PACE: A Probabilistic Atlas for Normal Tissue Complication Estimation in Radiation Oncology (265 views)
Front Oncol (ISSN: 2234-943xlinking), 2019 Mar 13; 9: 130-130.
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Paper type: Journal Article,
Impact factor: 4.137, 5-year impact factor: 0
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Keywords: Normal Tissue Complication Probability, Radiation Therapy, Radiation-Induced Morbidity, Radio-Sensitivity, Voxel-Based Analysis,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy., IRCCS SDN, Naples, Italy., Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy., Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy.,
References:
Not available.
Front Oncol (ISSN: 2234-943xlinking), 2019 Mar 13; 9: 130-130.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.137, 5-year impact factor: 0
Url: Not available.
Keywords: Normal Tissue Complication Probability, Radiation Therapy, Radiation-Induced Morbidity, Radio-Sensitivity, Voxel-Based Analysis,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy., IRCCS SDN, Naples, Italy., Department of Engineering, University of Campania Luigi Vanvitelli, Aversa, Italy., Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy.,
References:
Not available.
PACE: A Probabilistic Atlas for Normal Tissue Complication Estimation in Radiation Oncology
In radiation oncology, the need for a modern Normal Tissue Complication Probability (NTCP) philosophy to include voxel-based evidence on organ radio-sensitivity (RS) has been acknowledged. Here a new formalism (Probabilistic Atlas for Complication Estimation, PACE) to predict radiation-induced morbidity (RIM) is presented. The adopted strategy basically consists in keeping the structure of a classical, phenomenological NTCP model, such as the Lyman-Kutcher-Burman (LKB), and replacing the dose distribution with a collection of RIM odds, including also significant non-dosimetric covariates, as input of the model framework. The theory was first demonstrated in silico on synthetic dose maps, classified according to synthetic outcomes. PACE was then applied to a clinical dataset of thoracic cancer patients classified for lung fibrosis. LKB models were trained for comparison. Overall, the obtained learning curves showed that the PACE model outperformed the LKB and predicted synthetic outcomes with an accuracy >0.8. On the real patients, PACE performance, evaluated by both discrimination and calibration, was significantly higher than LKB. This trend was confirmed by cross-validation. Furthermore, the capability to infer the spatial pattern of underlying RS map for the analyzed RIM was successfully demonstrated, thus paving the way to new perspectives of NTCP models as learning tools.
In radiation oncology, the need for a modern Normal Tissue Complication Probability (NTCP) philosophy to include voxel-based evidence on organ radio-sensitivity (RS) has been acknowledged. Here a new formalism (Probabilistic Atlas for Complication Estimation, PACE) to predict radiation-induced morbidity (RIM) is presented. The adopted strategy basically consists in keeping the structure of a classical, phenomenological NTCP model, such as the Lyman-Kutcher-Burman (LKB), and replacing the dose distribution with a collection of RIM odds, including also significant non-dosimetric covariates, as input of the model framework. The theory was first demonstrated in silico on synthetic dose maps, classified according to synthetic outcomes. PACE was then applied to a clinical dataset of thoracic cancer patients classified for lung fibrosis. LKB models were trained for comparison. Overall, the obtained learning curves showed that the PACE model outperformed the LKB and predicted synthetic outcomes with an accuracy >0.8. On the real patients, PACE performance, evaluated by both discrimination and calibration, was significantly higher than LKB. This trend was confirmed by cross-validation. Furthermore, the capability to infer the spatial pattern of underlying RS map for the analyzed RIM was successfully demonstrated, thus paving the way to new perspectives of NTCP models as learning tools.
PACE: A Probabilistic Atlas for Normal Tissue Complication Estimation in Radiation Oncology
| ▼ Molecular imaging for personalized therapy in oncology |
PACE: A Probabilistic Atlas for Normal Tissue Complication Estimation in Radiation Oncology
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Impact Factor: 2.526
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Impact Factor: 2.485
View Export to BibTeX Export to EndNote
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Palma G, Monti S, Conson M, Pacelli R, Cella L
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Semin Oncol (ISSN: 0093-7754linking), 2019 Jun; 46(3): 210-218.
Impact Factor: 3.606
View Export to BibTeX Export to EndNote
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* Technological evolution of radiation treatment: Implications for clinical applications (215 views)
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Impact Factor: 3.606
View Export to BibTeX Export to EndNote
Palma G, Cella L
* A new formalism of Dose Surface Histograms for robust modeling of skin toxicity in radiation therapy (216 views)
Phys Med (ISSN: 1120-1797linking), 2019 Mar; 59: 75-78.
