Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH(287 views) Anemone A, Consolino L, Arena F, Capozza M, Longo DL
Cancer Metastasis Rev (ISSN: 0167-7659linking), 2019 Jun; 38(1-2): 25-49.
Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Review,
Impact factor: 6.667, 5-year impact factor: 0
Url: Not available.
Keywords: Acidosis, Diagnostic Imaging, Metabolism, Pathology, Animals, Humans, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Methods, Neoplasms, Chemical Exchange Saturation Transfer (cest) Imaging, Iopamidol, Magnetic Resonance Imaging, Tumor Acidosis, Ph Imaging, Ph-Responsive Probes, Acidosis Diagnostic Imaging Metabolism Pathology
, Magnetic Resonance Spectroscopy Methods
, Neoplasms Diagnostic Imaging Metabolism Pathology,
Affiliations: *** IBB - CNR ***
Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, Turin, Italy., Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Via Nizza 52, Turin, Italy., Center for Preclinical Imaging, Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Ribes 5, Colleretto Giacosa, Italy., Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, Turin, Italy. dario.longo@unito.it., Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Via Nizza 52, Turin, Italy. dario.longo@unito.it.,
Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Via Nizza 52, Turin, Italy.
Center for Preclinical Imaging, Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Ribes 5, Colleretto Giacosa, Italy.
References: Not available.
Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH
Cancer cells are characterized by a metabolic shift in cellular energy production, orchestrated by the transcription factor HIF-1alpha, from mitochondrial oxidative phosphorylation to increased glycolysis, regardless of oxygen availability (Warburg effect). The constitutive upregulation of glycolysis leads to an overproduction of acidic metabolic products, resulting in enhanced acidification of the extracellular pH (pHe ~ 6.5), which is a salient feature of the tumor microenvironment. Despite the importance of pH and tumor acidosis, there is currently no established clinical tool available to image the spatial distribution of tumor pHe. The purpose of this review is to describe various imaging modalities for measuring intracellular and extracellular tumor pH. For each technique, we will discuss main advantages and limitations, pH accuracy and sensitivity of the applied pH-responsive probes and potential translatability to the clinic. Particular attention is devoted to methods that can provide pH measurements at high spatial resolution useful to address the task of tumor heterogeneity and to studies that explored tumor pH imaging for assessing treatment response to anticancer therapies.
Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH
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