Flogging a Dead Salmon? Reduced Dose Posterior to Prostate Correlates With Increased PSA Progression in Voxel-Based Analysis of 3 Randomized Phase 3 Trials
Flogging a Dead Salmon? Reduced Dose Posterior to Prostate Correlates With Increased PSA Progression in Voxel-Based Analysis of 3 Randomized Phase 3 Trials(88 views) Shortall J, Palma G, Mistry H, Vasquez Osorio E, Mcwilliam A, Choudhury A, Aznar M, Van Herk M, Green A
Division of Cancer Science, University of Manchester, Manchester, United Kingdom
National Research Council, Institute of Biostructures and Bioimaging, Napoli, Italy
Christie Medical Physics & Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom
References: Reduced dose posterior to prostate correlates with increased PSA progression in voxel-based analysis of 3 randomised phase 3 trials. Int J Radiat Oncol. 2020; 108: 1304-1318
Relationships between rectal and perirectal doses and rectal bleeding or tenes-mus in pooled voxel-based analysis of 3 randomised phase III trials. Radiother Oncol. 2020; 150: 281-292
Increased dose to organs in urinary tract associates with measures of genitourinary toxicity in pooled voxel-based analysis of 3 randomized phase III trials.Front Oncol. 2020; 10: 1174
Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: An argument for multiple comparisons correction. Neuroimage. 2009; 47: S125
Multiple comparisons permutation test for image based data mining in radiotherapy. Radiat Oncol. 2013; 8: 293
Image based data mining using per-voxel cox regression. Front Oncol. 2020; 10: 1178
Radiation dose to heart base linked with poorer survival in lung cancer patients. Eur J Cancer. 2017; 85: 106-113
Mass univariate analysis of event-related brain potentials/fields I: A critical tutorial review. 1993
Voxel-based analysis in radiation oncology: A methodological cookbook. Phys Med, 69 (2020), pp. 192-204
Penalized likelihood and multiple testing. Biometrical J. 2019; 61: 62-72
A significance test for the lasso. Ann Stat. 2014; 42: 413-468
Estimation and accuracy after model selection. J Am Stat Assoc. 2014; 109: 991-1007
Post-selection inference for ℓ1-penalized likelihood models. Can J Stat. 2018; 46: 41-61
Statistical learning and selective inference. Proc Natl Acad Sci U S A. 2015; 112: 7629-7634
Voxelwise encoding models with non-spherical multivariate normal priors. Neuroimage. 2019; 197: 482-492
Characterizing the functional MRI response using Tikhonov regularization. Stat Med. 2007; 26: 3830-3844
Exploring the brain network: A review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol. 2010; 20: 519-534
The cost of dichotomising continuous variables. The cost of dichotomising continuous variables. Br Med J, 332 (2006), p. 1080
Flogging a Dead Salmon? Reduced Dose Posterior to Prostate Correlates With Increased PSA Progression in Voxel-Based Analysis of 3 Randomized Phase 3 Trials
Image-based data mining (IBDM) and voxel-based analysis (VBA) have shown great promise in the retrospective analysis of routine clinical data, offering a way to analyze a patient population without selection. In radiation therapy, IBDM analyzes whole dose distributions for their effect on a given outcome with no prior assumptions. Recent extensions in IBDM methodologies include per voxel survival analyses, allowing the generation of more robust and testable hypotheses. An essential aspect to produce solid conclusions includes applying the correct statistical techniques to account for multiple testing. There is a growing interest in applying IBDM/VBA techniques in radiation therapy, which is a relatively new area with limited examples in the literature. We present this editorial to discuss guidelines for best practice. In doing so, we highlight 3 recently published papers applying IBDM techniques to radiation therapy data and suggest alternative, more robust analysis methods.
Flogging a Dead Salmon? Reduced Dose Posterior to Prostate Correlates With Increased PSA Progression in Voxel-Based Analysis of 3 Randomized Phase 3 Trials
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Flogging a Dead Salmon? Reduced Dose Posterior to Prostate Correlates With Increased PSA Progression in Voxel-Based Analysis of 3 Randomized Phase 3 Trials