Retinal Vascular Changes in Radiation Maculopathy after Intravitreal Ranibizumab by Optical Coherence Tomography Angiography (63 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 May 27; 9(6): N/D-N/D.
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Paper type: Journal Article,
Impact factor: 6.78, 5-year impact factor: 0
Url: Not available.
Keywords: Foveal Avascular Zone, Optical Coherence Tomography Angiography, Plaque Brachytherapy, Radiation Maculopathy, Retinal Vessel Density,
Affiliations:
*** IBB - CNR ***
Eye Clinic, Public Health Department, University of Naples "Federico II", 80131 Naples, Italy.
Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples "Federico II", 80131 Naples, Italy.
Functional and Morphologic Department of Radiotherapy and Legal Medicine, University of Naples "Federico II", 80131 Naples, Italy.
Institute of Biostructure and Bioimaging, National Research Council (CNR), 80145 Naples, Italy.
Department of Surgical Sciences, University of Torino, 10124 Torino, Italy.
References:
Not available.
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 May 27; 9(6): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.78, 5-year impact factor: 0
Url: Not available.
Keywords: Foveal Avascular Zone, Optical Coherence Tomography Angiography, Plaque Brachytherapy, Radiation Maculopathy, Retinal Vessel Density,
Affiliations:
*** IBB - CNR ***
Eye Clinic, Public Health Department, University of Naples "Federico II", 80131 Naples, Italy.
Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples "Federico II", 80131 Naples, Italy.
Functional and Morphologic Department of Radiotherapy and Legal Medicine, University of Naples "Federico II", 80131 Naples, Italy.
Institute of Biostructure and Bioimaging, National Research Council (CNR), 80145 Naples, Italy.
Department of Surgical Sciences, University of Torino, 10124 Torino, Italy.
References:
Not available.
Retinal Vascular Changes in Radiation Maculopathy after Intravitreal Ranibizumab by Optical Coherence Tomography Angiography
In this prospective study, we investigated the structural and vascular retinal changes at baseline and after Ranibizumab injections at the last follow up to one year in patients affected by Radiation Maculopathy (RM) after plaque brachytheraphy in choroidal melanoma, using Spectral Domain Optical Coherence Tomography (SD-OCT) and OCT Angiography (OCTA). A total of 40 eyes with RM of 40 patients (18 females, 22 males, mean age 51.9 ± 11 years) that underwent ruthenium-106 plaque brachytherapy were included. All patients received one monthly intravitreal injection of Ranibizumab (Pro Re Nata regimen). We analyzed the Foveal Avascular Zone (FAZ) area, the retinal vessel density (VD) of the superficial capillary plexus (SCP) and of the deep capillary plexus (DCP), using OCTA, and we detected the Central Foveal Thickness (CFT) by SD-OCT at baseline and after treatment. At the last follow up, we found a significant improvement of the CFT (p < 0.001) while OCTA parameters revealed no change in VD of the SCP (p = 0.402), DCP (p = 0.282), and FAZ area (p = 0.255), resulting in a stabilization of the visual acuity (p = 0.210) respect to baseline. The absence of functional improvement, despite the anatomical recovery of the macula, could be due to the absence of improvement in FAZ area and in retinal VD after treatment. OCTA parameters could represent predictive biomarkers to anti-vascular endothelial growth factor (anti-VEGF) intravitreal response and to help to better understand the physiopathological mechanisms of the RM.
In this prospective study, we investigated the structural and vascular retinal changes at baseline and after Ranibizumab injections at the last follow up to one year in patients affected by Radiation Maculopathy (RM) after plaque brachytheraphy in choroidal melanoma, using Spectral Domain Optical Coherence Tomography (SD-OCT) and OCT Angiography (OCTA). A total of 40 eyes with RM of 40 patients (18 females, 22 males, mean age 51.9 ± 11 years) that underwent ruthenium-106 plaque brachytherapy were included. All patients received one monthly intravitreal injection of Ranibizumab (Pro Re Nata regimen). We analyzed the Foveal Avascular Zone (FAZ) area, the retinal vessel density (VD) of the superficial capillary plexus (SCP) and of the deep capillary plexus (DCP), using OCTA, and we detected the Central Foveal Thickness (CFT) by SD-OCT at baseline and after treatment. At the last follow up, we found a significant improvement of the CFT (p < 0.001) while OCTA parameters revealed no change in VD of the SCP (p = 0.402), DCP (p = 0.282), and FAZ area (p = 0.255), resulting in a stabilization of the visual acuity (p = 0.210) respect to baseline. The absence of functional improvement, despite the anatomical recovery of the macula, could be due to the absence of improvement in FAZ area and in retinal VD after treatment. OCTA parameters could represent predictive biomarkers to anti-vascular endothelial growth factor (anti-VEGF) intravitreal response and to help to better understand the physiopathological mechanisms of the RM.
