Neuroprotective Properties of Clove (Syzygium aromaticum): State of the Art and Future Pharmaceutical Applications for Alzheimer’s Disease (25 views) (PDF public 12 views)
Biomolecules, 2025 Mar; 15: 452-452.
Export to BibTeX Export to EndNote
Paper type: Review Journal Article
Impact factor: 4.8, 5-year impact factor: 0
Url: https://www.mdpi.com/2218-273X/15/3/452
Keywords: Cloves, Herbal Medicine, Nutrition, Alzheimer’s Disease, Neurodegeneration
Affiliations:
*** IBB - CNR ***
Tatevik Sargsyan 1,2,†, Hayarpi M. Simonyan 2,†, Lala Stepanyan 1, Avetis Tsaturyan 1,2, Caterina Vicidomini 3,*,
Raffaele Pastore 4, Germano Guerra 4 and Giovanni N. Roviello 3,*
1 Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan Str., Yerevan 0056, Armenia;
tatev-sargsyan@ysu.am (T.S.); lala_stepanyan@rambler.ru (L.S.)
2 Institute of Pharmacy, Yerevan State University, 1 Alex Manoogian Str., Yerevan 0025, Armenia
3 Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR), Area di Ricerca
Site and Headquarters, Via Pietro Castellino 111, 80131 Naples, Italy
4 Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, via F. De Santis,
86100 Campobasso, Italy
* Correspondence: caterina.vicidomini@ibb.cnr.it (C.V.); giovanni.roviello@cnr.it (G.N.R.);
Tel.: +39-0812203415 (C.V.)
† These authors contributed equally to this work.
References:
Not available.
Biomolecules, 2025 Mar; 15: 452-452.
Export to BibTeX Export to EndNote
Paper type: Review Journal Article
Impact factor: 4.8, 5-year impact factor: 0
Url: https://www.mdpi.com/2218-273X/15/3/452
Keywords: Cloves, Herbal Medicine, Nutrition, Alzheimer’s Disease, Neurodegeneration
Affiliations:
*** IBB - CNR ***
Tatevik Sargsyan 1,2,†, Hayarpi M. Simonyan 2,†, Lala Stepanyan 1, Avetis Tsaturyan 1,2, Caterina Vicidomini 3,*,
Raffaele Pastore 4, Germano Guerra 4 and Giovanni N. Roviello 3,*
1 Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan Str., Yerevan 0056, Armenia;
tatev-sargsyan@ysu.am (T.S.); lala_stepanyan@rambler.ru (L.S.)
2 Institute of Pharmacy, Yerevan State University, 1 Alex Manoogian Str., Yerevan 0025, Armenia
3 Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR), Area di Ricerca
Site and Headquarters, Via Pietro Castellino 111, 80131 Naples, Italy
4 Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, via F. De Santis,
86100 Campobasso, Italy
* Correspondence: caterina.vicidomini@ibb.cnr.it (C.V.); giovanni.roviello@cnr.it (G.N.R.);
Tel.: +39-0812203415 (C.V.)
† These authors contributed equally to this work.
References:
Not available.
Neuroprotective Properties of Clove (Syzygium aromaticum): State of the Art and Future Pharmaceutical Applications for Alzheimer’s Disease
This study explores the neuropharmacological potential of various molecular
and amino acid components derived from Syzygium aromaticum (clove), an aromatic spice
with a long history of culinary and medicinal use. Key bioactive compounds such as
eugenol, α-humulene, β-caryophyllene, gallic acid, quercetin, and luteolin demonstrate
antioxidant, anti-inflammatory, and neuroprotective properties by scavenging free
radicals, modulating calcium channels, and reducing neuroinflammation and oxidative
stress. Moreover, gallic acid and asiatic acid may exhibit protective effects, including
neuronal apoptosis inhibition, while other useful properties of clove phytocompounds
include NF-κB pathway inhibition, membrane stabilization, and suppression of proinflammatory
pathways, possibly in neurons or other relevant cell types, further
contributing to neuroprotection and cognitive enhancement. Amino acid analysis
revealed essential and non-essential amino acids such as aspartic acid, serine, glutamic
acid, glycine, histidine, and arginine in various clove parts (buds, fruits, branches, and
leaves). These amino acids play crucial roles in neurotransmitter synthesis, immune
modulation, antioxidant defense, and metabolic regulation. Collectively, these bioactive
molecules and amino acids contribute to clove’s antioxidant, anti-inflammatory,
neurotrophic, and neurotransmitter-modulating effects, highlighting its potential as a
preventive and therapeutic candidate for neurodegenerative disorders. While
preliminary preclinical studies support these neuroprotective properties, further
research, including clinical trials, is needed to validate the efficacy and safety of clovebased
interventions in neuroprotection.
This study explores the neuropharmacological potential of various molecular
and amino acid components derived from Syzygium aromaticum (clove), an aromatic spice
with a long history of culinary and medicinal use. Key bioactive compounds such as
eugenol, α-humulene, β-caryophyllene, gallic acid, quercetin, and luteolin demonstrate
antioxidant, anti-inflammatory, and neuroprotective properties by scavenging free
radicals, modulating calcium channels, and reducing neuroinflammation and oxidative
stress. Moreover, gallic acid and asiatic acid may exhibit protective effects, including
neuronal apoptosis inhibition, while other useful properties of clove phytocompounds
include NF-κB pathway inhibition, membrane stabilization, and suppression of proinflammatory
pathways, possibly in neurons or other relevant cell types, further
contributing to neuroprotection and cognitive enhancement. Amino acid analysis
revealed essential and non-essential amino acids such as aspartic acid, serine, glutamic
acid, glycine, histidine, and arginine in various clove parts (buds, fruits, branches, and
leaves). These amino acids play crucial roles in neurotransmitter synthesis, immune
modulation, antioxidant defense, and metabolic regulation. Collectively, these bioactive
molecules and amino acids contribute to clove’s antioxidant, anti-inflammatory,
neurotrophic, and neurotransmitter-modulating effects, highlighting its potential as a
preventive and therapeutic candidate for neurodegenerative disorders. While
preliminary preclinical studies support these neuroprotective properties, further
research, including clinical trials, is needed to validate the efficacy and safety of clovebased
interventions in neuroprotection.
Neuroprotective Properties of Clove (Syzygium aromaticum): State of the Art and Future Pharmaceutical Applications for Alzheimer’s Disease
Neuroprotective Properties of Clove (Syzygium aromaticum): State of the Art and Future Pharmaceutical Applications for Alzheimer’s Disease
Other filter: ([btitle,keywords] "Herbal Medicine" OR ...
Falanga AP, Piccialli I, Greco F, D'Errico S, Nolli MG, Borbone N, Oliviero G, Roviello GN
* Nanostructural Modulation of G-Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches (31 views)
Journal Of Neurochemistry, 2025 Jan 20; N/D: N/D-N/D.
Impact Factor: 4.2
View Export to BibTeX Export to EndNote
Vicidomini C, Fontanella F, D'Alessandro T, Roviello GN
* A Survey on Computational Methods in Drug Discovery for Neurodegenerative Diseases (240 views)
Biomolecules, 2024 Oct; 14: 1330-1330.
Impact Factor: 4.8
View Export to BibTeX Export to EndNote
Cipriano L, Minino R, Liparoti M, Polverino A, Romano A, Bonavita S, Pirozzi MA, Quarantelli M, Jirsa V, Sorrentino G, Sorrentino P, Troisi Lopez E
* Flexibility of brain dynamics is increased and predicts clinical impairment in relapsing-remitting but not in secondary progressive multiple sclerosis (232 views)
Brain Commun (ISSN: 2632-1297linking), 2024 Apr 2; 6 (2 ): fcae112-N/D.
