A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment (701 views) (PDF public 187 views)
Front Mol Biosci (ISSN: 2296-889xlinking), 2020 Aug 3; 7: 186-186.
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Paper type: Jounal Journal Article, Paper,
Impact factor: 4.188, 5-year impact factor: 6.11
Url: Not available.
Keywords: Ace2, Galectin, Ganglioside, Integrin, Spike Protein,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, Naples, Italy.
CIRPEB, University of Naples Federico II, Naples, Italy.
Institute of Crystallography, CNR, Bari, Italy.
CESTEV, University of Naples Federico II, Naples, Italy.
References:
Not available.
Front Mol Biosci (ISSN: 2296-889xlinking), 2020 Aug 3; 7: 186-186.
Export to BibTeX Export to EndNote
Paper type: Jounal Journal Article, Paper,
Impact factor: 4.188, 5-year impact factor: 6.11
Url: Not available.
Keywords: Ace2, Galectin, Ganglioside, Integrin, Spike Protein,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, Naples, Italy.
CIRPEB, University of Naples Federico II, Naples, Italy.
Institute of Crystallography, CNR, Bari, Italy.
CESTEV, University of Naples Federico II, Naples, Italy.
References:
Not available.
A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment
The public health has declared an international state of emergency due to the spread of a new coronavirus (SARS-CoV-2) representing a real pandemic threat so that to find potential therapeutic agents is a dire need.
To this aim, the SARS-CoV-2 spike (S) glycoprotein represents a crucial target for vaccines, therapeutic antibodies, and diagnostics.
Since virus binding to ACE-2 alone could not be sufficient to justify such severe infection, in order to facilitate medical countermeasure development and to search for new targets, two further regions of S protein have been taken into consideration here.
One is represented by the recently identified ganglioside binding site, exactly localized in our study in the galectin-like domain, and the other one by the putative integrin binding sites contained in the RBD.
We propose that a cooperating therapy using inhibitors against multiple targets altogether i.e., ACE2, integrins and sugars could be definitely more effective.
The public health has declared an international state of emergency due to the spread of a new coronavirus (SARS-CoV-2) representing a real pandemic threat so that to find potential therapeutic agents is a dire need.
To this aim, the SARS-CoV-2 spike (S) glycoprotein represents a crucial target for vaccines, therapeutic antibodies, and diagnostics.
Since virus binding to ACE-2 alone could not be sufficient to justify such severe infection, in order to facilitate medical countermeasure development and to search for new targets, two further regions of S protein have been taken into consideration here.
One is represented by the recently identified ganglioside binding site, exactly localized in our study in the galectin-like domain, and the other one by the putative integrin binding sites contained in the RBD.
We propose that a cooperating therapy using inhibitors against multiple targets altogether i.e., ACE2, integrins and sugars could be definitely more effective.
A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment
| ▼ A multi-targeting approach to fight COVID-19 |
| ▼ Understanding SARS-CoV-2 interaction with its host of for therapeutic applications |
A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment
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7 Records (7 excluding Abstracts).
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Total 5 year impact factor: 25.2 (25.2 excluding Abstracts).
Total impact factor: 24.25 (24.25 excluding Abstracts).
Total 5 year impact factor: 25.2 (25.2 excluding Abstracts).
701 views. Last view on Thursday 26 September 2024, 19:41:26
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