Biofeedback Rehabilitation and Visual Cortex Response in Stargardt's Disease: A Randomized Controlled Trial (165 views)
Transl Vis Sci Technol (ISSN: 2164-2591electronic, 2164-2591linking), 2020 May 11; 9(6): 6-6.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Randomized Controlled Trial
Impact factor: 2.135, 5-year impact factor: 0
Url: Not available.
Keywords: Stargardt Disease, Biofeedback, Visual Cortex, Visual Rehabilitation, Atp-Binding Cassette Transporters , Psychology , Humans , Macular Degeneration Diagnostic Imaging , Visual Acuity , Visual Cortex Diagnostic Imaging
Affiliations:
*** IBB - CNR ***
Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy
References:
Not available.
Transl Vis Sci Technol (ISSN: 2164-2591electronic, 2164-2591linking), 2020 May 11; 9(6): 6-6.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Randomized Controlled Trial
Impact factor: 2.135, 5-year impact factor: 0
Url: Not available.
Keywords: Stargardt Disease, Biofeedback, Visual Cortex, Visual Rehabilitation, Atp-Binding Cassette Transporters , Psychology , Humans , Macular Degeneration Diagnostic Imaging , Visual Acuity , Visual Cortex Diagnostic Imaging
Affiliations:
*** IBB - CNR ***
Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy
References:
Not available.
Biofeedback Rehabilitation and Visual Cortex Response in Stargardt's Disease: A Randomized Controlled Trial
Purpose: to evaluate the effect of biofeedback (BF) rehabilitation on the visual function and on the activity of primary visual cortex (PVC) in patients with Stargardt's disease owing to mutations in the ABCA4 gene (STGD1). Methods: This was a single-center, controlled, randomized study. Twenty-four patients with STGD1 were randomized into two groups: a treatment group (TG) undergoing BF rehabilitation and a control group (CG). Treatment with BF consisted of a 10-minute session per eye performed weekly for 12 weeks. The subjects underwent a baseline and 3-month follow-up visits, including best-corrected visual acuity (BCVA), reading test, microperimetry, and functional magnetic resonance imaging (fMRI). The fMRI studies were acquired sequentially using a passive viewing condition and an active reading task. The primary outcomes were the change in the fMRI activation of primary visual cortex and the change in reading ability. Results: After treatment, the patients in the TG were able to read smaller characters (P = 0.002) with a greater reading speed (P = 0.014) compared with patients in the CG. The fMRI studies showed a significant effect (P < 0.001) of BF on primary visual cortex activation in the TG compared with the CG. Finally, we observed significant (P < 0.05) improvements of best-corrected visual acuity, macular sensitivity, and fixation stability parameters in the TG compared with the CG. Conclusions: Our study showed that visual rehabilitation using BF improved the usage of residual visual function in patients with STGD1. Translational Relevance: Our findings show that the BF treatment compared with no treatment at all resulted in benefits. The specificity of the treatment could be examined to determine whether BF can be included in clinical practice.
Purpose: to evaluate the effect of biofeedback (BF) rehabilitation on the visual function and on the activity of primary visual cortex (PVC) in patients with Stargardt's disease owing to mutations in the ABCA4 gene (STGD1). Methods: This was a single-center, controlled, randomized study. Twenty-four patients with STGD1 were randomized into two groups: a treatment group (TG) undergoing BF rehabilitation and a control group (CG). Treatment with BF consisted of a 10-minute session per eye performed weekly for 12 weeks. The subjects underwent a baseline and 3-month follow-up visits, including best-corrected visual acuity (BCVA), reading test, microperimetry, and functional magnetic resonance imaging (fMRI). The fMRI studies were acquired sequentially using a passive viewing condition and an active reading task. The primary outcomes were the change in the fMRI activation of primary visual cortex and the change in reading ability. Results: After treatment, the patients in the TG were able to read smaller characters (P = 0.002) with a greater reading speed (P = 0.014) compared with patients in the CG. The fMRI studies showed a significant effect (P < 0.001) of BF on primary visual cortex activation in the TG compared with the CG. Finally, we observed significant (P < 0.05) improvements of best-corrected visual acuity, macular sensitivity, and fixation stability parameters in the TG compared with the CG. Conclusions: Our study showed that visual rehabilitation using BF improved the usage of residual visual function in patients with STGD1. Translational Relevance: Our findings show that the BF treatment compared with no treatment at all resulted in benefits. The specificity of the treatment could be examined to determine whether BF can be included in clinical practice.
Biofeedback Rehabilitation and Visual Cortex Response in Stargardt's Disease: A Randomized Controlled Trial
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Biofeedback Rehabilitation and Visual Cortex Response in Stargardt's Disease: A Randomized Controlled Trial
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* Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells (216 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2019 Jul 31; 20(15): N/D-N/D.
Impact Factor: 4.183
View Export to BibTeX Export to EndNote
Melillo P, Prinster A, Di Iorio V, Olivo G, D'Alterio FM, Cocozza S, Orrico A, Quarantelli M, Testa F, Brunetti A, Simonelli F
* Visual Cortex Activation in Patients With Stargardt Disease (346 views)
Invest Ophth Vis Sci (ISSN: 0146-0404linking, 1552-5783electronic), 2018 Mar 1; 59(3): 1503-1511.
Impact Factor: 3.303
View Export to BibTeX Export to EndNote
Gaia O, Melillo P, Sirio C, D'Alterio FM, Prinster A, Testa F, Brunetti A, Simonelli F, Quarantelli M
* Cerebral Involvement in Stargardt's Disease: A VBM and TBSS Study (568 views)
Invest Ophth Vis Sci (ISSN: 0146-0404, 0146-0404linking, 1552-5783electronic), 2015 Nov; 56(12): 7388-7397.
Impact Factor: 3.427
View Export to BibTeX Export to EndNote
Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
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Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 May 15; 9(5): e96560-e96560.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
4 Records (4 excluding Abstracts).
Total impact factor: 14.147 (14.147 excluding Abstracts).
Total 5 year impact factor: 13.783 (13.783 excluding Abstracts).
Total impact factor: 14.147 (14.147 excluding Abstracts).
Total 5 year impact factor: 13.783 (13.783 excluding Abstracts).
165 views. Last view on Saturday 06 July 2024, 12:06:21
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