Inflammatory bowel disease course in liver transplant versus non-liver transplant patients for primary sclerosing cholangitis: LIVIBD, an IG-IBD study (106 views)
Dig Liver Dis (ISSN: 1590-8658linking), 2021 Jun; 53(6): 712-716.
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Paper type: Journal Article,
Impact factor: 3.57, 5-year impact factor: 2.871
Url: Not available.
Keywords: Olt, Orthotopic Liver Transplantation, Primary Sclerosing Cholangitis,
Affiliations:
*** IBB - CNR ***
Department of Medical Sciences, Division of Gastroenterology, University of Torino, Torino, Italy. Electronic address: davrib_1998@yahoo.com.
Gastroenterology Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy
Gastroenterology and Endoscopy Unit, AORN Antonio Cardarelli, Naples, Italy.
IBD Referral Center, Gastroenterology Department, Careggi University Hospital, Florence, Italy.
Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Unit of Gastroenterology, Campus Bio-Medico University, Rome, Italy.
Institute of Biostructure and Bioimaging (CNR), Molecular Biotechnology Center, Turin, Italy.
General Surgery 2U, Liver Transplant Center, Department of Surgical Sciences, University of Turin, Turin, Italy.
Italian Group for the study of Inflammatory Bowel Disease IG-IBD, Florence, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Department of General and Specialist Medicine, Gastroenterologia-U, Città della Salute e della Scienza di Torino, Turin, Italy.
References:
Not available.
Dig Liver Dis (ISSN: 1590-8658linking), 2021 Jun; 53(6): 712-716.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.57, 5-year impact factor: 2.871
Url: Not available.
Keywords: Olt, Orthotopic Liver Transplantation, Primary Sclerosing Cholangitis,
Affiliations:
*** IBB - CNR ***
Department of Medical Sciences, Division of Gastroenterology, University of Torino, Torino, Italy. Electronic address: davrib_1998@yahoo.com.
Gastroenterology Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy
Gastroenterology and Endoscopy Unit, AORN Antonio Cardarelli, Naples, Italy.
IBD Referral Center, Gastroenterology Department, Careggi University Hospital, Florence, Italy.
Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Unit of Gastroenterology, Campus Bio-Medico University, Rome, Italy.
Institute of Biostructure and Bioimaging (CNR), Molecular Biotechnology Center, Turin, Italy.
General Surgery 2U, Liver Transplant Center, Department of Surgical Sciences, University of Turin, Turin, Italy.
Italian Group for the study of Inflammatory Bowel Disease IG-IBD, Florence, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Department of General and Specialist Medicine, Gastroenterologia-U, Città della Salute e della Scienza di Torino, Turin, Italy.
References:
Not available.
Inflammatory bowel disease course in liver transplant versus non-liver transplant patients for primary sclerosing cholangitis: LIVIBD, an IG-IBD study
BACKGROUND: Data regarding the effect of orthotopic liver transplantation (OLT) for primary sclerosing cholangitis (PSC) on inflammatory bowel disease (IBD) course are scarce and conflicting. AIMS: To compare the incidence of refractory IBD in two groups (OLT and non-OLT) of patients affected by IBD and PSC. METHODS: An observational, multicentre, cohort retrospective study was conducted by the Italian Group for the study of IBD in Italy. The primary outcome was the need for biologic therapy or bowel resection for medically refractory IBD or hospitalization due to IBD relapse during the follow-up. Secondary outcomes were rate of colonic dysplasia, colorectal cancer, other solid tumours, lymphoma. RESULTS: Eighty-four patients were included in the study. The primary outcome was not different between OLT and non-OLT groups (11/27, 40.7%, versus 20/57, 35.1%, respectively, p = 0.62). The lymphoma and other tumours (thyroid cancer, kidney cancer, ileal tumour, ovarian cancer, cervical cancer) rates were significantly higher in the OLT group (p = 0.04 and p = 0.005, respectively), at the limit of statistical significance for high-grade colonic dysplasia (p = 0.06). CONCLUSION: OLT in patients affected by IBD and PSC is not a risk factor for a more severe IBD course, but it is associated with a higher occurrence of cancer.
BACKGROUND: Data regarding the effect of orthotopic liver transplantation (OLT) for primary sclerosing cholangitis (PSC) on inflammatory bowel disease (IBD) course are scarce and conflicting. AIMS: To compare the incidence of refractory IBD in two groups (OLT and non-OLT) of patients affected by IBD and PSC. METHODS: An observational, multicentre, cohort retrospective study was conducted by the Italian Group for the study of IBD in Italy. The primary outcome was the need for biologic therapy or bowel resection for medically refractory IBD or hospitalization due to IBD relapse during the follow-up. Secondary outcomes were rate of colonic dysplasia, colorectal cancer, other solid tumours, lymphoma. RESULTS: Eighty-four patients were included in the study. The primary outcome was not different between OLT and non-OLT groups (11/27, 40.7%, versus 20/57, 35.1%, respectively, p = 0.62). The lymphoma and other tumours (thyroid cancer, kidney cancer, ileal tumour, ovarian cancer, cervical cancer) rates were significantly higher in the OLT group (p = 0.04 and p = 0.005, respectively), at the limit of statistical significance for high-grade colonic dysplasia (p = 0.06). CONCLUSION: OLT in patients affected by IBD and PSC is not a risk factor for a more severe IBD course, but it is associated with a higher occurrence of cancer.
Inflammatory bowel disease course in liver transplant versus non-liver transplant patients for primary sclerosing cholangitis: LIVIBD, an IG-IBD study
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