A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (444 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
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Paper type: Journal Article,
Impact factor: 2.773, 5-year impact factor: 2.751
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952240564&partnerID=40&md5=f0a185472554530c6ce54fec0f6a1265
Keywords: Colorectal Cancer, Dyslipidemia, Loss-Of-Function Mutation, Peroxisome Proliferator-Activated Receptor, High Density Lipoprotein Cholesterol, Insulin, Low Density Lipoprotein Cholesterol, Peroxisome Proliferator Activated Receptor Gamma, Triacylglycerol, Adult, Aged, Amino Acid Substitution, Article, Cancer Localization, Cell Proliferation, Cholesterol Blood Level, Clinical Article, Colon Carcinogenesis, Colon Polyp, Colonoscopy, Controlled Study, Female, Gene Mutation, Genetic Association, Germ Line, Glucose Blood Level, Histopathology, Human, Human Cell, Human Tissue, Hypertension, In Vitro Study, In Vivo Study, Insulin Blood Level, Ligand Binding, Lipid Metabolism, Liver Metastasis, Loss Of Function Mutation, Non Insulin Dependent Diabetes Mellitus, Nucleotide Sequence, Obesity, Priority Journal, Protein Expression, Protein Function, Triacylglycerol Blood Level, Wild Type, Adenocarcinoma, Adolescent, 80 And Over, Animals, Base Sequence, Binding Sites, Cercopithecus Aethiops, Colonic Neoplasms, Cos Cells, Dna Primers, Germ-Line Mutation, Intestinal Polyps, Loss Of Heterozygosity, Middle Aged, Models, Molecular, Nih 3t3 Cells, Pedigree, Ppar Gamma, Recombinant Proteins, Transfection, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Biological and Environmental Sciences, University of Sannio, Via Port'Arsa, 11, 82100 Benevento, Italy
Institute of Genetics and Biophysics, A. Buzzati-Traverso CNR, Via P. Castellino, 113, 80131 Napoli, Italy
Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini, 5, 80131 Napoli, Italy
Fatebenefratelli Hospital, Division of Medical Oncology, Viale Principe di Napoli, 82100 Benevento, Italy
Department of Chemistry, University of Naples Federico II, Monte S. Angelo, 80100 Napoli, Italy
References:
Not available.
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.773, 5-year impact factor: 2.751
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952240564&partnerID=40&md5=f0a185472554530c6ce54fec0f6a1265
Keywords: Colorectal Cancer, Dyslipidemia, Loss-Of-Function Mutation, Peroxisome Proliferator-Activated Receptor, High Density Lipoprotein Cholesterol, Insulin, Low Density Lipoprotein Cholesterol, Peroxisome Proliferator Activated Receptor Gamma, Triacylglycerol, Adult, Aged, Amino Acid Substitution, Article, Cancer Localization, Cell Proliferation, Cholesterol Blood Level, Clinical Article, Colon Carcinogenesis, Colon Polyp, Colonoscopy, Controlled Study, Female, Gene Mutation, Genetic Association, Germ Line, Glucose Blood Level, Histopathology, Human, Human Cell, Human Tissue, Hypertension, In Vitro Study, In Vivo Study, Insulin Blood Level, Ligand Binding, Lipid Metabolism, Liver Metastasis, Loss Of Function Mutation, Non Insulin Dependent Diabetes Mellitus, Nucleotide Sequence, Obesity, Priority Journal, Protein Expression, Protein Function, Triacylglycerol Blood Level, Wild Type, Adenocarcinoma, Adolescent, 80 And Over, Animals, Base Sequence, Binding Sites, Cercopithecus Aethiops, Colonic Neoplasms, Cos Cells, Dna Primers, Germ-Line Mutation, Intestinal Polyps, Loss Of Heterozygosity, Middle Aged, Models, Molecular, Nih 3t3 Cells, Pedigree, Ppar Gamma, Recombinant Proteins, Transfection, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Biological and Environmental Sciences, University of Sannio, Via Port'Arsa, 11, 82100 Benevento, Italy
Institute of Genetics and Biophysics, A. Buzzati-Traverso CNR, Via P. Castellino, 113, 80131 Napoli, Italy
Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini, 5, 80131 Napoli, Italy
Fatebenefratelli Hospital, Division of Medical Oncology, Viale Principe di Napoli, 82100 Benevento, Italy
Department of Chemistry, University of Naples Federico II, Monte S. Angelo, 80100 Napoli, Italy
References:
Not available.
A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia
We report a novel PPARG germline mutation in a patient affected by colorectal cancer that replaces serine 289 with cysteine in the mature protein (S289C). The mutant has impaired transactivation potential and acts as dominant negative to the wild type receptor. In addition, it no longer restrains cell proliferation both in vitro and in vivo. Interestingly, the S289C mutant poorly activates target genes and interferes with the inflammatory pathway in tumor tissues and proximal normal mucosa. Consistently, only mutation carriers exhibit colonic lesions that can evolve to dysplastic polyps. The proband presented also dyslipidemia, hypertension and overweight, not associated to type 2 diabetes; of note, family members tested positive for the mutation and display only a dyslipidemic profile at variable penetrance with other biochemical parameters in the normal range. Finally, superimposing the mutation to the crystal structure of the ligand binding domain, the new Cys289 becomes so closely positioned to Cys285 to form an S-S bridge. This would reduce the depth of the ligand binding pocket and impede agonist positioning, explaining the biological effects and subcellular distribution of the mutant protein. This is the first PPARG germline mutation associated with dyslipidemia and colonic polyp formation that can progress to full-blown adenocarcinoma. © 2010 Elsevier B.V.
We report a novel PPARG germline mutation in a patient affected by colorectal cancer that replaces serine 289 with cysteine in the mature protein (S289C). The mutant has impaired transactivation potential and acts as dominant negative to the wild type receptor. In addition, it no longer restrains cell proliferation both in vitro and in vivo. Interestingly, the S289C mutant poorly activates target genes and interferes with the inflammatory pathway in tumor tissues and proximal normal mucosa. Consistently, only mutation carriers exhibit colonic lesions that can evolve to dysplastic polyps. The proband presented also dyslipidemia, hypertension and overweight, not associated to type 2 diabetes; of note, family members tested positive for the mutation and display only a dyslipidemic profile at variable penetrance with other biochemical parameters in the normal range. Finally, superimposing the mutation to the crystal structure of the ligand binding domain, the new Cys289 becomes so closely positioned to Cys285 to form an S-S bridge. This would reduce the depth of the ligand binding pocket and impede agonist positioning, explaining the biological effects and subcellular distribution of the mutant protein. This is the first PPARG germline mutation associated with dyslipidemia and colonic polyp formation that can progress to full-blown adenocarcinoma. © 2010 Elsevier B.V.
A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia
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A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia
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Impact Factor: 5.339
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D'Alterio C, Zannetti A, Trotta AM, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S
* New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer (152 views) (PDF 47 views)
Cancers (ISSN: 2072-6694linking), 2020 Jul 18; 12(7): 1952-1952.
Impact Factor: 6.126
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Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
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Cimmino I, Margheri F, Prisco F, Perruolo G, D'Esposito V, Laurenzana A, Fibbi G, Paciello O, Doti N, Ruvo M, Miele C, Beguinot F, Formisano P, Oriente F
* Prep1 regulates angiogenesis through a PGC-1alpha-mediated mechanism (221 views)
Faseb J (ISSN: 0892-6638linking), 2019 Oct 15; 33(12): 13893-13904.
Impact Factor: 5.391
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Mainenti PP, Stanzione A, Guarino S, Romeo V, Ugga L, Romano F, Storto G, Maurea S, Brunetti A
* Colorectal cancer: Parametric evaluation of morphological, functional and molecular tomographic imaging (145 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2019 Sep 21; 25 (35 ): 5233-5256.
Impact Factor: 2.24
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Barresi V, Valenti G, Spampinato G, Musso N, Castorina S, Rizzarelli E, Condorelli DF
* Transcriptome analysis reveals an altered expression profile of zinc transporters in colorectal cancer (212 views)
J Cell Biochem (ISSN: 0730-2312linking), 2018 Dec; 119(12): 9707-9719.
Impact Factor: 2.959
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Caprio MG, Simonetti I, Tarotto L, Trovato P, Mainolfi CG, Salvatore B, Pace L
* 18-F-FDG PET, PET/CT AND MDCT IN LOCALLY ADVANCED COLORECTAL CANCER (163 views) (PDF 159 views)
Int J Of Current Res, 2017 Jul; 9: 53960-53964.
Impact Factor: 7.086
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Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (366 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
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Caviglia GP, Cabianca L, Fagoonee S, Gili FM
* Colorectal cancer detection in an asymptomatic population: Fecal immunochemical test for hemoglobin vs. Fecal M2-type pyruvate kinase (353 views)
Biochem Medica (ISSN: 1330-0962), 2016; 26(1): 114-120.
Impact Factor: 2.934
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Mainenti PP, Romano F, Pizzuti L, Segreto S, Storto G, Mannelli L, Imbriaco M, Camera L, Maurea S
* Non-invasive diagnostic imaging of colorectal liver metastases (254 views)
World J Radiol (ISSN: 1949-8470electronic, 1949-8470linking), 2015 Jul 28; 7(7): 157-169.
Impact Factor: 0.567
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Greco A, D'Alterio C, Auletta L, Albanese S, Napolitano M, Portella L, Santagata S, Ierano C, Brunetti A, Scala S, Zannetti A
* Longitudinal evaluation with High Frequency Ultrasound imaging of response to CXCR4 new cyclic peptide antagonist with conventional chemotherapy in colorectal cancer mice model (398 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42: S425-S425.
Impact Factor: 5.537
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (473 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Napolitano S, Troiani T, Morgillo F, Ciardiello F, Belli G, Cioffi L, Sirignano C, Martinelli E
* Predictive Biomarkers To Anti-Egfr Inhibitors Treatment In The Management Of Metastatic Colorectal Cancer (249 views) (PDF 14 views)
Journal Of Carcinogenesis & Mutagenesis, 2014; N/D: 2157-2518.
Impact Factor: 3.445
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Vitale M, Luongo D, Naviglio D, Bozzetto L, Mirabella M, Rivieccio AM, Giacco A, Rivellese AA
* Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids (443 views)
Acta Diabetol (ISSN: 0940-5429, 1432-5233electronic), 2013 Aug; 50(4): 651-654.
Impact Factor: 3.679
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Giacomobono S, Gallicchio R, Capacchione D, Nardelli A, Gattozzi D, Lettini G, Molinari L, Mainenti P, Cammarota A, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (307 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 2013 Jul 12; 28(12): 1699-1705.
Impact Factor: 2.415
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (686 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (493 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (356 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (413 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
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Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, De Palma GD, Salvatore M, Pace L
* Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging? (350 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2011 Mar 21; 17(11): 1427-1433.
Impact Factor: 2.471
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (516 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Giacomobono S, Capacchione D, Lancellotti M, Nardelli A, Gallicchio R, Improta G, Nappi A, Cammarota A, Di Leo A, Pace L, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (279 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
Impact Factor: 4.531
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (399 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
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Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (393 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
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Salvatore B, Simeone R, Fonti R, Marciano R, Bianco R, Damiano V, Tortora G, Pace L, Del Vecchio S, Salvatore M
* 18F-FDG PET/CT in the assessment of early response to chemotherapy and molecularly targeted agents in metastatic colorectal cancer (250 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Vettor R, Granzotto M, De Stefani D, Trevellin E, Rossato M, Farina MG, Milan G, Pilon C, Nigro A, Federspil G, Vigneri R, Vitiello L, Rizzuto R, Baratta R, Frittitta L
* Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization (831 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2008 Sep; 93(9): 3541-3550.
Impact Factor: 6.325
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (326 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Caprio MG, Cantalupo T, Mainenti PP, Mainolfi CG, Varrone A, Salvatore B, Persico F, D'Antonio D, Pace L, Salvatore M
* 18F-fdg pet, pet/ct and ce-mdct in locally advanced colorectal cancer (343 views) (PDF 159 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Storto G, Mainenti PP, Varrone A, Mainolfi C, Salvatore B, Caprio MG, Cella L, Soricelli A, Pace L, Salvatore M
* Role of FDG-PET/CT in the staging of colorectal cancer (427 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (317 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (458 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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Mainenti PP, Romano M, Imbriaco M, Camera L, Pace L, D'Antonio D, Bucci L, Galloro G, Salvatore M
* Added value of CT colonography after a positive conventional colonoscopy: Impact on treatment strategy (452 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2005 Jan; 30(1): 42-47.
Impact Factor: 1.034
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Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (500 views)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (746 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (442 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (656 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (319 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (488 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (2912 views)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
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42 Records (38 excluding Abstracts).
Total impact factor: 149.619 (132.474 excluding Abstracts).
Total 5 year impact factor: 114.279 (95.934 excluding Abstracts).
Total impact factor: 149.619 (132.474 excluding Abstracts).
Total 5 year impact factor: 114.279 (95.934 excluding Abstracts).
444 views. Last view on Monday 11 September 2023, 5:45:42
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