Long-Term Outcomes in Uveal Melanoma After Ruthenium-106 Brachytherapy (339 views)
Front Oncol (ISSN: 2234-943xelectronic), 2022 Jan 03; 11: N/D-N/D.
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Paper type: Journal Article,
Impact factor: 5.66, 5-year impact factor: 0
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Affiliations:
*** IBB - CNR ***
Eye Clinic, Public Health Department, University of Naples “Federico II”, Naples, Italy
Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Naples, Italy
Radiotherapy Unit, University of Naples “Federico II”, Naples, Italy
Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
Institute of Biostructure and Bioimaging, National Research Council (CNR), Naples, Italy
References:
Not available.
Front Oncol (ISSN: 2234-943xelectronic), 2022 Jan 03; 11: N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.66, 5-year impact factor: 0
Url: Not available.
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
Eye Clinic, Public Health Department, University of Naples “Federico II”, Naples, Italy
Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Naples, Italy
Radiotherapy Unit, University of Naples “Federico II”, Naples, Italy
Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
Institute of Biostructure and Bioimaging, National Research Council (CNR), Naples, Italy
References:
Not available.
Long-Term Outcomes in Uveal Melanoma After Ruthenium-106 Brachytherapy
Uveal melanoma is the most common primary intraocular malignancy. The aim of this retrospective study was to report the results after ruthenium-106 (Ru-106) plaque brachytherapy for uveal melanoma in terms of tumor control, visual acuity, radiation-related complications, tumor recurrence, metastases, and patients’ survival rate during 4 years’ follow-up. A total of 355 eyes from 355 patients have been treated with Ru-106 plaque brachytherapy for uveal melanoma between February 2011 and March 2020. Five patients were lost to follow-up, and then 350 eyes of 350 patients (mean age 58 ± 11 years) were enrolled in this retrospective study. All patients underwent a complete ophthalmic examination including echography and spectral domain–optical coherence tomography. The mean follow-up was 4 years (3 months to 9 years). After treatment, the mean tumor thickness was reduced to 1.75 ± 0.21 mm. Radiation complications were found in 63% of patients: 38% showed radiation maculopathy, 11% had optic neuropathy, and 14% developed cataracts. Cancer-free survival was 99%, 97%, and 85%, respectively, at 5, 7, and 9 years. Ru-106 plaque brachytherapy represents a reliable treatment of uveal melanoma. This technique is valid and safe with a low rate of ocular complications during a long-term follow-up.
Uveal melanoma is the most common primary intraocular malignancy. The aim of this retrospective study was to report the results after ruthenium-106 (Ru-106) plaque brachytherapy for uveal melanoma in terms of tumor control, visual acuity, radiation-related complications, tumor recurrence, metastases, and patients’ survival rate during 4 years’ follow-up. A total of 355 eyes from 355 patients have been treated with Ru-106 plaque brachytherapy for uveal melanoma between February 2011 and March 2020. Five patients were lost to follow-up, and then 350 eyes of 350 patients (mean age 58 ± 11 years) were enrolled in this retrospective study. All patients underwent a complete ophthalmic examination including echography and spectral domain–optical coherence tomography. The mean follow-up was 4 years (3 months to 9 years). After treatment, the mean tumor thickness was reduced to 1.75 ± 0.21 mm. Radiation complications were found in 63% of patients: 38% showed radiation maculopathy, 11% had optic neuropathy, and 14% developed cataracts. Cancer-free survival was 99%, 97%, and 85%, respectively, at 5, 7, and 9 years. Ru-106 plaque brachytherapy represents a reliable treatment of uveal melanoma. This technique is valid and safe with a low rate of ocular complications during a long-term follow-up.
Long-Term Outcomes in Uveal Melanoma After Ruthenium-106 Brachytherapy
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Long-Term Outcomes in Uveal Melanoma After Ruthenium-106 Brachytherapy
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* Local tumor control and treatment related toxicity after plaque brachytherapy for uveal melanoma: A systematic review and a data pooled analysis (171 views)
Radiother Oncol (ISSN: 0167-8140linking, 1879-0887), 2022 Jan; 166: 15-25.
Impact Factor: 6.28
View Export to BibTeX Export to EndNote
Itta F, Liuzzi R, Farella A, Porri G, Pacelli R, Conson M, Oliviero C, Buonanno F, Breve MA, Cennamo G, Clemente S, Cella L
* Personalized treatment planning in eye brachytherapy for ocular melanoma: Dosimetric analysis on ophthalmic structure at risk (270 views)
Phys Med (ISSN: 1120-1797linking), 2020 Aug; 76: 285-293.
Impact Factor: 3.177
View Export to BibTeX Export to EndNote
Cennamo G, Montorio D, Bernardo R, Farella A, Liuzzi R, Breve MA, Reibaldi M, Cennamo G
* Retinal Vascular Changes in Radiation Maculopathy after Intravitreal Ranibizumab by Optical Coherence Tomography Angiography (319 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 May 27; 9(6): N/D-N/D.
