Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved
Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved(245 views) Di Gaetano S, Bedini E, Landolfi A, Pedone E, Pirone L, Saviano M, Traboni S, Capasso D, Iadonisi A
Carbohyd Res (ISSN: 0008-6215linking), 2019 Aug 1; 482: 107740-107740.
Paper type: Journal Article, Paper, Comparative Study, Jounal Journal Article,
Impact factor: 1.91, 5-year impact factor: 1.957
Url: Not available.
Keywords: Antineoplastic Agents Chemical Synthesis Chemistry Pharmacology, Cell Proliferation Drug Effects, Chemistry Techniques, Synthetic, Drug Screening Assays, Antitumor, Glycosylation, Hela Cells, Humans, Sugars Chemistry, Sulfides Chemical Synthesis Chemistry Pharmacology, Anti-Proliferative Activity, Galectins, Glycosyl Disulfide, Glycosyl Sulfide, Tumor Cells,
Affiliations: *** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR Via Mezzocannone 16, 80134, Naples, Italy.
Department of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126, Naples, Italy.
Institute of Crystallography, CNR, Via Amendola 122/o, 70126, Bari, Italy.
Department of Pharmacy, University of Naples Federico II, Via Mezzocannone 16, 80134, Naples, Italy. Electronic address: domenica.capasso@unina.it.
References: Not available.
Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved
A mini-library of symmetrical and unsymmetrical diglycosyl (di)sulfides, containing d-galactose, l-fucose and N-acetyl glucosamine units, were synthesized and tested for the antiproliferative activity against cervix carcinoma (HeLa) and melanoma (A375) tumor cell lines as well as healthy fibroblasts (HDF). Comparative analysis of results seems to indicate that the most relevant antiproliferative effect is not primarily influenced by interactions with galectins, as the most cytotoxic compound observed for HeLa and A375 is not a ligand for such receptors. The most active molecules against HeLa and A375 lines also exhibited a good selectivity, showing a low toxicity to HDF cells. Obtained results offer useful indications for future design of structurally simple antitumor molecules based on sugar moieties with bridging sulfur atoms.
Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved
No results.
Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved