Improved synthesis on solid phase of dithiocarbamic cRGD-derivative and (99m) Tc-radiolabelling(325 views) Caporale A, Bolzati C, Incisivo GM, Salvarese N, Grieco P, Ruvo M
IBB-CNR, Naples, 80134, Italy., Univ. di Napoli "Federico II", CIRPeB, Naples, 80134, Italy., ICMATE-CNR Padova, Padova, 35127, Italy., Dept. Pharmacy, Univ. di Napoli "Federico II", Naples, 80131, Italy.,
References: Not available.
Improved synthesis on solid phase of dithiocarbamic cRGD-derivative and (99m) Tc-radiolabelling
In the field of angiogenesis, small cyclic pentapeptides containing the RGD motif are playing a relevant role for their high affinity and specificity for integrin receptors and for the possibility to act at both therapeutic and diagnostic level by inhibiting pathological angiogenesis and by serving as shuttles to deliver imaging-probe including SPECT/PET radionuclides to specific tissues. In the last decade, several new protocols were reported in literature for the direct synthesis of cyclic RDG either in solution or by SPPS. Here, we have elaborated and tested some alternative approaches using different resins and different protective groups. The introduction of the dithiocarbamate function, useful to complex radio-metals suitable for nuclear medicine applications, has also been considered and achieved.
Improved synthesis on solid phase of dithiocarbamic cRGD-derivative and (99m) Tc-radiolabelling
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(911 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote