Probing thoracic dose patterns associated to pericardial effusion and mortality in patients treated with photons and protons for locally advanced non-small-cell lung cancer (200 views)
Radiother Oncol (ISSN: 0167-8140linking, 1879-0887), 2021 May 9; 160: 148-158.
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Paper type: Journal Article, Research Support, N. I. H. , Extramural,
Impact factor: 4.856, 5-year impact factor: 4.502
Url: Not available.
Keywords: Intensity Modulated Photon Radiotherapy, Non-Small-Cell Lung Cancer, Passive Scattering Proton Therapy, Pericardial Effusion, Voxel Based Analysis, Carcinoma, Non-Small-Cell Lung Radiotherapy , Humans , Lung Neoplasms Radiotherapy , Pericardial Effusion Etiology , Proton Therapy Adverse Effects , Radiotherapy Dosage , Intensity-Modulated Adverse Effects,
Affiliations:
*** IBB - CNR ***
National Research Council, Institute of Biostructures and Bioimaging, Napoli, Italy. Electronic address: laura.cella@cnr.it.
MD Anderson Cancer Center, Department of Radiation Oncology, Houston, USA.
Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Napoli, Italy.
GSI Helmholtz Centre for Heavy Ion Research, Department of Biophysics, Darmstadt, Germany.
References:
Not available.
Radiother Oncol (ISSN: 0167-8140linking, 1879-0887), 2021 May 9; 160: 148-158.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, N. I. H. , Extramural,
Impact factor: 4.856, 5-year impact factor: 4.502
Url: Not available.
Keywords: Intensity Modulated Photon Radiotherapy, Non-Small-Cell Lung Cancer, Passive Scattering Proton Therapy, Pericardial Effusion, Voxel Based Analysis, Carcinoma, Non-Small-Cell Lung Radiotherapy , Humans , Lung Neoplasms Radiotherapy , Pericardial Effusion Etiology , Proton Therapy Adverse Effects , Radiotherapy Dosage , Intensity-Modulated Adverse Effects,
Affiliations:
*** IBB - CNR ***
National Research Council, Institute of Biostructures and Bioimaging, Napoli, Italy. Electronic address: laura.cella@cnr.it.
MD Anderson Cancer Center, Department of Radiation Oncology, Houston, USA.
Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Napoli, Italy.
GSI Helmholtz Centre for Heavy Ion Research, Department of Biophysics, Darmstadt, Germany.
References:
Not available.
Probing thoracic dose patterns associated to pericardial effusion and mortality in patients treated with photons and protons for locally advanced non-small-cell lung cancer
PURPOSE: To investigate thoracic dose-response patterns for pericardial effusion (PCE) and mortality in patients treated for locally advanced Non-Small-Cell Lung Cancer (NSCLC) by Intensity Modulated RT (IMRT) or Passive-Scattering Proton Therapy (PSPT). METHODS: Among 178 patients, 43.5% developed grade ≥ 2 PCE. Clinical and dosimetric factors associated with PCE or overall survival (OS) were identified via multi-variable Cox proportional hazards modeling. The Voxel-Based Analyses (VBAs) of local dose differences between patients with and without PCE and mortality was performed. The robustness of VBA results was assessed by a novel characterization of spatial properties of dose distributions based on probabilistic independent component analysis (PICA) and connectograms. RESULTS: Several non-dosimetric variables were selected by the multivariable analysis for the considered outcomes, while the time-dependent PCE onset was uncorrelated with the OS (p = 0.34) at a multi-variable Cox analysis. Despite the significant PSPT dosimetric advantage, the RT technique did not affect the occurrence of PCE or OS. VBAs highlighted largely overlapping clusters significantly associated with PCE endpoints in heart and lungs. No significant dosimetric patterns related to mortality endpoints were found. PICA identified 43 components homogeneously scattered within thorax, while connectograms showed modest correlations between doses in main cardio-pulmonary substructures. CONCLUSIONS: Spatially resolved analysis highlighted dose patterns related to radiation-induced cardiac toxiciy and the observed organ-based dose-response mismatch in PSPT and IMRT. Indeed, the thoracic regions spared by PSPT poorly overlapped with the areas involved in PCE development, as highlited by VBA. PICA and connectograms proved valuable tools for assessing the robusteness of obtained VBA inferences.
