Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams(173 views) Palma G, Taffelli A, Fellin F, D'Avino V, Scartoni D, Tommasino F, Scifoni E, Durante M, Amichetti M, Schwarz M, Amelio D, Cella L
National Research Council, Institute of Biostructures and Bioimaging, Napoli, Italy.
Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics and Applications, Trento, Italy.
Trento Proton Therapy Center, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy.
University of Trento, Physics Department, Trento, Italy.
GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, Darmstadt, Germany
Technische Universitat Darmstadt, Institut fur Festkorperphysik, Darmstadt, Germany.
References: Not available.
Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams
PURPOSE: To develop normal tissue complication probability (NTCP) models for radiation-induced alopecia (RIA) in brain tumor patients treated with proton therapy (PT). METHODS AND MATERIALS: We analyzed 116 brain tumor adult patients undergoing scanning beam PT (median dose 54 GyRBE; range 36-72) for CTCAE v.4 grade 2 (G2) acute (90 days) and permanent (>12 months) RIA. The relative dose-surface histogram (DSH) of the scalp was extracted and used for Lyman-Kutcher-Burman (LKB) modelling. Moreover, DSH metrics (Sx: the surface receiving >/= X Gy, D2%: near maximum dose, Dmean: mean dose) and non-dosimetric variables were included in a multivariable logistic regression NTCP model. Model performances were evaluated by the cross-validated area under the receiver operator curve (ROC-AUC). RESULTS: Acute, late and permanent G2-RIA was observed in 52%, 35% and 19% of the patients, respectively. The LKB models showed a weak dose-surface effect (0.09
Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams
No results.
Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams