Helicobacter pylori eradication with a clarithromycin-based triple therapy in elderly patients: a case-control study (45 views)
Panminerva Med (ISSN: 0031-0808linking, 1827-1898electronic), 2021 Jul 26; N/D: N/D-N/D.
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Paper type: Journal Article,
Impact factor: 5.197, 5-year impact factor: 1.488
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Affiliations:
*** IBB - CNR ***
Department of Medical Sciences, University of Turin, Turin, Italy - marilena.durazzo@unito.it.
Section of Geriatrics, Department of Medical Sciences, University of Turin, Turin, Italy - marilena.durazzo@unito.it.
Institute for Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Centre, Turin, Italy.
Unit of Gastroenterology, Città della Salute e della Scienza-Molinette Hospital, Turin, Italy.
References:
Not available.
Panminerva Med (ISSN: 0031-0808linking, 1827-1898electronic), 2021 Jul 26; N/D: N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.197, 5-year impact factor: 1.488
Url: Not available.
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
Department of Medical Sciences, University of Turin, Turin, Italy - marilena.durazzo@unito.it.
Section of Geriatrics, Department of Medical Sciences, University of Turin, Turin, Italy - marilena.durazzo@unito.it.
Institute for Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Centre, Turin, Italy.
Unit of Gastroenterology, Città della Salute e della Scienza-Molinette Hospital, Turin, Italy.
References:
Not available.
Helicobacter pylori eradication with a clarithromycin-based triple therapy in elderly patients: a case-control study
BACKGROUND: Helicobacter pylori (H. pylori), main agents of several gastroduodenal diseases, represents a therapeutic challenge. Since the influence of age on the success of bacterial treatment remains uncertain, in this case-control study we assessed the efficacy of a standard H. pylori eradication therapy among elderly patients. METHODS: In this retrospective study, a total of 361 naïve patients (194 males, mean age 79.8± 3.4 years) aged more than 65 years and treated with a triple therapy regimen comprising a standard dose of omeprazole twice daily, amoxicillin 1g twice daily and clarithromycin 500 mg twice daily, for 7, 10 or 14 days, were included. They were compared with naïve patients, younger than 65 years (mean age 43± 2.7 years). Since in the year 2017, we began to use the three-in-one single capsule bismuth-containing quadruple therapy, the search was ended at 31 December 2016. RESULTS: Overall, H. pylori eradication rate in the intention-to-treat (ITT) analysis, was 70.9% (256/361) among elderly patients versus 70.9% (256/361) among young patients. Dividing by treatment duration, among elderly patients, eradication was obtained in 78.1% (50/64), 69.1% (139/201) and 69.7% (67/96) elderly patients within 7-day, 10-day and 14-day regimens, respectively, without statistical difference. Out of 361 elderly patients, 11 were excluded from the per protocol (PP) analysis because of discontinuations (7 for adverse events). One subject discontinued treatment among young patients. Also the PP analysis showed no statistical difference, with an eradication rate of 73.1% (256/350) among elderly patients versus 71.1% (256/360) among young patients. CONCLUSIONS: Elderly does not affect efficacy or safety of a clarithromycin-based triple therapy for H. pylori eradication.
BACKGROUND: Helicobacter pylori (H. pylori), main agents of several gastroduodenal diseases, represents a therapeutic challenge. Since the influence of age on the success of bacterial treatment remains uncertain, in this case-control study we assessed the efficacy of a standard H. pylori eradication therapy among elderly patients. METHODS: In this retrospective study, a total of 361 naïve patients (194 males, mean age 79.8± 3.4 years) aged more than 65 years and treated with a triple therapy regimen comprising a standard dose of omeprazole twice daily, amoxicillin 1g twice daily and clarithromycin 500 mg twice daily, for 7, 10 or 14 days, were included. They were compared with naïve patients, younger than 65 years (mean age 43± 2.7 years). Since in the year 2017, we began to use the three-in-one single capsule bismuth-containing quadruple therapy, the search was ended at 31 December 2016. RESULTS: Overall, H. pylori eradication rate in the intention-to-treat (ITT) analysis, was 70.9% (256/361) among elderly patients versus 70.9% (256/361) among young patients. Dividing by treatment duration, among elderly patients, eradication was obtained in 78.1% (50/64), 69.1% (139/201) and 69.7% (67/96) elderly patients within 7-day, 10-day and 14-day regimens, respectively, without statistical difference. Out of 361 elderly patients, 11 were excluded from the per protocol (PP) analysis because of discontinuations (7 for adverse events). One subject discontinued treatment among young patients. Also the PP analysis showed no statistical difference, with an eradication rate of 73.1% (256/350) among elderly patients versus 71.1% (256/360) among young patients. CONCLUSIONS: Elderly does not affect efficacy or safety of a clarithromycin-based triple therapy for H. pylori eradication.
Helicobacter pylori eradication with a clarithromycin-based triple therapy in elderly patients: a case-control study
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Helicobacter pylori eradication with a clarithromycin-based triple therapy in elderly patients: a case-control study
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 0.913
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Greco A, Di Benedetto A, Howard CM, Kelly S, Nande R, Dementieva Y, Miranda M, Brunetti A, Salvatore M, Claudio L, Sarkar D, Dent P, Curiel DT, Fisher PB, Claudio PP
* Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach (480 views)
Mol Ther (ISSN: 1525-0024e, 1525-0016linking), 2010 Feb 18; 18(2): 295-306.
Impact Factor: 7.149
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Esposito L, Seydel A, Aiello R, Sorrentino G, Cendron L, Zanotti G, Zagari
* The crystal structure of the superoxide dismutase from Helicobacter pylori reveals a structured C-terminal extension (498 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Nov; 1784(11): 1601-1606.
Impact Factor: 2.233
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Loguercio S, Dian C, Flagiello A, Scannella A, Pucci P, Terradot L, Zagari A
* In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure (330 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2008 Oct 15; 582(23-24): 3537-3541.
Impact Factor: 3.264
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Bashan A, Zarivach R, Schluenzen F, Agmon I, Harms J, Auerbach T, Baram D, Berisio R, Bartels H, Hansen HAS, Fucini P, Wilson D, Peretz M, Kessler M, Yonath A
* Ribosomal crystallography: Peptide bond formation and its inhibition (644 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Sep; 70(1): 19-41.
Impact Factor: 2.733
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Perrella O, Liguori G, Cattaneo D, Morelli L, Precchia E, Morisco E, Fonti R, Marinelli P
Ig antibody levels to Helicobacter pylori and histology of antral gastritis and duodenal ulcer: What is the correlation? (363 views)
G Mal Infett Parassit (ISSN: 0017-0321), 1992; 44(1): 65-68.
Impact Factor: 0
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Perrella O, Liguori G, Cattaneo D, Morelli L, Precchia E, Morisco E, Fonti R, Marinelli P
Ig antibody levels to Helicobacter pylori and histology of antral gastritis and duodenal ulcer: What is the correlation? [LIVELLI DI IG AD ISOTIPO DIVERSO E QUADRO ISTOLOGICO NELLA PATOLOGIA GASTRICA ASSOCIATA ALL'HELICOBACTER PYLORI: QUALE CORRELAZIONE?] (465 views)
G Mal Infett Parassit (ISSN: 0017-0321), 1992; 44: 65-68.
Impact Factor: 0
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28 Records (27 excluding Abstracts).
Total impact factor: 195.284 (195.284 excluding Abstracts).
Total 5 year impact factor: 144.475 (144.475 excluding Abstracts).
Total impact factor: 195.284 (195.284 excluding Abstracts).
Total 5 year impact factor: 144.475 (144.475 excluding Abstracts).
45 views. Last view on Friday 13 September 2024, 8:30:42
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