Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study (302 views)
J Clin Med (ISSN: 2077-0383electronic, 2077-0383linking), 2021 Dec 23; 11 (1 ): N/D-N/D.
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Paper type: Journal Article
Impact factor: 0, 5-year impact factor: 0
Url: Not available.
Keywords: Rdoc , Deficit Syndrome , Motivation Circuits , Negative Symptoms , Positive Valence System , Salience System , Schizophrenia
Affiliations:
*** IBB - CNR ***
Department of Psychiatry, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
pezzella.pasquale3@gmail.com (P.P.)
paolabucci456@gmail.com (P.B.)
andreaperrottelli@gmail.com (A.P.)
luigi.giuliani.91@gmail.com (L.G.)
michele.fabrazzo@unicampania.it (M.F.)
silvana.galderisi@gmail.com (S.G.)
Biostructure and Bioimaging Institute, National Research Council, 80134 Naples, Italy
quarante@unina.it (M.Q.)
anna.prinster@ibb.cnr.it (A.P.)
Department of Integrated Imaging, IRCCS SDN, 80143 Naples, Italy
andrea.soricelli@uniparthenope.it
References:
Not available.
J Clin Med (ISSN: 2077-0383electronic, 2077-0383linking), 2021 Dec 23; 11 (1 ): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article
Impact factor: 0, 5-year impact factor: 0
Url: Not available.
Keywords: Rdoc , Deficit Syndrome , Motivation Circuits , Negative Symptoms , Positive Valence System , Salience System , Schizophrenia
Affiliations:
*** IBB - CNR ***
Department of Psychiatry, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
pezzella.pasquale3@gmail.com (P.P.)
paolabucci456@gmail.com (P.B.)
andreaperrottelli@gmail.com (A.P.)
luigi.giuliani.91@gmail.com (L.G.)
michele.fabrazzo@unicampania.it (M.F.)
silvana.galderisi@gmail.com (S.G.)
Biostructure and Bioimaging Institute, National Research Council, 80134 Naples, Italy
quarante@unina.it (M.Q.)
anna.prinster@ibb.cnr.it (A.P.)
Department of Integrated Imaging, IRCCS SDN, 80143 Naples, Italy
andrea.soricelli@uniparthenope.it
References:
Not available.
Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study
Deficit schizophrenia is a subtype of schizophrenia presenting primary and enduring negative symptoms (NS). Although one of the most updated hypotheses indicates a relationship between NS and impaired motivation, only a few studies have investigated abnormalities of motivational circuits in subjects with deficit schizophrenia (DS). Our aim was to investigate structural connectivity within motivational circuits in DS. We analyzed diffusion tensor imaging (DTI) data from 46 subjects with schizophrenia (SCZ) and 35 healthy controls (HCs). SCZ were classified as DS (n = 9) and non-deficit (NDS) (n = 37) using the Schedule for Deficit Syndrome. The connectivity index (CI) and the Fractional Anisotropy (FA) of the connections between selected brain areas involved in motivational circuits were examined. DS, as compared with NDS and HCs, showed increased CI between the right amygdala and dorsal anterior insular cortex and increased FA of the pathway connecting the left nucleus accumbens with the posterior insular cortex. Our results support previous evidence of distinct neurobiological alterations underlying different clinical subtypes of schizophrenia. DS, as compared with NDS and HCs, may present an altered pruning process (consistent with the hyperconnectivity) in cerebral regions involved in updating the stimulus value to guide goal-directed behavior.
Deficit schizophrenia is a subtype of schizophrenia presenting primary and enduring negative symptoms (NS). Although one of the most updated hypotheses indicates a relationship between NS and impaired motivation, only a few studies have investigated abnormalities of motivational circuits in subjects with deficit schizophrenia (DS). Our aim was to investigate structural connectivity within motivational circuits in DS. We analyzed diffusion tensor imaging (DTI) data from 46 subjects with schizophrenia (SCZ) and 35 healthy controls (HCs). SCZ were classified as DS (n = 9) and non-deficit (NDS) (n = 37) using the Schedule for Deficit Syndrome. The connectivity index (CI) and the Fractional Anisotropy (FA) of the connections between selected brain areas involved in motivational circuits were examined. DS, as compared with NDS and HCs, showed increased CI between the right amygdala and dorsal anterior insular cortex and increased FA of the pathway connecting the left nucleus accumbens with the posterior insular cortex. Our results support previous evidence of distinct neurobiological alterations underlying different clinical subtypes of schizophrenia. DS, as compared with NDS and HCs, may present an altered pruning process (consistent with the hyperconnectivity) in cerebral regions involved in updating the stimulus value to guide goal-directed behavior.
Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study
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Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study
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Amodio A, Quarantelli M, Mucci A, Prinster A, Soricelli A, Vignapiano A, Giordano GM, Merlotti E, Nicita A, Galderisi S
* Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex (639 views)
Clin Eeg Neurosci (ISSN: 2169-5202electronic, 1550-0594linking), 2018 Jan; 49(1): 55-65.
Impact Factor: 2.163
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Volpe U, Mucci A, Quarantelli M, Galderisi S, Maj M
* Dorsolateral prefrontal cortex volume in patients with deficit or nondeficit schizophrenia (927 views) (PDF 279 views)
Prog Neuropsychopharmacol Biol Psychiatry (ISSN: 0278-5846, 0278-5846linking), 2012 Jun 1; 37(2): 264-269.
Impact Factor: 3.552
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Galderisi S, Quarantelli M, Volpe U, Mucci A, Cassano GB, Invernizzi G, Rossi A, Vita A, Pini S, Cassano P, Daneluzzo E, De Peri L, Stratta P, Brunetti A, Maj M
* Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia (920 views) (PDF 237 views)
Schizophr Bull (ISSN: 0586-7614, 1745-1701electronic, 0586-7614linking), 2008 Mar; 34(2): 393-401.
Impact Factor: 6.592
View Export to BibTeX Export to EndNote
* Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex (639 views)
Clin Eeg Neurosci (ISSN: 2169-5202electronic, 1550-0594linking), 2018 Jan; 49(1): 55-65.
Impact Factor: 2.163
View Export to BibTeX Export to EndNote
Volpe U, Mucci A, Quarantelli M, Galderisi S, Maj M
* Dorsolateral prefrontal cortex volume in patients with deficit or nondeficit schizophrenia (927 views) (PDF 279 views)
Prog Neuropsychopharmacol Biol Psychiatry (ISSN: 0278-5846, 0278-5846linking), 2012 Jun 1; 37(2): 264-269.
Impact Factor: 3.552
View Export to BibTeX Export to EndNote
Galderisi S, Quarantelli M, Volpe U, Mucci A, Cassano GB, Invernizzi G, Rossi A, Vita A, Pini S, Cassano P, Daneluzzo E, De Peri L, Stratta P, Brunetti A, Maj M
* Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia (920 views) (PDF 237 views)
Schizophr Bull (ISSN: 0586-7614, 1745-1701electronic, 0586-7614linking), 2008 Mar; 34(2): 393-401.
Impact Factor: 6.592
View Export to BibTeX Export to EndNote
3 Records (3 excluding Abstracts).
Total impact factor: 12.307 (12.307 excluding Abstracts).
Total 5 year impact factor: 12.386 (12.386 excluding Abstracts).
Total impact factor: 12.307 (12.307 excluding Abstracts).
Total 5 year impact factor: 12.386 (12.386 excluding Abstracts).
302 views. Last view on Monday 14 April 2025, 12:13:00
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