Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis (203 views)
Am J Neuroradiol (ISSN: 0195-6108linking, 1936-959xelectronic), 2021 Jul; 42(7): 1223-1230.
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Paper type: Journal Article,
Impact factor: 3.825, 5-year impact factor: 3.774
Url: Not available.
Keywords: Atrophy Pathology , Brain Diagnostic Imaging Pathology , Brain Chemistry , Gray Matter Chemistry Diagnostic Imaging Pathology , Humans , Iron Analysis , Magnetic Resonance Imaging , Multiple Sclerosis Diagnostic Imaging Pathology , Myelin Sheath,
Affiliations:
*** IBB - CNR ***
From the Departments of Advanced Biomedical Sciences (G.P., E.T., A.E., A.B., S.C.).
Neurosciences and Reproductive and Odontostomatological Sciences (M.P., C.C., R.L., V.B.M.), University "Federico II," Naples, Italy.
Institute of Biostructure and Bioimaging, (S.M., M.Q., G.P.) National Research Council, Naples, Italy.
References:
Not available.
Am J Neuroradiol (ISSN: 0195-6108linking, 1936-959xelectronic), 2021 Jul; 42(7): 1223-1230.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.825, 5-year impact factor: 3.774
Url: Not available.
Keywords: Atrophy Pathology , Brain Diagnostic Imaging Pathology , Brain Chemistry , Gray Matter Chemistry Diagnostic Imaging Pathology , Humans , Iron Analysis , Magnetic Resonance Imaging , Multiple Sclerosis Diagnostic Imaging Pathology , Myelin Sheath,
Affiliations:
*** IBB - CNR ***
From the Departments of Advanced Biomedical Sciences (G.P., E.T., A.E., A.B., S.C.).
Neurosciences and Reproductive and Odontostomatological Sciences (M.P., C.C., R.L., V.B.M.), University "Federico II," Naples, Italy.
Institute of Biostructure and Bioimaging, (S.M., M.Q., G.P.) National Research Council, Naples, Italy.
References:
Not available.
Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis
BACKGROUND AND PURPOSE:: Modifications of magnetic susceptibility have been consistently demonstrated in the subcortical gray matter of MS patients, but some uncertainties remain concerning the underlying neurobiological processes and their clinical relevance. We applied quantitative susceptibility mapping and longitudinal relaxation rate relaxometry to clarify the relative contribution of atrophy and iron and myelin changes to deep gray matter damage and disability in MS. MATERIALS AND METHODS:: Quantitative susceptibility mapping and longitudinal relaxation rate maps were computed for 91 patients and 55 healthy controls from MR images acquired at 3T. Applying an external model, we estimated iron and myelin concentration maps for all subjects. Subsequently, changes of deep gray matter iron and myelin concentration (atrophy-dependent) and content (atrophy-independent) were investigated globally (bulk analysis) and regionally (voxel-based and atlas-based thalamic subnuclei analyses). The clinical impact of the observed MRI modifications was evaluated via regression models. RESULTS:: We identified reduced thalamic (P < .001) and increased pallidal (P < .001) mean iron concentrations in patients with MS versus controls. Global myelin and iron content in the basal ganglia did not differ between the two groups, while actual iron depletion was present in the thalamus (P < .001). Regionally, patients showed increased iron concentration in the basal ganglia (P ≤ .001) and reduced iron and myelin content in thalamic posterior-medial regions (P ≤ .004), particularly in the pulvinar (P ≤ .001). Disability was predicted by thalamic volume (B = –0.341, P = .02), iron concentration (B = -0.379, P = .005) and content (B = –0.406, P = .009), as well as pulvinar iron (B = –0.415, P = .003) and myelin (B = −0.415, P = .02) content, independent of atrophy. CONCLUSIONS:: Quantitative MRI suggests an atrophy-related iron increase within the basal ganglia of patients with MS, along with an atrophy-independent reduction of thalamic iron and myelin correlating with disability. Absolute depletions of thalamic iron and myelin may represent sensitive markers of subcortical GM damage, which add to the clinical impact of thalamic atrophy in MS.
BACKGROUND AND PURPOSE:: Modifications of magnetic susceptibility have been consistently demonstrated in the subcortical gray matter of MS patients, but some uncertainties remain concerning the underlying neurobiological processes and their clinical relevance. We applied quantitative susceptibility mapping and longitudinal relaxation rate relaxometry to clarify the relative contribution of atrophy and iron and myelin changes to deep gray matter damage and disability in MS. MATERIALS AND METHODS:: Quantitative susceptibility mapping and longitudinal relaxation rate maps were computed for 91 patients and 55 healthy controls from MR images acquired at 3T. Applying an external model, we estimated iron and myelin concentration maps for all subjects. Subsequently, changes of deep gray matter iron and myelin concentration (atrophy-dependent) and content (atrophy-independent) were investigated globally (bulk analysis) and regionally (voxel-based and atlas-based thalamic subnuclei analyses). The clinical impact of the observed MRI modifications was evaluated via regression models. RESULTS:: We identified reduced thalamic (P < .001) and increased pallidal (P < .001) mean iron concentrations in patients with MS versus controls. Global myelin and iron content in the basal ganglia did not differ between the two groups, while actual iron depletion was present in the thalamus (P < .001). Regionally, patients showed increased iron concentration in the basal ganglia (P ≤ .001) and reduced iron and myelin content in thalamic posterior-medial regions (P ≤ .004), particularly in the pulvinar (P ≤ .001). Disability was predicted by thalamic volume (B = –0.341, P = .02), iron concentration (B = -0.379, P = .005) and content (B = –0.406, P = .009), as well as pulvinar iron (B = –0.415, P = .003) and myelin (B = −0.415, P = .02) content, independent of atrophy. CONCLUSIONS:: Quantitative MRI suggests an atrophy-related iron increase within the basal ganglia of patients with MS, along with an atrophy-independent reduction of thalamic iron and myelin correlating with disability. Absolute depletions of thalamic iron and myelin may represent sensitive markers of subcortical GM damage, which add to the clinical impact of thalamic atrophy in MS.
Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis
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Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis
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* Stratification of multiple sclerosis patients using unsupervised machine learning: a single-visit MRI-driven approach (37 views)
Eur Radiol (ISSN: 0938-7994linking), 2022 Aug; 32 (8 ): 5382-5391.
Impact Factor:
View Export to BibTeX Export to EndNote
Cocozza S, Pontillo G, De Michele G, Perillo T, Guerriero E, Ugga L, Salvatore E, Galatolo D, Riso V, Saccà F, Quarantelli M, Brunetti A
* The "crab sign": an imaging feature of spinocerebellar ataxia type 48 (158 views)
Neuroradiology (ISSN: 0028-3940linking, 1432-1920electronic), 2020 Sep; 62(9): 1095-1103.
Impact Factor: 2.238
View Export to BibTeX Export to EndNote
Cassiano MT, Lanzillo R, Alfano B, Costabile T, Comerci M, Prinster A, Moccia M, Megna R, Morra VB, Quarantelli M, Brunetti A
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Impact Factor: 2.526
View Export to BibTeX Export to EndNote
Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
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Impact Factor: 7.469
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View Export to BibTeX Export to EndNote
Cocozza S, Sacca F, Cervo A, Marsili A, Russo CV, Giorgio SM, De Michele G, Filla A, Brunetti A, Quarantelli M
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View Export to BibTeX Export to EndNote
Saccà F, Puorro G, Brunetti A, Capasso G, Cervo A, Cocozza S, De Leva M, Marsili A, Pane C, Quarantelli M, Russo CV, Trepiccione F, De Michele G, Filla A, Morra VB
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Impact Factor: 3.408
View Export to BibTeX Export to EndNote
Molino I, Cavaliere C, Salvatore E, Quarantelli M, Colucci L, Fasanaro AM
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Impact Factor: 4.151
View Export to BibTeX Export to EndNote
Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
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Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Santoro L, Breedveld GJ, Manganelli F, Iodice R, Pisciotta C, Nolano M, Punzo F, Quarantelli M, Pappata S, Di Fonzo A, Oostra BA, Bonifati V
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Impact Factor: 3.354
View Export to BibTeX Export to EndNote
Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
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J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Amorosi S, Vigliano I, Del Giudice E, Panico L, Maruotti GM, Fusco A, Quarantelli M, Ciccone C, Ursini MV, Martinelli P, Pignata C
* Brain alteration in a Nude/SCID fetus carrying FOXN1 homozygous mutation (687 views)
J Neurol Sci (ISSN: 0022-510x, 0022-510xlinking), 2010 Nov 15; 298(1-2): 121-123.
Impact Factor: 2.167
View Export to BibTeX Export to EndNote
Cervenka S, Varrone A, Fransen E, Halldin C, Farde L
* PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans (730 views)
Synapse (ISSN: 0887-4476), 2010 Jun; 64(6): 478-485.
Impact Factor: 2.925
View Export to BibTeX Export to EndNote
Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
* Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (577 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1117-1125.
Impact Factor: 2.605
View Export to BibTeX Export to EndNote
Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
* Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (667 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
Impact Factor: 5.694
View Export to BibTeX Export to EndNote
Barbarulo AM, Pappata S, Puoti G, Prinster A, Grossi D, Cotrufo R, Salvatore M, Trojano L
* Rehabilitation of gesture imitation: a case study with fMRI (555 views)
Neurocase (ISSN: 1465-3656, 1355-4794), 2008; 14(4): 293-306.
Impact Factor: 0.918
View Export to BibTeX Export to EndNote
Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (439 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
View Export to BibTeX Export to EndNote
20 Records (19 excluding Abstracts).
Total impact factor: 67.206 (63.055 excluding Abstracts).
Total 5 year impact factor: 71.81 (67.445 excluding Abstracts).
Total impact factor: 67.206 (63.055 excluding Abstracts).
Total 5 year impact factor: 71.81 (67.445 excluding Abstracts).
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