SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus (635 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2020 Apr 16; 27(27): 4536-4541.
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Paper type: Journal Article,
Impact factor: 4.184, 5-year impact factor: 4.961
Url: http://www.eurekaselect.com/181009/article, Doi: 10. 2174/0929867327666200416131117
Keywords: Sars-Cov-2, Coronavirus, Covid-19, Antiviral Drugs, Hydroxychloroquine, Remdesivir, Favipiravir, Lopinavir, Ritonavir, Adenosine Monophosphate Analogs, Derivatives, Alanine Analogs, Amides, Antiviral Agents Therapeutic Use, Betacoronavirus, China, Coronavirus Infections Drug Therapy, Darunavir, Drug Combinations, Humans, Indoles, Pandemics, Pneumonia, Viral Drug Therapy, Pyrazines,
Affiliations:
*** IBB - CNR ***
1Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples
'Federico II', Via S. Pansini 5, I-80131 Naples, Italy; 2CEINGE - Biotecnologie Avanzate Scarl, Via G. Salvatore
486, I-80145, Naples, Italy; 3School of Medicine and Surgery, University of Naples 'Federico II', Via S.
Istituto di Biostrutture e Bioimmagini IBB - CNR
Via Mezzocannone 16, I80134 Naples. Italy.
Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples 'Federico II', Via S. Pansini 5, I-80131 Naples, Italy.
School of Medicine and Surgery, University of Naples 'Federico II', Via S. Pansini 5, I-80131 Naples, Italy.
Instituto di Biostrutture e Bioimmagini IBB - CNR
References:
Not available.
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2020 Apr 16; 27(27): 4536-4541.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.184, 5-year impact factor: 4.961
Url: http://www.eurekaselect.com/181009/article, Doi: 10. 2174/0929867327666200416131117
Keywords: Sars-Cov-2, Coronavirus, Covid-19, Antiviral Drugs, Hydroxychloroquine, Remdesivir, Favipiravir, Lopinavir, Ritonavir, Adenosine Monophosphate Analogs, Derivatives, Alanine Analogs, Amides, Antiviral Agents Therapeutic Use, Betacoronavirus, China, Coronavirus Infections Drug Therapy, Darunavir, Drug Combinations, Humans, Indoles, Pandemics, Pneumonia, Viral Drug Therapy, Pyrazines,
Affiliations:
*** IBB - CNR ***
1Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples
'Federico II', Via S. Pansini 5, I-80131 Naples, Italy; 2CEINGE - Biotecnologie Avanzate Scarl, Via G. Salvatore
486, I-80145, Naples, Italy; 3School of Medicine and Surgery, University of Naples 'Federico II', Via S.
Istituto di Biostrutture e Bioimmagini IBB - CNR
Via Mezzocannone 16, I80134 Naples. Italy.
Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples 'Federico II', Via S. Pansini 5, I-80131 Naples, Italy.
School of Medicine and Surgery, University of Naples 'Federico II', Via S. Pansini 5, I-80131 Naples, Italy.
Instituto di Biostrutture e Bioimmagini IBB - CNR
References:
Not available.
SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus
Here we report on the most recent updates on experimental drugs successfully employed
in the treatment of the disease caused by SARS-CoV-2 coronavirus, also referred to as
COVID-19 (COronaVIrus Disease 19). In particular, several cases of recovered patients have
been reported after being treated with lopinavir/ritonavir (which is widely used to treat human
immunodeficiency virus (HIV) infection) in combination with the anti-flu drug oseltamivir. In
addition, remdesivir, which has been previously administered to Ebola virus patients, has also
proven effective in the U.S. against coronavirus, while antimalarial chloroquine and hydroxychloroquine,
favipiravir and co-administered darunavir and umifenovir (in patient therapies)
were also recently recorded as having anti-SARS-CoV-2 effects. Since the recoveries/deaths
ratio in the last weeks significantly increased, especially in China, it is clear that the experimental
antiviral therapy, together with the availability of intensive care unit beds in hospitals
and rigorous government control measures, all play an important role in dealing with this virus.
This also stresses the urgent need for the scientific community to devote its efforts to the
development of other more specific antiviral strategies.
Here we report on the most recent updates on experimental drugs successfully employed
in the treatment of the disease caused by SARS-CoV-2 coronavirus, also referred to as
COVID-19 (COronaVIrus Disease 19). In particular, several cases of recovered patients have
been reported after being treated with lopinavir/ritonavir (which is widely used to treat human
immunodeficiency virus (HIV) infection) in combination with the anti-flu drug oseltamivir. In
addition, remdesivir, which has been previously administered to Ebola virus patients, has also
proven effective in the U.S. against coronavirus, while antimalarial chloroquine and hydroxychloroquine,
favipiravir and co-administered darunavir and umifenovir (in patient therapies)
were also recently recorded as having anti-SARS-CoV-2 effects. Since the recoveries/deaths
ratio in the last weeks significantly increased, especially in China, it is clear that the experimental
antiviral therapy, together with the availability of intensive care unit beds in hospitals
and rigorous government control measures, all play an important role in dealing with this virus.
This also stresses the urgent need for the scientific community to devote its efforts to the
development of other more specific antiviral strategies.
SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus
SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus
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Impact Factor:
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Megna R
* Inferring a cause-effect relationship between lockdown restrictions and COVID-19 pandemic trend during the first wave (323 views)
Health Policy (ISSN: 0168-8510, 0168-8510linking), 2021 Nov; 125(11): 1441-1447.
Impact Factor: 2.98
View Export to BibTeX Export to EndNote
Roviello V, Roviello GN
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Impact Factor: 9.027
View Export to BibTeX Export to EndNote
Testino G, Di Biagio A, Fagoonee S, Pellicano R
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Perrella F, Coppola F, Petrone A, Platella C, Montesarchio D, Stringaro A, Ravagnan G, Fuggetta MP, Rega N, Musumeci D
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View Export to BibTeX Export to EndNote
Roviello V, Musumeci D, Mokhir A, Roviello GN
* Evidence of Protein Binding by a Nucleopeptide Based on a Thyminedecorated L-Diaminopropanoic Acid through CD and In Silico Studies (195 views) (PDF 47 views)
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Impact Factor: 4.53
View Export to BibTeX Export to EndNote
Vicidomini C, Roviello V, Roviello GN
* In Silico Investigation on the Interaction of Chiral Phytochemicals from Opuntia ficus-indica with SARS-CoV-2 Mpro (127 views)
Symmetry, 2021 Jul; 13: 1041-1048.
Impact Factor: 2.713
View Export to BibTeX Export to EndNote
Di Gaetano S, Capasso D, Delre P, Pirone L, Saviano M, Pedone E, Mangiatordi GF
* More Is Always Better Than One: The N-Terminal Domain of the Spike Protein as Another Emerging Target for Hampering the SARS-CoV-2 Attachment to Host Cells (240 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic), 2021 Jun 16; 22 (12 ): N/D-N/D.
Impact Factor: 2.598
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Costanzo M, De Giglio MAR, Roviello GN
* Anti-Coronavirus Vaccines: Past Investigations on SARS-CoV-1 and MERS-CoV, the Approved Vaccines from BioNTech/Pfizer, Moderna, Oxford/AstraZeneca and others under Development Against SARS-CoV-2 Infection (218 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021 May 21; DOI:10.2174/09298673: 1-1.
Impact Factor: 4.53
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Tito A, Colantuono C, Pirone L, Pedone E, Intartaglia D, Giamundo G, Conte I, Vitaglione P, Apone F
* Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs (268 views) (PDF 48 views)
Front Chem (ISSN: 2296-2646linking), 2021 Apr 28; 9: 638187-638187.
Impact Factor: 3.693
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Vicidomini C, Roviello V, Roviello GN
* Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L. ) and Clues to Its Anti-COVID-19 Utility (453 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Mar 26; 26(7): 1880-1886.
Impact Factor: 4.411
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Borbone N, Piccialli G, Roviello GN, Oliviero G
* Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses (274 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Feb 13; 26(4): 986-1002.
Impact Factor: 4.411
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Actis GC, Ribaldone DG, Fagoonee S, Pellicano R
* COVID-19: a user's guide, status of the art, and an original proposal to terminate viral recurrence (253 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2021 Feb; 112(1): 144-152.
Impact Factor: 3.031
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Nappi C, Megna R, Acampa W, Assante R, Zampella E, Gaudieri V, Mannarino T, Green R, Cantoni V, Petretta M, Cuocolo A
* Effects of the COVID-19 pandemic on myocardial perfusion imaging for ischemic heart disease (213 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7070print, 1619-7089electronic), 2021 Feb; 48(2): 421-427.
Impact Factor: 7.081
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Roviello V, Roviello GN
* Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants (411 views)
Environ Chem Lett (ISSN: 1610-3653linking), 2021 Jan; 19: 699-710.
Impact Factor: 9.027
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Ponsiglione A, Nappi C, Imbriaco M, Ascione R, Megna R, Petretta M, Cuocolo A
* Cardiac magnetic resonance imaging during the COVID-19 pandemic: A southern Italian single-center experience (237 views)
Eur J Radiol Open (ISSN: 2352-0477electronic, 2352-0477linking), 2021; 8: 100319-100319.
Impact Factor: 0.654
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Vincenzi M, Leone M
* The fight against human viruses: how NMR can help (199 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(22): 4380-4453.
Impact Factor: 4.184
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Squeglia F, Romano M, Ruggiero A, Maga G, Berisio R
* Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins (198 views)
Front Chem (ISSN: 2296-2646linking), 2020 Dec 10; 8: 602162-602162.
Impact Factor: 3.693
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Megna R
* First month of the epidemic caused by COVID-19 in Italy: current status and real-time outbreak development forecast (945 views)
Glob Health Res Policy (ISSN: 2397-0642linking), 2020 Oct 1; 5: 43-43.
Impact Factor: 8.7
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Cella L, Gagliardi G, Hedman M, Palma G
* Injuries From Asymptomatic COVID-19 Disease: New Hidden Toxicity Risk Factors in Thoracic Radiation Therapy (180 views) (PDF 50 views)
Int J Radiat Oncol (ISSN: 0360-3016linking, 1879-355x), 2020 Oct 1; 108(2): 394-396.
Impact Factor: 5.859
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Yaccob A, Kridin K, Mari A, Fagoonee S
* Cutaneous involvement of hepatitis C virus. Which future after new antiviral drugs? (160 views)
G Ital Dermatol Venereol (ISSN: 0392-0488linking), 2020 Oct; 155(5): 599-601.
Impact Factor: 1.056
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Pirone L, Del Gatto A, Di Gaetano S, Saviano M, Capasso D, Zaccaro L, Pedone E
* A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment (777 views) (PDF 213 views)
Front Mol Biosci (ISSN: 2296-889xlinking), 2020 Aug 3; 7: 186-186.
Impact Factor: 4.188
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Scarpellini E, Fagoonee S, Rinninella E, Rasetti C, Aquila I, Larussa T, Ricci P, Luzza F, Abenavoli L
* Gut Microbiota and Liver Interaction through Immune System Cross-Talk: A Comprehensive Review at the Time of the SARS-CoV-2 Pandemic (208 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Aug 3; 9(8): N/D-N/D.
Impact Factor: 6.78
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Romano M, Ruggiero A, Squeglia F, Maga G, Berisio R
* A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping (950 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2020 May 20; 9(5): 1297-1297.
Impact Factor: 6.6
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Testino G, Fagoonee S
* Coronavirus disease 2019 outbreak: liver disease a prognostic tool? (200 views)
Panminerva Med (ISSN: 0031-0808linking, 1827-1898electronic), 2020 May 14; N/D: N/D-N/D.
Impact Factor: 3.467
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D'Andrea A, Radmilovic J, Carbone A, Forni A, Tagliamonte E, Riegler L, Liccardo B, Crescibene F, Sirignano C, Esposito G, Bossone E
* Multimodality imaging in COVID-19 patients: A key role from diagnosis to prognosis (184 views) (PDF 36 views)
World Journal Of Radiology, 2020 May; 21(5): 345-353.
Impact Factor: 0.57
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38 Records (37 excluding Abstracts).
Total impact factor: 171.274 (167.581 excluding Abstracts).
Total 5 year impact factor: 137.629 (133.79 excluding Abstracts).
Total impact factor: 171.274 (167.581 excluding Abstracts).
Total 5 year impact factor: 137.629 (133.79 excluding Abstracts).
635 views. Last view on Wednesday 04 December 2024, 19:11:17
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