Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era (110 views)
International Journal Of Molecular Sciences, 2022 Jun; 23: 4359-4375.
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Paper type: Review Journal Article,
Impact factor: 5.924, 5-year impact factor: 0
Url: https://www.mdpi.com/1422-0067/23/8/4359/htm
Keywords: Dna, Rna, Oligonucleotides, Nucleic Acid Analogs, Covid-19, Antisense, Mrna Vaccines, Antigene, Nanomedicine,
Affiliations:
*** IBB - CNR ***
Nicola Borbone 1, Ilaria Piccialli 2, Andrea Patrizia Falanga 1, Vincenzo Piccialli 3, Giovanni N. Roviello 4,*and Giorgia Oliviero 51 Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49,80131 Naples, Italy; nicola.borbone@unina.it (N.B.); andreapatrizia.falanga@unina.it (A.P.F.)2 Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatological Sciences,University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy; ilaria.piccialli@unina.it3 Department of Chemical Sciences, University of Naples Federico II, Via Cintia 26, 80126 Naples, Italy;vinpicci@unina.it4 Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR),Area di Ricerca Site and Headquarters, Via Pietro Castellino 111, 80131 Naples, Italy5 Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II,Via Sergio Pansini 5, 80131 Naples, Italy; giorgia.oliviero@unina.it* Correspondence: GN Roviello giroviel@unina.it
References:
Not available.
International Journal Of Molecular Sciences, 2022 Jun; 23: 4359-4375.
Export to BibTeX Export to EndNote
Paper type: Review Journal Article,
Impact factor: 5.924, 5-year impact factor: 0
Url: https://www.mdpi.com/1422-0067/23/8/4359/htm
Keywords: Dna, Rna, Oligonucleotides, Nucleic Acid Analogs, Covid-19, Antisense, Mrna Vaccines, Antigene, Nanomedicine,
Affiliations:
*** IBB - CNR ***
Nicola Borbone 1, Ilaria Piccialli 2, Andrea Patrizia Falanga 1, Vincenzo Piccialli 3, Giovanni N. Roviello 4,*and Giorgia Oliviero 51 Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49,80131 Naples, Italy; nicola.borbone@unina.it (N.B.); andreapatrizia.falanga@unina.it (A.P.F.)2 Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatological Sciences,University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy; ilaria.piccialli@unina.it3 Department of Chemical Sciences, University of Naples Federico II, Via Cintia 26, 80126 Naples, Italy;vinpicci@unina.it4 Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR),Area di Ricerca Site and Headquarters, Via Pietro Castellino 111, 80131 Naples, Italy5 Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II,Via Sergio Pansini 5, 80131 Naples, Italy; giorgia.oliviero@unina.it* Correspondence: GN Roviello giroviel@unina.it
References:
Not available.
Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era
Abstract: The recent development of mRNA vaccines against the SARS-CoV-2 infection has turned
the spotlight on the potential of nucleic acids as innovative prophylactic agents and as diagnostic
and therapeutic tools. Until now, their use has been severely limited by their reduced half-life in the
biological environment and the difficulties related to their transport to target cells. These limiting
aspects can now be overcome by resorting to chemical modifications in the drug and using appropriate nanocarriers, respectively. Oligonucleotides can interact with complementary sequences of
nucleic acid targets, forming stable complexes and determining their loss of function. An alternative
strategy uses nucleic acid aptamers that, like the antibodies, bind to specific proteins to modulate
their activity. In this review, the authors will examine the recent literature on nucleic acids-based
strategies in the COVID-19 era, focusing the attention on their applications for the prophylaxis of
COVID-19, but also on antisense- and aptamer-based strategies directed to the diagnosis and therapy of the coronavirus pandemic
Abstract: The recent development of mRNA vaccines against the SARS-CoV-2 infection has turned
the spotlight on the potential of nucleic acids as innovative prophylactic agents and as diagnostic
and therapeutic tools. Until now, their use has been severely limited by their reduced half-life in the
biological environment and the difficulties related to their transport to target cells. These limiting
aspects can now be overcome by resorting to chemical modifications in the drug and using appropriate nanocarriers, respectively. Oligonucleotides can interact with complementary sequences of
nucleic acid targets, forming stable complexes and determining their loss of function. An alternative
strategy uses nucleic acid aptamers that, like the antibodies, bind to specific proteins to modulate
their activity. In this review, the authors will examine the recent literature on nucleic acids-based
strategies in the COVID-19 era, focusing the attention on their applications for the prophylaxis of
COVID-19, but also on antisense- and aptamer-based strategies directed to the diagnosis and therapy of the coronavirus pandemic
Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era
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Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era
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View Export to BibTeX Export to EndNote
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Musumeci D, Rozza L, Merlino A, Paduano L, Marzo T, Massai L, Messori L, Montesarchio D
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
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Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
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Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (748 views)
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De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
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Impact Factor: 2.15
View Export to BibTeX Export to EndNote
* Enhanced molecular dynamic simulation studies unravel long-range effects caused by sequence variations and partner binding in RNA aptamers (33 views)
Mol Ther Nucleic Acids (ISSN: 2162-2531linking), 2023 Dec 12; 34: 102039-102039.
Impact Factor:
View Export to BibTeX Export to EndNote
Greco F, Marzano M, Falanga AP, Terracciano M, Piccialli G, Roviello GN, D , #xerrico S, Borbone N, Oliviero G
* Cytosine-rich oligonucleotides incorporating a non-nucleotide loop: A further step towards the obtainment of physiologically stable i-motif DNA (90 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2022 Oct 31; 219: 626-636.
Impact Factor: 8.025
View Export to BibTeX Export to EndNote
Agnello L, Tortorella S, D’argenio A, Carbone C, Camorani S, Locatelli E, Auletta L, Sorrentino D, Fedele M, Zannetti A, Franchini MC, Cerchia L
* Optimizing cisplatin delivery to triple-negative breast cancer through novel EGFR aptamer-conjugated polymeric nanovectors (85 views)
J Exp Clin Canc Res (ISSN: 1756-9966electronic, 0392-9078linking), 2021 Jul 22; 40(1): 239-239.
Impact Factor: 11.161
View Export to BibTeX Export to EndNote
Ogloblina AM, Iaccarino N, Capasso D, Di Gaetano S, Garzarella EU, Dolinnaya NG, Yakubovskaya MG, Pagano B, Amato J, Randazzo A
* Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives (142 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Oct 21; 21(20): N/D-N/D.
Impact Factor: 4.556
View Export to BibTeX Export to EndNote
Marzano M, Falanga AP, D'Errico S, Pinto B, Roviello GN, Piccialli G, Oliviero G, Borbone N
* New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes (384 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2019 Feb 12; 24(3): 654-654.
Impact Factor: 3.06
View Export to BibTeX Export to EndNote
Martinez Fernandez L, Muñoz-losa A, Esposito L, Improta R
* The optical properties of adenine cation in different oligonucleotides: a PCM/TD‑DFT study (246 views) (PDF 168 views)
Theor Chem Acc (ISSN: 1432-881x), 2018; 137(3): N/D-N/D.
Impact Factor: 1.545
View Export to BibTeX Export to EndNote
Piras L, Avitabile C, D'Andrea LD, Saviano M, Romanelli A
* Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2 (360 views)
Biochem Bioph Res Co (ISSN: 0006-291x), 2017 Sep 15; N/D: N/D-N/D.
Impact Factor: 2.559
View Export to BibTeX Export to EndNote
Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (704 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
View Export to BibTeX Export to EndNote
Filippi M, Catanzaro V, Patrucco D, Botta M, Tei L, Terreno E
* First in vivo MRI study on theranostic dendrimersomes (422 views)
J Control Release (ISSN: 0168-3659), 2017 Feb 28; 248: 45-52.
Impact Factor: 7.877
View Export to BibTeX Export to EndNote
Improta R, Santoro F, Blancafort L
* Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases (1623 views)
Chem Rev (ISSN: 0009-2665), 2016; 116(6): 3540-3593.
Impact Factor: 47.928
View Export to BibTeX Export to EndNote
Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (595 views)
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Avitabile C, D'Andrea LD, Romanelli A
* Exploring the dark matter of the human genome using oligonucleotide-based molecules (367 views)
Future Med Chem (ISSN: 1756-8919, 1756-8919linking, 1756-8927electronic), 2015; 7(13): 1627-1630.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Musumeci D, Rozza L, Merlino A, Paduano L, Marzo T, Massai L, Messori L, Montesarchio D
* Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (865 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(31): 13914-13925.
Impact Factor: 4.177
View Export to BibTeX Export to EndNote
Morelli G, Saviano M, Grieco P
* The renaissance era of peptides in drug discovery at the 14th Naples workshop on bioactive peptides (564 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 321-322.
Impact Factor: 1.951
View Export to BibTeX Export to EndNote
Zhang Y, Dood J, Beckstead AA, Li X-B, Nguyen KV, Burrows CJ, Improta R, Kohler B
* Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide (510 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Sep 12; 111(32): 11612-11617.
Impact Factor: 9.674
View Export to BibTeX Export to EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (1179 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
View Export to BibTeX Export to EndNote
Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (417 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
View Export to BibTeX Export to EndNote
Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C
* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (627 views)
Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
Impact Factor: 3.978
View Export to BibTeX Export to EndNote
Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (1088 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (487 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
View Export to BibTeX Export to EndNote
Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (748 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
View Export to BibTeX Export to EndNote
Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (573 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
View Export to BibTeX Export to EndNote
De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (498 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
View Export to BibTeX Export to EndNote
23 Records (23 excluding Abstracts).
Total impact factor: 154.869 (154.869 excluding Abstracts).
Total 5 year impact factor: 155.471 (155.471 excluding Abstracts).
Total impact factor: 154.869 (154.869 excluding Abstracts).
Total 5 year impact factor: 155.471 (155.471 excluding Abstracts).
110 views. Last view on Sunday 06 October 2024, 19:39:31
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