Retinal Vascular Changes in Radiation Maculopathy after Intravitreal Ranibizumab by Optical Coherence Tomography Angiography
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Retinal Vascular Changes in Radiation Maculopathy after Intravitreal Ranibizumab by Optical Coherence Tomography Angiography
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Buonanno F, Conson M, De Almeida Ribeiro C, Oliviero C, Itta F, Liuzzi R, Pacelli R, Cella L, Clemente S
* Local tumor control and treatment related toxicity after plaque brachytherapy for uveal melanoma: A systematic review and a data pooled analysis (55 views)
Radiother Oncol (ISSN: 0167-8140linking, 1879-0887), 2022 Jan; 166: 15-25.
Impact Factor: 6.28
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Itta F, Liuzzi R, Farella A, Porri G, Pacelli R, Conson M, Oliviero C, Buonanno F, Breve MA, Cennamo G, Clemente S, Cella L
* Personalized treatment planning in eye brachytherapy for ocular melanoma: Dosimetric analysis on ophthalmic structure at risk (70 views)
Phys Med (ISSN: 1120-1797linking), 2020 Aug; 76: 285-293.
Impact Factor: 3.177
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Cennamo G, Rossi C, Breve MA, Velotti N, Farella A, Liuzzi R, Cennamo G
* Evaluation of vascular changes with optical coherence tomography angiography after ruthenium-106 brachytherapy of circumscribed choroidal hemangioma (340 views)
Eye (ISSN: 0950-222xlinking, 1476-5454electronic), 2018 Aug; 32(8): 1401-1405.
Impact Factor: 2.275
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Cennamo G, Breve MA, Velotti N, Sparnelli F, Iovino C, Farella A, Liuzzi R, De Crecchio G, Cennamo G
* Evaluation of Vascular Changes with Optical Coherence Tomography Angiography after Plaque Radiotherapy of Choroidal Melanoma (372 views)
Ophthalmic Res (ISSN: 0030-3747linking), 2018 May; 60(4): 238-242.
Impact Factor: 1.826
View Export to BibTeX Export to EndNote
* Local tumor control and treatment related toxicity after plaque brachytherapy for uveal melanoma: A systematic review and a data pooled analysis (55 views)
Radiother Oncol (ISSN: 0167-8140linking, 1879-0887), 2022 Jan; 166: 15-25.
Impact Factor: 6.28
View Export to BibTeX Export to EndNote
Itta F, Liuzzi R, Farella A, Porri G, Pacelli R, Conson M, Oliviero C, Buonanno F, Breve MA, Cennamo G, Clemente S, Cella L
* Personalized treatment planning in eye brachytherapy for ocular melanoma: Dosimetric analysis on ophthalmic structure at risk (70 views)
Phys Med (ISSN: 1120-1797linking), 2020 Aug; 76: 285-293.
Impact Factor: 3.177
View Export to BibTeX Export to EndNote
Cennamo G, Rossi C, Breve MA, Velotti N, Farella A, Liuzzi R, Cennamo G
* Evaluation of vascular changes with optical coherence tomography angiography after ruthenium-106 brachytherapy of circumscribed choroidal hemangioma (340 views)
Eye (ISSN: 0950-222xlinking, 1476-5454electronic), 2018 Aug; 32(8): 1401-1405.
Impact Factor: 2.275
View Export to BibTeX Export to EndNote
Cennamo G, Breve MA, Velotti N, Sparnelli F, Iovino C, Farella A, Liuzzi R, De Crecchio G, Cennamo G
* Evaluation of Vascular Changes with Optical Coherence Tomography Angiography after Plaque Radiotherapy of Choroidal Melanoma (372 views)
Ophthalmic Res (ISSN: 0030-3747linking), 2018 May; 60(4): 238-242.
Impact Factor: 1.826
View Export to BibTeX Export to EndNote
4 Records (4 excluding Abstracts).
Total impact factor: 13.558 (13.558 excluding Abstracts).
Total 5 year impact factor: 6.214 (6.214 excluding Abstracts).
Total impact factor: 13.558 (13.558 excluding Abstracts).
Total 5 year impact factor: 6.214 (6.214 excluding Abstracts).
63 views. Last view on Monday 22 April 2024, 11:00:02
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