Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L. ) and Clues to Its Anti-COVID-19 Utility (350 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Mar 26; 26(7): 1880-1886.
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Paper type: Review Journal Article,
Impact factor: 4.411, 5-year impact factor: 2.411
Url: https://www.mdpi.com/1420-3049/26/7/1880/htm
Keywords: Coronavirus Infections, Pandemics, Natural Compounds, Clove, Syzygium Aromaticum, Eugenol, Eugeniin, Sars-Cov-2, Covid-19, Phytochemicals, Herbal Medicine, Adjuvants, Immunologic Chemistry Pharmacology, Anti-Inflammatory Agents, Non-Steroidal Chemistry Pharmacology, Antiviral Agents Chemistry Pharmacology, Covid-19 Drug Therapy Prevention, Control, Fibrinolytic Agents Pharmacology, Herbal Medicine Methods, Humans, Phytochemicals Chemistry Pharmacology, Plants, Medicinal Chemistry, Syzygium Chemistry,
Affiliations:
*** IBB - CNR ***
Last modified by Giovanni Nicola Roviello on Tuesday 25 January 2022, 22:06:36Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Mar 26; 26(7): 1880-1886.
Export to BibTeX Export to EndNote
Paper type: Review Journal Article,
Impact factor: 4.411, 5-year impact factor: 2.411
Url: https://www.mdpi.com/1420-3049/26/7/1880/htm
Keywords: Coronavirus Infections, Pandemics, Natural Compounds, Clove, Syzygium Aromaticum, Eugenol, Eugeniin, Sars-Cov-2, Covid-19, Phytochemicals, Herbal Medicine, Adjuvants, Immunologic Chemistry Pharmacology, Anti-Inflammatory Agents, Non-Steroidal Chemistry Pharmacology, Antiviral Agents Chemistry Pharmacology, Covid-19 Drug Therapy Prevention, Control, Fibrinolytic Agents Pharmacology, Herbal Medicine Methods, Humans, Phytochemicals Chemistry Pharmacology, Plants, Medicinal Chemistry, Syzygium Chemistry,
Affiliations:
*** IBB - CNR ***
1
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Not available.
References:
Not available.
Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L. ) and Clues to Its Anti-COVID-19 Utility
The current COronaVIrus Disease 19 (COVID-19) pandemic caused by SARS-CoV-2 infection is enormously affecting the worldwide health and economy. In the wait for an effective global immunization, the development of a specific therapeutic protocol to treat COVID-19 patients is clearly necessary as a short-term solution of the problem. Drug repurposing and herbal medicine represent two of the most explored strategies for an anti-COVID-19 drug discovery. Clove (Syzygium aromaticum L.) is a well-known culinary spice that has been used for centuries in folk medicine in many disorders. Interestingly, traditional medicines have used clove since ancient times to treat respiratory ailments, whilst clove ingredients show antiviral and anti-inflammatory properties. Other interesting features are the clove antithrombotic, immunostimulatory, and antibacterial effects. Thus, in this review, we discuss the potential role of clove in the frame of anti-COVID-19 therapy, focusing on the antiviral, anti-inflammatory, and antithrombotic effects of clove and its molecular constituents described in the scientific literature.
The current COronaVIrus Disease 19 (COVID-19) pandemic caused by SARS-CoV-2 infection is enormously affecting the worldwide health and economy. In the wait for an effective global immunization, the development of a specific therapeutic protocol to treat COVID-19 patients is clearly necessary as a short-term solution of the problem. Drug repurposing and herbal medicine represent two of the most explored strategies for an anti-COVID-19 drug discovery. Clove (Syzygium aromaticum L.) is a well-known culinary spice that has been used for centuries in folk medicine in many disorders. Interestingly, traditional medicines have used clove since ancient times to treat respiratory ailments, whilst clove ingredients show antiviral and anti-inflammatory properties. Other interesting features are the clove antithrombotic, immunostimulatory, and antibacterial effects. Thus, in this review, we discuss the potential role of clove in the frame of anti-COVID-19 therapy, focusing on the antiviral, anti-inflammatory, and antithrombotic effects of clove and its molecular constituents described in the scientific literature.
Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L. ) and Clues to Its Anti-COVID-19 Utility
Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L. ) and Clues to Its Anti-COVID-19 Utility
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Impact Factor: 9.027
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Testino G, Di Biagio A, Fagoonee S, Pellicano R
* SARS-CoV-2, alcohol consumption and liver injury (48 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2021 Oct 21; N/D: N/D-N/D.
Impact Factor: 4.806
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Fatima N, Baqri SSR, Alsulimani A, Fagoonee S, Slama P, Kesari KK, Roychoudhury S, Haque S
* Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer (65 views)
Antioxidants (ISSN: 2076-3921linking), 2021 Oct 13; 10 (10 ): N/D-N/D.
Impact Factor:
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Capasso D, Di Gaetano S, Selvaraj C, Pedone E
* Editorial: Molecular Studies of Covid-19 Chemistry (81 views)
Front Chem (ISSN: 2296-2646linking), 2021 Aug 31; 9: 729142-729142.
Impact Factor: 4.62
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Sadremomtaz A, Al-dahmani ZM, Ruiz-moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-velázquez MA, De Jong D, De Jonge J, Smit J, Dömling A, Van Goor H, Groves MR
* Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein (108 views)
J Med Chem (ISSN: 0022-2623linking, 0022-2623print), 2021 Jul 30; N/D: N/D-N/D.
Impact Factor: 5.207
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Perrella F, Coppola F, Petrone A, Platella C, Montesarchio D, Stringaro A, Ravagnan G, Fuggetta MP, Rega N, Musumeci D
* Interference of Polydatin/Resveratrol in the ACE2: Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays (128 views)
Biomolecules (ISSN: 2218-273xlinking), 2021 Jul 16; 11(7): N/D-N/D.
Impact Factor: 4.57
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Roviello V, Musumeci D, Mokhir A, Roviello GN
* Evidence of Protein Binding by a Nucleopeptide Based on a Thyminedecorated L-Diaminopropanoic Acid through CD and In Silico Studies (149 views) (PDF 28 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021 Jul; 28(24): 5004-5015.
Impact Factor: 4.53
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Vicidomini C, Roviello V, Roviello GN
* In Silico Investigation on the Interaction of Chiral Phytochemicals from Opuntia ficus-indica with SARS-CoV-2 Mpro (65 views)
Symmetry, 2021 Jul; 13: 1041-1048.
Impact Factor: 2.713
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Di Gaetano S, Capasso D, Delre P, Pirone L, Saviano M, Pedone E, Mangiatordi GF
* More Is Always Better Than One: The N-Terminal Domain of the Spike Protein as Another Emerging Target for Hampering the SARS-CoV-2 Attachment to Host Cells (176 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic), 2021 Jun 16; 22 (12 ): N/D-N/D.
Impact Factor: 2.598
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Costanzo M, De Giglio MAR, Roviello GN
* Anti-Coronavirus Vaccines: Past Investigations on SARS-CoV-1 and MERS-CoV, the Approved Vaccines from BioNTech/Pfizer, Moderna, Oxford/AstraZeneca and others under Development Against SARS-CoV-2 Infection (170 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021 May 21; DOI:10.2174/09298673: 1-1.
Impact Factor: 4.53
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Tito A, Colantuono C, Pirone L, Pedone E, Intartaglia D, Giamundo G, Conte I, Vitaglione P, Apone F
* Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs (224 views) (PDF 38 views)
Front Chem (ISSN: 2296-2646linking), 2021 Apr 28; 9: 638187-638187.
Impact Factor: 3.693
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Borbone N, Piccialli G, Roviello GN, Oliviero G
* Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses (241 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Feb 13; 26(4): 986-1002.
Impact Factor: 4.411
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Actis GC, Ribaldone DG, Fagoonee S, Pellicano R
* COVID-19: a user's guide, status of the art, and an original proposal to terminate viral recurrence (216 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2021 Feb; 112(1): 144-152.
Impact Factor: 3.031
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Nappi C, Megna R, Acampa W, Assante R, Zampella E, Gaudieri V, Mannarino T, Green R, Cantoni V, Petretta M, Cuocolo A
* Effects of the COVID-19 pandemic on myocardial perfusion imaging for ischemic heart disease (152 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7070print, 1619-7089electronic), 2021 Feb; 48(2): 421-427.
Impact Factor: 7.081
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Roviello V, Roviello GN
* Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants (339 views)
Environ Chem Lett (ISSN: 1610-3653linking), 2021 Jan; 19: 699-710.
Impact Factor: 9.027
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Ponsiglione A, Nappi C, Imbriaco M, Ascione R, Megna R, Petretta M, Cuocolo A
* Cardiac magnetic resonance imaging during the COVID-19 pandemic: A southern Italian single-center experience (176 views)
Eur J Radiol Open (ISSN: 2352-0477electronic, 2352-0477linking), 2021; 8: 100319-100319.
Impact Factor: 0.654
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Vincenzi M, Leone M
* The fight against human viruses: how NMR can help (157 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(22): 4380-4453.
Impact Factor: 4.184
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Squeglia F, Romano M, Ruggiero A, Maga G, Berisio R
* Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins (164 views)
Front Chem (ISSN: 2296-2646linking), 2020 Dec 10; 8: 602162-602162.
Impact Factor: 3.693
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Megna R
* First month of the epidemic caused by COVID-19 in Italy: current status and real-time outbreak development forecast (584 views)
Glob Health Res Policy (ISSN: 2397-0642linking), 2020 Oct 1; 5: 43-43.
Impact Factor: 8.7
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Cella L, Gagliardi G, Hedman M, Palma G
* Injuries From Asymptomatic COVID-19 Disease: New Hidden Toxicity Risk Factors in Thoracic Radiation Therapy (149 views) (PDF 39 views)
Int J Radiat Oncol (ISSN: 0360-3016linking, 1879-355x), 2020 Oct 1; 108(2): 394-396.
Impact Factor: 5.859
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Pirone L, Del Gatto A, Di Gaetano S, Saviano M, Capasso D, Zaccaro L, Pedone E
* A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment (721 views) (PDF 193 views)
Front Mol Biosci (ISSN: 2296-889xlinking), 2020 Aug 3; 7: 186-186.
Impact Factor: 4.188
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Scarpellini E, Fagoonee S, Rinninella E, Rasetti C, Aquila I, Larussa T, Ricci P, Luzza F, Abenavoli L
* Gut Microbiota and Liver Interaction through Immune System Cross-Talk: A Comprehensive Review at the Time of the SARS-CoV-2 Pandemic (172 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Aug 3; 9(8): N/D-N/D.
Impact Factor: 6.78
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Romano M, Ruggiero A, Squeglia F, Maga G, Berisio R
* A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping (779 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2020 May 20; 9(5): 1297-1297.
Impact Factor: 6.6
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D'Andrea A, Radmilovic J, Carbone A, Forni A, Tagliamonte E, Riegler L, Liccardo B, Crescibene F, Sirignano C, Esposito G, Bossone E
* Multimodality imaging in COVID-19 patients: A key role from diagnosis to prognosis (156 views) (PDF 21 views)
World Journal Of Radiology, 2020 May; 21(5): 345-353.
Impact Factor: 0.57
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Costanzo M, De Giglio MAR, Roviello GN
* SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus (558 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2020 Apr 16; 27(27): 4536-4541.
Impact Factor: 4.184
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Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D
* A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage (380 views) (PDF 124 views)
Bba-Gen Subjects (ISSN: 0005-2736print, 0005-2736linking), 2018 Mar 17; N/D: 1793-1902.
Impact Factor: 4.647
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Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D
* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (475 views) (PDF 211 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2017 Jun 09; N/D: N/D-N/D.
Impact Factor: 4.211
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (5441 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (503 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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45 Records (44 excluding Abstracts).
Total impact factor: 201.196 (197.503 excluding Abstracts).
Total 5 year impact factor: 168.016 (164.177 excluding Abstracts).
Total impact factor: 201.196 (197.503 excluding Abstracts).
Total 5 year impact factor: 168.016 (164.177 excluding Abstracts).
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