Design and synthesis of new benzoxazole derivatives and study of their interactions with a G4 model by UV spectroscopy and in silico methods (110 views)
Journal Of Molecular Liquids, 2024 Jul; N/D: N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Research Journal Article
Impact factor: 5.3, 5-year impact factor: 0
Url: https://doi.org/10.1016/j.molliq.2024.125491
Keywords: Uv Spectroscopy, G-Quadruplex, Click Chemistry, Docking
Affiliations:
*** IBB - CNR ***
References:
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Walter, Molecular Biology of the Cell, 2022, W.W. Norton &
2) V.A. Zakian, Exp. Cell Res., 318, (2012), 1456.
3) W. Lu, Y. Zhang, D. Liu, Z. Songyang and M. Wan, Exp. Cell
Res., 319, (2013), 133.
4) C.W. Greider and E.H. Blackburn, Cell, 43, (1985), 405.
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Ma, K. Iida, K. Nagasawa, Biochem. Biophys. Res. Commun.,
7) M. Ruden and N. Puri, Cancer Treat. Rev., 39, (2013), 444;
Roger R. Reddel, Curr. Pharm. Des., 20, (2014), 6361; G.M.
Arndt and K.L. MacKenzie, Nat. Rev. Cancer, 16, (2016), 508.
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Carvalho, J.L. Mergny, G.F. Salgado, J.A. Queiroz, C. Cruz,
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Bioorg. Chem., 99, (2020), 103866; Y. Venkata Suseela, P.
Sengupta, T. Roychowdhury, S. Panda, S. Talukdar, S.
Chattopadhyay, S. Chatterjee and T. Govindaraju, ACS Bio.
Med. Chem. Au. 2, (2022), 125.
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Chen, Z.-S. Huang and J.-H. Tan, J. Med. Chem., 66, (2023),
12) A. Majumder, S.K. Mondal, S. Mukhoty, S. Bag, A. Mondal,
Y. Begum, K. Sharma and A. Banik, Food Chem., 13, (2022),
13) A.M.S. Soares, S.P.G. Costa and M.S.T. Gonçalves,
Tetrahedron, 66, (2010), 8189.
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Richman, W. DuBay, J.D. Butler, G. Wells and C.L. Liotta, RSC
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Acids Res., 45, (2017), W365; Y. Yan, H. Tao, J. He and S-Y.
Huang, Nat. Protoc., 15, (2020), 1829.
18) F. Greco, A.P. Falanga, M. Terracciano, C. D’Ambrosio, G.
Piccialli, G. Oliviero, G.N. Roviello and N. Borbone, Biomol., 12,
19) S.-Y. Huang and X. Zou, Proteins, 72, (2008), 557.
20) A.M. Burger, F. Dai, C.M. Schultes, A.P. Reszka, M.J.
Moore, J.A. Double and S. Neidle, Cancer Res., 65, (2005),
1489; T. Tauchi, K. Shin-Ya, G. Sashida, M. Sumi, S. Okabe, J. H.
Ohyashiki and K. Ohyashiki, Oncogene, 25, (2006), 5719.
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S. Neidle, J.E Moses, J Am Chem Soc, 128, (2006), 15972.
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Chem., 2009, unit 17.1.1; Olsen and L.A. Marky G-Quadruplex
DNA. Methods in Molecular Biology, 608, (2010), 147 P.
Baumann eds; F. Zarrilli, F. Amato, C. M. Morgillo, B. Pinto, G.
Santarpia, N. Borbone, S. D’Errico, B. Catalanotti, G. Piccialli,
G. Castaldo and G. Oliviero, Molecules, 22, (2017), 1144.
26) Y. Sun, F. Ji, R. Liu, J. Lin, Q. Xu and C. Gao, J. Lumin., 132,
(2012), 507; S. Bhattacharjee, P.K. Sengupta and S. Bhowmik,
RSC Adv, 7, (2017), 37230.
27) C. Riccardi, D. Capasso, G.M. Rozza, C. Platella, D.
