AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (411 views visite)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 6.051, 5-year impact factor Impact factor a 5 anni: 6.183
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77956602248&partnerID=40&md5=895e31d57baac83e8566efac26416163
Keywords Parole chiave: Heart Failure, Mitochondria, Oxygen Radicals, Protein Kinase A, Cyclic Amp, Cyclic Amp Dependent Protein Kinase Anchoring Protein, Protein Akap121, Reactive Oxygen Metabolite, Scaffold Protein, Synthetic Peptide, Unclassified Drug, Animal Experiment, Animal Model, Apoptosis, Article, Cell Death, Cell Survival, Disorders Of Mitochondrial Functions, Down Regulation, Heart Left Ventricle Hypertrophy, Heart Muscle Cell, Heart Ventricle Hypertrophy, In Vivo Study, Mitochondrial Membrane, Nonhuman, Oxidative Stress, Priority Journal, A Kinase Anchor Proteins, Newborn, Binding, Competitive, Cultured, Disease Models, Down-Regulation, Left Ventricular, Inbred C57bl, Myocytes, Cardiac, Smooth Muscle, Wistar, Second Messenger Systems,
Affiliations Affiliazioni:
*** IBB - CNR ***
Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Via Pansini 5, Naples 80131, Italy
Istituto Neurologico Mediterraneo, Pozzilli (IS), Italy
Department of Molecular and Cellular Pathology, Federico II University, Via Pansini 5, Naples 80131, Italy
Istituto di Biostrutture e Bioimmagini (CNR), Naples, Italy
Magna Graecia University, Catanzaro, Italy
References Riferimenti:
Perrino, C., Naga Prasad, S.V., Mao, L., Noma, T., Yan, Z., Kim, H.S., Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction (2006) J Clin Invest, 116, pp. 1547-156
Rockman, H.A., Koch, W.J., Lefkowitz, R.J., Seven-transmembrane-spanning receptors and heart function (2002) Nature, 415, pp. 206-212
Zakhary, D.R., Moravec, C.S., Bond, M., Regulation of PKA binding to AKAPs in the heart: Alterations in human heart failure (2000) Circulation, 101, pp. 1459-1464
Mauban, J.R., O'Donnell, M., Warrier, S., Manni, S., Bond, M., AKAP-scaffolding proteins and regulation of cardiac physiology (2009) Physiology (Bethesda), 24, pp. 78-87
Dodge-Kafka, K.L., Langeberg, L., Scott, J.D., Compartmentation of cyclic nucleotide signaling in the heart: The role of A-kinase anchoring proteins (2006) Circ Res, 98, pp. 993-1001
Indolfi, C., Stabile, E., Coppola, C., Gallo, A., Perrino, C., Allevato, G., Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals (2001) Circ Res, 88, pp. 319-324
Carnegie, G.K., Soughayer, J., Smith, F.D., Pedroja, B.S., Zhang, F., Diviani, D., AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway (2008) Mol Cell, 32, pp. 169-179
Pare, G.C., Bauman, A.L., McHenry, M., Michel, J.J., Dodge-Kafka, K.L., Kapiloff, M.S., The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling (2005) J Cell Sci, 118, pp. 5637-5646
De Windt, L.J., Lim, H.W., Bueno, O.F., Liang, Q., Delling, U., Braz, J.C., Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo (2001) Proc Natl Acad Sci USA, 98, pp. 3322-3327
Carlucci, A., Lignitto, L., Feliciello, A., Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome (2008) Trends Cell Biol, 18, pp. 604-613
Feliciello, A., Rubin, C.S., Avvedimento, E.V., Gottesman, M.E., Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells (1998) J Biol Chem, 273, pp. 23361-23366
Cardone, L., Carlucci, A., Affaitati, A., Livigni, A., Decristofaro, T., Garbi, C., Mitochon-drial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling (2004) Mol Cell Biol, 24, pp. 4613-4626
Livigni, A., Scorziello, A., Agnese, S., Adornetto, A., Carlucci, A., Garbi, C., Mitochon-drial AKAP121 links cAMP and src signaling to oxidative metabolism (2006) Mol Biol Cell, 17, pp. 263-271
Scholten, A., Van Veen, T.A., Vos, M.A., Heck, A.J., Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue (2007) J Proteome Res, 6, pp. 1705-1717
Abrenica, B., Alshaaban, M., Czubryt, M.P., The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy (2009) J Mol Cell Cardiol, 46, pp. 674-681
Indolfi, C., Di Lorenzo, E., Perrino, C., Stingone, A.M., Curcio, A., Torella, D., Hydro-xymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation (2002) Circulation, 106, pp. 2118-2124
Feliciello, A., Gottesman, M.E., Avvedimento, E.V., CAMP-PKA signaling to the mitochondria: Protein scaffolds, mRNA and phosphatases (2005) Cell Signal, 17, pp. 279-287
De Capua, A., Del Gatto, A., Zaccaro, L., Saviano, G., Carlucci, A., Livigni, A., A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A confor-mational study (2004) Biopolymers, 76, pp. 459-466
Baschong, W., Suetterlin, R., Laeng, R.H., Control of autofluorescence of archival formaldehyde-fixed, paraffin-embedded tissue in confocal laser scanning microscopy (CLSM) (2001) J Histochem Cytochem, 49, pp. 1565-1572
Carlucci, A., Adornetto, A., Scorziello, A., Viggiano, D., Foca, M., Cuomo, O., Proteol-ysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia (2008) EMBO J, 27, pp. 1073-1084
Takimoto, E., Kass, D.A., Role of oxidative stress in cardiac hypertrophy and remodeling (2007) Hypertension, 49, pp. 241-248
Papa, S., Scacco, S., Sardanelli, A.M., Petruzzella, V., Vergari, R., Signorile, A., Complex i and the cAMP cascade in human physiopathology (2002) Biosci Rep, 22, pp. 3-16
Harada, H., Becknell, B., Wilm, M., Mann, M., Huang, L.J., Taylor, S.S., Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A (1999) Mol Cell, 3, pp. 413-422
Rockman, H. A., Koch, W. J., Lefkowitz, R. J., Seven-transmembrane-spanning receptors and heart function (2002) Nature, 415, pp. 206-212
Zakhary, D. R., Moravec, C. S., Bond, M., Regulation of PKA binding to AKAPs in the heart: Alterations in human heart failure (2000) Circulation, 101, pp. 1459-1464
Mauban, J. R., O'Donnell, M., Warrier, S., Manni, S., Bond, M., AKAP-scaffolding proteins and regulation of cardiac physiology (2009) Physiology (Bethesda), 24, pp. 78-87
Dodge-Kafka, K. L., Langeberg, L., Scott, J. D., Compartmentation of cyclic nucleotide signaling in the heart: The role of A-kinase anchoring proteins (2006) Circ Res, 98, pp. 993-1001
Carnegie, G. K., Soughayer, J., Smith, F. D., Pedroja, B. S., Zhang, F., Diviani, D., AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway (2008) Mol Cell, 32, pp. 169-179
Pare, G. C., Bauman, A. L., McHenry, M., Michel, J. J., Dodge-Kafka, K. L., Kapiloff, M. S., The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling (2005) J Cell Sci, 118, pp. 5637-5646
De Windt, L. J., Lim, H. W., Bueno, O. F., Liang, Q., Delling, U., Braz, J. C., Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo (2001) Proc Natl Acad Sci USA, 98, pp. 3322-3327
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 6.051, 5-year impact factor Impact factor a 5 anni: 6.183
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77956602248&partnerID=40&md5=895e31d57baac83e8566efac26416163
Keywords Parole chiave: Heart Failure, Mitochondria, Oxygen Radicals, Protein Kinase A, Cyclic Amp, Cyclic Amp Dependent Protein Kinase Anchoring Protein, Protein Akap121, Reactive Oxygen Metabolite, Scaffold Protein, Synthetic Peptide, Unclassified Drug, Animal Experiment, Animal Model, Apoptosis, Article, Cell Death, Cell Survival, Disorders Of Mitochondrial Functions, Down Regulation, Heart Left Ventricle Hypertrophy, Heart Muscle Cell, Heart Ventricle Hypertrophy, In Vivo Study, Mitochondrial Membrane, Nonhuman, Oxidative Stress, Priority Journal, A Kinase Anchor Proteins, Newborn, Binding, Competitive, Cultured, Disease Models, Down-Regulation, Left Ventricular, Inbred C57bl, Myocytes, Cardiac, Smooth Muscle, Wistar, Second Messenger Systems,
Affiliations Affiliazioni:
*** IBB - CNR ***
Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Via Pansini 5, Naples 80131, Italy
Istituto Neurologico Mediterraneo, Pozzilli (IS), Italy
Department of Molecular and Cellular Pathology, Federico II University, Via Pansini 5, Naples 80131, Italy
Istituto di Biostrutture e Bioimmagini (CNR), Naples, Italy
Magna Graecia University, Catanzaro, Italy
References Riferimenti:
Perrino, C., Naga Prasad, S.V., Mao, L., Noma, T., Yan, Z., Kim, H.S., Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction (2006) J Clin Invest, 116, pp. 1547-156
Rockman, H.A., Koch, W.J., Lefkowitz, R.J., Seven-transmembrane-spanning receptors and heart function (2002) Nature, 415, pp. 206-212
Zakhary, D.R., Moravec, C.S., Bond, M., Regulation of PKA binding to AKAPs in the heart: Alterations in human heart failure (2000) Circulation, 101, pp. 1459-1464
Mauban, J.R., O'Donnell, M., Warrier, S., Manni, S., Bond, M., AKAP-scaffolding proteins and regulation of cardiac physiology (2009) Physiology (Bethesda), 24, pp. 78-87
Dodge-Kafka, K.L., Langeberg, L., Scott, J.D., Compartmentation of cyclic nucleotide signaling in the heart: The role of A-kinase anchoring proteins (2006) Circ Res, 98, pp. 993-1001
Indolfi, C., Stabile, E., Coppola, C., Gallo, A., Perrino, C., Allevato, G., Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals (2001) Circ Res, 88, pp. 319-324
Carnegie, G.K., Soughayer, J., Smith, F.D., Pedroja, B.S., Zhang, F., Diviani, D., AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway (2008) Mol Cell, 32, pp. 169-179
Pare, G.C., Bauman, A.L., McHenry, M., Michel, J.J., Dodge-Kafka, K.L., Kapiloff, M.S., The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling (2005) J Cell Sci, 118, pp. 5637-5646
De Windt, L.J., Lim, H.W., Bueno, O.F., Liang, Q., Delling, U., Braz, J.C., Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo (2001) Proc Natl Acad Sci USA, 98, pp. 3322-3327
Carlucci, A., Lignitto, L., Feliciello, A., Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome (2008) Trends Cell Biol, 18, pp. 604-613
Feliciello, A., Rubin, C.S., Avvedimento, E.V., Gottesman, M.E., Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells (1998) J Biol Chem, 273, pp. 23361-23366
Cardone, L., Carlucci, A., Affaitati, A., Livigni, A., Decristofaro, T., Garbi, C., Mitochon-drial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling (2004) Mol Cell Biol, 24, pp. 4613-4626
Livigni, A., Scorziello, A., Agnese, S., Adornetto, A., Carlucci, A., Garbi, C., Mitochon-drial AKAP121 links cAMP and src signaling to oxidative metabolism (2006) Mol Biol Cell, 17, pp. 263-271
Scholten, A., Van Veen, T.A., Vos, M.A., Heck, A.J., Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue (2007) J Proteome Res, 6, pp. 1705-1717
Abrenica, B., Alshaaban, M., Czubryt, M.P., The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy (2009) J Mol Cell Cardiol, 46, pp. 674-681
Indolfi, C., Di Lorenzo, E., Perrino, C., Stingone, A.M., Curcio, A., Torella, D., Hydro-xymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation (2002) Circulation, 106, pp. 2118-2124
Feliciello, A., Gottesman, M.E., Avvedimento, E.V., CAMP-PKA signaling to the mitochondria: Protein scaffolds, mRNA and phosphatases (2005) Cell Signal, 17, pp. 279-287
De Capua, A., Del Gatto, A., Zaccaro, L., Saviano, G., Carlucci, A., Livigni, A., A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A confor-mational study (2004) Biopolymers, 76, pp. 459-466
Baschong, W., Suetterlin, R., Laeng, R.H., Control of autofluorescence of archival formaldehyde-fixed, paraffin-embedded tissue in confocal laser scanning microscopy (CLSM) (2001) J Histochem Cytochem, 49, pp. 1565-1572
Carlucci, A., Adornetto, A., Scorziello, A., Viggiano, D., Foca, M., Cuomo, O., Proteol-ysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia (2008) EMBO J, 27, pp. 1073-1084
Takimoto, E., Kass, D.A., Role of oxidative stress in cardiac hypertrophy and remodeling (2007) Hypertension, 49, pp. 241-248
Papa, S., Scacco, S., Sardanelli, A.M., Petruzzella, V., Vergari, R., Signorile, A., Complex i and the cAMP cascade in human physiopathology (2002) Biosci Rep, 22, pp. 3-16
Harada, H., Becknell, B., Wilm, M., Mann, M., Huang, L.J., Taylor, S.S., Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A (1999) Mol Cell, 3, pp. 413-422
Rockman, H. A., Koch, W. J., Lefkowitz, R. J., Seven-transmembrane-spanning receptors and heart function (2002) Nature, 415, pp. 206-212
Zakhary, D. R., Moravec, C. S., Bond, M., Regulation of PKA binding to AKAPs in the heart: Alterations in human heart failure (2000) Circulation, 101, pp. 1459-1464
Mauban, J. R., O'Donnell, M., Warrier, S., Manni, S., Bond, M., AKAP-scaffolding proteins and regulation of cardiac physiology (2009) Physiology (Bethesda), 24, pp. 78-87
Dodge-Kafka, K. L., Langeberg, L., Scott, J. D., Compartmentation of cyclic nucleotide signaling in the heart: The role of A-kinase anchoring proteins (2006) Circ Res, 98, pp. 993-1001
Carnegie, G. K., Soughayer, J., Smith, F. D., Pedroja, B. S., Zhang, F., Diviani, D., AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway (2008) Mol Cell, 32, pp. 169-179
Pare, G. C., Bauman, A. L., McHenry, M., Michel, J. J., Dodge-Kafka, K. L., Kapiloff, M. S., The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling (2005) J Cell Sci, 118, pp. 5637-5646
De Windt, L. J., Lim, H. W., Bueno, O. F., Liang, Q., Delling, U., Braz, J. C., Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo (2001) Proc Natl Acad Sci USA, 98, pp. 3322-3327
AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress
The aim of the present study was to determine the function and the role of the scaffold protein AKAP121, tethering cAMP dependent protein kinase A to the outer wall of mitochondria, in neonatal ventricular myocytes and the heart. Competitive peptides displacing AKAP121 from mitochondria in the tissue and in the cells were used to investigate the role of AKAP121 in mitochondrial function, reactive oxygen species (ROS) generation, and cell survival. Displacement of AKAP121 from mitochondria by synthetic peptides triggers the death program in cardiomyocytes. Under pathological conditions in vivo, in a rat model of cardiac hypertrophy induced by ascending aorta banding, the levels of AKAP121 are significantly down-regulated. Disappearance of AKAP121 is associated with mitochondrial dysfunction, high oxidative stress, and apoptosis. In vivo delocalization of AKAP121 by competitive peptides replicates some of the molecular signatures induced by pressure overload: mitochondrial dysfunction, increased mitochondrial ROS, and apoptosis. These data suggest that AKAP121 regulates the response to stress in cardiomyocytes, and therefore AKAP121 downregulation might represent an important event contributing to the development of cardiac dysfunction.
The aim of the present study was to determine the function and the role of the scaffold protein AKAP121, tethering cAMP dependent protein kinase A to the outer wall of mitochondria, in neonatal ventricular myocytes and the heart. Competitive peptides displacing AKAP121 from mitochondria in the tissue and in the cells were used to investigate the role of AKAP121 in mitochondrial function, reactive oxygen species (ROS) generation, and cell survival. Displacement of AKAP121 from mitochondria by synthetic peptides triggers the death program in cardiomyocytes. Under pathological conditions in vivo, in a rat model of cardiac hypertrophy induced by ascending aorta banding, the levels of AKAP121 are significantly down-regulated. Disappearance of AKAP121 is associated with mitochondrial dysfunction, high oxidative stress, and apoptosis. In vivo delocalization of AKAP121 by competitive peptides replicates some of the molecular signatures induced by pressure overload: mitochondrial dysfunction, increased mitochondrial ROS, and apoptosis. These data suggest that AKAP121 regulates the response to stress in cardiomyocytes, and therefore AKAP121 downregulation might represent an important event contributing to the development of cardiac dysfunction.
AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress
AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (442 visite)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Lelli D, Pedone C, Rossi FF, Incalzi RA
* Clinical and echocardiographic characteristics of elderly hospitalized patients with high levels of NT-proBNP without clinical diagnosis of heart failure (221 visite)
Aging Clin Exp Res (ISSN: 1594-0667, 1720-8319), 2014 Dec; 26(6): 607-613.
Impact Factor: 1.215
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (389 visite)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
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Petretta M, Pellegrino T, Cuocolo A
* Cardiac Neuronal Imaging With 123i-Meta-Iodobenzylguanidine In Heart Failure: Implications Of Endpoint Selection And Quantitative Analysis On Clinical Decisions (261 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Sep; 41(9): 1663-1665.
Impact Factor: 5.383
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (486 visite)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Giua R, Pedone C, Scarlata S, Carrozzo I, Rossi FF, Valiani V, Incalzi RA
* Relationship between respiratory muscle strength and physical performance in elderly hospitalized patients (272 visite)
Rejuv Res (ISSN: 1549-1684, 1557-8577), 2014 Sep; 17(4): 366-371.
Impact Factor: 3.311
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (895 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
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Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G
* Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization (230 visite)
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2014 Apr 8; 10: 3-7.
Impact Factor: 2.256
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Petretta M, Cuocolo A
Letter by Petretta and Cuocolo regarding article, "Four-variable risk model in men and women with heart failure" (267 visite)
Circ-Heart Fail (ISSN: 1941-3289), 2014 Mar 1; 7(2): 380-380.
Impact Factor: 5.867
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (525 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Petretta M, Petretta A, Pellegrino T, Nappi C, Cantoni V, Cuocolo A
* Nuclear Cardiology in Heart Failure (333 visite)
Curr Cardiovasc Imaging Rep (ISSN: 1941-9066), 2014 Jan; 7(3): 1-7.
Impact Factor: 0
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Giuffrida ML, Rizzarelli E, Tomaselli GA, Satriano C, Trusso Sfrazzetto G
* A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging (347 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2014; 50(69): 9835-9838.
Impact Factor: 6.834
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (502 visite)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
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Petretta M, Pellegrino T, Cuocolo A
* The "gray Zone" For The Heart To Mediastinum Mibg Uptake Ratio (284 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2014; 21(5): 921-924.
Impact Factor: 2.942
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Paolillo S, Rengo G, Pellegrino T, Formisano R, Savarese G, Pagano G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Insulin Resistance is Associated With Impaired Cardiac Sympathetic Innervation in Patients Affected by Heart Failure (237 visite)
Amyloid, 2013 Nov 26; 34: N/D-N/D.
Impact Factor: 2.51
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Pellegrino T, Petretta M, Paolillo S, Boemio A, Carotenuto R, Petretta MP, Di Nuzzo C, Perrone-filardi P, Cuocolo A
* Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure (369 visite)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2013 Oct; 40(10): 1549-1557.
Impact Factor: 5.217
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Pellegrino T, Petretta M, Boemio A, Carotenuto R, Petretta MP, Paolillo S, Filardi PP, Cuocolo A
* Reliability and Agreement of Planar and Single-Photon Emission Computed Tomography 123I-Metaiodobenzylguanidine Cardiac Imaging in Patients with Heart Failure (221 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (288 visite)
Diabetes Care (ISSN: 1935-5548, 0149-5992), 2013 Sep; 36(8): 2395-2401.
Impact Factor: 8.57
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (391 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (440 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Scala O, Paolillo S, Rengo G, Pagano G, Formisano R, Pellegrino T, De Michele F, Starace A, Cirillo A, Vitagliano A, Formisano T, Leosco D, Cuocolo A, Perrone-Filardi P
* EFFECTS OF SLEEP APNEA ON CARDIAC SYMPATHETIC ACTIVITY IN PATIENTS WITH SEVERE SYSTOLIC HEART FAILURE: A (123)MIBG SCINTIGRAPHIC STUDY (211 visite)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2013 Mar 12; 61(10): N/D-N/D.
Impact Factor: 15.343
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* IMPACT OF DIABETES MELLITUS IN IODINE-123 META-IODOBENZYLGUANIDINE (I123MIBG) CARDIAC UPTAKE IN PATIENTS WITH HEART FAILURE (221 visite)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2013 Mar 12; 61(10): 2395-2401.
Impact Factor: 15.343
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Camera L, Campanile F, Imbriaco M, Ippolito R, Sirignano C, Santoro C, Galderisi M, Salvatore M
* Idiopathic pulmonary fibrosis complicated by acute thromboembolic disease: Chest X-ray, HRCT and multi-detector row CT angiographic findings (258 visite) (PDF 4 visite)
J Thorac Dis (ISSN: 2072-1439), 2013 Feb; 5(1): 82-86.
Impact Factor: 0.895
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Petretta M, Acampa W, Fiumara G, Cuocolo A
* Cardiovascular risk stratification in diabetic patients (162 visite)
Clin Transl Imaging (ISSN: 2281-5872, 2281-5872print, 2281-7565online), 2013; 1(5): 325-339.
Impact Factor: 0
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (358 visite)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (356 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (433 visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Pellegrino T, Gargiulo P, Rengo G, Pagano G, Tuccillo M, Boemio A, Leosco D, Filardi PP, Cuocolo A
* Diabetes-dependent Cardiac Sympathetic Denervation in Patients with Left Ventricular Dysfunction is Independent from Heart Failure Status (228 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
Impact Factor: 5.114
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (2337 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Gargiulo P, Rengo G, Pagano G, Pellegrino T, Liccardo D, Femminella GD, De Lucia C, Attena E, Leosco D, Cuocolo A, Filardi PP
* DIABETES IS ASSOCIATED WITH HIGHER CARDIAC SYMPATHETIC DENERVATION IN PATIENTS WITH LEFT VENTRICLE DYSFUNCTION INDEPENDENTLY FROM HEART FAILURE STATUS (226 visite)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2012 Mar 27; 59(13): N/D-N/D.
Impact Factor: 14.086
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (307 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (386 visite)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (353 visite)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
* Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal (303 visite)
Heart (ISSN: 1468-201x, 1355-6037), 2011 Nov; 97(22): 1828-1833.
Impact Factor: 4.223
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (480 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (342 visite)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (238 visite)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Impact Factor: 4.512
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (343 visite)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (407 visite)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (509 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (404 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (740 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (481 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (469 visite)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (453 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (541 visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (314 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (374 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (322 visite)
J Cardiovasc Electrophysiol (ISSN: 1045-3873), 2007; 18(4): 425-433.
Impact Factor: 3.475
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (518 visite)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (316 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (324 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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Dellegrottaglie S, Perrone-filardi P, Pace L, Prastaro M, Corrado L, Cafiero M, Della Morte AM, Zarrilli A, Camerino R, Polimeno M, Chiarillo M
* The identification of reversible dysfunctional myocardium is influenced by the severity of contractile dysfunction and by the length of follow-up (250 visite)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2005 Apr; 26(4): 337-343.
Impact Factor: 1.097
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Acampa W, Petretta M, Evangelista L, Petretta A, Cuocolo A
* Radionuclide Imaging in Patients with Ischemic Heart Failure (197 visite)
Curr Med Imaging Rev (ISSN: 1573-4056, 1573-4056linking), 2005 Jan; 1(1): N/D-N/D.
Impact Factor: 1.059
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Santomauro M, Pace L, Duilio C, Ottaviano L, Borrelli A, Ferro A, Monteforte N, Cuocolo A, Salvatore M, Chiariello M
* Left ventricular pacing in patients with heart failure: Evaluation study with Fourier analysis of radionuclide ventriculography (248 visite)
Ital Heart J (ISSN: 1129-471x), 2004 Dec; 5(12): 906-911.
Impact Factor: 6.023
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (427 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (371 visite)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (484 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Petretta M, Vicario ML, Spinelli L, Ferro A, Cuocolo A, Condorelli M, Bonaduce D
* Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy (286 visite)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2002 Dec; 4(6): 727-735.
Impact Factor: 2.134
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (443 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (426 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Ferro A, Salvatore M, Cuocolo A
* Radionuclide monitoring of left ventricular function after sublingual nifedipine administration at rest and during moderate physical activity (274 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2001 Sep; 8(6): 669-676.
Impact Factor: 1.868
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Pace L, Nappi A, Imbriaco M, Cuocolo A, Varrone A, Romano M, Trimarco B, Salvatore M
Relationship between exercise capacity and left ventricular function at rest in patients with heart failure. An ambulatory left ventricular monitoring study (243 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 100(3): 120-125.
Impact Factor: 1.368
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (365 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
[Effects left ventricle asynchrony on systolic and diastolic function in patients with non-ischemic heart failure] (214 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998 Jul; 96(1-2): 68-72.
Impact Factor: 0.967
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Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
Influence of left ventricular asynchrony on systolic and diastolic function in patients with nonischemic heart failure (261 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998; 96(1-2): 68-72.
Impact Factor: 0.967
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (311 visite)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Nappi A, Cuocolo A, Imbriaco M, Nicolai E, Varrone A, Morisco C, Romano M, Trimarco B, Salvatore M
Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure (276 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Jun; 38(6): 948-953.
Impact Factor: 3.491
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Pace L, Nappi A, Cuocolo A, Varrone A, Romano M, Salvatore M
Exercise capacity and left ventricular function at rest in patients with heart failure (219 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Morisco C, Cuocolo A, Romano M, Nappi A, Iaccarino G, Volpe M, Salvatore M, Trimarco B
Influence of digitalis on left ventricular functional response to exercise in congestive heart failure (382 visite)
Am J Cardiol (ISSN: 0002-9149), 1996 Mar 1; 77(7): 480-485.
Impact Factor: 2.402
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (450 visite)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Russo R, Rao MA, Romano M, Scotto Di Santolo M, Cardei S, Giunta A, Cuocolo A, Volpe M
Prospects of pharmacologic treatment of post-ischemic heart failure (190 visite)
Cardiologia (ISSN: 0393-1978), 1995 Dec; 40(12Suppl1): 533-537.
Impact Factor: 0
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Morisco C, Nappi A, Argenziano L, Sarno D, Fonatana D, Imbriaco M, Nicolai E, Romano M, Rosiello G, Cuocolo A
Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: Effects of short-term Coenzyme Q10 treatment (314 visite)
Molecular Aspects Of Medicine (ISSN: 0098-2997, 1872-9452), 1994; 15(SUPPL.1): s155-s155.
Impact Factor: 2
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Morisco C, Argenziano L, Sarno D, Cuocolo A, Romano M, Trimarco B
The practical aspects of treatment in heart failure (328 visite)
Ann Ital Med Int (ISSN: 0393-9340), 1993 Oct; 8Suppl: 14S-19S.
Impact Factor: 0
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91 Records (78 escludendo Abstract e Conferenze).
Impact factor totale: 401.497 (334.152 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 387.04 (309.891 escludendo Abstract e Conferenze).
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Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O , #rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N
* Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy (108 visite)
Sci Transl Med (ISSN: 1946-6234linking), 2021 Feb 17; 13(581): N/D-N/D.
Impact Factor: 17.956
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (85 visite) (PDF 79 visite)
J Clin Med (ISSN: 2077-0383linking), 2020 Jan 4; 9(1): N/D-N/D.
Impact Factor: 5.688
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Palmiero G, Melillo E, Ferro A, Carlomagno G, Sordelli C, Ascione R, Monda V, Severino S, Ascione L, Caso P
* Significant functional mitral regurgitation affects left atrial function in heart failure patients: haemodynamic correlations and prognostic implications (126 visite)
Eur Heart J-Card Img (ISSN: 2047-2404linking, 2047-2412), 2019 Mar 12; 20(9): 1012-1019.
Impact Factor: 3.669
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Barone R, Alaimo S, Messina M, Pulvirenti A, Bastin J, Group MIMIC-A, F , Frye RE, Rizzo (mimic-ag A, Fiumara R, Meli C, Gulisano M, Maugeri F, Prato A, Russo G, Tabbì G
* A Subset of Patients With Autism Spectrum Disorders Show a Distinctive Metabolic Profile by Dried Blood Spot Analyses (156 visite) (PDF 96 visite)
Front Psychiatry (ISSN: 1664-0640linking), 2018 Dec 7; 9: 636-636.
Impact Factor: 2.857
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De Michele G, Sorrentino P, Nesti C, Rubegni A, Ruggiero L, Peluso S, Antenora A, Quarantelli M, Filla A, De Michele G, Santorelli FM
* Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome (244 visite)
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 30; 9(AUG): 728-728.
Impact Factor: 3.508
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Cocozza S, Costabile T, Tedeschi E, Abate F, Russo C, Liguori A, Del Vecchio W, Paciello F, Quarantelli M, Filla A, Brunetti A, Saccà F
* Cognitive and functional connectivity alterations in Friedreich's ataxia (446 visite)
Ann Clin Transl Neurol (ISSN: 2328-9503linking, 2328-9503electronic), 2018 Apr 14; 5(6): 677-686.
Impact Factor: 4.649
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Skiba J, Bernas T, Trzybinski D, Wozniak K, Ferraro G, Marasco D, Merlino A, Shafikov MZ, Czerwieniec R, Kowalski K
* Mitochondria Targeting with Luminescent Rhenium(I) Complexes (301 visite)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2017 May 15; 22(5): N/D-N/D.
Impact Factor: 3.098
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Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
* Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (443 visite)
Acs Med Chem Lett (ISSN: 1948-5875), 2016 Sep 26; 7(12): 1145-1150.
Impact Factor: 3.746
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Rengo G, Pagano G, Vitale DF, Formisano R, Komici K, Petraglia L, Parisi V, Femminella GD, De Lucia C, Paolillo S, Cannavo A, Attena E, Pellegrino T, Dellegrottaglie S, Memmi A, Trimarco B, Cuocolo A, Filardi PP, Leosco D, Ferrara N
* Impact of aging on cardiac sympathetic innervation measured by 123I-mIBG imaging in patients with systolic heart failure (177 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jun 10; N/D: N/D-N/D.
Impact Factor: 7.277
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Parisi V, Rengo G, Perrone-filardi P, Pagano G, Femminella GD, Paolillo S, Petraglia L, Gambino G, Caruso A, Grimaldi MG, Baldascino F, Nolano M, Elia A, Cannavo A, De Bellis A, Coscioni E, Pellegrino T, Cuocolo A, Ferrara N, Leosco D
* Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure (184 visite)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2016 Apr 15; 118(8): 1244-1253.
Impact Factor: 13.965
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Magri A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V
* Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes (327 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Mar 4; 1857(6): 789-798.
Impact Factor: 4.932
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Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (228 visite)
Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315.
Impact Factor: 0
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De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (614 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (432 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
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Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
* New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (355 visite)
Br J Cancer (ISSN: 0007-0920, 0007-0920print), 2015 Jan 6; 112(1): 77-85.
Impact Factor: 5.569
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Pellegrino T, Piscopo V, Petretta M, Cuocolo A
* 123I-Metaiodobenzylguanidine cardiac innervation imaging: methods and interpretation (189 visite)
Clin Transl Imaging (ISSN: 2281-5872, 2281-5872print, 2281-7565online), 2015; 3(5): 357-363.
Impact Factor: 0
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Leosco D, Parisi V, Pellegrino T, Pagano G, Femminella GD, Bevilacqua A, Paolillo S, Formisano R, Ferro G, de Lucia C, Prastaro M, Filardi PP, Cuocolo A, Rengo G, Ferrara N
* Alterations of left ventricular deformation and cardiac sympathetic derangement in patients with systolic heart failure: a 3D speckle tracking echocardiography and cardiac 123I-MIBG study (320 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42(10): 1601-1611.
Impact Factor: 5.537
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (442 visite)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Lelli D, Pedone C, Rossi FF, Incalzi RA
* Clinical and echocardiographic characteristics of elderly hospitalized patients with high levels of NT-proBNP without clinical diagnosis of heart failure (221 visite)
Aging Clin Exp Res (ISSN: 1594-0667, 1720-8319), 2014 Dec; 26(6): 607-613.
Impact Factor: 1.215
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (389 visite)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
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Petretta M, Pellegrino T, Cuocolo A
* Cardiac Neuronal Imaging With 123i-Meta-Iodobenzylguanidine In Heart Failure: Implications Of Endpoint Selection And Quantitative Analysis On Clinical Decisions (261 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Sep; 41(9): 1663-1665.
Impact Factor: 5.383
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (486 visite)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Giua R, Pedone C, Scarlata S, Carrozzo I, Rossi FF, Valiani V, Incalzi RA
* Relationship between respiratory muscle strength and physical performance in elderly hospitalized patients (272 visite)
Rejuv Res (ISSN: 1549-1684, 1557-8577), 2014 Sep; 17(4): 366-371.
Impact Factor: 3.311
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (895 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
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Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G
* Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization (230 visite)
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2014 Apr 8; 10: 3-7.
Impact Factor: 2.256
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Petretta M, Cuocolo A
Letter by Petretta and Cuocolo regarding article, "Four-variable risk model in men and women with heart failure" (267 visite)
Circ-Heart Fail (ISSN: 1941-3289), 2014 Mar 1; 7(2): 380-380.
Impact Factor: 5.867
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (525 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Petretta M, Petretta A, Pellegrino T, Nappi C, Cantoni V, Cuocolo A
* Nuclear Cardiology in Heart Failure (333 visite)
Curr Cardiovasc Imaging Rep (ISSN: 1941-9066), 2014 Jan; 7(3): 1-7.
Impact Factor: 0
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Giuffrida ML, Rizzarelli E, Tomaselli GA, Satriano C, Trusso Sfrazzetto G
* A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging (347 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2014; 50(69): 9835-9838.
Impact Factor: 6.834
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (502 visite)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
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Petretta M, Pellegrino T, Cuocolo A
* The "gray Zone" For The Heart To Mediastinum Mibg Uptake Ratio (284 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2014; 21(5): 921-924.
Impact Factor: 2.942
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Paolillo S, Rengo G, Pellegrino T, Formisano R, Savarese G, Pagano G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Insulin Resistance is Associated With Impaired Cardiac Sympathetic Innervation in Patients Affected by Heart Failure (237 visite)
Amyloid, 2013 Nov 26; 34: N/D-N/D.
Impact Factor: 2.51
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Pellegrino T, Petretta M, Paolillo S, Boemio A, Carotenuto R, Petretta MP, Di Nuzzo C, Perrone-filardi P, Cuocolo A
* Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure (369 visite)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2013 Oct; 40(10): 1549-1557.
Impact Factor: 5.217
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Pellegrino T, Petretta M, Boemio A, Carotenuto R, Petretta MP, Paolillo S, Filardi PP, Cuocolo A
* Reliability and Agreement of Planar and Single-Photon Emission Computed Tomography 123I-Metaiodobenzylguanidine Cardiac Imaging in Patients with Heart Failure (221 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (288 visite)
Diabetes Care (ISSN: 1935-5548, 0149-5992), 2013 Sep; 36(8): 2395-2401.
Impact Factor: 8.57
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (391 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (440 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Scala O, Paolillo S, Rengo G, Pagano G, Formisano R, Pellegrino T, De Michele F, Starace A, Cirillo A, Vitagliano A, Formisano T, Leosco D, Cuocolo A, Perrone-Filardi P
* EFFECTS OF SLEEP APNEA ON CARDIAC SYMPATHETIC ACTIVITY IN PATIENTS WITH SEVERE SYSTOLIC HEART FAILURE: A (123)MIBG SCINTIGRAPHIC STUDY (211 visite)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2013 Mar 12; 61(10): N/D-N/D.
Impact Factor: 15.343
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* IMPACT OF DIABETES MELLITUS IN IODINE-123 META-IODOBENZYLGUANIDINE (I123MIBG) CARDIAC UPTAKE IN PATIENTS WITH HEART FAILURE (221 visite)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2013 Mar 12; 61(10): 2395-2401.
Impact Factor: 15.343
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Camera L, Campanile F, Imbriaco M, Ippolito R, Sirignano C, Santoro C, Galderisi M, Salvatore M
* Idiopathic pulmonary fibrosis complicated by acute thromboembolic disease: Chest X-ray, HRCT and multi-detector row CT angiographic findings (258 visite) (PDF 4 visite)
J Thorac Dis (ISSN: 2072-1439), 2013 Feb; 5(1): 82-86.
Impact Factor: 0.895
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Petretta M, Acampa W, Fiumara G, Cuocolo A
* Cardiovascular risk stratification in diabetic patients (162 visite)
Clin Transl Imaging (ISSN: 2281-5872, 2281-5872print, 2281-7565online), 2013; 1(5): 325-339.
Impact Factor: 0
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (358 visite)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (356 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (433 visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Pellegrino T, Gargiulo P, Rengo G, Pagano G, Tuccillo M, Boemio A, Leosco D, Filardi PP, Cuocolo A
* Diabetes-dependent Cardiac Sympathetic Denervation in Patients with Left Ventricular Dysfunction is Independent from Heart Failure Status (228 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
Impact Factor: 5.114
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (2337 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Gargiulo P, Rengo G, Pagano G, Pellegrino T, Liccardo D, Femminella GD, De Lucia C, Attena E, Leosco D, Cuocolo A, Filardi PP
* DIABETES IS ASSOCIATED WITH HIGHER CARDIAC SYMPATHETIC DENERVATION IN PATIENTS WITH LEFT VENTRICLE DYSFUNCTION INDEPENDENTLY FROM HEART FAILURE STATUS (226 visite)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2012 Mar 27; 59(13): N/D-N/D.