Impact Factor: 2.485
View Export to BibTeX Export to EndNote
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Impact Factor: 0
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Monti S, Palma G, D'Avino V, Gerardi M, Marvaso G, Ciardo D, Pacelli R, Jereczek-fossa BA, Alterio D, Cella L
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Impact Factor: 1.167
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Conson M, Cella L, Pacelli R
* Risk stratification in prostate cancer treated with radiation therapy: a window of opportunity for new clinical trials (321 views)
Translational Cancer Research, 2016; N/D: N/D-N/D.
Impact Factor: 1.2
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Liuzzi R, Savino F, D'Avino V, Pugliese M, Cella L
* Evaluation of LiF: Mg, Ti (TLD-100) for Intraoperative Electron Radiation Therapy Quality Assurance (453 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Oct 1; 10(10): e0139287-e0139287.
Impact Factor: 3.057
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Cella L, D'Avino V, Palma G, Conson M, Liuzzi R, Picardi M, Pressello MC, Boboc GI, Battistini R, Donato V, Pacelli R
* Modeling the risk of radiation-induced lung fibrosis: Irradiated heart tissue is as important as irradiated lung (774 views) (PDF 228 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 0167-8140linking), 2015 Aug 12; 117(1): 36-43.
Impact Factor: 4.817
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Perri F, Pisconti S, Conson M, Pacelli R, Della Vittoria Scarpati G, Gnoni A, D'Aniello C, Cavaliere C, Licchetta A, Cella L, Giuliano M, Schiavone C, Falivene S, Di Lorenzo G, Buonerba C, Ravo V, Muto P
* Adjuvant treatment in patients at high risk of recurrence of thymoma: efficacy and safety of a three-dimensional conformal radiation therapy regimen (346 views)
Oncotargets Ther (ISSN: 1178-6930, 1178-6930linking), 2015 Jun 8; 8: 1345-1349.
Impact Factor: 2.272
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D'Avino V, Palma G, Liuzzi R, Conson M, Doria F, Salvatore M, Pacelli R, Cella L
* Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (555 views)
Radiat Oncol (ISSN: 1748-717x), 2015 Apr 8; 10(1): 80-80.
Impact Factor: 2.466
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Savino F, Pugliese M, D'Avino V, Cella L, Liuzzi R
* Non linear response of TLD-100 irradiate by an Intra Operative Radiation Therapy linear accelerator: preliminary results (384 views)
Physics&medicine, 2014 Nov 07; N/D: N/D-N/D.
Impact Factor: 0
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Cella L, Palma G, Deasy JO, Oh JH, Liuzzi R, D'Avino V, Conson M, Pugliese N, Picardi M, Salvatore M, Pacelli R
* Complication probability models for radiation-induced heart valvular dysfunction: Do heart-lung interactions play a role? (828 views) (PDF 229 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Oct 31; 9(10): 11175301-11175311.
Impact Factor: 3.234
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (782 views)
Neuroimage Clin (ISSN: 2213-1582, 2213-1582electronic, 2213-1582linking), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
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Pedicini P, Strigari L, Benassi M, Caivano R, Fiorentino A, Nappi A, Salvatore M, Storto G
* Critical dose and toxicity index of organs at risk in radiotherapy: analyzing the calculated effects of modified dose fractionation in non-small cell lung cancer (923 views)
Med Dosim (ISSN: 0958-3947, 1873-4022), 2014 Mar; 39(1): 23-30.
Impact Factor: 0.76
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Avino S, D'Avino V, Giorgini A, Pacelli R, Liuzzi R, Cella L, Gagliardi G, De Natale P
* Radiation Dosimetry With Fiber Bragg Gratings (493 views)
Proc Spie Int Soc Opt Eng (ISSN: 0277-786x, 0277-786x9781628411751), 2014; 9157: N/D-N/D.
Impact Factor: 0.958
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Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of heart valve dysfunction in Hodgkin lymphoma survivors (532 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Oct 1; 87(2): 304-310.
Impact Factor: 4.176
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Cella L, D'Avino V, Liuzzi R, Conson M, Doria F, Faiella A, Loffredo F, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (679 views)
Radiation Oncology (ISSN: 1748-717x), 2013 Sep 23; 8(1): 221-221.
Impact Factor: 2.36
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (640 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Pedicini P, Strigari L, Caivano R, Fiorentino A, Califano G, Nappi A, Improta G, Storto G, Cozzolino M, Chiumento C, Fusco V, Vavassori A, Benassi M, Orecchia R, Salvatore M
* Local tumor control probability to evaluate an applicator-guided volumetric-modulated arc therapy solution as alternative of 3D brachytherapy for the treatment of the vaginal vault in patients affected by gynecological cancer (802 views)
Journal Of Applied Clinical Medical Physics (ISSN: 1526-9914), 2013 Mar 04; 14(2): 4N/D-4N/D.