Montesarchio, S. Di Gaetano, T. Marzo, A. Pratesi, L. Messori,
G.N. Roviello and D. Musumeci, J. Inorg. Biochem., 203,
28) N.H. Campbell, G.N. Parkinson, A.P. Reszka and S. Neidle,
J. Am. Chem. Soc., 130, (2008), 6722.
29) M. Sirajuddin, S. Ali, A. Badshah, J. Photochem. Photobiol.
30) S. Cosconati, L. Marinelli, R. Trotta, A. Virno, S. De Tito, R.
Romagnoli, B. Pagano, V. Limongelli, C. Giancola, P.G. Baraldi,
L. Mayol, E. Novellino and A. Randazzo, J. Am. Chem. Soc., 132,
31) S. Mulliri, A. Laaksonen, P. Spanu, R. Farris, M. Farci, F.
Mingoia, G.N. Roviello, F. Mocci, Int. J. Mol. Sci., 22, (2021),
32) M.A. Fik-Jaskółka, A.F. Mkrtchyan, A.S. Saghyan, R.
Palumbo, A. Belter, L.A. Hayriyan, H. Simonyan, V. Roviello,
G.N. Roviello, Spectrochim Acta A Mol Biomol Spectrosc., 229,
33) P.L. Scognamiglio, C. Riccardi, R. Palumbo, T.F. Gale, D.
Musumeci, G.N. Roviello, J. Nanostructure Chem. (2023); V.
Roviello, D. Musumeci, A. Mokhir, G.N. Roviello, Curr Med
Chem. 28, (2021), 5004.
34) R. Galindo-Murillo, D.R. Roe, T.E. Cheatham, Biochimica et
Biophysica Acta (BBA) - General Subjects, 1850, (2015), 1041;
S. Vangaveti, S.V. Ranganathan, A.A. Chen, WIREs RNA, 8
(2016); I. Autiero, M. Saviano, E. Langella, Phys. Chem. Chem.
Phys. 16, (2014), 1868.
Journal Of Molecular Liquids, 2024 Jul; N/D: N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Research Journal Article
Impact factor: 5.3, 5-year impact factor: 0
Url: https://doi.org/10.1016/j.molliq.2024.125491
Keywords: Uv Spectroscopy, G-Quadruplex, Click Chemistry, Docking
Affiliations:
*** IBB - CNR ***
- a
- Institute of Biomolecular Chemistry, National Research Council of Italy (ICB-CNR), Research Site of Sassari Traversa La Crucca 3, I-07100 Sassari, Italy
- b
- Institute of Biostructures and Bioimaging, National Research Council of Italy (IBB-CNR), Area di Ricerca Site and Headquarters, Via Pietro Castellino 111, 80131 Naples, Italy
References:
1) B. Alberts, R. Heald, D. Morgan, M. Raff, K. Roberts and P.
Walter, Molecular Biology of the Cell, 2022, W.W. Norton &
2) V.A. Zakian, Exp. Cell Res., 318, (2012), 1456.
3) W. Lu, Y. Zhang, D. Liu, Z. Songyang and M. Wan, Exp. Cell
Res., 319, (2013), 133.
4) C.W. Greider and E.H. Blackburn, Cell, 43, (1985), 405.
5) J.R. Williamson, M.K. Raghuraman and T.R. Cech, Cell, 59,
6) J. Choi and T. Majima, Chem. Soc. Rev., 40, (2011), 5893; Y.
Ma, K. Iida, K. Nagasawa, Biochem. Biophys. Res. Commun.,
7) M. Ruden and N. Puri, Cancer Treat. Rev., 39, (2013), 444;
Roger R. Reddel, Curr. Pharm. Des., 20, (2014), 6361; G.M.
Arndt and K.L. MacKenzie, Nat. Rev. Cancer, 16, (2016), 508.
8) S. Neidle, J. Med. Chem., 59, (2016), 5987; S. Neidle, Nat.
Rev. Chem., 1, (2017), 0041; S. Asamitsu, S. Obata, Z. Yu, T.
Bando and H. Sugiyama, Molecules, 24, (2019), 429; J.
Carvalho, J.L. Mergny, G.F. Salgado, J.A. Queiroz, C. Cruz,
Trends Mol. Med., 26, (2020), 849; N. Kosiol, S. Juranek, P.
Brossart, A. Heine, K. Paeschke, Mol. Cancer, 20, (2021), 40.
9) A.R. Duarte, E. Cadoni, A.S. Ressurreição, R. Moreira and A.
Paulo ChemMedChem, 13, (2018), 869.
10) T.-Y. Wu, Q. Huang, Z.-S. Huang, M.-H. Hu and J.-H. Tan,
Bioorg. Chem., 99, (2020), 103866; Y. Venkata Suseela, P.
Sengupta, T. Roychowdhury, S. Panda, S. Talukdar, S.
Chattopadhyay, S. Chatterjee and T. Govindaraju, ACS Bio.
Med. Chem. Au. 2, (2022), 125.
11) T.-Y. Wu, X.-C. Chen, G.-X. Tang, W. Shao, Z.-C. Li, S.-B.
Chen, Z.-S. Huang and J.-H. Tan, J. Med. Chem., 66, (2023),
12) A. Majumder, S.K. Mondal, S. Mukhoty, S. Bag, A. Mondal,
Y. Begum, K. Sharma and A. Banik, Food Chem., 13, (2022),
13) A.M.S. Soares, S.P.G. Costa and M.S.T. Gonçalves,
Tetrahedron, 66, (2010), 8189.
14) W.L. Heaner IV, C.S. Gelbaum, L. Gelbaum, P. Pollet, K.W.
Richman, W. DuBay, J.D. Butler, G. Wells and C.L. Liotta, RSC
Adv., 3, (2013), 13232.
15) Y. Wang and D.J. Patel, Structure, 1, (1993), 263.
16) S.S. Pawar and S.H. Rohane, Asian J. Research Chem., 14,
17) Y. Yan, D. Zhang, P. Zhou, B. Li and S.-Y. Huang, Nucleic
Acids Res., 45, (2017), W365; Y. Yan, H. Tao, J. He and S-Y.
Huang, Nat. Protoc., 15, (2020), 1829.
18) F. Greco, A.P. Falanga, M. Terracciano, C. D’Ambrosio, G.
Piccialli, G. Oliviero, G.N. Roviello and N. Borbone, Biomol., 12,
19) S.-Y. Huang and X. Zou, Proteins, 72, (2008), 557.
20) A.M. Burger, F. Dai, C.M. Schultes, A.P. Reszka, M.J.
Moore, J.A. Double and S. Neidle, Cancer Res., 65, (2005),
1489; T. Tauchi, K. Shin-Ya, G. Sashida, M. Sumi, S. Okabe, J. H.
Ohyashiki and K. Ohyashiki, Oncogene, 25, (2006), 5719.
21) A.D Moorhouse, A.M. Santos, M. Gunaratnam, M. Moore,
S. Neidle, J.E Moses, J Am Chem Soc, 128, (2006), 15972.
22) R.M. Moorman, M.B. Collier, B.H. Frohock, M.D. Womble
and J.M. Chalker, Org. Biomol. Chem., 13, (2015), 1974.
23) V.V. Rostovtsev, L.G. Green, V.V. Fokin and K.B. Sharpless,
Angew. Chem. Int. Ed., 41, (2002), 2596.
24) D. Giunta, A. Arras, P. Peluso and M. Solinas, Results
Chem., 3, (2021), 100122.
25) J.L. Mergny and L. Lacroix, Curr. Protoc. Nucleic Acid
Chem., 2009, unit 17.1.1; Olsen and L.A. Marky G-Quadruplex
DNA. Methods in Molecular Biology, 608, (2010), 147 P.
Baumann eds; F. Zarrilli, F. Amato, C. M. Morgillo, B. Pinto, G.
Santarpia, N. Borbone, S. D’Errico, B. Catalanotti, G. Piccialli,
G. Castaldo and G. Oliviero, Molecules, 22, (2017), 1144.
26) Y. Sun, F. Ji, R. Liu, J. Lin, Q. Xu and C. Gao, J. Lumin., 132,
(2012), 507; S. Bhattacharjee, P.K. Sengupta and S. Bhowmik,
RSC Adv, 7, (2017), 37230.
27) C. Riccardi, D. Capasso, G.M. Rozza, C. Platella, D.
