A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (384 views visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.773, 5-year impact factor Impact factor a 5 anni: 2.751
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952240564&partnerID=40&md5=f0a185472554530c6ce54fec0f6a1265
Keywords Parole chiave: Colorectal Cancer, Dyslipidemia, Loss-Of-Function Mutation, Peroxisome Proliferator-Activated Receptor, High Density Lipoprotein Cholesterol, Insulin, Low Density Lipoprotein Cholesterol, Peroxisome Proliferator Activated Receptor Gamma, Triacylglycerol, Adult, Aged, Amino Acid Substitution, Article, Cancer Localization, Cell Proliferation, Cholesterol Blood Level, Clinical Article, Colon Carcinogenesis, Colon Polyp, Colonoscopy, Controlled Study, Female, Gene Mutation, Genetic Association, Germ Line, Glucose Blood Level, Histopathology, Human, Human Cell, Human Tissue, Hypertension, In Vitro Study, In Vivo Study, Insulin Blood Level, Ligand Binding, Lipid Metabolism, Liver Metastasis, Loss Of Function Mutation, Non Insulin Dependent Diabetes Mellitus, Nucleotide Sequence, Obesity, Priority Journal, Protein Expression, Protein Function, Triacylglycerol Blood Level, Wild Type, Adenocarcinoma, Adolescent, 80 And Over, Animals, Base Sequence, Binding Sites, Cercopithecus Aethiops, Colonic Neoplasms, Cos Cells, Dna Primers, Germ-Line Mutation, Intestinal Polyps, Loss Of Heterozygosity, Middle Aged, Models, Molecular, Nih 3t3 Cells, Pedigree, Ppar Gamma, Recombinant Proteins, Transfection, Young Adult,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Biological and Environmental Sciences, University of Sannio, Via Port'Arsa, 11, 82100 Benevento, Italy
Institute of Genetics and Biophysics, A. Buzzati-Traverso CNR, Via P. Castellino, 113, 80131 Napoli, Italy
Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini, 5, 80131 Napoli, Italy
Fatebenefratelli Hospital, Division of Medical Oncology, Viale Principe di Napoli, 82100 Benevento, Italy
Department of Chemistry, University of Naples Federico II, Monte S. Angelo, 80100 Napoli, Italy
References Riferimenti:
Francis, G.A., Fayard, E., Picard, F., Auwerx, J., Nuclear receptors and the control of metabolism (2003) Ann. Rev. Physiol., 65, pp. 261-31
Spiegelman, B.M., PPARγ: adipogenic regulator and thiazolidinedione receptor (1998) Diabetes, 47, pp. 507-514
Feige, J.N., Gelman, L., Michalik, L., Desvergne, B., Wahli, W., From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions (2006) Prog. Lipid Res., 45, pp. 120-159
Willson, T.M., Lambert, M.H., Kliewer, S.A., Peroxisome proliferator-activated receptor γ and metabolic disease (2001) Annu. Rev. Biochem., 70, pp. 341-367
Knouff, C., Auwerx, J., Peroxisome proliferator-activated receptor-γ calls for activation in moderation: lessons from genetics and pharmacology (2004) Endocr. Rev., 25, pp. 899-918
Sarraf, P., Mueller, E., Smith, W.M., Wright, H.M., Kum, J.B., Aaltonen, L.A., de la Chapelle, A., Eng, C., Loss-of-function mutations in PPARγ associated with human colon cancer (1999) Mol Cell, 3, pp. 799-804
Ristow, M., Muller-Wieland, D., Pfeiffer, A., Krone, W., Kahn, C.R., Obesity associated with a mutation in a genetic regulator of adipocyte differentiation (1998) N. Engl. J. Med., 339, pp. 953-959
Grommes, C., Landreth, G., Heneka, M.T., Antineoplastic effects of peroxisome proliferator activated receptor γ agonists (2004) Lancet Oncol., 7, pp. 419-429
Sabatino, L., Casamassimi, A., Peluso, G., Barone, M.V., Capaccio, D., Migliore, C., Monelli, P., Colantuoni, V., A novel peroxisome proliferator-activated receptor γ isoform with dominant negative activity generated by alternative splicing (2005) J. Biol. Chem., 280, pp. 26517-26525
Barroso, I., Gurnell, M., Crowley, V.E., Agostini, M., Schwabe, J.W., Soos, M.A., Maslen, G.L., O'Rahilly, S., Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension (1999) Nature, 402, pp. 880-883
Savage, D.B., Tan, G.D., Acerini, C.L., Jebb, S.A., Agostini, M., Gurnell, M., Williams, R.L., O'Rahilly, S., Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor γ (2003) Diabetes, 52, pp. 910-917
Peverali, F.A., Ramqvist, T., Saffrich, R., Pepperkok, R., Barone, M.V., Philipson, L., Regulation of G1 progression by E2A and Id helix-loop-helix proteins (1994) EMBO J., 13, pp. 4291-4301
Barone, M.V., Courtneidge, S.A., Myc but not Fos rescue of PDGF signaling block caused by kinase-inactive Src (1995) Nature, 378, pp. 509-512
Pancione, M., Forte, N., Sabatino, L., Tomaselli, E., Parente, D., Febbraro, A., Colantuoni, V., Reduced γ-catenin and peroxisome proliferator-activated receptor γ expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome (2009) Hum. Pathol., 40, pp. 714-725
Yeh, J.J., Marsh, D.J., Zedenius, J., Dwight, T., Delbridge, L., Robinson, B.G., Eng, C., Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways (1999) Genes Chromosomes Cancer, 26, pp. 322-328
Kinzler, K.W., Vogelstein, B., Lessons from hereditary colorectal cancer (1996) Cell, 87, pp. 159-170
Gupta, R.A., Sarraf, P., Mueller, E., Brockman, J.A., Prusakiewicz, J.J., Eng, C., Willson, T.M., DuBois, R.N., Peroxisome proliferator-activated receptor γ mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms (2003) J. Biol. Chem., 278, pp. 22669-22677
Girnun, G.D., Smith, W.M., Drori, S., Sarraf, P., Mueller, E., Eng, C., Nambiar, P., Spiegelman, B.M., APC-dependent suppression of colon carcinogenesis by PPARγ (2002) Proc. Natl. Acad. Sci. U.S.A., 99, pp. 13771-13776
Teresi, R.E., Shaiu, C.W., Chen, C.S., Chatterjee, V.K., Waite, K.A., Eng, C., Increased PTEN expression due to transcriptional activation of PPARγ by lovastatin and rosiglitazone (2006) Int. J. Cancer, 118, pp. 2390-2398
Annicotte, J.S., Iankova, I., Miard, S., Fritz, V., Sarruf, D., Abella, A., Berthe, M.L., Iborra, F., Peroxisome proliferator-activated receptor γ regulates E-cadherin expression and inhibits growth and invasion of prostate cancer (2006) Mol. Cell. Biol., 26, pp. 7561-7574
Wang, D., Dubois, R.N., Peroxisome proliferator-activated receptors and progression of colorectal cancer (2008) PPAR Res, p. 931074
Pascual, G., Fong, A.L., Ogawa, S., Gamliel, A., Li, A.C., Perissi, V., Rose, D.W., Glass, C.K., A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPARγ (2005) Nature, 437, pp. 759-763
Iatropoulos, M.J., Williams, G.M., Proliferation markers (1996) Exp. Toxicol. Pathol., 48, pp. 175-181
Platt, A.M., Mowat, A.M., Mucosal macrophages and the regulation of immune responses in the intestine (2008) Immunol. Lett., 119, pp. 22-31
Mori, M., Shimono, R., Adachi, Y., Matsuda, H., Kuwano, H., Sugimachi, K., Ikeda, M., Saku, M., Transitional mucosa in human colorectal lesions (1990) Dis. Colon Rectum, 33, pp. 498-501
Gampe, R.T., Montana, V.G., Lambert, M.H., Miller, A.B., Bledsoe, R.K., Milburn, M.V., Kliever, S.A., Xu, E.H., Asymmetry in the PPARγ /RXRγ crystal structure reveals the molecular basis of heterodimerization among nuclear receptors (2000) Mol. Cell, 5, pp. 545-555
Uppenberg, J., Svensson, C., Jaki, M., Bertilsson, G., Jendeberg, L., Berkenstam, A., Crystal structure of the ligand binding domain of the human nuclear receptor PPARγ (1998) J. Biol. Chem., 273, pp. 31108-31112
Petersen, M.T., Jonson, P.H., Petersen, S.B., Amino acid neighbours and detailed conformational analysis of cysteines in proteins (1999) Protein Eng., 12, pp. 535-548
Kraulis, P.J., MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures (1991) J. Appl. Crystallogr., 24, pp. 946-950
Rogler, G., Significance of anti-inflammatory effects of PPARγ agonists? (2006) Gut, 55, pp. 1067-1069
Alberici, P., Gaspar, C., Franken, P., Gorski, M.M., de Vries, I., Scott, R.J., Ristimäki, A., Fodde, R., Smad4 haploinsufficiency: a matter of dosage (2008) Pathogenetics, 1, pp. 2-12
Eng, C., Schneider, K., Fraumeni, J.F., Li, F.P., Third international workshop on collaborative interdisciplinary studies of p53 and other predisposing genes in Li-Fraumeni syndrome (1997) Cancer Epidemiol. Biomarkers Prev., 6, pp. 379-383
Russell-Swetek, A., West, A.N., Mintern, J.E., Jenkins, J., Rodriguez-Galindo, C., Ribeiro, R., Zambetti, G.P., Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma (2008) J. Med. Genet., 45, pp. 603-606
Ikezoe, T., Miller, C.W., Kawano, S., Heaney, A., Williamson, E.A., Hisatake, J., Green, E., Koeffler, H.P., Mutational analysis of the peroxisome proliferator-activated receptor gamma gene in human malignancies (2001) Cancer Res., 61, pp. 5307-5310
Tsai, Y.S., Kim, H.J., Takahashi, N., Kim, H.S., Hagaman, J.R., Kim, J.K., Maeda, N., Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ (2004) J. Clin. Invest, 114, pp. 163-175
Meredith, D., Panchatcharam, M., Miriyala, S., Tsai, Y.S., Morris, A.J., Maeda, N., Stouffer, G.A., Smyth, S.S., Dominant-negative loss of PPARγ function enhances smooth muscle cell proliferation, migration, and vascular remodeling (2009) Arterioscler. Thromb. Vasc. Biol., 29, pp. 465-471
Francis, G. A., Fayard, E., Picard, F., Auwerx, J., Nuclear receptors and the control of metabolism (2003) Ann. Rev. Physiol., 65, pp. 261-31
Spiegelman, B. M., PPAR: adipogenic regulator and thiazolidinedione receptor (1998) Diabetes, 47, pp. 507-514
Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., Wahli, W., From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions (2006) Prog. Lipid Res., 45, pp. 120-159
Willson, T. M., Lambert, M. H., Kliewer, S. A., Peroxisome proliferator-activated receptor and metabolic disease (2001) Annu. Rev. Biochem., 70, pp. 341-367
Savage, D. B., Tan, G. D., Acerini, C. L., Jebb, S. A., Agostini, M., Gurnell, M., Williams, R. L., O'Rahilly, S., Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor (2003) Diabetes, 52, pp. 910-917
Peverali, F. A., Ramqvist, T., Saffrich, R., Pepperkok, R., Barone, M. V., Philipson, L., Regulation of G1 progression by E2A and Id helix-loop-helix proteins (1994) EMBO J., 13, pp. 4291-4301
Barone, M. V., Courtneidge, S. A., Myc but not Fos rescue of PDGF signaling block caused by kinase-inactive Src (1995) Nature, 378, pp. 509-512
Yeh, J. J., Marsh, D. J., Zedenius, J., Dwight, T., Delbridge, L., Robinson, B. G., Eng, C., Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways (1999) Genes Chromosomes Cancer, 26, pp. 322-328
Kinzler, K. W., Vogelstein, B., Lessons from hereditary colorectal cancer (1996) Cell, 87, pp. 159-170
Gupta, R. A., Sarraf, P., Mueller, E., Brockman, J. A., Prusakiewicz, J. J., Eng, C., Willson, T. M., DuBois, R. N., Peroxisome proliferator-activated receptor mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms (2003) J. Biol. Chem., 278, pp. 22669-22677
Girnun, G. D., Smith, W. M., Drori, S., Sarraf, P., Mueller, E., Eng, C., Nambiar, P., Spiegelman, B. M., APC-dependent suppression of colon carcinogenesis by PPAR (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 13771-13776
Teresi, R. E., Shaiu, C. W., Chen, C. S., Chatterjee, V. K., Waite, K. A., Eng, C., Increased PTEN expression due to transcriptional activation of PPAR by lovastatin and rosiglitazone (2006) Int. J. Cancer, 118, pp. 2390-2398
Annicotte, J. S., Iankova, I., Miard, S., Fritz, V., Sarruf, D., Abella, A., Berthe, M. L., Iborra, F., Peroxisome proliferator-activated receptor regulates E-cadherin expression and inhibits growth and invasion of prostate cancer (2006) Mol. Cell. Biol., 26, pp. 7561-7574
Iatropoulos, M. J., Williams, G. M., Proliferation markers (1996) Exp. Toxicol. Pathol., 48, pp. 175-181
Platt, A. M., Mowat, A. M., Mucosal macrophages and the regulation of immune responses in the intestine (2008) Immunol. Lett., 119, pp. 22-31
Gampe, R. T., Montana, V. G., Lambert, M. H., Miller, A. B., Bledsoe, R. K., Milburn, M. V., Kliever, S. A., Xu, E. H., Asymmetry in the PPAR /RXR crystal structure reveals the molecular basis of heterodimerization among nuclear receptors (2000) Mol. Cell, 5, pp. 545-555
Petersen, M. T., Jonson, P. H., Petersen, S. B., Amino acid neighbours and detailed conformational analysis of cysteines in proteins (1999) Protein Eng., 12, pp. 535-548
Kraulis, P. J., MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures (1991) J. Appl. Crystallogr., 24, pp. 946-950
Tsai, Y. S., Kim, H. J., Takahashi, N., Kim, H. S., Hagaman, J. R., Kim, J. K., Maeda, N., Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPAR (2004) J. Clin. Invest, 114, pp. 163-175
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.773, 5-year impact factor Impact factor a 5 anni: 2.751
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952240564&partnerID=40&md5=f0a185472554530c6ce54fec0f6a1265
Keywords Parole chiave: Colorectal Cancer, Dyslipidemia, Loss-Of-Function Mutation, Peroxisome Proliferator-Activated Receptor, High Density Lipoprotein Cholesterol, Insulin, Low Density Lipoprotein Cholesterol, Peroxisome Proliferator Activated Receptor Gamma, Triacylglycerol, Adult, Aged, Amino Acid Substitution, Article, Cancer Localization, Cell Proliferation, Cholesterol Blood Level, Clinical Article, Colon Carcinogenesis, Colon Polyp, Colonoscopy, Controlled Study, Female, Gene Mutation, Genetic Association, Germ Line, Glucose Blood Level, Histopathology, Human, Human Cell, Human Tissue, Hypertension, In Vitro Study, In Vivo Study, Insulin Blood Level, Ligand Binding, Lipid Metabolism, Liver Metastasis, Loss Of Function Mutation, Non Insulin Dependent Diabetes Mellitus, Nucleotide Sequence, Obesity, Priority Journal, Protein Expression, Protein Function, Triacylglycerol Blood Level, Wild Type, Adenocarcinoma, Adolescent, 80 And Over, Animals, Base Sequence, Binding Sites, Cercopithecus Aethiops, Colonic Neoplasms, Cos Cells, Dna Primers, Germ-Line Mutation, Intestinal Polyps, Loss Of Heterozygosity, Middle Aged, Models, Molecular, Nih 3t3 Cells, Pedigree, Ppar Gamma, Recombinant Proteins, Transfection, Young Adult,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Biological and Environmental Sciences, University of Sannio, Via Port'Arsa, 11, 82100 Benevento, Italy
Institute of Genetics and Biophysics, A. Buzzati-Traverso CNR, Via P. Castellino, 113, 80131 Napoli, Italy
Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini, 5, 80131 Napoli, Italy
Fatebenefratelli Hospital, Division of Medical Oncology, Viale Principe di Napoli, 82100 Benevento, Italy
Department of Chemistry, University of Naples Federico II, Monte S. Angelo, 80100 Napoli, Italy
References Riferimenti:
Francis, G.A., Fayard, E., Picard, F., Auwerx, J., Nuclear receptors and the control of metabolism (2003) Ann. Rev. Physiol., 65, pp. 261-31
Spiegelman, B.M., PPARγ: adipogenic regulator and thiazolidinedione receptor (1998) Diabetes, 47, pp. 507-514
Feige, J.N., Gelman, L., Michalik, L., Desvergne, B., Wahli, W., From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions (2006) Prog. Lipid Res., 45, pp. 120-159
Willson, T.M., Lambert, M.H., Kliewer, S.A., Peroxisome proliferator-activated receptor γ and metabolic disease (2001) Annu. Rev. Biochem., 70, pp. 341-367
Knouff, C., Auwerx, J., Peroxisome proliferator-activated receptor-γ calls for activation in moderation: lessons from genetics and pharmacology (2004) Endocr. Rev., 25, pp. 899-918
Sarraf, P., Mueller, E., Smith, W.M., Wright, H.M., Kum, J.B., Aaltonen, L.A., de la Chapelle, A., Eng, C., Loss-of-function mutations in PPARγ associated with human colon cancer (1999) Mol Cell, 3, pp. 799-804
Ristow, M., Muller-Wieland, D., Pfeiffer, A., Krone, W., Kahn, C.R., Obesity associated with a mutation in a genetic regulator of adipocyte differentiation (1998) N. Engl. J. Med., 339, pp. 953-959
Grommes, C., Landreth, G., Heneka, M.T., Antineoplastic effects of peroxisome proliferator activated receptor γ agonists (2004) Lancet Oncol., 7, pp. 419-429
Sabatino, L., Casamassimi, A., Peluso, G., Barone, M.V., Capaccio, D., Migliore, C., Monelli, P., Colantuoni, V., A novel peroxisome proliferator-activated receptor γ isoform with dominant negative activity generated by alternative splicing (2005) J. Biol. Chem., 280, pp. 26517-26525
Barroso, I., Gurnell, M., Crowley, V.E., Agostini, M., Schwabe, J.W., Soos, M.A., Maslen, G.L., O'Rahilly, S., Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension (1999) Nature, 402, pp. 880-883
Savage, D.B., Tan, G.D., Acerini, C.L., Jebb, S.A., Agostini, M., Gurnell, M., Williams, R.L., O'Rahilly, S., Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor γ (2003) Diabetes, 52, pp. 910-917
Peverali, F.A., Ramqvist, T., Saffrich, R., Pepperkok, R., Barone, M.V., Philipson, L., Regulation of G1 progression by E2A and Id helix-loop-helix proteins (1994) EMBO J., 13, pp. 4291-4301
Barone, M.V., Courtneidge, S.A., Myc but not Fos rescue of PDGF signaling block caused by kinase-inactive Src (1995) Nature, 378, pp. 509-512
Pancione, M., Forte, N., Sabatino, L., Tomaselli, E., Parente, D., Febbraro, A., Colantuoni, V., Reduced γ-catenin and peroxisome proliferator-activated receptor γ expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome (2009) Hum. Pathol., 40, pp. 714-725
Yeh, J.J., Marsh, D.J., Zedenius, J., Dwight, T., Delbridge, L., Robinson, B.G., Eng, C., Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways (1999) Genes Chromosomes Cancer, 26, pp. 322-328
Kinzler, K.W., Vogelstein, B., Lessons from hereditary colorectal cancer (1996) Cell, 87, pp. 159-170
Gupta, R.A., Sarraf, P., Mueller, E., Brockman, J.A., Prusakiewicz, J.J., Eng, C., Willson, T.M., DuBois, R.N., Peroxisome proliferator-activated receptor γ mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms (2003) J. Biol. Chem., 278, pp. 22669-22677
Girnun, G.D., Smith, W.M., Drori, S., Sarraf, P., Mueller, E., Eng, C., Nambiar, P., Spiegelman, B.M., APC-dependent suppression of colon carcinogenesis by PPARγ (2002) Proc. Natl. Acad. Sci. U.S.A., 99, pp. 13771-13776
Teresi, R.E., Shaiu, C.W., Chen, C.S., Chatterjee, V.K., Waite, K.A., Eng, C., Increased PTEN expression due to transcriptional activation of PPARγ by lovastatin and rosiglitazone (2006) Int. J. Cancer, 118, pp. 2390-2398
Annicotte, J.S., Iankova, I., Miard, S., Fritz, V., Sarruf, D., Abella, A., Berthe, M.L., Iborra, F., Peroxisome proliferator-activated receptor γ regulates E-cadherin expression and inhibits growth and invasion of prostate cancer (2006) Mol. Cell. Biol., 26, pp. 7561-7574
Wang, D., Dubois, R.N., Peroxisome proliferator-activated receptors and progression of colorectal cancer (2008) PPAR Res, p. 931074
Pascual, G., Fong, A.L., Ogawa, S., Gamliel, A., Li, A.C., Perissi, V., Rose, D.W., Glass, C.K., A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPARγ (2005) Nature, 437, pp. 759-763
Iatropoulos, M.J., Williams, G.M., Proliferation markers (1996) Exp. Toxicol. Pathol., 48, pp. 175-181
Platt, A.M., Mowat, A.M., Mucosal macrophages and the regulation of immune responses in the intestine (2008) Immunol. Lett., 119, pp. 22-31
Mori, M., Shimono, R., Adachi, Y., Matsuda, H., Kuwano, H., Sugimachi, K., Ikeda, M., Saku, M., Transitional mucosa in human colorectal lesions (1990) Dis. Colon Rectum, 33, pp. 498-501
Gampe, R.T., Montana, V.G., Lambert, M.H., Miller, A.B., Bledsoe, R.K., Milburn, M.V., Kliever, S.A., Xu, E.H., Asymmetry in the PPARγ /RXRγ crystal structure reveals the molecular basis of heterodimerization among nuclear receptors (2000) Mol. Cell, 5, pp. 545-555
Uppenberg, J., Svensson, C., Jaki, M., Bertilsson, G., Jendeberg, L., Berkenstam, A., Crystal structure of the ligand binding domain of the human nuclear receptor PPARγ (1998) J. Biol. Chem., 273, pp. 31108-31112
Petersen, M.T., Jonson, P.H., Petersen, S.B., Amino acid neighbours and detailed conformational analysis of cysteines in proteins (1999) Protein Eng., 12, pp. 535-548
Kraulis, P.J., MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures (1991) J. Appl. Crystallogr., 24, pp. 946-950
Rogler, G., Significance of anti-inflammatory effects of PPARγ agonists? (2006) Gut, 55, pp. 1067-1069
Alberici, P., Gaspar, C., Franken, P., Gorski, M.M., de Vries, I., Scott, R.J., Ristimäki, A., Fodde, R., Smad4 haploinsufficiency: a matter of dosage (2008) Pathogenetics, 1, pp. 2-12
Eng, C., Schneider, K., Fraumeni, J.F., Li, F.P., Third international workshop on collaborative interdisciplinary studies of p53 and other predisposing genes in Li-Fraumeni syndrome (1997) Cancer Epidemiol. Biomarkers Prev., 6, pp. 379-383
Russell-Swetek, A., West, A.N., Mintern, J.E., Jenkins, J., Rodriguez-Galindo, C., Ribeiro, R., Zambetti, G.P., Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma (2008) J. Med. Genet., 45, pp. 603-606
Ikezoe, T., Miller, C.W., Kawano, S., Heaney, A., Williamson, E.A., Hisatake, J., Green, E., Koeffler, H.P., Mutational analysis of the peroxisome proliferator-activated receptor gamma gene in human malignancies (2001) Cancer Res., 61, pp. 5307-5310
Tsai, Y.S., Kim, H.J., Takahashi, N., Kim, H.S., Hagaman, J.R., Kim, J.K., Maeda, N., Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ (2004) J. Clin. Invest, 114, pp. 163-175
Meredith, D., Panchatcharam, M., Miriyala, S., Tsai, Y.S., Morris, A.J., Maeda, N., Stouffer, G.A., Smyth, S.S., Dominant-negative loss of PPARγ function enhances smooth muscle cell proliferation, migration, and vascular remodeling (2009) Arterioscler. Thromb. Vasc. Biol., 29, pp. 465-471
Francis, G. A., Fayard, E., Picard, F., Auwerx, J., Nuclear receptors and the control of metabolism (2003) Ann. Rev. Physiol., 65, pp. 261-31
Spiegelman, B. M., PPAR: adipogenic regulator and thiazolidinedione receptor (1998) Diabetes, 47, pp. 507-514
Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., Wahli, W., From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions (2006) Prog. Lipid Res., 45, pp. 120-159
Willson, T. M., Lambert, M. H., Kliewer, S. A., Peroxisome proliferator-activated receptor and metabolic disease (2001) Annu. Rev. Biochem., 70, pp. 341-367
Savage, D. B., Tan, G. D., Acerini, C. L., Jebb, S. A., Agostini, M., Gurnell, M., Williams, R. L., O'Rahilly, S., Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor (2003) Diabetes, 52, pp. 910-917
Peverali, F. A., Ramqvist, T., Saffrich, R., Pepperkok, R., Barone, M. V., Philipson, L., Regulation of G1 progression by E2A and Id helix-loop-helix proteins (1994) EMBO J., 13, pp. 4291-4301
Barone, M. V., Courtneidge, S. A., Myc but not Fos rescue of PDGF signaling block caused by kinase-inactive Src (1995) Nature, 378, pp. 509-512
Yeh, J. J., Marsh, D. J., Zedenius, J., Dwight, T., Delbridge, L., Robinson, B. G., Eng, C., Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways (1999) Genes Chromosomes Cancer, 26, pp. 322-328
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A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia
We report a novel PPARG germline mutation in a patient affected by colorectal cancer that replaces serine 289 with cysteine in the mature protein (S289C). The mutant has impaired transactivation potential and acts as dominant negative to the wild type receptor. In addition, it no longer restrains cell proliferation both in vitro and in vivo. Interestingly, the S289C mutant poorly activates target genes and interferes with the inflammatory pathway in tumor tissues and proximal normal mucosa. Consistently, only mutation carriers exhibit colonic lesions that can evolve to dysplastic polyps. The proband presented also dyslipidemia, hypertension and overweight, not associated to type 2 diabetes; of note, family members tested positive for the mutation and display only a dyslipidemic profile at variable penetrance with other biochemical parameters in the normal range. Finally, superimposing the mutation to the crystal structure of the ligand binding domain, the new Cys289 becomes so closely positioned to Cys285 to form an S-S bridge. This would reduce the depth of the ligand binding pocket and impede agonist positioning, explaining the biological effects and subcellular distribution of the mutant protein. This is the first PPARG germline mutation associated with dyslipidemia and colonic polyp formation that can progress to full-blown adenocarcinoma. © 2010 Elsevier B.V.
We report a novel PPARG germline mutation in a patient affected by colorectal cancer that replaces serine 289 with cysteine in the mature protein (S289C). The mutant has impaired transactivation potential and acts as dominant negative to the wild type receptor. In addition, it no longer restrains cell proliferation both in vitro and in vivo. Interestingly, the S289C mutant poorly activates target genes and interferes with the inflammatory pathway in tumor tissues and proximal normal mucosa. Consistently, only mutation carriers exhibit colonic lesions that can evolve to dysplastic polyps. The proband presented also dyslipidemia, hypertension and overweight, not associated to type 2 diabetes; of note, family members tested positive for the mutation and display only a dyslipidemic profile at variable penetrance with other biochemical parameters in the normal range. Finally, superimposing the mutation to the crystal structure of the ligand binding domain, the new Cys289 becomes so closely positioned to Cys285 to form an S-S bridge. This would reduce the depth of the ligand binding pocket and impede agonist positioning, explaining the biological effects and subcellular distribution of the mutant protein. This is the first PPARG germline mutation associated with dyslipidemia and colonic polyp formation that can progress to full-blown adenocarcinoma. © 2010 Elsevier B.V.
A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia
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A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia
Manco M, Ala U, Cantarella D, Tolosano E, Medico E, Altruda F, Fagoonee S
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40 Records (36 escludendo Abstract e Conferenze).
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Manco M, Ala U, Cantarella D, Tolosano E, Medico E, Altruda F, Fagoonee S
* The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells (2 visite)
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Impact Factor: 6.126
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Susana F, Fagoonee S, Alessandro S, Valentina G, Chiara R, Marco P, Fiorella A, Danilo D
* Impedance-based drug-resistance characterization of colon cancer cells through real-time cell culture monitoring (71 visite)
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Impact Factor: 5.339
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D'Alterio C, Zannetti A, Trotta AM, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S
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* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (109 visite)
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Impact Factor: 2.598
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Impact Factor: 5.391
Dettagli Esporta in BibTeX Esporta in EndNote
Mainenti PP, Stanzione A, Guarino S, Romeo V, Ugga L, Romano F, Storto G, Maurea S, Brunetti A
* Colorectal cancer: Parametric evaluation of morphological, functional and molecular tomographic imaging (123 visite)
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Barresi V, Valenti G, Spampinato G, Musso N, Castorina S, Rizzarelli E, Condorelli DF
* Transcriptome analysis reveals an altered expression profile of zinc transporters in colorectal cancer (168 visite)
J Cell Biochem (ISSN: 0730-2312linking), 2018 Dec; 119(12): 9707-9719.
Impact Factor: 2.959
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Caprio MG, Simonetti I, Tarotto L, Trovato P, Mainolfi CG, Salvatore B, Pace L
* 18-F-FDG PET, PET/CT AND MDCT IN LOCALLY ADVANCED COLORECTAL CANCER (152 visite) (PDF 154 visite)
Int J Of Current Res, 2017 Jul; 9: 53960-53964.
Impact Factor: 7.086
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Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (321 visite)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
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Caviglia GP, Cabianca L, Fagoonee S, Gili FM
* Colorectal cancer detection in an asymptomatic population: Fecal immunochemical test for hemoglobin vs. Fecal M2-type pyruvate kinase (302 visite)
Biochem Medica (ISSN: 1330-0962), 2016; 26(1): 114-120.
Impact Factor: 2.934
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Mainenti PP, Romano F, Pizzuti L, Segreto S, Storto G, Mannelli L, Imbriaco M, Camera L, Maurea S
* Non-invasive diagnostic imaging of colorectal liver metastases (231 visite)
World J Radiol (ISSN: 1949-8470electronic, 1949-8470linking), 2015 Jul 28; 7(7): 157-169.
Impact Factor: 0.567
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Greco A, D'Alterio C, Auletta L, Albanese S, Napolitano M, Portella L, Santagata S, Ierano C, Brunetti A, Scala S, Zannetti A
* Longitudinal evaluation with High Frequency Ultrasound imaging of response to CXCR4 new cyclic peptide antagonist with conventional chemotherapy in colorectal cancer mice model (358 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42: S425-S425.
Impact Factor: 5.537
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (375 visite)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Napolitano S, Troiani T, Morgillo F, Ciardiello F, Belli G, Cioffi L, Sirignano C, Martinelli E
* Predictive Biomarkers To Anti-Egfr Inhibitors Treatment In The Management Of Metastatic Colorectal Cancer (216 visite) (PDF 7 visite)
Journal Of Carcinogenesis & Mutagenesis, 2014; N/D: 2157-2518.
Impact Factor: 3.445
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Vitale M, Luongo D, Naviglio D, Bozzetto L, Mirabella M, Rivieccio AM, Giacco A, Rivellese AA
* Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids (349 visite)
Acta Diabetol (ISSN: 0940-5429, 1432-5233electronic), 2013 Aug; 50(4): 651-654.
Impact Factor: 3.679
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Giacomobono S, Gallicchio R, Capacchione D, Nardelli A, Gattozzi D, Lettini G, Molinari L, Mainenti P, Cammarota A, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (267 visite)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 2013 Jul 12; 28(12): 1699-1705.
Impact Factor: 2.415
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (556 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (341 visite)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (307 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (335 visite)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
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Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, De Palma GD, Salvatore M, Pace L
* Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging? (300 visite)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2011 Mar 21; 17(11): 1427-1433.
Impact Factor: 2.471
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (378 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Giacomobono S, Capacchione D, Lancellotti M, Nardelli A, Gallicchio R, Improta G, Nappi A, Cammarota A, Di Leo A, Pace L, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (217 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
Impact Factor: 4.531
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (341 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
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Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (357 visite)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
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Salvatore B, Simeone R, Fonti R, Marciano R, Bianco R, Damiano V, Tortora G, Pace L, Del Vecchio S, Salvatore M
* 18F-FDG PET/CT in the assessment of early response to chemotherapy and molecularly targeted agents in metastatic colorectal cancer (221 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Vettor R, Granzotto M, De Stefani D, Trevellin E, Rossato M, Farina MG, Milan G, Pilon C, Nigro A, Federspil G, Vigneri R, Vitiello L, Rizzuto R, Baratta R, Frittitta L
* Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization (324 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2008 Sep; 93(9): 3541-3550.
Impact Factor: 6.325
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (297 visite)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Caprio MG, Cantalupo T, Mainenti PP, Mainolfi CG, Varrone A, Salvatore B, Persico F, D'Antonio D, Pace L, Salvatore M
* 18F-fdg pet, pet/ct and ce-mdct in locally advanced colorectal cancer (242 visite) (PDF 154 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Storto G, Mainenti PP, Varrone A, Mainolfi C, Salvatore B, Caprio MG, Cella L, Soricelli A, Pace L, Salvatore M
* Role of FDG-PET/CT in the staging of colorectal cancer (261 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (290 visite)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (399 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
Dettagli Esporta in BibTeX Esporta in EndNote
Mainenti PP, Romano M, Imbriaco M, Camera L, Pace L, D'Antonio D, Bucci L, Galloro G, Salvatore M
* Added value of CT colonography after a positive conventional colonoscopy: Impact on treatment strategy (336 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2005 Jan; 30(1): 42-47.
Impact Factor: 1.034
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Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (372 visite)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (428 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (334 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (300 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (254 visite)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (309 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (2514 visite)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
40 Records (36 escludendo Abstract e Conferenze).
Impact factor totale: 143.298 (126.153 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 114.279 (95.934 escludendo Abstract e Conferenze).
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