Impact Factor: 6.78
View Export to BibTeX Export to EndNote
D'Amora A, Cucciolito M, E , Iannitti R, Morelli G, Palumbo R, Ruffo F, Tesauro D
* Pyridine Ruthenium(III) complexes entrapped in liposomes with enhanced cytotoxic properties in PC-3 prostate cancer cells (439 views)
Journal Of Drug Delivery Science And Technology, 2019; 51: 552-558.
Impact Factor: 2.606
View Export to BibTeX Export to EndNote
Cennamo G, Rossi C, Breve MA, Velotti N, Farella A, Liuzzi R, Cennamo G
* Evaluation of vascular changes with optical coherence tomography angiography after ruthenium-106 brachytherapy of circumscribed choroidal hemangioma (616 views)
Eye (ISSN: 0950-222xlinking, 1476-5454electronic), 2018 Aug; 32(8): 1401-1405.
Impact Factor: 2.275
View Export to BibTeX Export to EndNote
Cennamo G, Breve MA, Velotti N, Sparnelli F, Iovino C, Farella A, Liuzzi R, De Crecchio G, Cennamo G
* Evaluation of Vascular Changes with Optical Coherence Tomography Angiography after Plaque Radiotherapy of Choroidal Melanoma (783 views)
Ophthalmic Res (ISSN: 0030-3747linking), 2018 May; 60(4): 238-242.
Impact Factor: 1.826
View Export to BibTeX Export to EndNote
Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (513 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Tamasi G, Merlino A, Scaletti F, Heffeter P, Legin AA, Jakupec MA, Berger W, Messori L, Keppler BK, Cini R
* {Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo (475 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2017 Feb 28; 46(9): 3025-3040.
Impact Factor: 4.099
View Export to BibTeX Export to EndNote
Musumeci D, Rozza L, Merlino A, Paduano L, Marzo T, Massai L, Messori L, Montesarchio D
* Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (1233 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(31): 13914-13925.
Impact Factor: 4.177
View Export to BibTeX Export to EndNote
Vergara A, Russo Krauss I, Montesarchio D, Paduano L, Merlino A
* Investigating the Ruthenium Metalation of Proteins: X-ray Structure and Raman Microspectroscopy of the Complex between RNase A and AziRu (524 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2013 Oct 7; 52(19): 10714-10716.
Impact Factor: 4.794
View Export to BibTeX Export to EndNote
Vergara A, D’Errico G, Montesarchio D, Mangiapia G, Paduano L, Merlino A
* Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu (718 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2013 Apr 15; 52(8): 4157-4159.
Impact Factor: 4.794
View Export to BibTeX Export to EndNote
Pedicini P, Strigari L, Caivano R, Fiorentino A, Califano G, Nappi A, Improta G, Storto G, Cozzolino M, Chiumento C, Fusco V, Vavassori A, Benassi M, Orecchia R, Salvatore M
* Local tumor control probability to evaluate an applicator-guided volumetric-modulated arc therapy solution as alternative of 3D brachytherapy for the treatment of the vaginal vault in patients affected by gynecological cancer (1693 views)
Journal Of Applied Clinical Medical Physics (ISSN: 1526-9914), 2013 Mar 04; 14(2): 4N/D-4N/D.
Impact Factor: 1.11
View Export to BibTeX Export to EndNote
Vergara A, Montesarchio D, Russo Krauss I, Paduano L, Merlino A
* Investigating The Ruthenium Metallation Of Proteins: X-Ray Structure And Raman Microspectroscopy Of The Complex Between Rnase A And Aziru (517 views)
Inorg Chem (ISSN: 0020-1669, 1520-510xe, 1520-510xelectronic), 2013; 52(19): 10714-10716.
Impact Factor: 4.794
View Export to BibTeX Export to EndNote
Randazzo R, Lauceri R, Mammana A, D'Urso A, Purrello R
* Interactions of Λ and Δ enantiomers of ruthenium(II) cationic complexes with achiral anionic porphyrins (671 views)
Chirality (ISSN: 0899-0042), 2009; 21(1): 92-96.
Impact Factor: 2.677
View Export to BibTeX Export to EndNote
Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
* Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (749 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2008; 47(51): 9879-9882.
Impact Factor: 10.879
View Export to BibTeX Export to EndNote
Castiglioni E, Abbate S, Longhi G, Gangemi R, Lauceri R, Purrello R
* Absorption flattening as one cause of distortion of circular dichroism spectra of Δ-RuPhen3·H2TPPS complex (574 views)
Chirality (ISSN: 0899-0042), 2007 Sep; 19(8): 642-646.
Impact Factor: 2.436
View Export to BibTeX Export to EndNote
Musumeci D, Roviello GN, Sica D
* The oxidation of Δ2, Δ2, 4 and Δ4, 6 steroids with RuO4 (877 views)
Steroids (ISSN: 0039-128x), 2004 Mar; 69(3): 173-179.
Impact Factor: 2.337
View Export to BibTeX Export to EndNote
17 Records (16 excluding Abstracts).
Total impact factor: 65.041 (63.931 excluding Abstracts).
Total 5 year impact factor: 47.717 (46.443 excluding Abstracts).
Total impact factor: 65.041 (63.931 excluding Abstracts).
Total 5 year impact factor: 47.717 (46.443 excluding Abstracts).
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