Impact Factor:
View Export to BibTeX Export to EndNote
Piccialli I, Greco F, Roviello GN, Sisalli MJ, Tedeschi V, Di Mola A, Borbone N, Oliviero G, De Feo V, Secondo A, Massa A, Pannaccione A
* 3-(3-oxoisoindolin-1-yl)pentane-2, 4-dione (ISOAC1) as a new molecule able to inhibit Amyloid ß aggregation and neurotoxicity (227 views)
Biomedicine & Pharmacotherapy, 2023 Oct; 168: 115745-115745.
Impact Factor: 7.5
View Export to BibTeX Export to EndNote
Guzzardi MA, La Rosa F, Campani D, Collado MC, Monleon D, Cacciato Insilla A, Tripodi M, Zega A, Dattilo A, Brunetto MR, Maffei M, Bonino F, Iozzo P
* Liver and White/Brown Fat Dystrophy Associates with Gut Microbiota and Metabolomic Alterations in 3xTg Alzheimer’s Disease Mouse Model (160 views)
Metabolites (ISSN: 2218-1989electronic), 2022 Mar 22; 12 (4 ): N/D-N/D.
Impact Factor:
View Export to BibTeX Export to EndNote
Caminiti SP, Sala A, Presotto L, Chincarini A, Sestini S, Perani D, Schillaci O, Berti V, Calcagni ML, Cistaro A, Morbelli S, Nobili F, Pappata S, Volterrani D, Gobbo CL
* Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps (367 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7070print, 1619-7089electronic), 2021 Jul; 48(8): 2486-2499.
Impact Factor: 9.236
View Export to BibTeX Export to EndNote
Coppola C, Saracino D, Oliva M, Cipriano L, Puoti G, Pappata S, Di Fede G, Catania M, Ricci M, Cimini S, Giaccone G, Bonavita S, Rossi G
* Singular cases of Alzheimer's disease disclose new and old genetic "acquaintances" (298 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2021 May; 42(5): 2021-2029.
Impact Factor: 1.447
View Export to BibTeX Export to EndNote
Vicidomini C, Roviello V, Roviello GN
* Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L. ) and Clues to Its Anti-COVID-19 Utility (675 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Mar 26; 26(7): 1880-1886.
Impact Factor: 4.411
View Export to BibTeX Export to EndNote
Rendina A, Drongitis D, Donizetti A, Fucci L, Milan G, Tripodi F, Giustezza F, Postiglione A, Pappata S, Ferrari R, Bossù P, Angiolillo A, Di Costanzo A, Caiazzo M, Vitale E
* CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia (414 views)
J Neuropathol Exp Neurol (ISSN: 0022-3069linking), 2020 Jul 10; 79(8): 891-901.
Impact Factor: 3.51
View Export to BibTeX Export to EndNote
Dubbioso R, Ruggiero L, Esposito M, Tarantino P, De Angelis M, Aruta F, Pappata S, Ugga L, Piperno A, Iorio R, Santoro L, Iodice R, Manganelli F
* Different cortical excitability profiles in hereditary brain iron and copper accumulation (452 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2020 Mar; 41(3): 679-685.
Impact Factor: 1.315
View Export to BibTeX Export to EndNote
Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (887 views)
Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (847 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D
* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (640 views) (PDF 240 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2017 Jun 09; N/D: N/D-N/D.
Impact Factor: 4.211
View Export to BibTeX Export to EndNote
Grasso G, Santoro AM, Lanza V, Sbardella D, Tundo GR, Ciaccio C, Marini S, Coletta M, Milardi D
* The double faced role of copper in Ab homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration (548 views)
Coordination Chemistry Reviews, 2017 Jun; N/D: 1-22.
Impact Factor: 13.324
View Export to BibTeX Export to EndNote
Florenzano F, Veronica C, Ciasca G, Ciotti MT, Pittaluga A, Olivero G, Feligioni M, Iannuzzi F, Latina V, Sciacca MFM, Sinopoli A, Milardi D, Pappalardo G, De Spirito M, Papi M, Atlante A, Bobba A, Borreca A, Calissano P, Amadoro G
* Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies (620 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Apr 22; N/D: N/D-N/D.
Impact Factor: 5.168
View Export to BibTeX Export to EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (508 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
View Export to BibTeX Export to EndNote
Palmieri G, Cocca E, Gogliettino M, Valentino R, Ruvo M, Cristofano G, Angiolillo A, Balestrieri M, Rossi M, Di Costanzo A
* Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? (626 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
Impact Factor: 3.476
View Export to BibTeX Export to EndNote
D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (1098 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (568 views) (PDF 234 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (1126 views)
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (903 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View Export to BibTeX Export to EndNote
Salvatore E, Tedeschi E, Mollica C, Vicidomini C, Varrone A, Coda ARD, Brunetti A, Salvatore M, De Michele G, Filla A, Pappata S
* Supratentorial and infratentorial damage in spinocerebellar ataxia 2: a diffusion-weighted MRI study (685 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2014 May; 29(6): 780-786.
Impact Factor: 5.68
View Export to BibTeX Export to EndNote
Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (343 views)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (1169 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (1198 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (956 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (539 views)
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
Impact Factor: 4.971
View Export to BibTeX Export to EndNote
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (661 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
View Export to BibTeX Export to EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (840 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (964 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (877 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
* Nanostructural Modulation of G-Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches (31 views)
Journal Of Neurochemistry, 2025 Jan 20; N/D: N/D-N/D.
Impact Factor: 4.2
View Export to BibTeX Export to EndNote
Vicidomini C, Fontanella F, D'Alessandro T, Roviello GN
* A Survey on Computational Methods in Drug Discovery for Neurodegenerative Diseases (240 views)
Biomolecules, 2024 Oct; 14: 1330-1330.
Impact Factor: 4.8
View Export to BibTeX Export to EndNote
Cipriano L, Minino R, Liparoti M, Polverino A, Romano A, Bonavita S, Pirozzi MA, Quarantelli M, Jirsa V, Sorrentino G, Sorrentino P, Troisi Lopez E
* Flexibility of brain dynamics is increased and predicts clinical impairment in relapsing-remitting but not in secondary progressive multiple sclerosis (232 views)
Brain Commun (ISSN: 2632-1297linking), 2024 Apr 2; 6 (2 ): fcae112-N/D.
Impact Factor:
View Export to BibTeX Export to EndNote
Piccialli I, Greco F, Roviello GN, Sisalli MJ, Tedeschi V, Di Mola A, Borbone N, Oliviero G, De Feo V, Secondo A, Massa A, Pannaccione A
* 3-(3-oxoisoindolin-1-yl)pentane-2, 4-dione (ISOAC1) as a new molecule able to inhibit Amyloid ß aggregation and neurotoxicity (227 views)
Biomedicine & Pharmacotherapy, 2023 Oct; 168: 115745-115745.
Impact Factor: 7.5
View Export to BibTeX Export to EndNote
Guzzardi MA, La Rosa F, Campani D, Collado MC, Monleon D, Cacciato Insilla A, Tripodi M, Zega A, Dattilo A, Brunetto MR, Maffei M, Bonino F, Iozzo P
* Liver and White/Brown Fat Dystrophy Associates with Gut Microbiota and Metabolomic Alterations in 3xTg Alzheimer’s Disease Mouse Model (160 views)
Metabolites (ISSN: 2218-1989electronic), 2022 Mar 22; 12 (4 ): N/D-N/D.
Impact Factor:
View Export to BibTeX Export to EndNote
Caminiti SP, Sala A, Presotto L, Chincarini A, Sestini S, Perani D, Schillaci O, Berti V, Calcagni ML, Cistaro A, Morbelli S, Nobili F, Pappata S, Volterrani D, Gobbo CL
* Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps (367 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7070print, 1619-7089electronic), 2021 Jul; 48(8): 2486-2499.
Impact Factor: 9.236
View Export to BibTeX Export to EndNote
Coppola C, Saracino D, Oliva M, Cipriano L, Puoti G, Pappata S, Di Fede G, Catania M, Ricci M, Cimini S, Giaccone G, Bonavita S, Rossi G
* Singular cases of Alzheimer's disease disclose new and old genetic "acquaintances" (298 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2021 May; 42(5): 2021-2029.
