Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries(109 views) Saccu G, Menchise V, Giordano C, Delli Castelli D, Dastrù W, Pellicano R, Tolosano E, Van Pham P, Altruda F, Fagoonee S
J Clin Med (ISSN: 2077-0383electronic, 2077-0383linking), 2021 Jan 16; 10(2): N/D-N/D.
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, 10126 Turin, Italy
gabrisaccu@gmail.com (G.S.)
daniela.dellicastelli@unito.it (D.D.C.)
walter.dastru@unito.it (W.D.)
emanuela.tolosano@unito.it (E.T.)
Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, 10126 Turin, Italy
Ophthalmology Veterinary Practice, c.so Galileo Ferraris 121, 10126 Turin, Italy
cristina.giordano@unito.it
Unit of Gastroenterology, Molinette Hospital, 10126 Turin, Italy
rinaldo_pellican@hotmail.com
Laboratory of Stem Cell Research and Application, and Stem Cell Institute, VNUHCM University of Science, Ho Chi Minh City 08000, Vietnam
pvphuc@hcmuns.edu.vn
References: Not available.
Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries
Ocular chemical and thermal burns are frequent causes of hospitalization and require immediate interventions and care. Various surgical and pharmacological treatment strategies are employed according to damage severity. Controlling inflammation and neovascularization while promoting normal ocular surface anatomy and function restoration is the principal aim. In the most severe cases, when epithelial healing is severely affected, reconstruction of the ocular surface may be a valid option, which, however, requires expertise, adequate instruments, and qualified donors. Numerous endogenous and exogenous strategies have been considered for corneal repair. Among these, stem cells and their derivatives have offered numerous attractive possibilities in finding an effective way in stimulating corneal regeneration. Limbal epithelial stem cells and mesenchymal cells from the ocular tissue as well as from various sources have demonstrated their effectiveness in dampening neovascularization, scarring, and inflammation, while promoting epithelialization of the injured cornea. Moreover, a plethora of cytokines and growth factors, and extracellular vesicles, which constitute the secretome of these cells, work in concert to enhance wound healing. In this review, we provide an update on the recent potential therapeutic avenues and clinical applications of stem cells and their products in corneal regeneration after burn injury, as well as current imaging strategies for monitoring therapeutic efficacy and damage resolution.
Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries
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Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries