Evidence of bystander effect induced by radiofrequency radiation in a human neuroblastoma cell line(255 views)(PDF public64 views) Zeni O, Romeo S, Sannino A, Palumbo R, Scarfì MR
Environ Res (ISSN: 0013-9351linking), 2021 May; 196: 110935-110935.
Keywords: Bystander Effect, In Vitro Study, Protective Effect, Radiofrequency, Hsp70 Levels, Cell Line
, Dna Damage
, Electromagnetic Fields Adverse Effects
, Humans
, Neuroblastoma
, Radio Waves Adverse Effects,
Affiliations: *** IBB - CNR ***
CNR-Institute for the Electromagnetic Sensing of the Environment, Via Diocleziano 328, 80124, Naples, Italy. Electronic address: zeni.o@irea.cnr.it., CNR-Institute for the Electromagnetic Sensing of the Environment, Via Diocleziano 328, 80124, Naples, Italy. Electronic address: romeo.s@irea.cnr.it., CNR-Institute for the Electromagnetic Sensing of the Environment, Via Diocleziano 328, 80124, Naples, Italy. Electronic address: sannino.a@irea.cnr.it., CNR-Institute for Biostructures and Bioimaging, Via Mezzocannone, 16, 80134, Naples, Italy. Electronic address: rosanna.palumbo@cnr.it., CNR-Institute for the Electromagnetic Sensing of the Environment, Via Diocleziano 328, 80124, Naples, Italy. Electronic address: scarfi.mr@irea.cnr.it.,
References: Not available.
Evidence of bystander effect induced by radiofrequency radiation in a human neuroblastoma cell line
In previous studies we demonstrated that radiofrequency (RF) electromagnetic fields (EMF) is able to reduce DNA damage induced by a subsequent treatment with genotoxic agents, resembling the adaptive response, a phenomenon well known in radiobiology. In this study we report on the capability of the culture medium from SH-SY5Y neuroblastoma cells exposed to 1950 MHz to elicit, in recipient non-exposed cells, a reduction of menadione-induced DNA damage (P < 0.05; comet assay), indicating the capability of non-ionizing radiation to elicit a bystander effect. A comparable reduction was also detected in cultures directly exposed to the same EMF conditions (P < 0.05), confirming the adaptive response. In the same exposure conditions, we also evidenced an increase of heat shock protein 70 (hsp70) in culture medium of cells exposed to RF with respect to sham exposed ones (P < 0.05; western blot analysis), while no differences were detected in the intracellular content of hsp70. On the whole, our results evidence a protective effect of RF against menadione-induced DNA damage in directly and non-directly exposed cells, and suggest hsp70 pathway to be investigated as one of the potential candidate underpinning the interaction between RF exposure and biological systems.
Evidence of bystander effect induced by radiofrequency radiation in a human neuroblastoma cell line
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Evidence of bystander effect induced by radiofrequency radiation in a human neuroblastoma cell line
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