PURPOSE: To investigate thoracic dose-response patterns for pericardial effusion (PCE) and mortality in patients treated for locally advanced Non-Small-Cell Lung Cancer (NSCLC) by Intensity Modulated RT (IMRT) or Passive-Scattering Proton Therapy (PSPT). METHODS: Among 178 patients, 43.5% developed grade ≥ 2 PCE. Clinical and dosimetric factors associated with PCE or overall survival (OS) were identified via multi-variable Cox proportional hazards modeling. The Voxel-Based Analyses (VBAs) of local dose differences between patients with and without PCE and mortality was performed. The robustness of VBA results was assessed by a novel characterization of spatial properties of dose distributions based on probabilistic independent component analysis (PICA) and connectograms. RESULTS: Several non-dosimetric variables were selected by the multivariable analysis for the considered outcomes, while the time-dependent PCE onset was uncorrelated with the OS (p = 0.34) at a multi-variable Cox analysis. Despite the significant PSPT dosimetric advantage, the RT technique did not affect the occurrence of PCE or OS. VBAs highlighted largely overlapping clusters significantly associated with PCE endpoints in heart and lungs. No significant dosimetric patterns related to mortality endpoints were found. PICA identified 43 components homogeneously scattered within thorax, while connectograms showed modest correlations between doses in main cardio-pulmonary substructures. CONCLUSIONS: Spatially resolved analysis highlighted dose patterns related to radiation-induced cardiac toxiciy and the observed organ-based dose-response mismatch in PSPT and IMRT. Indeed, the thoracic regions spared by PSPT poorly overlapped with the areas involved in PCE development, as highlited by VBA. PICA and connectograms proved valuable tools for assessing the robusteness of obtained VBA inferences.
Probing thoracic dose patterns associated to pericardial effusion and mortality in patients treated with photons and protons for locally advanced non-small-cell lung cancer
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Probing thoracic dose patterns associated to pericardial effusion and mortality in patients treated with photons and protons for locally advanced non-small-cell lung cancer
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Monti S, Paganelli C, Buizza G, Preda L, Valvo F, Baroni G, Palma G, Cella L
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Palma G, Monti S, Xu T, Scifoni E, Yang P, Hahn SM, Durante M, Mohan R, Liao Z, Cella L
* Spatial Dose Patterns Associated With Radiation Pneumonitis in a Randomized Trial Comparing Intensity-Modulated Photon Therapy With Passive Scattering Proton Therapy for Locally Advanced Non-Small Cell Lung Cancer (308 views)
Int J Radiat Oncol (ISSN: 0360-3016linking, 1879-355x), 2019 Aug 1; 104(5): 1124-1132.
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Nappi A, Gallicchio R, Simeon V, Nardelli A, Pelagalli A, Zupa A, Vita G, Venetucci A, Di Cosola M, Barbato F, Storto G
* [F-18] FDG-PET/CT parameters as predictors of outcome in inoperable NSCLC patients (363 views)
Radiol Oncol (ISSN: 1318-2099), 2015 Nov 27; 49(4): 320-326.
Impact Factor: 1.736
View Export to BibTeX Export to EndNote
* A novel framework for spatial normalization of dose distributions in voxel-based analyses of brain irradiation outcomes (168 views)
Phys Med (ISSN: 1120-1797linking), 2020 Jan; 69: 164-169.
Impact Factor: 2.485
View Export to BibTeX Export to EndNote
Palma G, Monti S, Xu T, Scifoni E, Yang P, Hahn SM, Durante M, Mohan R, Liao Z, Cella L
* Spatial Dose Patterns Associated With Radiation Pneumonitis in a Randomized Trial Comparing Intensity-Modulated Photon Therapy With Passive Scattering Proton Therapy for Locally Advanced Non-Small Cell Lung Cancer (308 views)
Int J Radiat Oncol (ISSN: 0360-3016linking, 1879-355x), 2019 Aug 1; 104(5): 1124-1132.
Impact Factor: 5.859
View Export to BibTeX Export to EndNote
Nappi A, Gallicchio R, Simeon V, Nardelli A, Pelagalli A, Zupa A, Vita G, Venetucci A, Di Cosola M, Barbato F, Storto G
* [F-18] FDG-PET/CT parameters as predictors of outcome in inoperable NSCLC patients (363 views)
Radiol Oncol (ISSN: 1318-2099), 2015 Nov 27; 49(4): 320-326.
Impact Factor: 1.736
View Export to BibTeX Export to EndNote
3 Records (3 excluding Abstracts).
Total impact factor: 10.08 (10.08 excluding Abstracts).
Total 5 year impact factor: 7.755 (7.755 excluding Abstracts).
Total impact factor: 10.08 (10.08 excluding Abstracts).
Total 5 year impact factor: 7.755 (7.755 excluding Abstracts).
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