchetti CG
Antioxid Redox Signal (ISSN: 1523-0864linking, 1557-7716, 1557-7716electronic), 2019 Nov 20; 31
(15
): 1166-1174.
Paper type: News, Journal Article
, Research Support, Non-U. S. Gov'T,
Impact factor: 7.581, 5-year impact factor: 6.853
Url: Not available.
Keywords: Adult Lymphoma
, Anthracycline Cardiotoxicity
, Cardiac Damage From Radiotherapy
, Echocardiography
, Oxidative Damage, 80 And Over
, Anthracyclines Adverse Effects Therapeutic Use
, Antibiotics, Antineoplastic Adverse Effects Therapeutic Use
, Antineoplastic Agents Adverse Effects Therapeutic Use
, Doxorubicin Adverse Effects Therapeutic Use
, Female
, Heart Diseases Diagnosis Etiology
, Humans
, Lymphoma Drug Therapy Radiotherapy
, Middle Aged
, Prospective Studies
, Young Adult,
Affiliations: *** IBB - CNR ***
Department of Translational Medical Sciences, Federico II University, Naples, Italy.
Department of Medicine and Surgery, Federico II University, Naples, Italy.
Institute of Biostructures and Bioimaging, National Research Council (CNR), Naples, Italy.
Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Interdepartmental Center for Clinical and Translational Research, Federico II University, Naples, Italy.
References: Not available.
What Is the Cardiac Impact of Chemotherapy and Subsequent Radiotherapy in Lymphoma Patients?
Anthracyclines are widely used in anticancer protocols, but can induce cardiotoxicity by mechanisms that mainly involve oxidative damage and mitochondrial dysfunction. Radiotherapy (RT) can also impair cardiac function by promoting myocardial fibrosis, microvascular damage, and decreased density of myocardial capillaries. Hence, we aim at investigating prospectively whether RT impacts heart function in lymphoma patients who had been already treated with anthracyclines. Twenty-nine consecutive patients with Hodgkin or non-Hodgkin lymphomas underwent echocardiography at baseline (before antineoplastic treatments), and then every 2 months, until 6 months after treatment completion. Echo evaluation included standard two-dimensional and speckle tracking. Twenty-two patients treated with anthracycline-based regimens were eligible. Out of the 22 patients, 8 received chemotherapy (CT) only (subgroup 1), while 14 underwent RT after CT [subgroup 2 (S2)]. At the end of CT, ejection fraction was significantly reduced in the whole population. At 6 months after completion of therapies, E/E' increased and global longitudinal strain was compromised in S2, suggesting additional damage induced by RT after CT. On the basis of the data from our small prospective study, we can hypothesize that in lymphoma patients, anthracyclines can worsen cardiac function, and RT may have an additional unfavorable myocardial impact.
What Is the Cardiac Impact of Chemotherapy and Subsequent Radiotherapy in Lymphoma Patients?
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(429 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote