MRI to assess deep myometrial invasion in patients with endometrial cancer: A multi-reader study to evaluate the diagnostic role of different sequences
MRI to assess deep myometrial invasion in patients with endometrial cancer: A multi-reader study to evaluate the diagnostic role of different sequences(11 views) Stanzione A, Maurea S, Danzi R, Cuocolo R, Galatola R, Romeo V, Raffone A, Travaglino A, Di Spiezio SA, Insabato L, Pace L, Scaglione M, Brunetti A, Mainenti PP
MRI to assess deep myometrial invasion in patients with endometrial cancer: A multi-reader study to evaluate the diagnostic role of different sequences
Objective: The identification of deep myometrial invasion (DMI) represents a fundamental aspect in patients with
endometrial cancer (EC) for accurate disease staging. It can be detected on MRI using T2-weighted (T2-w),
diffusion weighted (DWI) and dynamic contrast enhanced sequences (DCE). Aim of the study was to perform a
multi-reader evaluation of such sequences to identify the most accurate and its reliability for the best protocol.
Methods: In this multicenter retrospective study, MRI were independently evaluated by 4 radiologists (2 senior
and 2 novice) with a sequence-based approach to identify DMI. The performance of the entire protocol was also
evaluated. A comparison between the different sequences assessed by the same reader was performed using
receiver operating curve and post-hoc analysis. Intraclass Correlation Coefficient (ICC) was used to assess interand
intra-observer variability.
Results: A total of 92 patients were included. The performance of the readers did not show significant differences
among DWI, DCE and the entire protocol. For only one senior radiologist, who reached the highest diagnostic
accuracy with the entire protocol (82,6 %), both DWI (p = 0,0197) and entire protocol (p = 0,0039) were found
significantly superior to T2-w. The highest inter-observer agreement was obtained with the entire protocol by
expert readers (ICC = 0,77).
Conclusions: For the detection of DMI, the performances of DWI and DCE alone and that of a complete protocol do
not significantly differ, even though the latter ensures the highest reliability particularly for expert readers. In
cases in which T2-w and DWI are consistent, an unenhanced protocol could be proposed.
MRI to assess deep myometrial invasion in patients with endometrial cancer: A multi-reader study to evaluate the diagnostic role of different sequences
MRI to assess deep myometrial invasion in patients with endometrial cancer: A multi-reader study to evaluate the diagnostic role of different sequences
Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-aranaz F, Di Pompo G, Distel M, Dorado-garcia H, Garcia-castro J, González-gonzález L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-esquivel C, Morales-molina Á, Musa J, Ohmura S, Ory B, Pereira-silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann D * Sarcoma treatment in the era of molecular medicine(53 views) Embo Mol Med (ISSN: 1757-4676linking), 2020 Oct 13; 12(11): e11131-N/D. Impact Factor:10.293 ViewExport to BibTeXExport to EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(710 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote