The Synthesis, Characterization, and Biological Evaluation of a Fluorenyl-Methoxycarbonyl-Containing Thioxo-Triazole-Bearing Dipeptide: Antioxidant, Antimicrobial, and BSA/DNA Binding Studies for Potential Therapeutic Applications in ROS Scavenging and Drug Transport (93 views)
Biomolecules, 2025 Jun; 15: 933-954.
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Paper type: Research Journal Article
Impact factor: 4.8, 5-year impact factor: 0
Url: https://www.mdpi.com/2218-273X/15/7/933
Keywords: Fluorenyl-Methoxycarbonyl, Fmoc, Thioxo-Triazole, Antioxidant Properties, Antimicrobial Activity, Bovine Serum Albumin, Dna Modulation, Bioactive Peptides, Caucasus-Endemic Plants
Affiliations:
*** IBB - CNR ***
Lala Stepanyan 1,†, Tatevik Sargsyan 1,2,† , Valentina Mittova 3, Zurab R. Tsetskhladze 3, Nino Motsonelidze 3,Ekaterine Gorgoshidze 3, Niccolò Nova 4, Monika Israyelyan 1, Hayarpi Simonyan 2, Franco Bisceglie 4,Lusine Sahakyan 1,2 , Karapet Ghazaryan 2 and Giovanni N. Roviello 5,*1 Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan Str., Yerevan 0056, Armenia;tatev-sargsyan@ysu.am (T.S.); lusine_sahakyan@ysu.am (L.S.)2Institute of Pharmacy, Yerevan State University, 1 Alex Manoogian Str., Yerevan 0025, Armenia3 Faculty of Medicine, University Geomedi, 4 King Solomon II Str., 0114 Tbilisi, Georgia;valentina.mittova@geomedi.edu.ge (V.M.); zurab.tsetskhladze@geomedi.edu.ge (Z.R.T.);ekaterine.gorgoshidze@geomedi.edu.ge (E.G.)4 Department of Chemical Science, Life and Environmental Sustainability, University of Parma, Parco Areadelle Scienze 17/A, 43124 Parma, Italy; niccolo.nova@studenti.unipr.it (N.N.)5Institute of Biostructures and Bioimaging (IBB), Italian National Council for Research (CNR), Area di RicercaSite and Headquarters, Via Pietro Castellino 111, 80131 Naples, Italy* Correspondence: giovanni.roviello@cnr.it† These authors contributed equally to this work.
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Biomolecules, 2025 Jun; 15: 933-954.
Export to BibTeX Export to EndNote
Paper type: Research Journal Article
Impact factor: 4.8, 5-year impact factor: 0
Url: https://www.mdpi.com/2218-273X/15/7/933
Keywords: Fluorenyl-Methoxycarbonyl, Fmoc, Thioxo-Triazole, Antioxidant Properties, Antimicrobial Activity, Bovine Serum Albumin, Dna Modulation, Bioactive Peptides, Caucasus-Endemic Plants
Affiliations:
*** IBB - CNR ***
Lala Stepanyan 1,†, Tatevik Sargsyan 1,2,† , Valentina Mittova 3, Zurab R. Tsetskhladze 3, Nino Motsonelidze 3,Ekaterine Gorgoshidze 3, Niccolò Nova 4, Monika Israyelyan 1, Hayarpi Simonyan 2, Franco Bisceglie 4,Lusine Sahakyan 1,2 , Karapet Ghazaryan 2 and Giovanni N. Roviello 5,*1 Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan Str., Yerevan 0056, Armenia;tatev-sargsyan@ysu.am (T.S.); lusine_sahakyan@ysu.am (L.S.)2Institute of Pharmacy, Yerevan State University, 1 Alex Manoogian Str., Yerevan 0025, Armenia3 Faculty of Medicine, University Geomedi, 4 King Solomon II Str., 0114 Tbilisi, Georgia;valentina.mittova@geomedi.edu.ge (V.M.); zurab.tsetskhladze@geomedi.edu.ge (Z.R.T.);ekaterine.gorgoshidze@geomedi.edu.ge (E.G.)4 Department of Chemical Science, Life and Environmental Sustainability, University of Parma, Parco Areadelle Scienze 17/A, 43124 Parma, Italy; niccolo.nova@studenti.unipr.it (N.N.)5Institute of Biostructures and Bioimaging (IBB), Italian National Council for Research (CNR), Area di RicercaSite and Headquarters, Via Pietro Castellino 111, 80131 Naples, Italy* Correspondence: giovanni.roviello@cnr.it† These authors contributed equally to this work.