Impact Factor: 1.11
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Pacelli R, Conson M, Cella L, Liuzzi R, Troncone G, Iorio V, Solla R, Farella A, Scala S, Pagliarulo C, Salvatore M
* Radiation therapy following surgery for localized breast cancer: Outcome prediction by classical prognostic factors and approximated genetic subtypes (498 views)
J Rad Res Journal Of Radiation Research (ISSN: 1349-9157, 0449-3060, 1349-9157electronic), 2013 Mar 1; 54(2): 292-298.
Impact Factor: 1.691
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Cella L, Conson M, Pressello MC, Molinelli S, Schneider U, Donato V, Orecchia R, Salvatore M, Pacelli R
* Hodgkin's lymphoma emerging radiation treatment techniques: Trade-offs between late radio-induced toxicities and secondary malignant neoplasms (522 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2013 Jan 30; 8(1): 22-22.
Impact Factor: 2.36
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Cella L, Conson M, Liuzzi R, Pacelli R
* In regard to boomsma et al (482 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Jan 1; 85(1): 11-11.
Impact Factor: 4.176
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Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis (596 views) (PDF 263 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2012 Dec 27; 7(1): 224-224.
Impact Factor: 2.107
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Pacelli R, Cella L, Conson M, Tranfa F, Strianese D, Liuzzi R, Solla R, Farella A, Salvatore M, Bonavolonta G
* Fractionated stereotactic radiation therapy for orbital optic nerve sheath meningioma - a single institution experience and a short review of the literature (431 views)
J Rad Res Journal Of Radiation Research (ISSN: 1349-9157electronic, 0449-3060linking), 2011; 52(1): 82-87.
Impact Factor: 1.683
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Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (477 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
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Cella L, Liuzzi R, Magliulo M, Conson M, Camera L, Salvatore M, Pacelli R
* Radiotherapy of large target volumes in Hodgkin's lymphoma: Normal tissue sparing capability of forward IMRT versus conventional techniques (655 views) (PDF 263 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2010 May 11; 5(1): 33-33.
Impact Factor: 2.409
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Pacelli R, Tranfa F, Strianese D, Nieddu V, Baronissi I, Solla R, Farella A, Cella L, Liuzzi R, Punzo G, Salvatore M, Bonovolontà G
* Fractionated stereotactic radiation therapy for optic nerve shaeth meningioma: reporton 5 cases (344 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2010; 96: N/D-N/D.
Impact Factor: 4.337
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De Cicco L, Cella L, Liuzzi R, Solla R, Farella A, Punzo G, Tranfa F, Strianese D, Conson M, Bonavolontà G, Salvatore M, Pacelli R
* Radiation therapy in primary orbital lymphoma: A single institution retrospective analysis (668 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2009 Dec 7; 4(1): 60-60.
Impact Factor: 2.36
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Varrone A, Pagani M, Salvatore E, Salmaso D, Sansone V, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Identification by [Tc-99]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease (667 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Jul; 34(7): 1071-1081.
Impact Factor: 4.101
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De Cicco L, Argenone A, Ciscognetti N, Solla R, Farella A, Gaetano M, Punzo G, Cella L, Totaro G, Di Stazio F, Liuzzi R, Pacelli R, Salvatore M
* Effectivenes And Toxicity Of Perioperative Radiation Therapy In Rectal Cancer: Report On 123 Consecutive Cases Of A Single Institution Experience (399 views)
Igrt - Orbi Posters, 2006 Oct; 0: 0-0.
Impact Factor: 0
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Varrone A, Pagani M, Salmaso D, Salvatore E, Sansone V, Nobili F, Rodriguez G, Barone P, Larsson SA, De Michele G, Filla A, Pappata S, Salvatore M
* Anterior Cingulate Hypoperfusion Can Differentiate Progressive Supranuclear Palsy From Parkinson's Disease; Voxel-Based Analysis And CBA-Based PCA Analysis Of 99mTc-ECD SPECT Data (384 views)
European Journal Of Nuclear Medicine And Molecular Imaging, 2005 Sep; 32: N/D-N/D.
Impact Factor: 5.563
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of IMRT and protons in the treatment of the breast and regional nodes (477 views)
Int J Rad Oncol Biol Phys, 2003 Mar 1; 48(3Supplement): 785-792.
Impact Factor: 0.155
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes (530 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003; 55(3): 785-792.
Impact Factor: 4.285
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44 Records (38 excluding Abstracts).
Total impact factor: 127.03 (115.062 excluding Abstracts).
Total 5 year impact factor: 98.571 (86.002 excluding Abstracts).
Total impact factor: 127.03 (115.062 excluding Abstracts).
Total 5 year impact factor: 98.571 (86.002 excluding Abstracts).
265 views. Last view on Thursday 05 December 2024, 4:22:37
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