MRI radiomics: A machine learning approach for the risk stratification of endometrial cancer patients(117 views)(PDF public31 views) Mainenti PP, Stanzione A, Cuocolo R, Del G, R , Danzi R, Romeo V, Raffone A, Di Psiezio A, Giordano E, Travaglino E, Insavato L, Scaglione M, Maurea S, Brunetti A
Purpose: To investigate radiomics and machine learning (ML) as possible tools to enhance MRI-based risk
stratification in patients with endometrial cancer (EC).
Method: From two institutions, 133 patients (Institution1 = 104 and Institution2 = 29) with EC and pre-operative
MRI were retrospectively enrolled and divided in two a low-risk and a high-risk group according to EC stage and
grade. T2-weighted (T2w) images were three-dimensionally annotated to obtain volumes of interest of the entire
tumor. A PyRadiomics based and previously validated pipeline was used to extract radiomics features and
perform feature selection. In particular, feature stability, variance and pairwise correlation were analyzed. Then,
the least absolute shrinkage and selection operator technique and recursive feature elimination were used to
obtain the final feature set. The performance of a Support Vector Machine (SVM) algorithm was assessed on the
dataset from Institution 1 via 2-fold cross-validation. Then, the model was trained on the entire Institution 1
dataset and tested on the external test set from Institution 2.
Results: In total, 1197 radiomics features were extracted. After the exclusion of unstable, low variance and
intercorrelated features least absolute shrinkage and selection operator and recursive feature elimination identified
4 features that were used to build the predictive ML model. It obtained an accuracy of 0.71 and 0.72 in the
train and test sets respectively.
Conclusions: Whole-lesion T2w-derived radiomics showed encouraging results and good generalizability for the
identification of low-risk EC patients.
References: Not available.
MRI radiomics: A machine learning approach for the risk stratification of endometrial cancer patients
Not available.
MRI radiomics: A machine learning approach for the risk stratification of endometrial cancer patients