References:
Science. Molecules 2021, 26, 2937. [CrossRef]
20. Reˇcnik, L.-M.; Kandioller, W.; Mindt, T.L. 1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of
Linear Peptides with Biological Activity. Molecules 2020, 25, 3576. [CrossRef]
21. Sargsyan, T.; Stepanyan, L.; Panosyan, H.; Hakobyan, H.; Israyelyan, M.; Tsaturyan, A.; Hovhannisyan, N.; Vicidomini, C.;
Mkrtchyan, A.; Saghyan, A.; et al. Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their
Dipeptides Against Aspergillus Species. Biomolecules 2025, 15, 61. [CrossRef] [PubMed]
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G.G.; Hovhannisyan, N.A. Modeling, Synthesis and In Vitro Testing of Peptides Based on Unusual Amino Acids as Potential
Antibacterial Agents. Biomed. Khim. 2024, 70, 413–420. [CrossRef] [PubMed]
23. Todorov, L.; Kostova, I. 1,2,3-Triazoles and Their Metal Chelates with Antimicrobial Activity. Front. Chem. 2023, 11, 1247805.
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Discovery and Development. Front. Chem. 2021, 9, 674705. [CrossRef] [PubMed]
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29. Roviello, G.N.; Mittova, V.; Tsetskhladze, Z.R.; Bidzinashvili, R.; Berdzenishvili, M.; Vakhania, M.; Mindiashvili, T.; Kobiashvili,
M. Antioxidant Properties of Some Caucasian Medicinal Plants. Mod. Issues Med. Manag. 2024, 27, 4–15. [CrossRef]
30. Parker, S.; May, B.; Zhang, C.; Zhang, A.L.; Lu, C.; Xue, C.C. A Pharmacological Review of Bioactive Constituents of Paeonia
lactiflora Pallas and Paeonia veitchii Lynch: Review of P. lactiflora Pallas and P. veitchii Lynch. Phytother. Res. 2016, 30, 1445–1473.
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review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: Current landscape
and future perspectives. Chin. Med. 2023, 18, 23. [CrossRef]
32. Bai, Z.-Z.; Ni, J.; Tang, J.-M.; Sun, D.-Y.; Yan, Z.-G.; Zhang, J.; Niu, L.-X.; Zhang, Y.-L. Bioactive Components, Antioxidant and
Antimicrobial Activities of Paeonia rockii Fruit during Development. Food Chem. 2021, 343, 128444. [CrossRef] [PubMed]
33. Markovi´c, T.; Cutovi´c, N.; Carevi´c, T.; Gaši´c, U.; Stojkovi´c, D.; Xue, J.; Jovanovi´c, A. ˇ Paeonia peregrina Mill Petals as a New Source
of Biologically Active Compounds: Chemical Characterization and Skin Regeneration Effects of the Extracts. Int. J. Mol. Sci. 2023,
24, 11764. [CrossRef]
34. Xin, Z.; Yang, W.; Niu, L.; Zhang, Y. Comprehensive Metabolite Profile Uncovers the Bioactive Components, Antioxidant and
Antibacterial Activities in Wild Tree Peony Leaves. Int. J. Mol. Sci. 2023, 24, 10609. [CrossRef] [PubMed]
35. Zheng, Y.; Li, P.; Shen, J.; Yang, K.; Wu, X.; Wang, Y.; Yuan, Y.-H.; Xiao, P.; He, C. Comprehensive Comparison of Different Parts of
Paeonia ostii, a Food-Medicine Plant, Based on Untargeted Metabolomics, Quantitative Analysis, and Bioactivity Analysis. Front.
Plant Sci. 2023, 14, 1243724. [CrossRef]
36. Abriata, L.A. A Simple Spreadsheet Program to Simulate and Analyze the Far-UV Circular Dichroism Spectra of Proteins. J. Chem.
Educ. 2011, 88, 1268–1273. [CrossRef]
Biomolecules 2025, 15, 933 21 of 22
37. Huang, S.Y.; Zou, X. An Iterative Knowledge-Based Scoring Function for Protein–Protein Recognition. Proteins 2008, 72, 557–579.
38. Schöning-Stierand, K.; Diedrich, K.; Fährrolfes, R.; Flachsenberg, F.; Meyder, A.; Nittinger, E.; Steinegger, R.; Rarey, M. Proteins
Plus: Interactive Analysis of Protein–Ligand Binding Interfaces. Nucleic Acids Res. 2020, 48, W48–W53. [CrossRef]
39. Galano, A.; Mazzone, G.; Alvarez-Diduk, R.; Marino, T.; Alvarez-Idaboy, J.R.; Russo, N. Food Antioxidants: Chemical Insights at
the Molecular Level. Annu. Rev. Food Sci. Technol. 2016, 7, 335–352. [CrossRef]
40. Leopoldini, M.; Marino, T.; Russo, N.; Toscano, M. Antioxidant properties of phenolic compounds: H-atom versus electron
transfer mechanism. J. Phys. Chem. A 2004, 108, 4916–4922. [CrossRef]
41. Ami´c, A.; Luˇci´c, B.; Stepani´c, V.; Markovi´c, Z.; Markovi´c, S.; Dimitri´c Markovi´c, J.M.; Ami´c, D. Free radical scavenging potency
of quercetin catecholic colonic metabolites: Thermodynamics of 2H+/2e– processes. Food Chem. 2017, 218, 144–151. [CrossRef]
42. Xue, Y.; Zheng, Y.; An, L.; Dou, Y.; Liu, Y. Density functional theory study of the structure–antioxidant activity of polyphenolic
deoxybenzoins. Food Chem. 2014, 151, 198–206. [CrossRef]
43. Verderi, L.; Nova, N.; Borghesani, V.; Tegoni, M.; Giannetto, M.; Fortunati, S.; Ronda, L.; Pinelli, S.; Mozzoni, P.; Nicastro, M.; et al.
Cytotoxic ROS-Consuming Mn (III) Synzymes: Structural Influence on Their Mechanism of Action. Int. J. Mol. Sci. 2025, 26, 150.
44. Frisch, M.J.; Trucks, G.W.; Schlegel, H.B.; Scuseria, G.E.; Robb, M.A.; Cheeseman, J.R.; Scalmani, G.; Barone, V.; Petersson, G.A.;
Nakatsuji, H.; et al. Gaussian 16; revision B.01; Gaussian, Inc.: Wallingford, CT, USA, 2016.
45. Xavier, S.; Periandy, S.; Carthigayan, K.; Sebastian, S. Molecular docking, TG/DTA, molecular structure, harmonic vibrational
frequencies, natural bond orbital and TD-DFT analysis of diphenyl carbonate by DFT approach. J. Mol. Struct. 2016, 1125, 204–216.
46. Tomasi, J.; Mennucci, B.; Cammi, R. Quantum mechanical continuum solvation models. Chem. Rev. 2005, 105, 2999–3094.
47. El-Sayed, D.S.; Hassan, S.S.; Jassim, L.S.; Issa, A.A.; Al-Oqaili, F.; Albayaty, M.K.; Hasoon, B.A.; Jabir, M.S.; Rasool, K.H.; Elbadawy,
H.A. Structural and topological analysis of thiosemicarbazone-based metal complexes: Computational and experimental study of
bacterial biofilm inhibition and antioxidant activity. BMC Chem. 2025, 19, 24. [CrossRef]
48. Parr, R.G.; von Szentpály, L.; Liu, S. Electrophilicity Index. J. Am. Chem. Soc. 1999, 121, 1922–1924. [CrossRef]
49. Kashar, T.I.; Aal, S.A. Spectral, DFT–TDDFT computational investigation and biological studies of transition metal complexes of
dehydroacetic acid Schiff base. J. Iran Chem. Soc. 2021, 18, 1625–1640. [CrossRef]
50. Yang, L.; Liu, H.; Xia, D.; Wang, S. Antioxidant properties of camphene-based thiosemicarbazones: Experimental and theoretical
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The Synthesis, Characterization, and Biological Evaluation of a Fluorenyl-Methoxycarbonyl-Containing Thioxo-Triazole-Bearing Dipeptide: Antioxidant, Antimicrobial, and BSA/DNA Binding Studies for Potential Therapeutic Applications in ROS Scavenging and Drug Transport
We report on the synthesis and characterization of a novel fluorenyl-methoxycarbonyl
(Fmoc)-containing thioxo-triazole-bearing dipeptide 5, evaluated for potential therapeutic
applications. The compound was tested for its antioxidant and antimicrobial properties,
demonstrating significant effects in scavenging reactive oxygen species (ROS) and inhibiting
microbial growth, particularly when combined with plant extracts from an endemic Peonia
species from the Caucasus. Circular dichroism (CD) binding studies with bovine serum
albumin (BSA) and calf thymus DNA revealed important interactions, suggesting the
dipeptide’s potential in biomedically relevant conditions that involve DNA modulation.
