Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging (120 views)
Front Oncol (ISSN: 2234-943xlinking), 2020 Feb 18; 10: 161-161.
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Paper type: Journal Article, Review,
Impact factor: 4.25, 5-year impact factor: 0
Url: Not available.
Keywords: Cest-Mri, Imaging, Therapy, Tumor Acidosis, Tumor Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Nanomedicines and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany.
Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Turin, Italy.
Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Turin, Italy.
University of Campania "Luigi Vanvitelli", Naples, Italy.
References:
Not available.
Front Oncol (ISSN: 2234-943xlinking), 2020 Feb 18; 10: 161-161.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Review,
Impact factor: 4.25, 5-year impact factor: 0
Url: Not available.
Keywords: Cest-Mri, Imaging, Therapy, Tumor Acidosis, Tumor Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Nanomedicines and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany.
Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Turin, Italy.
Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Turin, Italy.
University of Campania "Luigi Vanvitelli", Naples, Italy.
References:
Not available.
Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging
Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biology. Within the magnetic resonance imaging (MRI) modality, the chemical exchange saturation transfer (CEST) approach has emerged as a new technique that provides high spatial resolution and sensitivity for in vivo imaging of tumor metabolism and acidosis. This mini-review describes CEST-based methods to non-invasively investigate tumor metabolism and important metabolites involved, such as glucose and lactate, as well as measurement of tumor acidosis. Approaches that have been exploited to assess response to anticancer therapies will also be reported for each specific technique.
Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biology. Within the magnetic resonance imaging (MRI) modality, the chemical exchange saturation transfer (CEST) approach has emerged as a new technique that provides high spatial resolution and sensitivity for in vivo imaging of tumor metabolism and acidosis. This mini-review describes CEST-based methods to non-invasively investigate tumor metabolism and important metabolites involved, such as glucose and lactate, as well as measurement of tumor acidosis. Approaches that have been exploited to assess response to anticancer therapies will also be reported for each specific technique.
Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging
| ▼ Imaging Tumor Acidosis |
Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging
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Anemone A, Consolino L, Arena F, Capozza M, Longo DL
* Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH (474 views)
Cancer Metastasis Rev (ISSN: 0167-7659linking), 2019 Jun; 38(1-2): 25-49.
Impact Factor: 6.667
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Longo DL, Bartoli A, Consolino L, Bardini P, Arena F, Schwaiger M, Aime S
* In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging (348 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 0008-5472linking), 2016 Nov 15; 76(22): 6463-6470.
Impact Factor: 9.122
View Export to BibTeX Export to EndNote
* Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH (474 views)
Cancer Metastasis Rev (ISSN: 0167-7659linking), 2019 Jun; 38(1-2): 25-49.
Impact Factor: 6.667
View Export to BibTeX Export to EndNote
Longo DL, Bartoli A, Consolino L, Bardini P, Arena F, Schwaiger M, Aime S
* In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging (348 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 0008-5472linking), 2016 Nov 15; 76(22): 6463-6470.
Impact Factor: 9.122
View Export to BibTeX Export to EndNote
2 Records (2 excluding Abstracts).
Total impact factor: 15.789 (15.789 excluding Abstracts).
Total 5 year impact factor: 9.826 (9.826 excluding Abstracts).
Total impact factor: 15.789 (15.789 excluding Abstracts).
Total 5 year impact factor: 9.826 (9.826 excluding Abstracts).
120 views. Last view on Sunday 01 December 2024, 4:06:35
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