Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck? (264 views)
Cancers (ISSN: 2072-6694linking), 2020 Sep 28; 12(10): N/D-N/D.
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Paper type: Journal Article,
Impact factor: 6.126, 5-year impact factor: 0
Url: Not available.
Keywords: Abscopal Effect, Electrochemotherapy, Immunologic Cell Death, Immunotherapy, Squamous Cell Carcinoma Of The Head And Neck,
Affiliations:
*** IBB - CNR ***
Department of Otolaryngology Surgery and Oncology, Ospedale Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Head and Neck Medical Oncology Unit, INT IRCCS Fondazione G. Pascale, 80131 Naples, Italy.
Medical Oncology Unit, Hospital of Pollena Trocchia, ASLNA3 sud, 80040 Naples, Italy.
Department of Radiation Oncology, INT IRCCS Fondazione G. Pascale, 80131 Naples, Italy.
Department of Experimental and Clinical Oncology, University of Naples "Federico II", 80131 Naples, Italy.
Italian National Research Council, Institute of Biostructure & Bioimaging, 80131 Naples, Italy.
References:
Not available.
Cancers (ISSN: 2072-6694linking), 2020 Sep 28; 12(10): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.126, 5-year impact factor: 0
Url: Not available.
Keywords: Abscopal Effect, Electrochemotherapy, Immunologic Cell Death, Immunotherapy, Squamous Cell Carcinoma Of The Head And Neck,
Affiliations:
*** IBB - CNR ***
Department of Otolaryngology Surgery and Oncology, Ospedale Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Head and Neck Medical Oncology Unit, INT IRCCS Fondazione G. Pascale, 80131 Naples, Italy.
Medical Oncology Unit, Hospital of Pollena Trocchia, ASLNA3 sud, 80040 Naples, Italy.
Department of Radiation Oncology, INT IRCCS Fondazione G. Pascale, 80131 Naples, Italy.
Department of Experimental and Clinical Oncology, University of Naples "Federico II", 80131 Naples, Italy.
Italian National Research Council, Institute of Biostructure & Bioimaging, 80131 Naples, Italy.
References:
Not available.
Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck?
Head and neck squamous cell carcinomas (SCCHN) are not rare malignancies and account for 7% of all solid tumors. Prognosis of SCCHN patients strongly depends on tumor extension, site of onset, and genetics. Advanced disease (recurrent/metastatic) is associated with poor prognosis, with a median overall survival of 13 months. In these patients, immunotherapy may represent an interesting option of treatment, given the good results reached by check-point inhibitors in clinical practice. Nevertheless, only a minor number of patients with advanced disease respond to immunotherapy, and, disease progressions/hyper-progressions are common. The latter could be a very difficult issue, especially in patients having a wide and highly symptomatic head/neck mass. Given the potentiality to boost the immune response of some local modalities, such as electrochemotherapy, a possible future approach may take into account the combination of electrochemotherapy and immunotherapy to treat patients affected by SCCHN, suffering from symptomatic lesions that need rapid debulking.
Head and neck squamous cell carcinomas (SCCHN) are not rare malignancies and account for 7% of all solid tumors. Prognosis of SCCHN patients strongly depends on tumor extension, site of onset, and genetics. Advanced disease (recurrent/metastatic) is associated with poor prognosis, with a median overall survival of 13 months. In these patients, immunotherapy may represent an interesting option of treatment, given the good results reached by check-point inhibitors in clinical practice. Nevertheless, only a minor number of patients with advanced disease respond to immunotherapy, and, disease progressions/hyper-progressions are common. The latter could be a very difficult issue, especially in patients having a wide and highly symptomatic head/neck mass. Given the potentiality to boost the immune response of some local modalities, such as electrochemotherapy, a possible future approach may take into account the combination of electrochemotherapy and immunotherapy to treat patients affected by SCCHN, suffering from symptomatic lesions that need rapid debulking.
Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck?
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Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck?
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.491
View Export to BibTeX Export to EndNote
23 Records (21 excluding Abstracts).
Total impact factor: 76.484 (68.461 excluding Abstracts).
Total 5 year impact factor: 73.057 (63.101 excluding Abstracts).
Total impact factor: 76.484 (68.461 excluding Abstracts).
Total 5 year impact factor: 73.057 (63.101 excluding Abstracts).
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