The role of Nodal and Cripto-1 in human oral squamous cell carcinoma
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The role of Nodal and Cripto-1 in human oral squamous cell carcinoma (162 views)

Daraghma H, Untiveros G, Raskind A, Iaccarino E, Sandomenico A, Ruvo M, Arnouk H, Ciancio MJ, Cuevas-nunez M, Strizzi L

Oral Dis (ISSN: 1354-523xlinking), 2021 Jul; 27(5): 1137-1147.

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Paper type: Journal Article,

Impact factor: 0.777, 5-year impact factor: 0

Url: Not available.

Keywords: Cripto-1, Nodal, Blocking Antibody, Inhibitory Peptide, Oral Squamous Cell Carcinoma, Therapeutic Targets, Adult , Cell Line, Tumor , Head And Neck Neoplasms , Humans , Mouth Neoplasms , Squamous Cell Carcinoma Of Head And Neck,

Affiliations:
*** IBB - CNR ***

Department of Pathology, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Institute of Biostructure and Bioimaging, National Research Council (IBB-CNR), Naples, Italy.
College of Dental Medicine Illinois, Midwestern University, Downers Grove, IL, USA.


References:
Not available.
The role of Nodal and Cripto-1 in human oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) is a common epithelial malignancy of the oral cavity. Nodal and Cripto-1 (CR-1) are important developmental morphogens expressed in several adult cancers and are associated with disease progression. Whether Nodal and CR-1 are simultaneously expressed in the same tumor and how this affects cancer biology are unclear. We investigate the expression and potential role of both Nodal and CR-1 in human OSCC. Immunohistochemistry results show that Nodal and CR-1 are both expressed in the same human OSCC sample and that intensity of Nodal staining is correlated with advanced-stage disease. However, this was not observed with CR-1 staining. Western blot analysis of lysates from two human OSCC line experiments shows expression of CR-1 and Nodal, and their respective signaling molecules, Src and ERK1/2. Treatment of SCC25 and SCC15 cells with both Nodal and CR-1 inhibitors simultaneously resulted in reduced cell viability and reduced levels of P-Src and P-ERK1/2. Further investigation showed that the combination treatment with both Nodal and CR-1 inhibitors was capable of reducing invasiveness of SCC25 cells. Our results show a possible role for Nodal/CR-1 function during progression of human OSCC and that targeting both proteins simultaneously may have therapeutic potential.
The role of Nodal and Cripto-1 in human oral squamous cell carcinoma

▼    Design and screening of molecular repertoires as a source for new bioactive compounds
▼    Monoclonal Antibodies and recombinant fragments for therapeutic and diagnostic applications
The role of Nodal and Cripto-1 in human oral squamous cell carcinoma

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11 Records (10 excluding Abstracts).
Total impact factor: 47.637 (45.53 excluding Abstracts).
Total 5 year impact factor: 40.576 (38.09 excluding Abstracts).

Last modified by Gennaro Angrisano on Friday 12 November 2021, 13:05:35
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