Deciphering the Relationship between SARS-CoV-2 and Cancer (87 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2023 Apr 25; 24(9): 7803-7803.
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Paper type: Review Journal Article
Impact factor: 5.6, 5-year impact factor: 6.2
Url: https://www.mdpi.com/1422-0067/24/9/7803
Keywords: Oncoviruses, Oncogenic Virus, Oncolytic Virus, Sars-Cov-2, Long Covid-19, Covidomics, Immunotherapy, Immune Escape, Metabolic Reprogramming, Coronavirus, Humans, Epstein-Barr Virus Infections Complications, Papillomavirus Infections Complications, Post-Acute Covid-19 Syndrome, Herpesvirus 4, Covid-19 Complications, Neoplasms Pathology, Oncogenic Viruses Genetics, Cell Transformation, Neoplastic, Hepatitis C Complications
Affiliations:
*** IBB - CNR ***
by Michele Costanzo 1,2,*ORCID,Maria Anna Rachele De Giglio 3 andGiovanni Nicola Roviello 4,*ORCID1Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy2CEINGE–Biotecnologie Avanzate Franco Salvatore s.c.ar.l., Via G. Salvatore 486, 80145 Naples, Italy3School of Medicine and Surgery, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy4Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR), Via P. Castellino 111, 80131 Naples, Italy*Authors to whom correspondence should be addressed.
References:
Not available.
Int J Mol Sci (ISSN: 1422-0067linking), 2023 Apr 25; 24(9): 7803-7803.
Export to BibTeX Export to EndNote
Paper type: Review Journal Article
Impact factor: 5.6, 5-year impact factor: 6.2
Url: https://www.mdpi.com/1422-0067/24/9/7803
Keywords: Oncoviruses, Oncogenic Virus, Oncolytic Virus, Sars-Cov-2, Long Covid-19, Covidomics, Immunotherapy, Immune Escape, Metabolic Reprogramming, Coronavirus, Humans, Epstein-Barr Virus Infections Complications, Papillomavirus Infections Complications, Post-Acute Covid-19 Syndrome, Herpesvirus 4, Covid-19 Complications, Neoplasms Pathology, Oncogenic Viruses Genetics, Cell Transformation, Neoplastic, Hepatitis C Complications
Affiliations:
*** IBB - CNR ***
by Michele Costanzo 1,2,*ORCID,Maria Anna Rachele De Giglio 3 andGiovanni Nicola Roviello 4,*ORCID1Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy2CEINGE–Biotecnologie Avanzate Franco Salvatore s.c.ar.l., Via G. Salvatore 486, 80145 Naples, Italy3School of Medicine and Surgery, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy4Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR), Via P. Castellino 111, 80131 Naples, Italy*Authors to whom correspondence should be addressed.
References:
Not available.
Deciphering the Relationship between SARS-CoV-2 and Cancer
Some viruses are known to be associated with the onset of specific cancers. These microorganisms, oncogenic viruses or oncoviruses, can convert normal cells into cancer cells by modulating the central metabolic pathways or hampering genomic integrity mechanisms, consequently inhibiting the apoptotic machinery and/or enhancing cell proliferation. Seven oncogenic viruses are known to promote tumorigenesis in humans: human papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), Epstein-Barr virus (EBV), human T-cell leukemia virus 1 (HTLV-1), Kaposi sarcoma-associated herpesvirus (KSHV), and Merkel cell polyomavirus (MCPyV). Recent research indicates that SARS-CoV-2 infection and COVID-19 progression may predispose recovered patients to cancer onset and accelerate cancer development. This hypothesis is based on the growing evidence regarding the ability of SARS-CoV-2 to modulate oncogenic pathways, promoting chronic low-grade inflammation and causing tissue damage. Herein, we summarize the main relationships known to date between virus infection and cancer, providing a summary of the proposed biochemical mechanisms behind the cellular transformation. Mechanistically, DNA viruses (such as HPV, HBV, EBV, and MCPyV) encode their virus oncogenes. In contrast, RNA viruses (like HCV, HTLV-1) may encode oncogenes or trigger host oncogenes through cis-/-trans activation leading to different types of cancer. As for SARS-CoV-2, its role as an oncogenic virus seems to occur through the inhibition of oncosuppressors or controlling the metabolic and autophagy pathways in the infected cells. However, these effects could be significant in particular scenarios like those linked to severe COVID-19 or long COVID. On the other hand, looking at the SARS-CoV-2─cancer relationship from an opposite perspective, oncolytic effects and anti-tumor immune response were triggered by SARS-CoV-2 infection in some cases. In summary, our work aims to recall comprehensive attention from the scientific community to elucidate the effects of SARS-CoV-2 and, more in general, β-coronavirus infection on cancer susceptibility for cancer prevention or supporting therapeutic approaches.