Impact Factor: 1.447
View Export to BibTeX Export to EndNote
Vicidomini C, Roviello V, Roviello GN
* Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L. ) and Clues to Its Anti-COVID-19 Utility (675 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Mar 26; 26(7): 1880-1886.
Impact Factor: 4.411
View Export to BibTeX Export to EndNote
Rendina A, Drongitis D, Donizetti A, Fucci L, Milan G, Tripodi F, Giustezza F, Postiglione A, Pappata S, Ferrari R, Bossù P, Angiolillo A, Di Costanzo A, Caiazzo M, Vitale E
* CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia (414 views)
J Neuropathol Exp Neurol (ISSN: 0022-3069linking), 2020 Jul 10; 79(8): 891-901.
Impact Factor: 3.51
View Export to BibTeX Export to EndNote
Dubbioso R, Ruggiero L, Esposito M, Tarantino P, De Angelis M, Aruta F, Pappata S, Ugga L, Piperno A, Iorio R, Santoro L, Iodice R, Manganelli F
* Different cortical excitability profiles in hereditary brain iron and copper accumulation (452 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2020 Mar; 41(3): 679-685.
Impact Factor: 1.315
View Export to BibTeX Export to EndNote
Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (887 views)
Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (847 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D
* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (640 views) (PDF 240 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2017 Jun 09; N/D: N/D-N/D.
Impact Factor: 4.211
View Export to BibTeX Export to EndNote
Grasso G, Santoro AM, Lanza V, Sbardella D, Tundo GR, Ciaccio C, Marini S, Coletta M, Milardi D
* The double faced role of copper in Ab homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration (548 views)
Coordination Chemistry Reviews, 2017 Jun; N/D: 1-22.
Impact Factor: 13.324
View Export to BibTeX Export to EndNote
Florenzano F, Veronica C, Ciasca G, Ciotti MT, Pittaluga A, Olivero G, Feligioni M, Iannuzzi F, Latina V, Sciacca MFM, Sinopoli A, Milardi D, Pappalardo G, De Spirito M, Papi M, Atlante A, Bobba A, Borreca A, Calissano P, Amadoro G
* Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies (620 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Apr 22; N/D: N/D-N/D.
Impact Factor: 5.168
View Export to BibTeX Export to EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (508 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
View Export to BibTeX Export to EndNote
Palmieri G, Cocca E, Gogliettino M, Valentino R, Ruvo M, Cristofano G, Angiolillo A, Balestrieri M, Rossi M, Di Costanzo A
* Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? (626 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
Impact Factor: 3.476
View Export to BibTeX Export to EndNote
D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (1098 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (568 views) (PDF 234 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (1126 views)
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (903 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View Export to BibTeX Export to EndNote
Salvatore E, Tedeschi E, Mollica C, Vicidomini C, Varrone A, Coda ARD, Brunetti A, Salvatore M, De Michele G, Filla A, Pappata S
* Supratentorial and infratentorial damage in spinocerebellar ataxia 2: a diffusion-weighted MRI study (685 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2014 May; 29(6): 780-786.
Impact Factor: 5.68
View Export to BibTeX Export to EndNote
Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (343 views)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (1169 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (1198 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (956 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (539 views)
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
Impact Factor: 4.971
View Export to BibTeX Export to EndNote
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (661 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
View Export to BibTeX Export to EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (840 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (964 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (877 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
31 Records (30 excluding Abstracts).
Total impact factor: 132.425 (127.454 excluding Abstracts).
Total 5 year impact factor: 96.736 (92.738 excluding Abstracts).
Total impact factor: 132.425 (127.454 excluding Abstracts).
Total 5 year impact factor: 96.736 (92.738 excluding Abstracts).
25 views. Last view on Wednesday 16 April 2025, 16:14:46
ibb.cnr.it