Montesarchio, S. Di Gaetano, T. Marzo, A. Pratesi, L. Messori,
G.N. Roviello and D. Musumeci, J. Inorg. Biochem., 203,
28) N.H. Campbell, G.N. Parkinson, A.P. Reszka and S. Neidle,
J. Am. Chem. Soc., 130, (2008), 6722.
29) M. Sirajuddin, S. Ali, A. Badshah, J. Photochem. Photobiol.
30) S. Cosconati, L. Marinelli, R. Trotta, A. Virno, S. De Tito, R.
Romagnoli, B. Pagano, V. Limongelli, C. Giancola, P.G. Baraldi,
L. Mayol, E. Novellino and A. Randazzo, J. Am. Chem. Soc., 132,
31) S. Mulliri, A. Laaksonen, P. Spanu, R. Farris, M. Farci, F.
Mingoia, G.N. Roviello, F. Mocci, Int. J. Mol. Sci., 22, (2021),
32) M.A. Fik-Jaskółka, A.F. Mkrtchyan, A.S. Saghyan, R.
Palumbo, A. Belter, L.A. Hayriyan, H. Simonyan, V. Roviello,
G.N. Roviello, Spectrochim Acta A Mol Biomol Spectrosc., 229,
33) P.L. Scognamiglio, C. Riccardi, R. Palumbo, T.F. Gale, D.
Musumeci, G.N. Roviello, J. Nanostructure Chem. (2023); V.
Roviello, D. Musumeci, A. Mokhir, G.N. Roviello, Curr Med
Chem. 28, (2021), 5004.
34) R. Galindo-Murillo, D.R. Roe, T.E. Cheatham, Biochimica et
Biophysica Acta (BBA) - General Subjects, 1850, (2015), 1041;
S. Vangaveti, S.V. Ranganathan, A.A. Chen, WIREs RNA, 8
(2016); I. Autiero, M. Saviano, E. Langella, Phys. Chem. Chem.
Phys. 16, (2014), 1868.
Design and synthesis of new benzoxazole derivatives and study of their interactions with a G4 model by UV spectroscopy and in silico methods
In this study, we synthesized novel benzoxazol-2-ylmethyl-(1H-1,2,3-triazol-4-yl)phenyl)-3-aminopropanamides (6a-d) in high yields by means of the Copper-catalysed Azide-Alkyne Cycloaddition (CuAAC) reaction. The synthetic pathway involves the conversion of 2-aminophenol to 2-(bromomethyl)benzoxazole 1, followed by its transformation into the azide derivative 2. Subsequent reaction with functionalized arylalkynes 5a-d under Sharpless’s reaction conditions yields the desired compounds 6a-d. These benzoxazoles were then evaluated as G-Quadruplex DNA (G4) ligands by UV spectroscopy studies using a telomeric sequence (Tel22) as G4 model. We studied how the absorbance at λmax varies over time for the 6a-d/Tel22 mixtures at different molar ratios. Moreover we carried out melting experiments in order to point out any possible stabilization effects arising by ligand interaction. Our findings indicate that Tel22 is slighlty but significantly stabilized by compound 6b at a 1:1 ratio. Furthermore for 6b, these results align well with in silico predictions suggesting that the ligand acts as groove binder interacting with six guanosine residues of the telomeric model.
In this study, we synthesized novel benzoxazol-2-ylmethyl-(1H-1,2,3-triazol-4-yl)phenyl)-3-aminopropanamides (6a-d) in high yields by means of the Copper-catalysed Azide-Alkyne Cycloaddition (CuAAC) reaction. The synthetic pathway involves the conversion of 2-aminophenol to 2-(bromomethyl)benzoxazole 1, followed by its transformation into the azide derivative 2. Subsequent reaction with functionalized arylalkynes 5a-d under Sharpless’s reaction conditions yields the desired compounds 6a-d. These benzoxazoles were then evaluated as G-Quadruplex DNA (G4) ligands by UV spectroscopy studies using a telomeric sequence (Tel22) as G4 model. We studied how the absorbance at λmax varies over time for the 6a-d/Tel22 mixtures at different molar ratios. Moreover we carried out melting experiments in order to point out any possible stabilization effects arising by ligand interaction. Our findings indicate that Tel22 is slighlty but significantly stabilized by compound 6b at a 1:1 ratio. Furthermore for 6b, these results align well with in silico predictions suggesting that the ligand acts as groove binder interacting with six guanosine residues of the telomeric model.