Some viruses are known to be associated with the onset of specific cancers. These microorganisms, oncogenic viruses or oncoviruses, can convert normal cells into cancer cells by modulating the central metabolic pathways or hampering genomic integrity mechanisms, consequently inhibiting the apoptotic machinery and/or enhancing cell proliferation. Seven oncogenic viruses are known to promote tumorigenesis in humans: human papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), Epstein-Barr virus (EBV), human T-cell leukemia virus 1 (HTLV-1), Kaposi sarcoma-associated herpesvirus (KSHV), and Merkel cell polyomavirus (MCPyV). Recent research indicates that SARS-CoV-2 infection and COVID-19 progression may predispose recovered patients to cancer onset and accelerate cancer development. This hypothesis is based on the growing evidence regarding the ability of SARS-CoV-2 to modulate oncogenic pathways, promoting chronic low-grade inflammation and causing tissue damage. Herein, we summarize the main relationships known to date between virus infection and cancer, providing a summary of the proposed biochemical mechanisms behind the cellular transformation. Mechanistically, DNA viruses (such as HPV, HBV, EBV, and MCPyV) encode their virus oncogenes. In contrast, RNA viruses (like HCV, HTLV-1) may encode oncogenes or trigger host oncogenes through cis-/-trans activation leading to different types of cancer. As for SARS-CoV-2, its role as an oncogenic virus seems to occur through the inhibition of oncosuppressors or controlling the metabolic and autophagy pathways in the infected cells. However, these effects could be significant in particular scenarios like those linked to severe COVID-19 or long COVID. On the other hand, looking at the SARS-CoV-2─cancer relationship from an opposite perspective, oncolytic effects and anti-tumor immune response were triggered by SARS-CoV-2 infection in some cases. In summary, our work aims to recall comprehensive attention from the scientific community to elucidate the effects of SARS-CoV-2 and, more in general, β-coronavirus infection on cancer susceptibility for cancer prevention or supporting therapeutic approaches.
Deciphering the Relationship between SARS-CoV-2 and Cancer
Deciphering the Relationship between SARS-CoV-2 and Cancer
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Vicidomini C, Roviello V, Roviello GN
* Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L. ) and Clues to Its Anti-COVID-19 Utility (452 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Mar 26; 26(7): 1880-1886.
Impact Factor: 4.411
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Borbone N, Piccialli G, Roviello GN, Oliviero G
* Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses (272 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Feb 13; 26(4): 986-1002.
Impact Factor: 4.411
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Actis GC, Ribaldone DG, Fagoonee S, Pellicano R
* COVID-19: a user's guide, status of the art, and an original proposal to terminate viral recurrence (253 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2021 Feb; 112(1): 144-152.
Impact Factor: 3.031
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Nappi C, Megna R, Acampa W, Assante R, Zampella E, Gaudieri V, Mannarino T, Green R, Cantoni V, Petretta M, Cuocolo A
* Effects of the COVID-19 pandemic on myocardial perfusion imaging for ischemic heart disease (210 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7070print, 1619-7089electronic), 2021 Feb; 48(2): 421-427.
Impact Factor: 7.081
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Roviello V, Roviello GN
* Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants (411 views)
Environ Chem Lett (ISSN: 1610-3653linking), 2021 Jan; 19: 699-710.
Impact Factor: 9.027
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Ponsiglione A, Nappi C, Imbriaco M, Ascione R, Megna R, Petretta M, Cuocolo A
* Cardiac magnetic resonance imaging during the COVID-19 pandemic: A southern Italian single-center experience (213 views)
Eur J Radiol Open (ISSN: 2352-0477electronic, 2352-0477linking), 2021; 8: 100319-100319.
Impact Factor: 0.654
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Vincenzi M, Leone M
* The fight against human viruses: how NMR can help (199 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(22): 4380-4453.
Impact Factor: 4.184
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Squeglia F, Romano M, Ruggiero A, Maga G, Berisio R
* Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins (198 views)
Front Chem (ISSN: 2296-2646linking), 2020 Dec 10; 8: 602162-602162.
Impact Factor: 3.693
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Megna R
* First month of the epidemic caused by COVID-19 in Italy: current status and real-time outbreak development forecast (945 views)
Glob Health Res Policy (ISSN: 2397-0642linking), 2020 Oct 1; 5: 43-43.
Impact Factor: 8.7
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Pirone L, Del Gatto A, Di Gaetano S, Saviano M, Capasso D, Zaccaro L, Pedone E
* A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment (776 views) (PDF 213 views)
Front Mol Biosci (ISSN: 2296-889xlinking), 2020 Aug 3; 7: 186-186.
Impact Factor: 4.188
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Scarpellini E, Fagoonee S, Rinninella E, Rasetti C, Aquila I, Larussa T, Ricci P, Luzza F, Abenavoli L
* Gut Microbiota and Liver Interaction through Immune System Cross-Talk: A Comprehensive Review at the Time of the SARS-CoV-2 Pandemic (206 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Aug 3; 9(8): N/D-N/D.
Impact Factor: 6.78
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Romano M, Ruggiero A, Squeglia F, Maga G, Berisio R
* A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping (949 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2020 May 20; 9(5): 1297-1297.
Impact Factor: 6.6
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Costanzo M, De Giglio MAR, Roviello GN
* SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus (634 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2020 Apr 16; 27(27): 4536-4541.
Impact Factor: 4.184
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (739 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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35 Records (34 excluding Abstracts).
Total impact factor: 163.813 (160.12 excluding Abstracts).
Total 5 year impact factor: 135.698 (131.859 excluding Abstracts).
Total impact factor: 163.813 (160.12 excluding Abstracts).
Total 5 year impact factor: 135.698 (131.859 excluding Abstracts).
87 views. Last view on Sunday 01 December 2024, 5:04:34
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