The structural connectome constrains fast brain dynamics (172 views)
Elife (ISSN: 2050-084xlinking), 2021 Jul 9; 10: N/D-N/D.
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Paper type: Journal Article
Impact factor: 7.08, 5-year impact factor: 0
Url: Not available.
Keywords: Brain Dynamics, Brain Networks, Computational Biology, Human, Magnetoencephalography, Systems Biology, Systems Neuroscience, Adult , Brain Physiology , Connectome Methods , Female , Magnetic Resonance Imaging , Nerve Net Physiology, Neurons
Affiliations:
*** IBB - CNR ***
Aix-Marseille University, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Department of Motor Sciences and Wellness, Parthenope University of Naples, Naples, Italy.
Institute for Diagnosis and Cure Hermitage Capodimonte, Naples, Italy.
Institute of Applied Sciences and Intelligent Systems, National Research Council, Pozzuoli, Italy.
University of Melbourne, Melbourne, Australia.
University of Campania Luigi Vanvitelli, Caserta, Italy.
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy.
References:
Not available.
Elife (ISSN: 2050-084xlinking), 2021 Jul 9; 10: N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article
Impact factor: 7.08, 5-year impact factor: 0
Url: Not available.
Keywords: Brain Dynamics, Brain Networks, Computational Biology, Human, Magnetoencephalography, Systems Biology, Systems Neuroscience, Adult , Brain Physiology , Connectome Methods , Female , Magnetic Resonance Imaging , Nerve Net Physiology, Neurons
Affiliations:
*** IBB - CNR ***
Aix-Marseille University, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Department of Motor Sciences and Wellness, Parthenope University of Naples, Naples, Italy.
Institute for Diagnosis and Cure Hermitage Capodimonte, Naples, Italy.
Institute of Applied Sciences and Intelligent Systems, National Research Council, Pozzuoli, Italy.
University of Melbourne, Melbourne, Australia.
University of Campania Luigi Vanvitelli, Caserta, Italy.
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy.
References:
Not available.
The structural connectome constrains fast brain dynamics
Brain activity during rest displays complex, rapidly evolving patterns in space and time. Structural connections comprising the human connectome are hypothesized to impose constraints on the dynamics of this activity. Here, we use magnetoencephalography (MEG) to quantify the extent to which fast neural dynamics in the human brain are constrained by structural connections inferred from diffusion MRI tractography. We characterize the spatio-temporal unfolding of whole-brain activity at the millisecond scale from source-reconstructed MEG data, estimating the probability that any two brain regions will significantly deviate from baseline activity in consecutive time epochs. We find that the structural connectome relates to, and likely affects, the rapid spreading of neuronal avalanches, evidenced by a significant association between these transition probabilities and structural connectivity strengths (r = 0.37, p<0.0001). This finding opens new avenues to study the relationship between brain structure and neural dynamics.
Brain activity during rest displays complex, rapidly evolving patterns in space and time. Structural connections comprising the human connectome are hypothesized to impose constraints on the dynamics of this activity. Here, we use magnetoencephalography (MEG) to quantify the extent to which fast neural dynamics in the human brain are constrained by structural connections inferred from diffusion MRI tractography. We characterize the spatio-temporal unfolding of whole-brain activity at the millisecond scale from source-reconstructed MEG data, estimating the probability that any two brain regions will significantly deviate from baseline activity in consecutive time epochs. We find that the structural connectome relates to, and likely affects, the rapid spreading of neuronal avalanches, evidenced by a significant association between these transition probabilities and structural connectivity strengths (r = 0.37, p<0.0001). This finding opens new avenues to study the relationship between brain structure and neural dynamics.
The structural connectome constrains fast brain dynamics
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The structural connectome constrains fast brain dynamics
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14 Records (13 excluding Abstracts).
Total impact factor: 60.336 (55.159 excluding Abstracts).
Total 5 year impact factor: 59.795 (54.435 excluding Abstracts).
Total impact factor: 60.336 (55.159 excluding Abstracts).
Total 5 year impact factor: 59.795 (54.435 excluding Abstracts).
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