Molecular docking and CD spectra deconvolution provided additional insights into the
binding mechanisms and structural characteristics of the formed complexes with the
biomolecular targets. The Fmoc group enhances the dipeptide’s lipophilicity, which may
facilitate its interaction with cellular membranes, supporting efficient drug delivery. A
computational evaluation at the ωB97XD/aug-cc-pVDZ level of theory was carried out,
confirming the experimental results and revealing a powerful potential of the peptide as
an antioxidant, through FMOs, MEP analysis, and antioxidant mechanism assessments.
Together, these findings suggest that this dipeptide could be valuable as an antimicrobial
and antioxidant agent, with potential applications in pathologies involving oxidative stress,
DNA modulation, and microbial infections.
We report on the synthesis and characterization of a novel fluorenyl-methoxycarbonyl
(Fmoc)-containing thioxo-triazole-bearing dipeptide 5, evaluated for potential therapeutic
applications. The compound was tested for its antioxidant and antimicrobial properties,
demonstrating significant effects in scavenging reactive oxygen species (ROS) and inhibiting
microbial growth, particularly when combined with plant extracts from an endemic Peonia
species from the Caucasus. Circular dichroism (CD) binding studies with bovine serum
albumin (BSA) and calf thymus DNA revealed important interactions, suggesting the
dipeptide’s potential in biomedically relevant conditions that involve DNA modulation.
Molecular docking and CD spectra deconvolution provided additional insights into the
binding mechanisms and structural characteristics of the formed complexes with the
biomolecular targets. The Fmoc group enhances the dipeptide’s lipophilicity, which may
facilitate its interaction with cellular membranes, supporting efficient drug delivery. A
computational evaluation at the ωB97XD/aug-cc-pVDZ level of theory was carried out,
confirming the experimental results and revealing a powerful potential of the peptide as
an antioxidant, through FMOs, MEP analysis, and antioxidant mechanism assessments.
Together, these findings suggest that this dipeptide could be valuable as an antimicrobial
and antioxidant agent, with potential applications in pathologies involving oxidative stress,
DNA modulation, and microbial infections.
The Synthesis, Characterization, and Biological Evaluation of a Fluorenyl-Methoxycarbonyl-Containing Thioxo-Triazole-Bearing Dipeptide: Antioxidant, Antimicrobial, and BSA/DNA Binding Studies for Potential Therapeutic Applications in ROS Scavenging and Drug Transport
| ▼ Peptides of therapeutic interest with antimicrobial and/ or antitumoral activity |
The Synthesis, Characterization, and Biological Evaluation of a Fluorenyl-Methoxycarbonyl-Containing Thioxo-Triazole-Bearing Dipeptide: Antioxidant, Antimicrobial, and BSA/DNA Binding Studies for Potential Therapeutic Applications in ROS Scavenging and Drug Transport
Other filter: ([btitle,keywords] "Fluorenyl-Methoxycar ...
Sargsyan T, Hakobyan H, Simonyan H, Soghomonyan T, Tsaturyan A, Hovhannisyan A, Sardaryan S, Saghyan A, Roviello GN
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Avitabile C, D'Andrea LD, D'Aversa E, Milani R, Gambari R, Romanelli A
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Chemmedchem (ISSN: 1860-7179linking, 1860-7187electronic), 2018 Aug 10; 13(15): 1549-1554.
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (1995 views)
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Tremonte P, Pannella G, Succi M, Tipaldi L, Sturchio M, Coppola R, Luongo D, Sorrentino E
* Antimicrobial activity of Lactobacillus plantarum strains isolated from different environments: a preliminary study (1065 views) (PDF 308 views)
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Scudiero O, Nigro E, Cantisani M, Colavita I, Leone M, Mercurio FA, Galdiero M, Pessi A, Daniele A, Salvatore F, Galdiero S
* Design and activity of a cyclic mini-beta-defensin analog: a novel antimicrobial tool (1812 views)
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Galdiero S, Falanga A, Berisio R, Grieco P, Morelli G, Galdiero M
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Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (1794 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
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Malgieri G, Avitabile C, Palmieri M, D'Andrea LD, Isernia C, Romanelli A, Fattorusso R
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Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S
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Calce E, Mignogna E, Bugatti V, Galdiero M, Vittoria V, De Luca S
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Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2014 Jul; 68: 28-32.
