Less COVID-19 deaths in southern and insular Italy explained by forest bathing, Mediterranean environment, and antiviral plant volatile organic compounds (131 views)
Environ Chem Lett (ISSN: 1610-3653linking), 2021 Nov; N/D: 1-11.
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Paper type: Research Journal Article,
Impact factor: 9.027, 5-year impact factor: 8.216
Url: https://doi.org/10.1007/s10311-021-01309-5
Keywords: Sars-Cov-2 · Covid-19 · Pandemics · Immunomodulatory Compounds · Forest Bathing · Mediterranean Vegetation · Volatile Organic Compounds · Plant Therapeutics · Angiotensin-Converting Enzyme 2 · Spike · Receptor Binding Domain,
Affiliations:
*** IBB - CNR ***
Roviello V1, Roviello GN*2
* Giovanni N. Roviellogiroviel@unina.it; giovanni.roviello@cnr.it
1 Department of Chemical, Materials and IndustrialProduction Engineering (DICMaPI), University of NaplesFederico II, Piazzale V. Tecchio 80, 80125 Naples, Italy2 Istituto Di Biostrutture E Bioimmagini, IBB–CNR, ViaMezzocannone 16, 80134 Naples, Italy
References:
Not available.
Environ Chem Lett (ISSN: 1610-3653linking), 2021 Nov; N/D: 1-11.
Export to BibTeX Export to EndNote
Paper type: Research Journal Article,
Impact factor: 9.027, 5-year impact factor: 8.216
Url: https://doi.org/10.1007/s10311-021-01309-5
Keywords: Sars-Cov-2 · Covid-19 · Pandemics · Immunomodulatory Compounds · Forest Bathing · Mediterranean Vegetation · Volatile Organic Compounds · Plant Therapeutics · Angiotensin-Converting Enzyme 2 · Spike · Receptor Binding Domain,
Affiliations:
*** IBB - CNR ***
Roviello V1, Roviello GN*2
* Giovanni N. Roviellogiroviel@unina.it; giovanni.roviello@cnr.it
1 Department of Chemical, Materials and IndustrialProduction Engineering (DICMaPI), University of NaplesFederico II, Piazzale V. Tecchio 80, 80125 Naples, Italy2 Istituto Di Biostrutture E Bioimmagini, IBB–CNR, ViaMezzocannone 16, 80134 Naples, Italy
References:
Not available.
Less COVID-19 deaths in southern and insular Italy explained by forest bathing, Mediterranean environment, and antiviral plant volatile organic compounds
The coronavirus disease 2019 (COVID-19) is causing major sanitary and socioeconomic issues, yet some locations are less impacted than others. While densely populated areas are likely to favor viral transmission, we hypothesize that other environmental factors could explain lower cases in some areas. We studied COVID-19 impact and population statistics in highly forested Mediterranean Italian regions versus some northern regions where the amount of trees per capita is much lower. We also evaluated the affinity of Mediterranean plant-emitted volatile organic compounds (VOCs) isoprene, α-pinene, linalool and limonene for COVID-19 protein targets by molecular docking modeling. Results show that while mean death number increased about 4 times from 2020 to 2021, the percentage of deaths per population (0.06–0.10%) was lower in the greener Mediterranean regions such as Sardinia, Calabria and Basilica versus northern regions with low forest coverage, such as Lombardy (0.33%) and Emilia Romagna (0.29%). Data also show that the pandemic severity cannot be explained solely by population density. Modeling reveals that plant organic compounds could bind and interfere with the complex formed by the receptor binding domain of the coronavirus spike protein with the human cell receptor. Overall, our findings are likely explained by sea proximity and mild climate, Mediterranean diet and the abundance of non-deciduous Mediterranean plants which emit immunomodulatory and antiviral compounds. Potential implications include ‘forest bathing’ as a therapeutic practice, designing nasal sprays containing plant volatile organic compounds, and preserving and increasing forest coverage.
The coronavirus disease 2019 (COVID-19) is causing major sanitary and socioeconomic issues, yet some locations are less impacted than others. While densely populated areas are likely to favor viral transmission, we hypothesize that other environmental factors could explain lower cases in some areas. We studied COVID-19 impact and population statistics in highly forested Mediterranean Italian regions versus some northern regions where the amount of trees per capita is much lower. We also evaluated the affinity of Mediterranean plant-emitted volatile organic compounds (VOCs) isoprene, α-pinene, linalool and limonene for COVID-19 protein targets by molecular docking modeling. Results show that while mean death number increased about 4 times from 2020 to 2021, the percentage of deaths per population (0.06–0.10%) was lower in the greener Mediterranean regions such as Sardinia, Calabria and Basilica versus northern regions with low forest coverage, such as Lombardy (0.33%) and Emilia Romagna (0.29%). Data also show that the pandemic severity cannot be explained solely by population density. Modeling reveals that plant organic compounds could bind and interfere with the complex formed by the receptor binding domain of the coronavirus spike protein with the human cell receptor. Overall, our findings are likely explained by sea proximity and mild climate, Mediterranean diet and the abundance of non-deciduous Mediterranean plants which emit immunomodulatory and antiviral compounds. Potential implications include ‘forest bathing’ as a therapeutic practice, designing nasal sprays containing plant volatile organic compounds, and preserving and increasing forest coverage.
Less COVID-19 deaths in southern and insular Italy explained by forest bathing, Mediterranean environment, and antiviral plant volatile organic compounds
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