Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides
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Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides (198 views)

Verdoliva V, Digilio G, Saviano M, De Luca S

Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Oct 11; 26(20): 1-9.

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Paper type: Journal Article

Impact factor: 4.411, 5-year impact factor: 2.411

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117246159&doi=10.3390%2fmolecules26206135&partnerID=40&md5=24f3c52fc7497d402f185a8fcbe172b6

Keywords: Aziridine , Lanthipeptide , Microwave Irradiation , Post-Synthetic Modification , Solid Basic Catalysis , Zeolites

Affiliations:
*** IBB - CNR ***

Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy.
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.
Department of Science and Technologic Innovation, Universitaà del Piemonte Orientale "A. Avogadro", 15121 Alessandria, Italy.
Institute of Crystallography, National Research Council, 70126 Bari, Italy.


References:
Not available.
Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides

Aziridine derivatives involved in nucleophilic ring-opening reactions have attracted great interest, since they allow the preparation of biologically active molecules. A chemoselective and mild procedure to convert a peptide cysteine residue into lanthionine via S-alkylation on aziridine substrates is presented in this paper. The procedure relies on a post-synthetic protocol promoted by molecular sieves to prepare lanthionine-containing peptides and is assisted by microwave irradiation. In addition, it represents a valuable alternative to the stepwise approach, in which the lanthionine precursor is incorporated into peptides as a building block.
Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides

▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides

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Calce E, Digilio G, Menchise V, Saviano M, De Luca S
* Chemoselective Glycosylation of Peptides through S-Alkylation Reaction (866 views) (PDF 202 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Apr 20; 24(23): 6231-6238.
Impact Factor: 5.476
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Calce E, Bugatti V, Vittoria V, De Luca S
* Solvent-Free Synthesis of Modified Pectin Compounds Promoted by Microwave Irradiation (603 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2012 Oct; 17(10): 12234-12242.
Impact Factor: 2.428
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2 Records (2 excluding Abstracts).
Total impact factor: 7.904 (7.904 excluding Abstracts).
Total 5 year impact factor: 8.156 (8.156 excluding Abstracts).

Last modified by Marco Comerci on Tuesday 09 April 2024, 12:56:57
198 views. Last view on Friday 13 December 2024, 11:20:12