The Structural Duality of Nucleobases in Guanine Quadruplexes Controls Their Low-Energy Photoionization(73 views) Balanikas E, Martinez-fernandez L, Improta R, Podbevšek P, Baldacchino G, Markovitsi D
Université Paris-Saclay, CEA, CNRS, LIDYL, F-91191 Gif-sur-Yvette, France.
Departamento de Química, Facultad de Ciencias and Institute for Advanced Research in Chemistry (IADCHEM), Universidad Autónoma de Madrid, Campus de Excelencia UAM-CSIC, Cantoblanco, 28049 Madrid, Spain.
Istituto Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Via Mezzocannone 16, I-80134 Napoli, Italy.
Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.
References: Not available.
The Structural Duality of Nucleobases in Guanine Quadruplexes Controls Their Low-Energy Photoionization
Guanine quadruplexes are four-stranded DNA/RNA structures composed of a guanine core (vertically stacked guanine tetrads) and peripheral groups (dangling ends and/or loops). Such a dual structural arrangement of the nucleobases favors their photoionization at energies significantly lower than the guanine ionization potential. This effect is important with respect to the oxidative DNA damage and for applications in the field of optoelectronics. Photoionization quantum yields, determined at 266 nm by nanosecond transient absorption spectroscopy, strongly depend on both the type and position of the peripheral nucleobases. The highest value (1.5 × 10(-2)) is found for the tetramolecular structure (AG(4)A)(4) in which adenines are intermittently stacked on the adjacent guanine tetrads, as determined by nuclear magnetic resonance spectroscopy. Quantum chemistry calculations show that peripheral nucleobases interfere in a key step preceding electron ejection: charge separation, initiated by the population of charge transfer states during the relaxation of electronic excited states.
The Structural Duality of Nucleobases in Guanine Quadruplexes Controls Their Low-Energy Photoionization
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The Structural Duality of Nucleobases in Guanine Quadruplexes Controls Their Low-Energy Photoionization
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79 Records (74 excluding Abstracts). Total impact factor: 443.825 (428.453 excluding Abstracts). Total 5 year impact factor: 488.053 (469.005 excluding Abstracts).