Clinical correlates of R1 relaxometry and magnetic susceptibility changes in multiple sclerosis: a multi-parameter quantitative MRI study of brain iron and myelin (44 views)
Eur Radiol (ISSN: 0938-7994linking), 2023 Mar; 33 (3 ): 2185-2194.
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Paper type: Journal Article
Impact factor: 0, 5-year impact factor: 0
Url: Not available.
Keywords: Humans , Multiple Sclerosis Pathology , Myelin Sheath , Cross-Sectional Studies , Iron , Disabled Persons , Motor Disorders Complications Pathology , Brain Diagnostic Imaging Pathology , Gray Matter Diagnostic Imaging Pathology , Magnetic Resonance Imaging , Brain Diseases Pathology , Atrophy Pathology , Quantitative Susceptibility , Relaxometry
Affiliations:
*** IBB - CNR ***
Department of Advanced Biomedical Sciences, University "Federico II", Via Pansini 5, 80131, Naples, Italy. giuseppe.pontillo@unina.it.
Department of Electrical Engineering and Information Technology, University "Federico II", Naples, Italy. giuseppe.pontillo@unina.it.
Department of Neurosciences and Reproductive and Odontostomatological Sciences, University "Federico II", Naples, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
Multiple Sclerosis Centre, II Division of Neurology, Department of Clinical and Experimental Medicine, "Luigi Vanvitelli" University, Naples, Italy.
Institute of Nanotechnology, National Research Council, Lecce, Italy.
References:
Not available.
Eur Radiol (ISSN: 0938-7994linking), 2023 Mar; 33 (3 ): 2185-2194.
Export to BibTeX Export to EndNote
Paper type: Journal Article
Impact factor: 0, 5-year impact factor: 0
Url: Not available.
Keywords: Humans , Multiple Sclerosis Pathology , Myelin Sheath , Cross-Sectional Studies , Iron , Disabled Persons , Motor Disorders Complications Pathology , Brain Diagnostic Imaging Pathology , Gray Matter Diagnostic Imaging Pathology , Magnetic Resonance Imaging , Brain Diseases Pathology , Atrophy Pathology , Quantitative Susceptibility , Relaxometry
Affiliations:
*** IBB - CNR ***
Department of Advanced Biomedical Sciences, University "Federico II", Via Pansini 5, 80131, Naples, Italy. giuseppe.pontillo@unina.it.
Department of Electrical Engineering and Information Technology, University "Federico II", Naples, Italy. giuseppe.pontillo@unina.it.
Department of Neurosciences and Reproductive and Odontostomatological Sciences, University "Federico II", Naples, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
Multiple Sclerosis Centre, II Division of Neurology, Department of Clinical and Experimental Medicine, "Luigi Vanvitelli" University, Naples, Italy.
Institute of Nanotechnology, National Research Council, Lecce, Italy.
References:
Not available.
Clinical correlates of R1 relaxometry and magnetic susceptibility changes in multiple sclerosis: a multi-parameter quantitative MRI study of brain iron and myelin
OBJECTIVES: The clinical impact of brain microstructural abnormalities in multiple sclerosis (MS) remains elusive. We aimed to characterize the topography of longitudinal relaxation rate (R1) and quantitative susceptibility (χ) changes, as indices of iron and myelin, together with brain atrophy, and to clarify their contribution to cognitive and motor disability in MS. METHODS: In this cross-sectional study, voxel-based morphometry, and voxel-based quantification analyses of R1 and χ maps were conducted in gray matter (GM) and white matter (WM) of 117 MS patients and 53 healthy controls. Voxel-wise between-group differences were assessed with nonparametric permutation tests, while correlations between MRI metrics and clinical variables (global disability, cognitive and motor performance) were assessed both globally and voxel-wise within clusters emerging from the between-group comparisons. RESULTS: MS patients showed widespread R1 decrease associated with more limited modifications of χ, with atrophy mainly involving deep GM, posterior and infratentorial regions (p < 0.02). While R1 and χ showed a parallel reduction in several WM tracts (p < 0.001), reduced GM R1 values (p < 0.001) were associated with decreased thalamic χ (p < 0.001) and small clusters of increased χ in the caudate nucleus and prefrontal cortex (p < 0.02). In addition to the atrophy, χ values in the cingulum and corona radiata correlated with global disability and motor performance, while focal demyelination correlated with cognitive performance (p < 0.04). CONCLUSIONS: We confirmed the presence of widespread R1 changes, involving both GM and WM, and atrophy in MS, with less extensive modifications of tissue χ. While atrophy and χ changes are related to global and motor disability, R1 changes are meaningful correlates of cognition. KEY POINTS: • Compared to healthy controls, multiple sclerosis patients showed R1 and χ changes suggestive of iron increase within the basal ganglia and reduced iron and myelin content within (subnuclei of) the thalamus. • Thalamic volume and χ changes significantly predicted clinical disability, as well as pulvinar R1 and χ changes, independently from atrophy. • Atrophy-independent R1 and χ changes, suggestive of thalamic iron and myelin depletion, may represent a sensitive marker of subclinical inflammation.
OBJECTIVES: The clinical impact of brain microstructural abnormalities in multiple sclerosis (MS) remains elusive. We aimed to characterize the topography of longitudinal relaxation rate (R1) and quantitative susceptibility (χ) changes, as indices of iron and myelin, together with brain atrophy, and to clarify their contribution to cognitive and motor disability in MS. METHODS: In this cross-sectional study, voxel-based morphometry, and voxel-based quantification analyses of R1 and χ maps were conducted in gray matter (GM) and white matter (WM) of 117 MS patients and 53 healthy controls. Voxel-wise between-group differences were assessed with nonparametric permutation tests, while correlations between MRI metrics and clinical variables (global disability, cognitive and motor performance) were assessed both globally and voxel-wise within clusters emerging from the between-group comparisons. RESULTS: MS patients showed widespread R1 decrease associated with more limited modifications of χ, with atrophy mainly involving deep GM, posterior and infratentorial regions (p < 0.02). While R1 and χ showed a parallel reduction in several WM tracts (p < 0.001), reduced GM R1 values (p < 0.001) were associated with decreased thalamic χ (p < 0.001) and small clusters of increased χ in the caudate nucleus and prefrontal cortex (p < 0.02). In addition to the atrophy, χ values in the cingulum and corona radiata correlated with global disability and motor performance, while focal demyelination correlated with cognitive performance (p < 0.04). CONCLUSIONS: We confirmed the presence of widespread R1 changes, involving both GM and WM, and atrophy in MS, with less extensive modifications of tissue χ. While atrophy and χ changes are related to global and motor disability, R1 changes are meaningful correlates of cognition. KEY POINTS: • Compared to healthy controls, multiple sclerosis patients showed R1 and χ changes suggestive of iron increase within the basal ganglia and reduced iron and myelin content within (subnuclei of) the thalamus. • Thalamic volume and χ changes significantly predicted clinical disability, as well as pulvinar R1 and χ changes, independently from atrophy. • Atrophy-independent R1 and χ changes, suggestive of thalamic iron and myelin depletion, may represent a sensitive marker of subclinical inflammation.
Clinical correlates of R1 relaxometry and magnetic susceptibility changes in multiple sclerosis: a multi-parameter quantitative MRI study of brain iron and myelin
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Clinical correlates of R1 relaxometry and magnetic susceptibility changes in multiple sclerosis: a multi-parameter quantitative MRI study of brain iron and myelin
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Pontillo G, Petracca M, Monti S, Quarantelli M, Criscuolo C, Lanzillo R, Tedeschi E, Elefante A, Brescia Morra V, Brunetti A, Cocozza S, Palma G
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Impact Factor: 3.825
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Tedeschi G, Dinacci D, Comerci M, Lavorgna L, Savettieri G, Quattrone A, Livrea P, Patti F, Morra VB, Servillo G, Orefice G, Paciello M, Prinster A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Brunetti A, Salemi G, D , #xamelio M, Simone I, Salvatore M, Bonavita V, Alfano B
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* Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis (203 views)
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Impact Factor: 3.825
View Export to BibTeX Export to EndNote
Pontillo G, Tozza S, Perillo T, Cocozza S, Dubbioso R, Severi D, Iodice R, Tedeschi E, Elefante A, Brunetti A, Manganelli F, Quarantelli M
* Diffuse brain connectivity changes in Charcot-Marie-Tooth type 1a patients: a resting-state functional magnetic resonance imaging study (154 views)
Eur J Neurol (ISSN: 1351-5101linking, 1468-1331electronic), 2021 Jan; 28(1): 305-313.
Impact Factor: 4.516
View Export to BibTeX Export to EndNote
Gullo D, Latina A, Frasca F, Squatrito S, Belfiore A, Vigneri R
* Seasonal variations in TSH serum levels in athyreotic patients under L-thyroxine replacement monotherapy (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 0300-0664linking), 2017 Aug; 87(2): 207-215.
Impact Factor: 3.077
View Export to BibTeX Export to EndNote
Ribaldone DG, Dileo I, Pellicano R, Resegotti A, Fagoonee S, Vernero M, Saracco G, Astegiano M
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Irish J Med Sci (ISSN: 0021-1265), 2017 Jul 29; 187(2): 385-392.
Impact Factor: 1.045
View Export to BibTeX Export to EndNote
Cocozza S, Pisani A, Olivo G, Saccà F, Ugga L, Riccio E, Migliaccio S, Brescia Morra V, Brunetti A, Quarantelli M, Tedeschi E
* Alterations of functional connectivity of the motor cortex in Fabry disease: An RS-fMRI study (25 views)
Neurology (ISSN: 0028-3878linking), 2017 May 9; 88 (19 ): 1822-1829.
Impact Factor:
View Export to BibTeX Export to EndNote
Cocozza S, Pisani A, Olivo G, Saccà F, Ugga L, Riccio E, Migliaccio S, Brescia Morra V, Brunetti A, Quarantelli M, Tedeschi E
* Alterations of functional connectivity of the motor cortex in Fabry disease: An RS-fMRI study (23 views)
Neurology (ISSN: 0028-3878linking), 2017 May 9; 88 (19 ): 1822-1829.
Impact Factor:
View Export to BibTeX Export to EndNote
Castiglione F, Mainenti P, Testa A, Imperatore N, Maurea S, Rea M, Nardone OM, Sanges M, Caporaso N, Rispo A
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Dig Liver Dis (ISSN: 1590-8658, 1590-8658linking), 2017 May; 49(5): 484-489.
Impact Factor: 3.287
View Export to BibTeX Export to EndNote
Cocozza S, Pisani A, Olivo G, Saccà F, Ugga L, Riccio E, Migliaccio S, Brescia Morra V, Brunetti A, Quarantelli M, Tedeschi E
* Alterations of functional connectivity of the motor cortex in Fabry disease: An RS-fMRI study (556 views)
Neurology (ISSN: 0028-3878, 1526-632x, 0028-3878linking), 2017; 88(19): 1822-1829.
Impact Factor: 8.055
View Export to BibTeX Export to EndNote
Parrino C, Vinciguerra F, La Spina N, Romeo L, Tumminia A, Baratta R, Squatrito S, Vigneri R, Frittitta L
* Influence of early-life and parental factors on childhood overweight and obesity (311 views)
J Endocrinol Invest (ISSN: 1720-8386, 0391-4097, 1720-8386electronic), 2016 Nov; 39(11): 1315-1321.
Impact Factor: 2.633
View Export to BibTeX Export to EndNote
Malandrino P, Russo M, Ronchi A, Minoia C, Cataldo D, Regalbuto C, Giordano C, Attard M, Squatrito S, Trimarchi F, Vigneri R
* Increased thyroid cancer incidence in a basaltic volcanic area is associated with non-anthropogenic pollution and biocontamination (340 views)
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2016 Aug; 53(2): 471-479.
Impact Factor: 3.131
View Export to BibTeX Export to EndNote
Santamaria F, Esposito M, Montella S, Cantone E, Mollica C, De Stefano S, Mirra V, Carotenuto M
* Sleep disordered breathing and airway disease in primary ciliary dyskinesia (760 views)
Respirology (ISSN: 1323-7799, 1440-1843electronic), 2014 May; 19(4): 570-575.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Lavorgna L, Bonavita S, Ippolito D, Lanzillo R, Salemi G, Patti F, Valentino P, Coniglio G, Buccafusca M, Paolicelli D, D'Ambrosio A, Bresciamorra V, Savettieri G, Zappia M, Alfano B, Gallo A, Simone I, Tedeschi G
* Clinical And Magnetic Resonance Imaging Predictors Of Disease Progression In Multiple Sclerosis: A Nine-Year Follow-Up Study (767 views) (PDF 262 views)
Mult Scler (ISSN: 1352-4585, 1477-0970), 2014 Feb; 20(2): 220-226.
Impact Factor: 4.822
View Export to BibTeX Export to EndNote
Pedone C, Napoli N, Pozzilli P, Lauretani F, Bandinelli S, Ferrucci L, Rossi FF, Antonelli Incalzi R
* Bone health as a function of adipokines and vitamin D pattern in elderly patients (365 views)
Rejuv Res (ISSN: 1557-8577, 1549-1684), 2013 Dec; 16(6): 467-474.
Impact Factor: 3.931
View Export to BibTeX Export to EndNote
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G
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Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780.
Impact Factor: 3.274
View Export to BibTeX Export to EndNote
Pedone C, Napoli N, Pozzilli P, Rossi FF, Lauretani F, Bandinelli S, Ferrucci L, Antonelli-Incalzi R
* Dietary pattern and bone density changes in elderly women: a longitudinal study (692 views)
J Am Coll Nutr (ISSN: 1541-1087, 0731-5724), 2011 Apr; 30(2): 149-154.
Impact Factor: 2.29
View Export to BibTeX Export to EndNote
Tedeschi G, Dinacci D, Comerci M, Lavorgna L, Savettieri G, Quattrone A, Livrea P, Patti F, Morra VB, Servillo G, Orefice G, Paciello M, Prinster A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Brunetti A, Salemi G, D , #xamelio M, Simone I, Salvatore M, Bonavita V, Alfano B
* Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study (610 views) (PDF 285 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2009 Feb; 15(2): 204-211.
Impact Factor: 3.279
View Export to BibTeX Export to EndNote
Tauchmanova L, Pivonello R, De Martino MC, Rusciano A, De Leo M, Ruosi C, Mainolfi C, Lombardi G, Salvatore M, Colao A
* Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism (508 views)
Eur J Endocrinol (ISSN: 0804-4643), 2007 Sep; 157(3): 359-366.
Impact Factor: 3.239
View Export to BibTeX Export to EndNote
Tauchmanovà L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A
* Bone demineralization and vertebral fractures in endogenous cortisol excess: Role of disease etiology and gonadal status (795 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2006 May; 91(5): 1779-1784.
Impact Factor: 5.799
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Tedeschi G, Lavorgna L, Russo P, Prinster A, Dinacci D, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone IL, Salvatore M, Bonavita V, Alfano B
* Brain atrophy and lesion load in a large population of patients with multiple sclerosis (671 views) (PDF 282 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2005 Jul 26; 65(2): 280-285.
Impact Factor: 5.065
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Molko N, Pappata S, Mangin JF, Poupon F, Lebihan D, Bousser MG, Chabriat H
* Monitoring disease progression in CADASIL with diffusion magnetic resonance imaging: A study with whole brain histogram analysis (842 views)
Stroke (ISSN: 0039-2499), 2002 Dec; 33(12): 2902-2908.
Impact Factor: 5.176
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (719 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
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Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (860 views) (PDF 628 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1998 Mar; 39(3): 497-499.
Impact Factor: 2.962
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Brunetti A, Tedeschi G, Di Costanzo A, Covelli EM, Aloj L, Bonavita S, Ciarmiello A, Alfano B, Salvatore M
White matter lesion detection in multiple sclerosis: Improved interobserver concordance with multispectral MRI display (484 views) (PDF 321 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 1997 Sep; 244(9): 586-590.
Impact Factor: 1.976
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (727 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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24 Records (24 excluding Abstracts).
Total impact factor: 78.562 (78.562 excluding Abstracts).
Total 5 year impact factor: 79.513 (79.513 excluding Abstracts).
Total impact factor: 78.562 (78.562 excluding Abstracts).
Total 5 year impact factor: 79.513 (79.513 excluding Abstracts).
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