NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements(173 views) Gadda G, Cocozza S, Gambaccini M, Taibi A, Tedeschi E, Zamboni P, Palma G
Med Biol Eng Comput (ISSN: 0140-0118linking), 2021 Sep; 59(9): 1889-1899.
Keywords: Blood Flow Simulation, Human Circulation, Hydrodynamic Phantom, Phase-Contrast Mri, Hemodynamics
, Magnetic Resonance Imaging
, Software,
Affiliations: *** IBB - CNR ***
Section of Ferrara, National Institute for Nuclear Physics (INFN), 44122, Ferrara, Italy.
Department of Advanced Biomedical Sciences, University of Naples "Federico II", 80131, Napoli, Italy.
Department of Physics and Earth Sciences, University of Ferrara, 44122, Ferrara, Italy.
Vascular Diseases Center - Translational Surgery Unit, University of Ferrara, 44124, Ferrara, Italy.
Institute of Biostructures and Bioimaging, National Research Council, 80145, Napoli, Italy.
References: Not available.
NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements
Accurate and reproducible measurement of blood flow profile is very important in many clinical investigations for diagnosing cardiovascular disorders. Given that many factors could affect human circulation, and several parameters must be set to properly evaluate blood flows with phase-contrast techniques, we developed an MRI-compatible hydrodynamic phantom to simulate different physiological blood flows. The phantom included a programmable hydraulic pump connected to a series of pipes immersed in a solution mimicking human soft tissues, with a blood-mimicking fluid flowing in the pipes. The pump is able to shape and control the flow by driving a piston through a dedicated software. Periodic waveforms are used as input to the pump to move the fluid into the pipes, with synchronization of the MRI sequences to the flow waveforms. A dedicated software is used to extract and analyze flow data from magnitude and phase images. The match between the nominal and the measured flows was assessed, and the scope of phantom variables useful for a reliable calibration of an MRI system was accordingly defined. Results showed that the NO-HYPE phantom is a valuable tool for the assessment of MRI scanners and sequence design for the MR evaluation of blood flows. Overview of the NOvel HYdrodynamic Phantom for the Evaluation of MRI flow measurements (NO-HYPE). Left: internal of the CompuFlow 1000 MR pump unit. Right: Setting of the NO-HYPE before a MRI acquisition session. Soft tissue mimicking material is hosted in the central part of the phantom (light blue chamber). Glass pipes pass through the chamber carrying the blood mimicking fluid.
NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements
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NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(1028 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote