Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor(654 views) Ayoub J, Buonanno M, Di Fiore A, De Simone G, Monti SM
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic), 2022 Feb 15; 23(4): 2160-2160.
Keywords: Amino Acid Sequence, Chromatin, Metabolism, Chromatin Assembly Factor-1, Chromosomal Proteins, Non-Histone, Dna Replication, Physiology, Dna-Binding Proteins, Humans, Protein Binding, Protein Domains, Protein Kinases, Protein Subunits, Saccharomyces Cerevisiae, Transcription Factors, Caf-1, Chaf1a, Dna Binding, Human P150, Human Diseases,
Affiliations: *** IBB - CNR ***
Institute of Biostructures and Bioimaging, Consiglio Nazionale delle Ricerche (IBB-CNR), Via Mezzocannone, 16, 80134 Naples, Italy., Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy., Medical Laboratory-Molecular Biology, Saint George Hospital Medical Center, Rmeil-Youssef Sursok Street, Beirut 166378, Lebanon.,
References: Not available.
Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor
The Chromatin Assembly Factor 1 is a heterotrimeric complex responsible for the nucleosome assembly during DNA replication and DNA repair. In humans, the largest subunit P150 is the major actor of this process. It has been recently considered as a tumor-associated protein due to its overexpression in many malignancies. Structural and functional studies targeting P150 are still limited and only scarce information about this subunit is currently available. Literature data and bioinformatics analysis assisted the identification of a stable DNA binding domain, encompassing residues from 721 to 860 of P150 within the full-length protein. This domain was recombinantly produced and in vitro investigated. An acidic region modulating its DNA binding ability was also identified and characterized. Results showed similarities and differences between the P150 and its yeast homologue, namely Cac-1, suggesting that, although sharing a common biological function, the two proteins may also possess different features.
Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor
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