Impact Factor: 14.086
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (307 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (386 visite)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (353 visite)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
* Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal (303 visite)
Heart (ISSN: 1468-201x, 1355-6037), 2011 Nov; 97(22): 1828-1833.
Impact Factor: 4.223
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (480 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (342 visite)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (238 visite)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Impact Factor: 4.512
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (343 visite)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (407 visite)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (509 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (404 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (740 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (481 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (469 visite)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (453 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (541 visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (314 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (374 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (322 visite)
J Cardiovasc Electrophysiol (ISSN: 1045-3873), 2007; 18(4): 425-433.
Impact Factor: 3.475
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (518 visite)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (316 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (324 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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Dellegrottaglie S, Perrone-filardi P, Pace L, Prastaro M, Corrado L, Cafiero M, Della Morte AM, Zarrilli A, Camerino R, Polimeno M, Chiarillo M
* The identification of reversible dysfunctional myocardium is influenced by the severity of contractile dysfunction and by the length of follow-up (250 visite)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2005 Apr; 26(4): 337-343.
Impact Factor: 1.097
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Acampa W, Petretta M, Evangelista L, Petretta A, Cuocolo A
* Radionuclide Imaging in Patients with Ischemic Heart Failure (197 visite)
Curr Med Imaging Rev (ISSN: 1573-4056, 1573-4056linking), 2005 Jan; 1(1): N/D-N/D.
Impact Factor: 1.059
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Santomauro M, Pace L, Duilio C, Ottaviano L, Borrelli A, Ferro A, Monteforte N, Cuocolo A, Salvatore M, Chiariello M
* Left ventricular pacing in patients with heart failure: Evaluation study with Fourier analysis of radionuclide ventriculography (248 visite)
Ital Heart J (ISSN: 1129-471x), 2004 Dec; 5(12): 906-911.
Impact Factor: 6.023
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (427 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (371 visite)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (484 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Petretta M, Vicario ML, Spinelli L, Ferro A, Cuocolo A, Condorelli M, Bonaduce D
* Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy (286 visite)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2002 Dec; 4(6): 727-735.
Impact Factor: 2.134
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (443 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (426 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Ferro A, Salvatore M, Cuocolo A
* Radionuclide monitoring of left ventricular function after sublingual nifedipine administration at rest and during moderate physical activity (274 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2001 Sep; 8(6): 669-676.
Impact Factor: 1.868
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Pace L, Nappi A, Imbriaco M, Cuocolo A, Varrone A, Romano M, Trimarco B, Salvatore M
Relationship between exercise capacity and left ventricular function at rest in patients with heart failure. An ambulatory left ventricular monitoring study (243 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 100(3): 120-125.
Impact Factor: 1.368
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (365 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
[Effects left ventricle asynchrony on systolic and diastolic function in patients with non-ischemic heart failure] (214 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998 Jul; 96(1-2): 68-72.
Impact Factor: 0.967
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Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
Influence of left ventricular asynchrony on systolic and diastolic function in patients with nonischemic heart failure (261 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998; 96(1-2): 68-72.
Impact Factor: 0.967
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (311 visite)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Nappi A, Cuocolo A, Imbriaco M, Nicolai E, Varrone A, Morisco C, Romano M, Trimarco B, Salvatore M
Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure (276 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Jun; 38(6): 948-953.
Impact Factor: 3.491
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Pace L, Nappi A, Cuocolo A, Varrone A, Romano M, Salvatore M
Exercise capacity and left ventricular function at rest in patients with heart failure (219 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Morisco C, Cuocolo A, Romano M, Nappi A, Iaccarino G, Volpe M, Salvatore M, Trimarco B
Influence of digitalis on left ventricular functional response to exercise in congestive heart failure (382 visite)
Am J Cardiol (ISSN: 0002-9149), 1996 Mar 1; 77(7): 480-485.
Impact Factor: 2.402
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (450 visite)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Russo R, Rao MA, Romano M, Scotto Di Santolo M, Cardei S, Giunta A, Cuocolo A, Volpe M
Prospects of pharmacologic treatment of post-ischemic heart failure (190 visite)
Cardiologia (ISSN: 0393-1978), 1995 Dec; 40(12Suppl1): 533-537.
Impact Factor: 0
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Morisco C, Nappi A, Argenziano L, Sarno D, Fonatana D, Imbriaco M, Nicolai E, Romano M, Rosiello G, Cuocolo A
Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: Effects of short-term Coenzyme Q10 treatment (314 visite)
Molecular Aspects Of Medicine (ISSN: 0098-2997, 1872-9452), 1994; 15(SUPPL.1): s155-s155.
Impact Factor: 2
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Morisco C, Argenziano L, Sarno D, Cuocolo A, Romano M, Trimarco B
The practical aspects of treatment in heart failure (328 visite)
Ann Ital Med Int (ISSN: 0393-9340), 1993 Oct; 8Suppl: 14S-19S.
Impact Factor: 0
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91 Records (78 escludendo Abstract e Conferenze).
Impact factor totale: 401.497 (334.152 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 387.04 (309.891 escludendo Abstract e Conferenze).
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