Design and synthesis of new benzoxazole derivatives and study of their interactions with a G4 model by UV spectroscopy and in silico methods
Design and synthesis of new benzoxazole derivatives and study of their interactions with a G4 model by UV spectroscopy and in silico methods
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Marzano M, Falanga AP, Marasco D, Borbone N, D , #errico S, Piccialli G, Roviello GN, Oliviero G
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Marzano M, Falanga AP, D'Errico S, Pinto B, Roviello GN, Piccialli G, Oliviero G, Borbone N
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Martinez-fernandez L, Banyasz A, Markovitsi D, Improta R
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Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
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Chino M, Leone L, Maglio O, D'Alonzo D, Pirro F, Pavone V, Nastri F, Lombardi A
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Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-baruffi M, Carvalho I, Campo VL
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Banyasz A, Martinez-fernandez L, Balty C, Perron M, Douki T, Improta R, Markovitsi D
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Impact Factor: 14.357
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Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
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D'Urso A, Randazzo R, Rizzo V, Gangemi CMA, Romanucci V, Zarrelli A, Tomaselli G, Milardi D, Borbone N, Purrello R, Piccialli G, Di Fabio G, Oliviero G
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Platella C, Riccardi C, Montesarchio D, Roviello GN, Musumeci D
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (597 views)
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Impact Factor: 5.317
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Esposito V, Pirone L, Mayol L, Pedone E, Virgilio A, Galeone A
* Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions (588 views)
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
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Impact Factor: 1.951
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Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
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Impact Factor: 5.353
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Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
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Impact Factor: 2.793
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Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
* A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (799 views)
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Impact Factor: 7.232
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Pica A, Russo Krauss I, Merlino A, Nagatoishi S, Sugimoto N, Sica F
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Impact Factor: 3.986
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Accardo A, Ringhieri P, Tesauro D, Morelli G
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Impact Factor: 3.159
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Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
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Impact Factor: 4.58
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
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Impact Factor: 5.925
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Haider SM, Autiero I, Neidle S
Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes (73 views)
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* Directing in Vitro Selection towards G-quadruplex-forming Aptamers to Inhibit HMGB1 Pathological Activity (94 views)
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Scognamiglio PL, Vicidomini C, Roviello GN
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Falanga AP, Terracciano M, Oliviero G, Roviello GN, Borbone N
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Greco F, Musumeci D, Borbone N, Falanga AP, D , #xerrico S, Terracciano M, Piccialli I, Roviello GN, Oliviero G
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Platella C, Capasso D, Riccardi C, Musumeci D, Dellagreca M, Montesarchio D
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Platella C, Gaglione R, Napolitano E, Arciello A, Pirota V, Doria F, Musumeci D, Montesarchio D
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Impact Factor: 2.598
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Balanikas E, Martinez-fernandez L, Improta R, Podbevšek P, Baldacchino G, Markovitsi D
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Platella C, Napolitano E, Riccardi C, Musumeci D, Montesarchio D
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Green JA, Asha H, Santoro F, Improta R
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Riccardi C, Napolitano E, Platella C, Musumeci D, Montesarchio D
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Ogloblina AM, Iaccarino N, Capasso D, Di Gaetano S, Garzarella EU, Dolinnaya NG, Yakubovskaya MG, Pagano B, Amato J, Randazzo A
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Platella C, Raucci U, Rega N, D’atri S, Levati L, Roviello GN, Fuggetta MP, Musumeci D, Montesarchio D
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Fik-jaskółka MA, Mkrtchyan AF, Saghyan AS, Palumbo R, Belter A, Hayriyan LA, Simonyan H, Roviello V, Roviello GN
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Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (406 views)
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Impact Factor: 3.224
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Marzano M, Falanga AP, Marasco D, Borbone N, D , #errico S, Piccialli G, Roviello GN, Oliviero G
* Evaluation of an Analogue of the Marine ε-PLL Peptide as a Ligand of G-quadruplex DNA Structures (292 views) (PDF 98 views)
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Impact Factor: 4.073
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Martinez-fernandez L, Changenet P, Banyasz A, Gustavsson T, Markovitsi D, Improta R
* Comprehensive Study of Guanine Excited State Relaxation and Photoreactivity in G-quadruplexes (136 views)
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Impact Factor: 6.687
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Marzano M, Falanga AP, D'Errico S, Pinto B, Roviello GN, Piccialli G, Oliviero G, Borbone N
* New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes (443 views)
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Impact Factor: 3.06
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Martinez-fernandez L, Banyasz A, Markovitsi D, Improta R
* Topology Controls the Electronic Absorption and Delocalization of Electron Holes in Guanine Quadruplexes (580 views)
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Impact Factor: 5.476
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Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
* Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (516 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.
