Flogging a Dead Salmon? Reduced Dose Posterior to Prostate Correlates With Increased PSA Progression in Voxel-Based Analysis of 3 Randomized Phase 3 Trials (112 views)
Int J Radiat Oncol (ISSN: 0360-3016linking, 1879-355x), 2021 Jul 1; 110(3): 696-699.
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Paper type: In Press Journal Pre-Proof, Comment, Journal Article,
Impact factor: 7.038, 5-year impact factor: 4.441
Url: https://doi.org/10.1016/j.ijrobp.2021.01.017
Keywords: Animals, Humans, Prostate-Specific Antigen, Prostatic Neoplasms Diagnostic Imaging Radiotherapy, Salmon,
Affiliations:
*** IBB - CNR ***
References:
Not available.
Int J Radiat Oncol (ISSN: 0360-3016linking, 1879-355x), 2021 Jul 1; 110(3): 696-699.
Export to BibTeX Export to EndNote
Paper type: In Press Journal Pre-Proof, Comment, Journal Article,
Impact factor: 7.038, 5-year impact factor: 4.441
Url: https://doi.org/10.1016/j.ijrobp.2021.01.017
Keywords: Animals, Humans, Prostate-Specific Antigen, Prostatic Neoplasms Diagnostic Imaging Radiotherapy, Salmon,
Affiliations:
*** IBB - CNR ***
- Division of Cancer Science, University of Manchester, Manchester, United Kingdom
- National Research Council, Institute of Biostructures and Bioimaging, Napoli, Italy
- Christie Medical Physics & Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom
References:
Not available.
Flogging a Dead Salmon? Reduced Dose Posterior to Prostate Correlates With Increased PSA Progression in Voxel-Based Analysis of 3 Randomized Phase 3 Trials
Image-based data mining (IBDM) and voxel-based analysis (VBA) have shown great promise in the retrospective analysis of routine clinical data, offering a way to analyze a patient population without selection. In radiation therapy, IBDM analyzes whole dose distributions for their effect on a given outcome with no prior assumptions. Recent extensions in IBDM methodologies include per voxel survival analyses, allowing the generation of more robust and testable hypotheses. An essential aspect to produce solid conclusions includes applying the correct statistical techniques to account for multiple testing. There is a growing interest in applying IBDM/VBA techniques in radiation therapy, which is a relatively new area with limited examples in the literature. We present this editorial to discuss guidelines for best practice. In doing so, we highlight 3 recently published papers applying IBDM techniques to radiation therapy data and suggest alternative, more robust analysis methods.
Image-based data mining (IBDM) and voxel-based analysis (VBA) have shown great promise in the retrospective analysis of routine clinical data, offering a way to analyze a patient population without selection. In radiation therapy, IBDM analyzes whole dose distributions for their effect on a given outcome with no prior assumptions. Recent extensions in IBDM methodologies include per voxel survival analyses, allowing the generation of more robust and testable hypotheses. An essential aspect to produce solid conclusions includes applying the correct statistical techniques to account for multiple testing. There is a growing interest in applying IBDM/VBA techniques in radiation therapy, which is a relatively new area with limited examples in the literature. We present this editorial to discuss guidelines for best practice. In doing so, we highlight 3 recently published papers applying IBDM techniques to radiation therapy data and suggest alternative, more robust analysis methods.
Flogging a Dead Salmon? Reduced Dose Posterior to Prostate Correlates With Increased PSA Progression in Voxel-Based Analysis of 3 Randomized Phase 3 Trials
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