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Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
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Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
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Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
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Impact Factor: 3.829
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Avitabile C, Capparelli R, Rigano MM, Fulgione A, Barone A, Pedone C, Romanelli A
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Impact Factor: 1.862
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Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
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Impact Factor: 4.451
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (2624 views)
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Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
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Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723, 0934-9723linking), 2012 Nov; 31(11): 3047-3055.
Impact Factor: 3.024
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Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (2294 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
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Pilla P, Sandomenico A, Malachovsk V, Borriello A, Giordano M, Cutolo A, Ruvo M, Cusano A
* A protein-based biointerfacing route toward label-free immunoassays with long period gratings in transition mode (2367 views)
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Romanelli A, Moggio L, Montella RC, Campiglia P, Iannaccone M, Capuano F, Pedone C, Capparelli R
* Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins (3485 views)
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Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (2772 views)
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Impact Factor: 4.672
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Scudiero O, Galdiero S, Cantisani M, Di Noto R, Galdiero M, D'Isanto M, Naclerio G, Pedone C, Castaldo G, Salvatore F
* Synthetic Analogs Of Human Beta-Defensins Display A More Effective Antimicrobial Activity Than Wild-Type Peptides (1549 views)
Antimicrob Agents Chemother, 2010; 54: 2312-2322.
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
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Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
* Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (2155 views)
Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633.
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Dalla Serra M, Cirioni O, Vitale RM, Renzone G, Coraiola M, Giacometti A, Potrich C, Baroni E, Guella G, Sanseverino M, De Luca S, Scalise G, Amodeo P, Scaloni A
* Structural features of distinctin affecting peptide biological and biochemical properties (2595 views)
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (2166 views)
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Impact Factor: 2.882
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Fogliano V, Monti SM, Ritieni A, Marchisano C, Peluso G, Randazzo G
An immunological approach to monitor protein lactosylation of heated food model systems (1388 views)
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Impact Factor: 0.812
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Marchetti P, Benzi L, Trischitta V, Brunetti A, Cecchetti P, Ciccarone AM, Pezzino V, Vigneri R, Navalesi R
Complementary use of gel permeation and reversed-phase liquid chromatography for the analysis of A14-[125I]insulin and its degradation products in isolated human monocytes (3046 views)
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* Biomacromolecular interactions and antioxidant properties of novel synthetic amino acids targeting DNA and serum albumin (65 views)
Journal Of Molecular Liquids, 2025 Oct 23; 128700: N/D-N/D.
Impact Factor: 5.2
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Di Fiore A, De Luca V, Langella E, Nocentini A, Buonanno M, Monti SM, Supuran CT, Capasso C, De Simone G
* Biochemical, structural, and computational studies of a γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei (1530 views)
Comput Struct Biotechnol J (ISSN: 2001-0370linking), 2022 Jul 27; 20: 4185-4194.
Impact Factor: 6.155
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Avitabile C, D'Andrea LD, D'Aversa E, Milani R, Gambari R, Romanelli A
* Effect of Acylation on the Antimicrobial Activity of Temporin B Analogues (1613 views)
Chemmedchem (ISSN: 1860-7179linking, 1860-7187electronic), 2018 Aug 10; 13(15): 1549-1554.
Impact Factor: 3.009
View Export to BibTeX Export to EndNote
Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (1995 views)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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Tremonte P, Pannella G, Succi M, Tipaldi L, Sturchio M, Coppola R, Luongo D, Sorrentino E
* Antimicrobial activity of Lactobacillus plantarum strains isolated from different environments: a preliminary study (1065 views) (PDF 308 views)
International Food Research Journal, 2017 Apr; 24(2): 852-859.
Impact Factor: 0
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Scudiero O, Nigro E, Cantisani M, Colavita I, Leone M, Mercurio FA, Galdiero M, Pessi A, Daniele A, Salvatore F, Galdiero S
* Design and activity of a cyclic mini-beta-defensin analog: a novel antimicrobial tool (1812 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2015 Oct 15; 10: 6523-6539.
Impact Factor: 4.32
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Berisio R, Grieco P, Morelli G, Galdiero M
* Antimicrobial peptides as an opportunity against bacterial diseases (2360 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 Mar 11; 22(14): 1665-1677.
Impact Factor: 3.455
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Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (1794 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
Impact Factor: 4.839
View Export to BibTeX Export to EndNote
Malgieri G, Avitabile C, Palmieri M, D'Andrea LD, Isernia C, Romanelli A, Fattorusso R
* Structural basis of a temporin 1b analogue antimicrobial activity against gram negative bacteria determined by CD and NMR techniques in cellular environment (2434 views)
Acs Chem Biol (ISSN: 1554-8929), 2015; 10(4): 965-969.