Impact Factor: 8.709
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Chino M, Leone L, Maglio O, D'Alonzo D, Pirro F, Pavone V, Nastri F, Lombardi A
* A De Novo Heterodimeric Due Ferri Protein Minimizes the Release of Reactive Intermediates in Dioxygen-Dependent Oxidation (382 views) (PDF 198 views)
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Impact Factor: 12.102
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Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-baruffi M, Carvalho I, Campo VL
* Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion (3013 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017 Nov 1; 25(21): 6049-6059.
Impact Factor: 2.881
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Banyasz A, Martinez-fernandez L, Balty C, Perron M, Douki T, Improta R, Markovitsi D
* Absorption of Low-Energy UV Radiation by Human Telomere G-Quadruplexes Generates Long-Lived Guanine Radical Cations (284 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2017 Aug 2; 139(30): 10561-10568.
Impact Factor: 14.357
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Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
* Antitumour activity of resveratrol on human melanoma cells: a possible mechanism related to its interaction with malignant cell telomerase (436 views)
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Impact Factor: 4.28
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D'Urso A, Randazzo R, Rizzo V, Gangemi CMA, Romanucci V, Zarrelli A, Tomaselli G, Milardi D, Borbone N, Purrello R, Piccialli G, Di Fabio G, Oliviero G
* Stabilization vs. destabilization of G-quadruplex superstructures: the role of the porphyrin derivative having spermine arms (364 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2017 Jul 14; 19(26): 17404-17410.
Impact Factor: 3.906
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Platella C, Riccardi C, Montesarchio D, Roviello GN, Musumeci D
* G-quadruplex-based aptamers against protein targets in therapy and diagnostics (500 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 1872-8006electronic), 2017 May; 1861(5PtB): 1429-1447.
Impact Factor: 3.679
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (597 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
View Export to BibTeX Export to EndNote
Esposito V, Pirone L, Mayol L, Pedone E, Virgilio A, Galeone A
* Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions (588 views)
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Impact Factor: 3.112
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (549 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
View Export to BibTeX Export to EndNote
Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (808 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Impact Factor: 5.353
View Export to BibTeX Export to EndNote
Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (445 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
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Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
* A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (799 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Pica A, Russo Krauss I, Merlino A, Nagatoishi S, Sugimoto N, Sica F
* Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer (676 views)
Febs Journal (ISSN: 1742-464x), 2013 Dec; 280(24): 6581-6588.
Impact Factor: 3.986
View Export to BibTeX Export to EndNote
Accardo A, Ringhieri P, Tesauro D, Morelli G
* Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (484 views)
New J Chem (ISSN: 1144-0546), 2013; 37(11): 3528-3534.
Impact Factor: 3.159
View Export to BibTeX Export to EndNote
Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (1175 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (651 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Haider SM, Autiero I, Neidle S
Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes (73 views)
Biochimie (ISSN: 0300-9084linking), 2011 Aug; 93 (8 ): 1275-1279.
Impact Factor:
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41 Records (40 excluding Abstracts).
Total impact factor: 225.522 (221.843 excluding Abstracts).
Total 5 year impact factor: 190.748 (185.938 excluding Abstracts).
Total impact factor: 225.522 (221.843 excluding Abstracts).
Total 5 year impact factor: 190.748 (185.938 excluding Abstracts).
110 views. Last view on Friday 06 December 2024, 6:33:11
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