Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)
European Laboratory for the Study of Food Induced Diseases (ELFID), 80131 Naples, Italy., Department of Translational Medical Sciences, Section of Paediatrics, University of Naples Federico II, 80131 Naples, Italy., Department of Biology, University of Naples Federico II, 80126 Naples, Italy., Institute for Experimental Endocrinology and Oncology, National Research Council (IEOS-CNR), 80131 Naples, Italy., Neuroimmunology Unit, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy., Institute of Biostructure and Bioimaging IBB, CNR, 80128 Naples, Italy., Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy., Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy., CEINGE- Biotecnologie Avanzate S.c.a r.l., 80145 Naples, Italy., Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy., Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy., Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.,
Department of Translational Medical Sciences, Section of Paediatrics, University of Naples Federico II, 80131 Naples, Italy.
Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Institute for Experimental Endocrinology and Oncology, National Research Council (IEOS-CNR), 80131 Naples, Italy.
Neuroimmunology Unit, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy.
Institute of Biostructure and Bioimaging IBB, CNR, 80128 Naples, Italy.
Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.
Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
CEINGE- Biotecnologie Avanzate S.c.a r.l., 80145 Naples, Italy.
Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II,
References: Not available.
Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)
Fatty liver disease is a serious complication of childhood obesity. Calorie-restricted regimen (RCR) is one of the effective therapy for this condition. Aim of the study was to evaluate the effect of lycopene-rich tomato sauce with oregano and basil extracts in obese children with fatty liver on RCR. 61 obese children with fatty liver were enrolled, 52 completed the study. A randomized cross over clinical trial was performed. Participants were assigned to RCR alone or with a supplement of lycopene-rich tomato juice for 60 days; subsequently, the groups were switched to the alternative regimen for the next 60 days. Reduction in BMI, HOMA-IR, cholesterol, triglycerides, liver size, and steatosis was more profound in tomato-supplemented group. Leptin decreased in both groups whereas adiponectin raised only after tomato supplementation. RCR is associated with the impaired engagement of T-cells glycolysis and proliferation, tomato-supplementation resulted in glycolytic metabolic activation of T-cells. Tomato juice ameliorates glucose and lipid metabolism in obese children, improve oxidative and inflammatory state and modulates the mitochondrial metabolism of T-cells contributing to a maintenance of a proper immune surveillance in children, impaired by RCR. The addition of tomato to RCR could be considered a protective and preventive support to obese child.
Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)
Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)
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