Impact Factor: 5.09
View Export to BibTeX Export to EndNote
Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S
* Structural insights into and activity analysis of the antimicrobial peptide myxinidin (3830 views)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2014 Sep; 58(9): 5280-5290.
Impact Factor: 4.476
View Export to BibTeX Export to EndNote
Calce E, Mignogna E, Bugatti V, Galdiero M, Vittoria V, De Luca S
* Pectin functionalized with natural fatty acids as antimicrobial agent (1577 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2014 Jul; 68: 28-32.
Impact Factor: 2.858
View Export to BibTeX Export to EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (2787 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
View Export to BibTeX Export to EndNote
Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (2351 views)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
Impact Factor: 4.451
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (2932 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
View Export to BibTeX Export to EndNote
Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
* Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (2888 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
Impact Factor: 3.829
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Avitabile C, Capparelli R, Rigano MM, Fulgione A, Barone A, Pedone C, Romanelli A
* Antimicrobial peptides from plants: Stabilization of the γ core of a tomato defensin by intramolecular disulfide bond (2031 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 240-245.
Impact Factor: 1.862
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Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
* Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines (1686 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2013 Apr; 57(4): 1701-1708.
Impact Factor: 4.451
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (2624 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
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Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
* Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds (1803 views)
Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723, 0934-9723linking), 2012 Nov; 31(11): 3047-3055.
Impact Factor: 3.024
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Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (2294 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
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Pilla P, Sandomenico A, Malachovsk V, Borriello A, Giordano M, Cutolo A, Ruvo M, Cusano A
* A protein-based biointerfacing route toward label-free immunoassays with long period gratings in transition mode (2367 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic, 0956-5663linking), 2012 Jan 15; 31(1): 486-491.
Impact Factor: 5.437
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Romanelli A, Moggio L, Montella RC, Campiglia P, Iannaccone M, Capuano F, Pedone C, Capparelli R
* Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins (3485 views)
J Pept Sci (ISSN: 1099-1387, 1075-2617, 1075-2617print), 2011 Dec 2; 17(5): 348-352.
Impact Factor: 1.799
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Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (2772 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Impact Factor: 4.672
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Scudiero O, Galdiero S, Cantisani M, Di Noto R, Galdiero M, D'Isanto M, Naclerio G, Pedone C, Castaldo G, Salvatore F
* Synthetic Analogs Of Human Beta-Defensins Display A More Effective Antimicrobial Activity Than Wild-Type Peptides (1549 views)
Antimicrob Agents Chemother, 2010; 54: 2312-2322.
Impact Factor: 3.445
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (3266 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
* Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (2155 views)
Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633.
Impact Factor: 6.594
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Dalla Serra M, Cirioni O, Vitale RM, Renzone G, Coraiola M, Giacometti A, Potrich C, Baroni E, Guella G, Sanseverino M, De Luca S, Scalise G, Amodeo P, Scaloni A
* Structural features of distinctin affecting peptide biological and biochemical properties (2595 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 29; 47(30): 7888-7899.
Impact Factor: 3.379
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (2166 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
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Fogliano V, Monti SM, Ritieni A, Marchisano C, Peluso G, Randazzo G
An immunological approach to monitor protein lactosylation of heated food model systems (1388 views)
Food Chem (ISSN: 0308-8146, 0308-8146print), 1997; 58(1-2): 53-58.
Impact Factor: 0.812
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Marchetti P, Benzi L, Trischitta V, Brunetti A, Cecchetti P, Ciccarone AM, Pezzino V, Vigneri R, Navalesi R
Complementary use of gel permeation and reversed-phase liquid chromatography for the analysis of A14-[125I]insulin and its degradation products in isolated human monocytes (3046 views)
J Chromatogr B Biomed Sci Appl (ISSN: 0378-4347), 1986 Apr 25; 377(C): 339-344.
Impact Factor: 1.588
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30 Records (30 excluding Abstracts).
Total impact factor: 104.179 (104.179 excluding Abstracts).
Total 5 year impact factor: 98.425 (98.425 excluding Abstracts).
Total impact factor: 104.179 (104.179 excluding Abstracts).
Total 5 year impact factor: 98.425 (98.425 excluding Abstracts).
93 views. Last view on Wednesday 10 December 2025, 9:55:31
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