Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex (186 views)
Pharmaceutics (ISSN: 1999-4923linking, 1999-4923electronic), 2020 Jul 4; 12(7): 627-627.
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Paper type: Journal Article,
Impact factor: 4.421, 5-year impact factor: 0
Url: Not available.
Keywords: Tubercidin, Cisplatin, Platinum Complexes, Nucleosides, Cancer, Cd Spectroscopy, Cell Viability Assay, Apoptosis, Esi-Ms Stability Studies,
Affiliations:
*** IBB - CNR ***
CESTEV, University of Naples Federico II, via Tommaso De Amicis, 95, 80145 Napoli, Italy.
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, via Sergio Pansini, 5, 80131 Napoli, Italy.
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone, 16, 80134 Napoli, Italy.
Dipartimento di Farmacia, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.
ISBE-IT-Candidate National Node of Italy for ISBE, Research Infrastructure for Systems Biology Europe, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.
References:
Not available.
Pharmaceutics (ISSN: 1999-4923linking, 1999-4923electronic), 2020 Jul 4; 12(7): 627-627.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.421, 5-year impact factor: 0
Url: Not available.
Keywords: Tubercidin, Cisplatin, Platinum Complexes, Nucleosides, Cancer, Cd Spectroscopy, Cell Viability Assay, Apoptosis, Esi-Ms Stability Studies,
Affiliations:
*** IBB - CNR ***
CESTEV, University of Naples Federico II, via Tommaso De Amicis, 95, 80145 Napoli, Italy.
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, via Sergio Pansini, 5, 80131 Napoli, Italy.
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone, 16, 80134 Napoli, Italy.
Dipartimento di Farmacia, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.
ISBE-IT-Candidate National Node of Italy for ISBE, Research Infrastructure for Systems Biology Europe, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.
References:
Not available.
Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex
Herein, we reported on the synthesis of a novel Pt(II) neutral complex having as ligand the nucleoside tubercidin, a potent anti-tumor agent extracted from the bacterium Streptomyces Tubercidicus. In detail, the chelation of the metal by a diamine linker installed at C6 purine position of tubercidin assured the introduction of a cisplatin-like unit in the molecular scaffold. The behavior of the synthesized complex with a double-strand DNA model was monitored by CD spectroscopy and compared with that of cisplatin and tubercidin. In addition, the cell viability was evaluated against HeLa, A375 and WM266 human cancer cell lines using the MTT test. Lastly, the results of the apoptotic assay (FITC Annexin V) performed on the HeLa cancer cell line are also reported.
Herein, we reported on the synthesis of a novel Pt(II) neutral complex having as ligand the nucleoside tubercidin, a potent anti-tumor agent extracted from the bacterium Streptomyces Tubercidicus. In detail, the chelation of the metal by a diamine linker installed at C6 purine position of tubercidin assured the introduction of a cisplatin-like unit in the molecular scaffold. The behavior of the synthesized complex with a double-strand DNA model was monitored by CD spectroscopy and compared with that of cisplatin and tubercidin. In addition, the cell viability was evaluated against HeLa, A375 and WM266 human cancer cell lines using the MTT test. Lastly, the results of the apoptotic assay (FITC Annexin V) performed on the HeLa cancer cell line are also reported.
Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex
| ▼ Functional characterization of synthetic organic molecules of therapeutic interest |
Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex
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Impact Factor: 6.165
View Export to BibTeX Export to EndNote
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Impact Factor: 3.528
View Export to BibTeX Export to EndNote
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Impact Factor: 4.411
View Export to BibTeX Export to EndNote
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Pharmaceuticals (ISSN: 1424-8247linking, 1424-8247print), 2020 Sep 30; 13(10): 284-284.
Impact Factor: 4.421
View Export to BibTeX Export to EndNote
Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
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Impact Factor: 3.224
View Export to BibTeX Export to EndNote
Pepino AJ, Segarra-marti J, Nenov A, Rivalta I, Improta R, Garavelli M
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Impact Factor: 3.454
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Impact Factor: 4.051
View Export to BibTeX Export to EndNote
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Impact Factor: 5.168
View Export to BibTeX Export to EndNote
Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
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Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Colucci-D'Amato L, Cicatiello AE, Reccia MG, Volpicelli F, Severino V, Russo R, Sandomenico A, Doti N, D'Esposito V, Formisano P, Chambery A
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Impact Factor: 4.079
View Export to BibTeX Export to EndNote
Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
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Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
Impact Factor: 2.337
View Export to BibTeX Export to EndNote
Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
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Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Stelitano V, Brandt A, Fernicola S, Franceschini S, Giardina G, Pica A, Rinaldo S, Sica F, Cutruzzola F
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Nucleic Acids Res (ISSN: 0305-1048, 0305-5104, 1362-4962), 2013 Apr; 41(7): e79-e79.
Impact Factor: 4.188
View Export to BibTeX Export to EndNote
Hunger K, Buschhaus L, Biemann L, Braun M, Kovalenko S, Improta R, Kleinermanns K
* UV-light-induced hydrogen transfer in guanosine-guanosine aggregates (615 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Apr; 19(17): 5425-5431.
Impact Factor: 5.696
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (724 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (696 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (706 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Impact Factor: 3.022
View Export to BibTeX Export to EndNote
Roviello GN, Ricci A, Bucci EM, Pedone C
* Synthesis, biological evaluation and supramolecular assembly of novel analogues of peptidyl nucleosides (1690 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1773-1778.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Roviello GN, Benedetti E, Pedone C, Bucci EM
* Nucleobase-containing peptides: An overview of their characteristic features and applications (1005 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jun; 39(1): 45-57.
Impact Factor: 4.106
View Export to BibTeX Export to EndNote
Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (741 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
View Export to BibTeX Export to EndNote
Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (455 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (573 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
View Export to BibTeX Export to EndNote
23 Records (22 excluding Abstracts).
Total impact factor: 98.794 (94.606 excluding Abstracts).
Total 5 year impact factor: 94.368 (87.205 excluding Abstracts).
Total impact factor: 98.794 (94.606 excluding Abstracts).
Total 5 year impact factor: 94.368 (87.205 excluding Abstracts).
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