Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features (158 views)
J Phys Chem B (ISSN: 1520-5207linking, 1520-6106), 2019 Jun 13; 123(23): 4950-4957.
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Paper type: Journal Article,
Impact factor: 3.603, 5-year impact factor: 4.425
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Affiliations:
*** IBB - CNR ***
LIDYL, CEA, CNRS, Universite Paris-Saclay , F-91191 Gif-sur-Yvette , France., Univ Lyon, ENS de Lyon, CNRS UMR 5182 , Universite Claude Bernard Lyon 1, Laboratoire de Chimie , F-69342 Lyon , France., Departamento de Quimica , Universidad Autonoma de Madrid , c/ Francisco Tomas y Valiente 7, Cantoblanco , 28049 Madrid , Spain., Univ. Grenoble-Alpes, CEA, CNRS, SyMMES UMR , 5819 Grenoble , France., Istituto Biostrutture e Bioimmagini-Consiglio Nazionale delle Ricerche , Via Mezzocannone 16 , I-80134 Napoli , Italy.,
References:
Not available.
J Phys Chem B (ISSN: 1520-5207linking, 1520-6106), 2019 Jun 13; 123(23): 4950-4957.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.603, 5-year impact factor: 4.425
Url: Not available.
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
LIDYL, CEA, CNRS, Universite Paris-Saclay , F-91191 Gif-sur-Yvette , France., Univ Lyon, ENS de Lyon, CNRS UMR 5182 , Universite Claude Bernard Lyon 1, Laboratoire de Chimie , F-69342 Lyon , France., Departamento de Quimica , Universidad Autonoma de Madrid , c/ Francisco Tomas y Valiente 7, Cantoblanco , 28049 Madrid , Spain., Univ. Grenoble-Alpes, CEA, CNRS, SyMMES UMR , 5819 Grenoble , France., Istituto Biostrutture e Bioimmagini-Consiglio Nazionale delle Ricerche , Via Mezzocannone 16 , I-80134 Napoli , Italy.,
References:
Not available.
Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features
G-quadruplexes are four-stranded DNA structures playing a key role in many biological functions and are promising for applications in the field of nanoelectronics. Characterizing the generation and fate of radical cations (electron holes) within these systems is important in relation to the DNA oxidative damage and/or conductivity issues. This study focuses on guanine radicals in G-quadruplexes formed by association of four TGGGGT strands in the presence of Na(+) cations, (TG4T)4/Na(+). Using nanosecond transient spectroscopy with 266 nm excitation, we quantitatively characterize hydrated ejected electrons and three types of guanine radicals. We show that, at an energy lower by 2.7 eV than the guanine ionization potential, one-photon ionization occurs with quantum yield of (3.5 +/- 0.5) x 10(-3). Deprotonation of the radical cations is completed within 20 mus, leading to the formation of (G-H2)(*) radicals, following a strongly nonexponential decay pattern. Within 10 ms, the latter undergoes tautomerization to deprotonated (G-H1)(*) radicals. The dynamics of the various radicals determined for (TG4T)4/Na(+), in connection to those reported previously for telomeric G-quadruplexes TEL21/Na(+), is correlated with energetic factors computed by quantum chemical methods. The faster deprotonation of radical cations in (TG4T)4/Na(+) compared to TEL21/Na(+) explains that irradiation of the former does not generate 8-oxodGuo, which is readily detected by high-performance liquid chromatography/mass spectrometry in the case of TEL21/Na(+).
G-quadruplexes are four-stranded DNA structures playing a key role in many biological functions and are promising for applications in the field of nanoelectronics. Characterizing the generation and fate of radical cations (electron holes) within these systems is important in relation to the DNA oxidative damage and/or conductivity issues. This study focuses on guanine radicals in G-quadruplexes formed by association of four TGGGGT strands in the presence of Na(+) cations, (TG4T)4/Na(+). Using nanosecond transient spectroscopy with 266 nm excitation, we quantitatively characterize hydrated ejected electrons and three types of guanine radicals. We show that, at an energy lower by 2.7 eV than the guanine ionization potential, one-photon ionization occurs with quantum yield of (3.5 +/- 0.5) x 10(-3). Deprotonation of the radical cations is completed within 20 mus, leading to the formation of (G-H2)(*) radicals, following a strongly nonexponential decay pattern. Within 10 ms, the latter undergoes tautomerization to deprotonated (G-H1)(*) radicals. The dynamics of the various radicals determined for (TG4T)4/Na(+), in connection to those reported previously for telomeric G-quadruplexes TEL21/Na(+), is correlated with energetic factors computed by quantum chemical methods. The faster deprotonation of radical cations in (TG4T)4/Na(+) compared to TEL21/Na(+) explains that irradiation of the former does not generate 8-oxodGuo, which is readily detected by high-performance liquid chromatography/mass spectrometry in the case of TEL21/Na(+).
Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features
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Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features
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Impact Factor: 2.598
View Export to BibTeX Export to EndNote
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Impact Factor: 6.475
View Export to BibTeX Export to EndNote
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Impact Factor: 5.923
View Export to BibTeX Export to EndNote
Platella C, Napolitano E, Riccardi C, Musumeci D, Montesarchio D
* Disentangling the Structure-Activity Relationships of Naphthalene Diimides as Anticancer G-Quadruplex-Targeting Drugs (145 views)
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Impact Factor: 7.446
View Export to BibTeX Export to EndNote
Green JA, Asha H, Santoro F, Improta R
* Excitonic Model for Strongly Coupled Multichromophoric Systems: The Electronic Circular Dichroism Spectra of Guanine Quadruplexes as Test Cases (217 views)
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Impact Factor: 5.39
View Export to BibTeX Export to EndNote
Martínez-fernández L, Esposito L, Improta R
* Studying the excited electronic states of guanine rich DNA quadruplexes by quantum mechanical methods: main achievements and perspectives (172 views)
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Impact Factor: 2.831
View Export to BibTeX Export to EndNote
Fik-jaskółka MA, Mkrtchyan AF, Saghyan AS, Palumbo R, Belter A, Hayriyan LA, Simonyan H, Roviello V, Roviello GN
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Impact Factor: 3.232
View Export to BibTeX Export to EndNote
Pelliccia S, Amato J, Capasso D, Di Gaetano S, Massarotti A, Piccolo M, Irace C, Tron GC, Pagano B, Randazzo A, Novellino E, Giustiniano M
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Impact Factor: 6.205
View Export to BibTeX Export to EndNote
Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (409 views)
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Impact Factor: 3.224
View Export to BibTeX Export to EndNote
Martinez-fernandez L, Changenet P, Banyasz A, Gustavsson T, Markovitsi D, Improta R
* Comprehensive Study of Guanine Excited State Relaxation and Photoreactivity in G-quadruplexes (140 views)
J Phys Chem Lett (ISSN: 1948-7185linking, 1948-7185electronic), 2019 Nov 7; 10(21): 6873-6877.
Impact Factor: 6.687
View Export to BibTeX Export to EndNote
Marzano M, Falanga AP, D'Errico S, Pinto B, Roviello GN, Piccialli G, Oliviero G, Borbone N
* New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes (448 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2019 Feb 12; 24(3): 654-654.
Impact Factor: 3.06
View Export to BibTeX Export to EndNote
Martinez-fernandez L, Banyasz A, Markovitsi D, Improta R
* Topology Controls the Electronic Absorption and Delocalization of Electron Holes in Guanine Quadruplexes (585 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Oct 12; 24(57): 15185-15189.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
* Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (524 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.
Impact Factor: 8.709
View Export to BibTeX Export to EndNote
Banyasz A, Martinez-fernandez L, Balty C, Perron M, Douki T, Improta R, Markovitsi D
* Absorption of Low-Energy UV Radiation by Human Telomere G-Quadruplexes Generates Long-Lived Guanine Radical Cations (288 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2017 Aug 2; 139(30): 10561-10568.
Impact Factor: 14.357
View Export to BibTeX Export to EndNote
Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
* Antitumour activity of resveratrol on human melanoma cells: a possible mechanism related to its interaction with malignant cell telomerase (440 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Aug 02; 1861(11PtA): 2843-2851.
Impact Factor: 4.28
View Export to BibTeX Export to EndNote
Platella C, Riccardi C, Montesarchio D, Roviello GN, Musumeci D
* G-quadruplex-based aptamers against protein targets in therapy and diagnostics (545 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 1872-8006electronic), 2017 May; 1861(5PtB): 1429-1447.
Impact Factor: 3.679
View Export to BibTeX Export to EndNote
Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (815 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Impact Factor: 5.353
View Export to BibTeX Export to EndNote
Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (462 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
View Export to BibTeX Export to EndNote
Hua Y, Changenet-Barret P, Improta R, Vaya I, Gustavsson T, Kotlyar AB, Zikich D, Sket P, Plavec J, Markovitsi D
* Cation effect on the electronic excited states of guanine nanostructures studied by time-resolved fluorescence spectroscopy (520 views)
J Phys Chem C (ISSN: 1932-7447), 2012 Jul 12; 116(27): 14682-14689.
Impact Factor: 4.814
View Export to BibTeX Export to EndNote
Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (1183 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Haider SM, Autiero I, Neidle S
Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes (76 views)
Biochimie (ISSN: 0300-9084linking), 2011 Aug; 93 (8 ): 1275-1279.
Impact Factor:
View Export to BibTeX Export to EndNote
Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F
* Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer (549 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309, 1532-2335electronic), 2010 Aug 1; 66(Pt8): 961-963.
Impact Factor: 0.563
View Export to BibTeX Export to EndNote
22 Records (20 excluding Abstracts).
Total impact factor: 107.675 (103.433 excluding Abstracts).
Total 5 year impact factor: 103.174 (97.885 excluding Abstracts).
Total impact factor: 107.675 (103.433 excluding Abstracts).
Total 5 year impact factor: 103.174 (97.885 excluding Abstracts).
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